• In human monocytic cell lines U-937 and THP-1, LeTx induced cell cycle arrest in Go-Gi phase by rapid down-regulation of cyclin D1/D2 and checkpoint kinase 1 through MEK1 inhibition. (uwo.ca)
  • cyclin dependent kinase 4 [Source:HGNC Symb. (gsea-msigdb.org)
  • cyclin dependent kinase inhibitor 1A [Sourc. (gsea-msigdb.org)
  • ATCC CCL-243) were probed with the mouse anti-human cyclin A antibody at concentration of 2.0 µg/mL (lane 1), 1.0 µg/mL (lane 2), and 0.5 µg/mL (lane 3). (bdbiosciences.com)
  • G1/S-specific cyclin-D2 is a protein that in humans is encoded by the CCND2 gene. (wikipedia.org)
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. (wikipedia.org)
  • In silico analysis of the mouse, rat, and human cyclin D2 promoters identified two CRE-binding protein sites, a conserved proximal element and a less conserved distal element relative to the translation start site. (montclair.edu)
  • In this study, we evaluated cyclin D1, D2 and D3 protein expression in AL amyloidosis, and compared cyclin D positivity to other conventional laboratory parameters as a diagnostic tool and as a potential biomarker for minimal residual disease. (bmj.com)
  • Specific substrates for cdk-cyclin complexes include nuclear lamins, histones, oncogenes (e.g., c-abl and SV40 large T-Ag), tumor suppressor genes (e.g., retinoblastoma protein, Rb), nucleolin and others. (bdbiosciences.com)
  • Faha B, Ewen ME, Tsai LH, Livingston DM, Harlow E. Interaction between human cyclin A and adenovirus E1A-associated p107 protein. (bdbiosciences.com)
  • In each of the two cases, the amplified cyclin gene was overexpressed at the protein or mRNA level. (elsevierpure.com)
  • Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. (cusabio.cn)
  • Our results provide novel insights into the function of EBNA3C on cell progression by regulating the cyclin D2 protein and raise the possibility of the development of new anticancer therapies against EBV-associated cancers. (cusabio.cn)
  • These data suggest that a variety of cyclin genes can play a role in human tumorigenesis and that cyclins D2 and E are particularly important in a subset of colorectal neoplasms. (elsevierpure.com)
  • The main cyclin-cdks complexes formed in vertebrate cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1 (G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins including p21 and p27Kip1. (bdbiosciences.com)
  • As normal cells entered density-dependent arrest, cyclin D1 decreased while cyclin D2 was induced and replaced D1 in Cdk4 complexes. (ku.dk)
  • Cyclins (regulatory subunits) bind to cdks (catalytic subunits) to form complexes that regulate the progression of the cell cycle. (bdbiosciences.com)
  • Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. (cusabio.cn)
  • Using primary cultures of rat granulosa cells and immortalized mouse granulosa cells, we demonstrate a mechanism for the regulation of cyclin D2 at the level of transcription via a PKA-dependent signaling mechanism. (montclair.edu)
  • In occasional cells, this crossing over may lead to increased 12p copy number and overexpression of cyclin D2. (medscape.com)
  • The genetic status of cyclin genes was examined in a panel of 47 colorectal carcinoma cell lines. (elsevierpure.com)
  • CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)
  • PTBP1 controls mRNA abundance and alternative splicing of important cell cycle regulators including CYCLIN-D2, c-MYC, p107 and CDC25B. (ox.ac.uk)
  • This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. (wikipedia.org)
  • The promoter activity of cyclin D2 was shown to be induced by FSH and the catalytic alpha subunit of PKA (PRKACA), and this activity was repressible by inducible cAMP early repressor (ICER), a cAMP response element (CRE) modulator isoform. (montclair.edu)
  • Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. (wikipedia.org)
  • Expression of cyclin D1, cyclin D2, and N-myc in embryos of the direct" by Kimberly Nath, Cara Fisher et al. (duq.edu)
  • cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression. (umassmed.edu)
  • the majority of patients have dysregulated cyclin D expression. (bmj.com)
  • Both CCND1- and CCND2-expressing MM cells arrested in S/G2/M, and did not differ in other cell-cycle proteins or sensitivity to IR.Differential expression of D-cyclin does not appear to affect cell-cycle response to IR, and is unlikely to underlie differential sensitivity to DNA damage. (cusabio.cn)
  • Cyclin D2 gene variance and expression level in pediatric acute lymphoblastic leukemia. (cdc.gov)
  • Activated Akt inhibited GSK3 and prevented proteasome-mediated cyclin D1 degradation in LeTx-intoxicated THP-1 cells. (uwo.ca)
  • These results showed a CRE within the upstream region of Ccnd2 that is (at least partly) implicated in the stimulation and repression of cyclin D2 transcription. (montclair.edu)
  • Human cyclin A has been reported to migrate between 54-60 kDa by SDS-PAGE and clone BF683 reportedly does not cross-react with mouse, rat or mink cyclin A. (bdbiosciences.com)
  • Surprisingly, this delayed arrest was molecularly distinct from contact inhibition of normal cells, as it occurred in the absence of p27 Kip1 induction and cyclin D1 levels remained high. (ku.dk)
  • Cyclin A may also form a complex with the adenovirus oncoprotein E1A which has DNA binding activity. (bdbiosciences.com)
  • Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. (wikipedia.org)
  • Cyclin A is involved in both S-phase and G2/M transitions of the cell cycle through its association with cdk2 and cdk1, respectively. (bdbiosciences.com)
  • Cyclin Dl, previously shown to be amplified in breast and other tumors, was not amplified in these cancers. (elsevierpure.com)