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  • dependent
  • The results question the role of calmodulin in the Ca2+-dependent rise in cyclic AMP evoked by glucose in pancreatic islets. (biochemj.org)
  • Transcription activation at two semi-synthetic Escherichia coli promoters, CC(-41.5) and CC(-72.5), is dependent on the cyclic AMP receptor protein (CRP) that binds to sites centred 41.5 and 72.5 bp upstream from the respective transcription startpoints. (biochemj.org)
  • It is suggested that, although desensitization of glucagon-stimulated adenylate cyclase is elicited by a cyclic AMP-independent process, the resensitization of adenylate cyclase can be inhibited by a process which is dependent on elevated cyclic AMP concentrations. (biochemj.org)
  • rise
  • giving 50% of maximal effect) of 26 +/- 5 microM, which was similar to the EC50 value of 22 +/- 6 microM observed for the ability of IBMX to augment the glucagon-stimulated rise in intracellular cyclic AMP concentrations. (biochemj.org)
  • Sutherland
  • Brain tissue is rich in cyclic AMP, which is unevenly distributed in rat brain particulate material associated with the nuclear and mitochondrial fractions (Sutherland et al . (springer.com)
  • Sutherland continued his work on cyclic AMP, receiving financial support from the Career Investigatorship awarded to him by the American Heart Association in 1967. (wikipedia.org)
  • While working in Cori's laboratory, Sutherland, with the help of his co-workers, made several discoveries concerning the mechanism of glycogen metabolism that, years later, led him to his discovery of the biological activity of cyclic AMP. (wikipedia.org)
  • mediates
  • The close parallelism between changes in contractile amplitude and in cyclic AMP produced by histamine in the absence and in the presence of burimamide is in accordance with the concept that cyclic AMP mediates the mechanical response of the heart to histamide. (springer.com)
  • inhibition
  • We discovered that CXCL12-dependent tumor growth is dependent upon sustained inhibition of cyclic AMP (cAMP) production, and that the antitumor activity of the specific CXCR4 antagonist AMD 3465 is associated with blocking cAMP suppression. (aacrjournals.org)
  • pathway
  • Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), belonging to the nucleotidyltransferase family, is a cytosolic DNA sensor that activates the type-I interferon pathway. (wikipedia.org)
  • production
  • This increase in the level of .cyclic AMP leads to a net increase in hepatic glucose production by at least three mechanisms: stimulation of phosphorylase activation, suppression of glycogen synthetase activity, and stimulation of gluconeogenesis. (diabetesjournals.org)
  • Karppanen, H. O., Neuvonen, P. J., Westermann, E.: Effect of some gastric stimulants on the production of cyclic AMP in minced gastric tissue. (springer.com)
  • hormone
  • Growth hormone release and release of thyroid stimulating hormone need cyclic AMP before they can be released from the pituitary gland. (nethealthbook.com)
  • Thyroid hormone will not be released into the blood stream without cyclic AMP and the sleep inducing melatonin hormone will not be produced from serotonin without cyclic AMP. (nethealthbook.com)
  • As a result your cyclic AMP levels may be chronically lower than normal changing certain hormone functions…" Bad for business, so it is not done. (nethealthbook.com)
  • cell
  • Forskolin is commonly used as a tool in biochemistry to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology. (wikipedia.org)
  • levels
  • It means that if we eat the wrong foods such as the typical North American diet with lots of starch in foods such as pasta, bread, potatoes, rice and refined cereal as well as sugar in its various disguises, the chances are that many people end up with chronically low cyclic AMP levels. (nethealthbook.com)
  • Interference with thyroid function from low cyclic AMP levels causes slow mentation, weight gain and low energy (hypothyroidism symptoms). (nethealthbook.com)
  • thus
  • Such as inhibitors can be used, for example, as a means of increasing cyclic AMP in neurons and thus treating neurological problems, such as long term memory loss, if not preventing such maladies entirely. (freepatentsonline.com)
  • activity
  • This enzyme catalyses the following chemical reaction adenosine 3',5'-cyclic phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } AMP This enzyme requires Mg2+ or Mn2+ for activity. (wikipedia.org)
  • heart
  • Cyclic AMP was measured in the isolated rat heart during anoxia in an attempt to demonstrate if this nucleotide is in any way related to the extent and rate of contractile failure. (springer.com)
  • In the isolated perfused guinea-pig heart, the increases in isotonic contraction and in cyclic AMP, produced by 2 μg of histamine were significantly and almost completely inhibited in the presence of 2 mg of burimamide, whereas the adrenergic β-receptor blocking drug Kö 592 (50 μg) was ineffective. (springer.com)
  • enzyme
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene. (wikipedia.org)
  • AMP can be regenerated to ATP as follows: AMP + ATP → 2 ADP (adenylate kinase in the opposite direction) ADP + Pi → ATP (this step is most often performed in aerobes by the ATP synthase during oxidative phosphorylation) AMP can be converted into IMP by the enzyme myoadenylate deaminase, freeing an ammonia group. (wikipedia.org)
  • consists
  • The channel encoding process in GPRS as well as EGPRS/EDGE consists of two steps: first, a cyclic code is used to add parity bits, which are also referred to as the Block Check Sequence, followed by coding with a possibly punctured convolutional code. (wikipedia.org)
  • The circuit consists of a feedback loop containing a switching device such as a transistor, comparator, relay, op amp, or a negative resistance device like a tunnel diode, that repetitively charges a capacitor or inductor through a resistance until it reaches a threshold level, then discharges it again. (wikipedia.org)
  • human
  • The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram" (pdf). (wikipedia.org)
  • High
  • AMP does not have the high energy pyrophosphate bond associated with ADP and ATP. (wikipedia.org)