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  • Cushing's
  • The most common endocrine gland manifestation is an ACTH-independent Cushing's syndrome due to primary pigmented nodular adrenocortical disease (PPNAD). (wikipedia.org)
  • This drug was approved for use in patients with endogenous Cushing's syndrome who have type 2 diabetes or glucose intolerance and are not candidates for surgery or who have not responded to prior surgery. (healthcanal.com)
  • Prior to FDA's approval of Korlym, there were no approved medical therapies for the treatment of endogenous Cushing's syndrome. (healthcanal.com)
  • Endogenous Cushing's syndrome is a serious, debilitating and rare multisystem disorder. (healthcanal.com)
  • The safety and efficacy of Korlym in patients with endogenous Cushing's syndrome was evaluated in a clinical trial with 50 patients. (healthcanal.com)
  • The most common side effects experienced by endogenous Cushing's syndrome patients treated with Korlym in clinical trials were nausea, fatigue, headache, arthralgia, vomiting, swelling of the extremities, dizziness and decreased appetite. (healthcanal.com)
  • Although pregnancy is an extremely rare occurrence in Cushing's syndrome patients because of the suppressive effect of excess cortisol on female reproductive function, Korlym will carry a Boxed Warning advising health care professionals and patients that the therapy will terminate a pregnancy. (healthcanal.com)
  • The FDA has determined that a Risk Evaluation and Mitigation Strategy (REMS) is not necessary for Korlym to ensure that the benefits outweigh the risks for patients with endogenous Cushing's syndrome. (healthcanal.com)
  • There are no other approved medical therapies for this debilitating form of Cushing's syndrome and very sick patients would suffer if impediments to access were imposed. (healthcanal.com)
  • The number of Cushing's syndrome patients who will require treatment with Korlym is small, with an estimated 5,000 patients being eligible for treatment. (healthcanal.com)
  • They are familiar with the risks of Korlym treatment in the endogenous Cushing's syndrome population and frequently monitor patient status. (healthcanal.com)
  • Most retail pharmacies are unlikely to keep adequate supplies of the drug for this rare condition and central distribution will give patients with Cushing's syndrome better access to Korlym. (healthcanal.com)

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  • striae
  • Other striking and distressing skin changes that may appear in Cushing's syndrome include facial acne, susceptibility to superficial fungus (dermatophyte and malassezia) infections, and the characteristic purplish, atrophic striae on the abdomen. (wikipedia.org)
  • Skin changes in Cushing's syndrome include thinning and bruising easily, developing striae and hyperpigmentation at skin folds. (wikipedia.org)
  • findings
  • Carney JA, Ho J, Kitsuda K, Young WF Jr, Stratakis CA. Massive neonatal adrenal enlargement due to cytomegaly, persistence of the transient cortex, and hyperplasia of the permanent cortex: findings in Cushing syndrome associated with hemihypertrophy. (springer.com)
  • 1998
  • Findlay CA, Macdonald JF, Wallace AM, Geddes N, Donaldson MDC (1998) Childhood Cushing's syndrome induced by betamethasone nose drops and repeat prescriptions. (springer.com)
  • treatment
  • Tempi syndrome Smoking Before any treatment of leg telangectasia (spider veins) is considered, it is essential to have duplex ultrasonography, the test that has replaced Doppler ultrasound. (wikipedia.org)