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  • gattii
  • Cryptococcus neoformans e Cryptococcus gattii são espécies causadoras de meningite criptocócica, implicadas no acometimento de pacientes imunocomprometidos e imunocompetentes, respectivamente. (iec.gov.br)
  • O modo de adesão, colonização e infecção de C. neoformans e C. gattii depende de alguns fatores de virulência, os quais permitem sua sobrevivência no organismo do hospedeiro. (iec.gov.br)
  • O presente trabalho investigou a atividade de exoenzimas (fosfolipase e proteinase), produção de biofilme e fator hemolítico por C. neoformans (n = 9) e C. gattii (n = 7) isolados em Belém, Estado do Pará, Brasil. (iec.gov.br)
  • Cryptococcus neoformans and Cryptococcus gattii cause cryptococcal meningitis and are implicated in the infection of immunocompromised and immunocompetent patients, respectively. (iec.gov.br)
  • This study investigated the activity of exoenzymes (phospholipase and proteinase), biofilm formation and production of a hemolytic factor by isolates of C. neoformans (n = 9) and C. gattii (n = 7) from Belém, Pará State, Brazil. (iec.gov.br)
  • activity
  • This is the first report of in vitro exoenzyme activity and biofilm formation by isolates of Cryptococcus in Pará State. (iec.gov.br)
  • To determine whether adjunctive sertraline will lead to a faster rate of fungal clearance from cerebrospinal fluid (CSF), as measured by early fungicidal activity (EFA) of clearance of the Cryptococcus colony forming units (cfu) per mL of CSF per day, compared to standard therapy alone. (clinicaltrials.gov)
  • yeasts
  • The differentiation of C. neoformans from other yeasts is based on biochemistry rather than direct observation and as such requires viable cultures of the organism. (emsl.com)
  • hyphae
  • C. neoformans makes hyphae during mating, and eventually creates basidiospores at the end of the hyphae before producing spores. (humpath.com)
  • The sexual state of C . neoformans is characterized by the formation of dikaryotic hyphae, which possess typical basidiomycetous clamp connections and bear terminal basidia. (rupress.org)
  • The molecular analysis of hyphae production in MATα C . neoformans has resulted in the identification of a gene named STE12α whose sequence displays similarity to the Saccharomyces cerevisiae STE12 gene ( 6 ). (rupress.org)
  • organism
  • Specific modulation of protein expression through introduction of double-stranded RNA thus operates in C. neoformans , which is the first demonstration of this technique in a fungal organism. (genetics.org)
  • Since 1999, there has been an outbreak of Cryptococcus gattii infections in eastern Vancouver Island, an area not generally thought to be endemic for this organism. (wikipedia.org)
  • Fungi
  • The analysis for C. neoformans can be performed in the typical 6-10 day turn around for viable cultures, but the test requires special media that do not allow other fungi to be reliably recovered or identified. (emsl.com)
  • Studies suggest that colonies of C. neoformans and related fungi growing on the ruins of the melted down reactor of the Chernobyl nuclear power plant may be able to use the energy of radiation for "radiotrophic" growth. (wikipedia.org)
  • intracellular
  • Cryptococcus neoformans was the first intracellular pathogen for which the non-lytic escape process termed vomocytosis was observed. (wikipedia.org)
  • One mechanism by which C. neoformans survives the hostile intracellular environment of the macrophage involves upregulation of expression of genes involved in responses to oxidative stress. (wikipedia.org)
  • In order to survive in the hostile intracellular environment of the macrophage, one of the responses of C. neoformans is to upregulate genes employed in responses to oxidative stress. (wikipedia.org)
  • Cryptococcus neoformans Obligate intracellular parasites cannot reproduce outside their host cell, meaning that the parasite's reproduction is entirely reliant on intracellular resources. (wikipedia.org)
  • hosts
  • Besides a prevalent asexual life cycle, C. neoformans also presents a bipolar mating cycle with two mating types, MATa and MATα, with the latter being the most prevalently isolated from hosts and the environment . (kenyon.edu)
  • These mechanisms are not very effective when C. neoformans infects hosts with intact immune defenses, but they can lead to disseminated disease in immunosuppressed individuals. (humpath.com)
  • C. neoformans can establish latent infections accompanied by granuloma formation but can reactivate in immunosuppressed hosts. (humpath.com)
  • Innate immune responses restrict the growth and invasion of C. neoformans in mammalian hosts ( 16 ). (spandidos-publications.com)
  • invasion
  • C. neoformans can also utilize the host plasminogen system to enhance degradation and invasion of tissues and penetrate the blood-brain barrier. (kenyon.edu)
  • J. Stie and D. Fox, "Blood-brain barrier invasion by Cryptococcus neoformans is enhanced by functional interactions with plasmin," Microbiology , vol. 158, part 1, pp. 240-258, 2012. (hindawi.com)
  • enzymes
  • Furthermore, C. neoformans induces the activation of antioxidant enzymes, including superoxide dismutase (SOD) and catalases, and the synthesis of antioxidants, such as glutathione (GSH), to adapt to oxidative attack ( 14 , 15 ). (spandidos-publications.com)
  • soil
  • C. neoformans is present in the soil and in bird (particularly pigeon) droppings and infects patients when it is inhaled. (humpath.com)
  • agar
  • For Andersen sampling the IAQ investigator should use Birdseed Agar (BBL) for the isolation medium, as it provides the quickest and most selective recovery of possible C. neoformans . (emsl.com)
  • gene
  • However, investigations of Cryptococcus are hampered by the technical difficulty of specific gene replacements. (genetics.org)
  • One recently developed method for downregulating gene function that may facilitate studies in C. neoformans is double-stranded RNA interference (RNAi). (genetics.org)
  • The Cryptococcus neoformans STE12 α gene, a homologue of Saccharomyces cerevisiae STE12 , exists only in mating type ( MAT ) α cells. (rupress.org)
  • The C . neoformans STE12α gene, while having conserved roles in morphogenesis, has one striking difference from the S . cerevisiae STE12 gene: it is found only in MATα cells ( 6 ). (rupress.org)
  • Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. (asm.org)
  • This system has the potential for targeted gene disruption, and its efficiency will also allow for screening of DNA libraries within C. neoformans. (asm.org)
  • gattii
  • Cryptococcus neoformans e Cryptococcus gattii são espécies causadoras de meningite criptocócica, implicadas no acometimento de pacientes imunocomprometidos e imunocompetentes, respectivamente. (iec.gov.br)
  • O modo de adesão, colonização e infecção de C. neoformans e C. gattii depende de alguns fatores de virulência, os quais permitem sua sobrevivência no organismo do hospedeiro. (iec.gov.br)
  • O presente trabalho investigou a atividade de exoenzimas (fosfolipase e proteinase), produção de biofilme e fator hemolítico por C. neoformans (n = 9) e C. gattii (n = 7) isolados em Belém, Estado do Pará, Brasil. (iec.gov.br)
  • Cryptococcus neoformans and Cryptococcus gattii cause cryptococcal meningitis and are implicated in the infection of immunocompromised and immunocompetent patients, respectively. (iec.gov.br)
  • This study investigated the activity of exoenzymes (phospholipase and proteinase), biofilm formation and production of a hemolytic factor by isolates of C. neoformans (n = 9) and C. gattii (n = 7) from Belém, Pará State, Brazil. (iec.gov.br)
  • activity
  • This is the first report of in vitro exoenzyme activity and biofilm formation by isolates of Cryptococcus in Pará State. (iec.gov.br)
  • To determine whether adjunctive sertraline will lead to a faster rate of fungal clearance from cerebrospinal fluid (CSF), as measured by early fungicidal activity (EFA) of clearance of the Cryptococcus colony forming units (cfu) per mL of CSF per day, compared to standard therapy alone. (clinicaltrials.gov)