• The SUR2/Kir6.2 channel is less sensitive than the SUR/Kir6.2 channel (the pancreatic beta cell KATP channel) to both ATP and the sulfonylurea glibenclamide and is activated by the cardiac K(ATP) channel openers, cromakalim and pinacidil, but not by diazoxide. (nih.gov)
  • Purpose: To evaluate the effect of ATP-sensitive potassium channel openers cromakalim prodrug 1 (CKLP1) and diazoxide on IOP in three independent mouse models of ocular hypertension. (bvsalud.org)
  • Pharmacological experiments showed that the channel response to the SUR1 agonist diazoxide, SUR2A/B agonist cromakalim, SUR1 antagonist tolbuiamide, and the SUR1/SUR2A/B-antagonist glibenclamide matched the SURs expression pattern. (northwestern.edu)
  • These results suggest NNC 55-9216 is a SUR1-selective PCO that requires structural determinants, which differ from those needed for activation of the K(ATP) channel by pinacidil and cromakalim. (ox.ac.uk)
  • Purpose: To evaluate pharmacokinetic parameters and ocular hypotensive effects of cromakalim prodrug 1 (CKLP1) in normotensive large animal models. (bvsalud.org)
  • We have identified cromakalim prodrug 1 (CKLP1), a novel water-soluble ATP-sensitive potassium channel opener, as a new ocular hypotensive agent. (bvsalud.org)
  • The duration of the hypotensive effect by NIP-121 was longer than that by cromakalim. (elsevierpure.com)
  • Intravenously administered NIP-121 also showed a more potent hypotensive action with longer duration than cromakalim in conscious SHRs. (elsevierpure.com)
  • The intravenous hypotensive potency of NIP-121 but not cromakalim was similar to that of p.o. administration. (elsevierpure.com)
  • Cromakalim (INN) is a potassium channel-opening vasodilator. (wikipedia.org)
  • The antihypertensive effects of NIP-121, a novel potassium channel opener, were examined in comparison with cromakalim and its active enantiomer, le-makalim. (elsevierpure.com)
  • The relaxant mechanisms of nicorandil were examined by comparing its effects with those of sodium nitroprusside and cromakalim in bovine tracheal smooth muscle. (karger.com)
  • Gurpinar T, Gok S. Vasodilator effects of cromakalim and HA 1077 in diabetic rat aorta. (smw.ch)
  • Cromakalim (BRL 34915), known as an airway smooth muscle relaxant, inhibited the releases of mediators in the antigen-induced mast cell activation. (kyobobook.co.kr)
  • This increased PLC activity was decreased by cromakalim pretreatment. (kyobobook.co.kr)
  • It has been suggested that cromakalim, in part, inhibited mediator releases by inhibiting the initial increase of 1,2-diacylglycerol (DAG) produced by the activation of the other phospholipase system which is different from phosphatidylcholine-phospholipase D pathway. (kyobobook.co.kr)
  • The aim of this study is to further examine the inhibitory mechanism of cromakalim on the mediator release in the mast cell activation. (kyobobook.co.kr)
  • PIP 2 also diminished activation of K ATP channels by the K + channel openers (KCOs) cromakalim and P1075. (aspetjournals.org)
  • Purpose: To evaluate the effect of ATP-sensitive potassium channel openers cromakalim prodrug 1 (CKLP1) and diazoxide on IOP in three independent mouse models of ocular hypertension. (bvsalud.org)
  • The properties of K channels activated by K channel openers (nicorandil, cromakalim, pinacidil, etc.) were investigated using conventional microelectrode and patchclamp methods. (elsevierpure.com)
  • For this purpose, we studied the antidepressant-like properties of fluoxetine, nitrazepam, glibenclamide, and cromakalim by both forced swimming test (FST) and tail suspension test (TST). (iomcworld.org)
  • Beside, cromakalim (0.1 mg/kg) could reverse the antidepressant-like effect of nitrazepam (0.5 mg/kg) in both FST and TST, while cromakalim and glibenclamide alone could not change the immobility time compared to control group (P40.05). (iomcworld.org)
  • Cromakalim (INN) is a potassium channel-opening vasodilator. (wikipedia.org)
  • Effect of Cromakalim, a Potassium Channel Opener, on Experimentally Induced Convulsions in Albino Rats. (humanjournals.com)
  • We have identified cromakalim prodrug 1 (CKLP1), a novel water-soluble ATP-sensitive potassium channel opener, as a new ocular hypotensive agent. (bvsalud.org)
  • Isofluane attenuated pulmonary vasorelaxation induced by bradykinin, A23187, and cromakalim but had no effect on relaxation induced by acetylcholine or SIN-1. (silverchair.com)
  • in vitro cardioprotective effects of zofenopril occur via modulation of ATP-sensitive potassium channels (K ATP ), through a mechanism which differs from that of cromakalim (a classical K ATP activator). (medscape.com)