Prophylactic cranial irradiation (PCI) is a technique used to combat the occurrence of metastasis to the brain in highly aggressive cancers that commonly metastasize to brain, most notably small-cell lung cancer. (wikipedia.org)
1999). "Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. (wikipedia.org)
In patients with non-small cell lung cancer (NSCLC) treated with chemoradiotherapy (CRT), prophylactic cranial irradiation (PCI) is not standard practice. (edu.au)
Prophylactic cranial irradiation may impose a detrimental effect on overall survival of patients with nonsmall cell lung cancer: a systematic review and meta-analysis. (1library.org)
The results showed that prophylactic cranial irradiation (PCI) reduced the risk of BM as compared with non-PCI in NSCLC patients (OR = 0.30, 95% [CI]: 0.21-0.43, p,0.00001). (1library.org)
Citation:Xie S-s, Li M, Zhou C-c, Song X-l, Wang C-h (2014) Prophylactic Cranial Irradiation May Impose a Detrimental Effect on Overall Survival of Patients with Nonsmall Cell Lung Cancer: A Systematic Review and Meta-Analysis. (1library.org)
In limited-stage SCLC, the overall survival rate has been significantly improved by adding dose-hyperfractionated thoracic radiotherapy and prophylactic cranial irradiation to systemic chemotherapy. (ersjournals.com)
In contrast, little progress has been made in the treatment of extensive-stage SCLC (ES-SCLC), apart from the recently documented survival gain by the addition of prophylactic cranial irradiation. (ersjournals.com)
Recently, prophylactic cranial irradiation (PCI) has been shown to improve outcome in patients with ES-SCLC 4 , but only small advances have been made otherwise. (ersjournals.com)
As the therapy is used, each leukemia subtype had its peculiarities regarding the treatment, especially the introduction of imatinib for chronic myeloid leukemia (CML) and prophylactic cranial irradiation for cases of ALL. (sld.cu)
The recommended treatment paradigms have remained virtually unchanged: surgery for stage I disease, cisplatin/etoposide plus concurrent thoracic radiation for limited-stage disease, combination chemotherapy for extensive-stage disease, and prophylactic cranial irradiation (PCI) for those with good response to initial therapy. (jnccn.org)
Must have RT or prophylactic cranial irradiation (PCI) within 14 days prior to Step 2. (swog.org)
Should All Small Cell Lung Cancer Patients Receive Prophylactic Cranial Irradiation? (cancergrace.org)
The doctors discuss the circumstances under which small cell lung cancer patients should receive prophylactic cranial irradiation. (cancergrace.org)
The mainstay of treatment remains platinum-based doublet chemotherapy and despite benefits from prophylactic cranial radiation (PCI) and thoracic radiotherapy systemic treatments have not changed over the last few decades [ 5 - 7 ]. (biomedcentral.com)
Meanwhile, though immunotherapy is being explored for limited-stage (LS)-SCLC as well, the standard treatment for such patients remains platinum/etoposide chemotherapy with concurrent radiation, plus or minus prophylactic cranial irradiation. (medpagetoday.com)
This preventive treatment-called prophylactic cranial irradiation-is usually reserved for patients who have had a good response to chemotherapy. (yourcancercare.com)
Controversy exists regarding the role of consolidative thoracic radiation therapy (TRT) and prophylactic cranial irradiation (PCI) in ES-SCLC due to high recurrence rates. (bvsalud.org)
Chemotherapy6
Extended intrathecal methotrexate may replace cranial irradiation for prevention of CNS relapse in children with intermediate-risk acute lymphoblastic leukemia treated with Berlin-Frankfurt-Münster-based intensive chemotherapy. (unimib.it)
Purpose: To assess the effect of treatment intensification and that of extended intrathecal methotrexate substitution for cranial irradiation in intermediate-risk acute lymphoblastic leukemia (ALL) children treated with a Berlin-Frankfurt-Munster (BFM)-based intensive chemotherapy. (unimib.it)
Conclusion: Cranial irradiation may be omitted safely in IR ALL patients treated with BFM-based intensive chemotherapy when extended intrathecal chemotherapy is given. (unimib.it)
She would undergo 63 rounds of cranial radiation along with chemotherapy treatment five days every month. (acco.org)
Impairments of Attention Following Treatment With Cranial Irradiation and Chemotherapy in Children. (bvsalud.org)
The impact of the temporal sequence by which cranial radiotherapy (CRT) and platin-based chemotherapy (PCth) are administered on sensorineural hearing loss (SNHL) in pediatric and adolescent central nervous system (CNS) and head-and-neck (HN) cancer patients has not yet been studied in detail. (bvsalud.org)
Radiotherapy3
Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. (wikipedia.org)
Cranial boost was therefore not associated with a reduction in CNS recurrence, especially in patients with only hematologic disease at presentation for which there were no failures regardless of the use of additional cranial radiotherapy. (johnshopkins.edu)
Radiation therapy is commonly used to treat known tumor occurrence in the brain, either with highly precise stereotactic radiation or therapeutic cranial irradiation. (wikipedia.org)
Acute2
Purpose: Total body irradiation (TBI) as part of a conditioning regimen before hematopoietic stem cell transplant (HSCT) is an important component in the management of acute lymphoblastic leukemia (ALL) that has relapsed or has other certain high-risk features. (johnshopkins.edu)
Acute Radiation Syndrome (ARS) (sometimes known as radiation toxicity or radiation sickness) is an acute illness caused by irradiation of the entire body (or most of the body) by a high dose of penetrating radiation in a very short period of time (usually a matter of minutes). (cdc.gov)
Remission1
Data including patient demographics, clinical features at presentation, conditioning regimen, donor source, use of a cranial boost, remission stage at transplant, histologic subtype, cytogenetics, and extramedullary site of presentation were retrospectively collected and correlated with the risk of subsequent CNS recurrence. (johnshopkins.edu)
Survival1
However, it disorders such as hypercalcaemia, urae- does not confirm that a long survival time mia and hyperviscosity or due to periph- might increase the prevalence, and a large eral neuro pathy, spinal cord compression series over several years might be needed to and cranial nerve infiltration [ 5 ]. (who.int)
Chemoradiotherapy1
The same volumes are used as in neoadjuvant chemoradiotherapy with the addition of elective lymph node irradiation (ENI) (1) as described below. (cancercentrum.se)
Patients6
cranial irradiation was given only to HR patients. (unimib.it)
Therefore, the aim of this study was to assess risk of CNS recurrence in ALL patients treated with TBI, to identify subsets of these high-risk patients at an increased or decreased risk of CNS recurrence after TBI, and to investigate whether regimens with higher doses of cranial irradiation further reduce the risk of CNS recurrence. (johnshopkins.edu)
Forty-one (61%) patients did not receive an extracranial boost of irradiation with TBI. (johnshopkins.edu)
Two of these patients (4.9%) suffered CNS failures compared with 1 of 26 (3.8%) who received a cranial boost (p = 0.84). (johnshopkins.edu)
None of the 40 patients who presented only with hematologic disease developed a CNS recurrence despite the fact that only 13 of 40 of these patients received a cranial boost after TBI. (johnshopkins.edu)
Conclusions: Patients who present with hematologic disease only at the time of HSCT have a low risk of CNS recurrence after TBI regardless of the use of a cranial boost, suggesting that a cranial boost may not be necessary in these patients. (johnshopkins.edu)
Treatment2
Most childhood medulloblastoma (MB) cases are curable using multimodal treatment, including craniospinal irradiation (CSI). (nih.gov)
Is Distortion Correction Necessary for Digital Subtraction Angiography in the Gamma Knife Treatment of Intra-Cranial Arteriovenous Malformations? (karger.com)
Curable2
ABSTRACT Multiple myeloma (MM) is a systemic malignancy of pathologic plasma cells that is treat able with chemotherapeutic agents and irradiation, but rarely curable. (who.int)
RÉSUMÉ Le myélome multiple est un cancer systémique caractérisé par des cellules plasmatiques anormales, qui peut être traité par des agents chimiothérapeutiques et par irradiation, mais qui est rarement curable. (who.int)
Lung1
Aim: To investigate the impact of tumor-cell expression of thyroid transcription factor 1 (TTF1) on outcomes after irradiation of limited-disease small cell lung cancer (LD-SCLC). (iiarjournals.org)
SCLC1
Conclusion: In contrast to other factors, TTF1-expression had no significant impact on outcomes after irradiation of LD-SCLC. (iiarjournals.org)
Absence1
Previous national trials have included a cranial boost in the absence of data to justify its use. (johnshopkins.edu)
Total2
She had to have cranial radiation and Total body irradiation to rid her body of all cancer and accept her sisters new stem cells. (acco.org)
CTV (total) = CTVT + CTVN + ENI + margins for motion management in case robust motion management techniques are not used (note that the cranial level does not extend above the cricoid cartilage as described above). (cancercentrum.se)
Results2
The results obtained in the study suggest that propolis and CAPE have free radical, scavenging activities in the irradiation-induced cataractogenesis. (uwi.edu)
however, cranial irradiation often results in intellectual impairment and cognitive deficits, such as impaired learning and memory. (gu.se)
Role1
Mice deficient in apoE ( Apoe −/− ) can be used to assess the potential role of apoE in the effects of cranial irradiation on hippocampal function. (bioone.org)
Risk1
Prior cranial irradiation is the only well-established environmental risk factor. (medscape.com)
Cells2
Efforts to decrease toxicity of irradiation to normal tissue, organs and cells have led to searching for cytoprotective agent. (uwi.edu)
Taken together, these data demonstrate the pronounced susceptibility of hippocampal stem cells to ionizing radiation, and highlight the importance of shielding this structure from irradiation to minimize functional consequences. (gu.se)