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  • thickness
  • Recently, there has been much discussion and articles written about clinical studies that address the role of oxygen tension and of post-lens tear layer thickness, polymer material Dk/t, effects on corneal metabolism, and how those correlate with hypoxia-related complications and corneal edema during scleral lens wear. (clspectrum.com)
  • This study is designed to evaluate the efficacy of the Hyper-CL™ lens contact lens on corneal edema thickness as compared with salt solution treatment only in subjects suffering from corneal edema. (clinicaltrials.gov)
  • Treatment with the Hyper-CL™ lens may result with greater reduction in edema thickness as compared with treatment with salt solution only in subjects suffering from corneal edema. (clinicaltrials.gov)
  • Primary endpoint will be the percent of subjects with corneal thickness decrease of at least 8% during the one week treatment with the Hyper-CL™ lens + salt solution. (clinicaltrials.gov)
  • Corneal thickness (total, stromal and epithelial) in the center, midperiphery and periphery was measured with the Holden-Payor optical pachometer in the morning after lens removal (am) and following 8-10 hours of no lens wear (pm), after 1, 4, 10 and 30 nights of wear. (arvojournals.org)
  • The purpose of this clinical research study is to investigate the efficacy of predosing patients undergoing cataract surgery with the potent corticosteroid difluprednate ophthalmic emulsion 0.05% compared to prednisolone acetate 1% on corneal edema (swelling), and retinal thickness. (clinicaltrials.gov)
  • All the corneas were scanned with the TPS Spectra 3000 Teraview Terahertz scanning system, as well as the anterior segment optical coherence tomography systems for the central corneal thickness (CCT). (arvojournals.org)
  • Central Corneal thickness was measured before and after swelling and after the treatment with modified osmolar agents using the Vevo 2100 high frequency, high resolution ultrasound imaging system (Fujifilm VisualSonics, Inc.), B-mode images were acquired using the MicroScan™ Transducers MS550D. (arvojournals.org)
  • In patients who had worn contact lenses for approximately five years or more, a 30 to 50 μm reduction in central and peripheral corneal thickness has been recorded. (wikipedia.org)
  • epithelial
  • In 1996, Chahine and Weissman reported that the use of low-Dk hydrogel contact lenses caused superficial limbal corneal vascularization, furrow staining, limbal epithelial hypertrophy, and conjunctival hyperemia.6 When silicone hydrogel contact lenses became available in 2002, changing from low-Dk hydrogel lenses to silicone hydrogel lenses resolved the occurrence of these problems in soft contact lens daily wear. (clspectrum.com)
  • Lisch epithelial corneal dystrophy is characterized by feather shaped opacities and microcysts in the corneal epithelium that are arranged in a band-shaped and sometimes whorled pattern. (wikipedia.org)
  • A healing of a corneal ulcer involves two processes: migration of surrounding epithelial cells followed by mitosis (dividing) of the cells, and introduction of blood vessels from the conjunctiva. (wikipedia.org)
  • Focal or diffuse reduction in corneal sensation develops following recurrent epithelial keratitis. (wikipedia.org)
  • Focal blisters of epithelial edema ("bullae") may be particularly painful when they burst. (wikipedia.org)
  • epithelium
  • Hypoxia The corneal epithelium receives most of the oxygen required for normal metabolism from atmospheric oxygen that dissolves in the tear layer. (clspectrum.com)
  • Fick's phenomenon) is a clouding of the corneal epithelium due to an insufficient supply of oxygen caused by the oxygen-impermeable contact lens creating a barrier to the acquisition of oxygen.5 With removal of these early scleral lenses, the corneal clouding quickly resolved. (clspectrum.com)
  • congenital
  • The typical infant who has congenital glaucoma usually is initially referred to an ophthalmologist because of apparent corneal edema. (wikipedia.org)
  • Some pedigrees suggest inherited primary congenital is autosomal dominant but three major autosomal recessive loci have been identified: GLC3A - on chromosome 2 (2p21) GLC3B - on chromosome 1 (1p36) GLC3C - on chromosome 14 (14q24.3) Corneal cloudiness may have a myriad of causes. (wikipedia.org)
  • Saline
  • In this study, we induce corneal edema in ex-vivo porcine eyes and compare the effects of 5% hypertonic saline drops to modified hypertonic and hyperosmolar agents as potential therapeutics in reducing corneal edema in ex-vivo porcine eyes. (arvojournals.org)
  • This corneal shrinkage with the combined hypertonic and hyperosmotic (50% glycerin) agent is more robust than using glycerin or the standard 5 % saline alone. (arvojournals.org)
  • Corneal edema may be improved significantly by combining the standard hypertonic saline therapy with a hyperosmotic agent like glycerol. (arvojournals.org)
  • photophobia
  • The commonly described triad of epiphora (excessive tearing), blepharospasm and photophobia may be missed until the corneal edema becomes apparent. (wikipedia.org)
  • Decreased corneal sensitivity, vision loss, and photophobia have also been observed in patients who have worn contact lenses for an extended period of time. (wikipedia.org)
  • glaucoma
  • Measurement of corneal diameter if greater than 11mm before the age of one year or corneal diameter greater than 13mm at any age is a diagnostic criteria for buphthalmos Untreated glaucoma leads to total blindness. (wikipedia.org)
  • Clinical
  • 13 However, most clinical studies report amounts of corneal edema that are within the range of physiological edema that occurs during sleep (4%), and, in most cases, this amount is less than 2%, despite post-lens tear layer thicknesses being greater than 250μm. (clspectrum.com)
  • Prospective open-label, randomized, crossover clinical study To evaluate the safety and efficacy of the Hyper-CL™ lens in subjects suffering from corneal edema. (clinicaltrials.gov)
  • Diagnosis can be established on clinical grounds and this may be enhanced with studies on surgically excised corneal tissue and in some cases with molecular genetic analyses. (wikipedia.org)
  • Laboratory tests are indicated in complicated cases when the clinical diagnosis is uncertain and in all cases of suspected neonatal herpes infection: Corneal smears or impression cytology specimens can be analyzed by culture, antigen detection, or fluorescent antibody testing. (wikipedia.org)
  • contact lenses
  • Many contact lens-induced changes in corneal structure are reversible if contact lenses are removed for an extended period of time. (wikipedia.org)
  • In certain instances, hard contact lenses were shown to cause the same changes in corneal structure as soft contact lenses, though these changes were more dramatic because rigid lenses are capable of inflicting greater trauma on the eyes. (wikipedia.org)
  • ulcers
  • Corneal ulcers are one of the most common eye diseases in dogs. (wikipedia.org)
  • Corneal ulcers are painful due to nerve exposure, and can cause tearing, squinting, and pawing at the eye. (wikipedia.org)
  • Treatment of corneal ulcers includes topical antibiotic therapy to prevent infection, and pain medications, including topical atropine to stop spasms of the ciliary muscle. (wikipedia.org)
  • corneas
  • The use of scleral lenses to treat complex corneal diseases (i.e., irregular corneas and/or ocular surface disease) also continues to grow. (clspectrum.com)
  • Fifty fresh porcine corneas and ten human cadaveric corneas with different extents of corneal edema resulting from different time duration after procurement were used. (arvojournals.org)
  • For the human cadaveric corneas with different extents of corneal edema, the AUC was positively and strongly correlated with the CCT ( r =0.81, P= 0.014). (arvojournals.org)
  • lesions
  • Primary infection typically presents as swelling of the conjunctiva and eyelids (blepharoconjunctivitis), accompanied by small white itchy lesions on the corneal surface. (wikipedia.org)
  • drops
  • The orbscan test showed that I had corneal swelling (edema) and they gave me drops but were at a loss to explain how or why this would happen suddenly at 3 months. (usaeyes.org)
  • Common side effects of trifluridine eye drops include transient burning, stinging, local irritation, and edema of the eyelids. (wikipedia.org)
  • diagnosis
  • A definitive diagnosis is established only after a positive culture report (lactophenol cotton blue, calcoflour medium), typically taking a week, from the corneal scraping. (wikipedia.org)
  • signs
  • Protein wasting in kwashiorkor generally leads to edema and ascites, while muscular wasting and loss of subcutaneous fat are the main clinical signs of marasmus. (wikipedia.org)
  • loss of vis
  • LSCD leads to conjunctivalization, with corneal vascularization and opacification and subsequent loss of vision. (meajo.org)
  • may be at risk of corneal adverse events, potentially resulting in loss of vision. (drugs.com)