• genomes
  • Moreover, due to the limited success of bioinformatics in producing efficient DNA binding site prediction tools (large false positive rates are often associated with in-silico motif discovery / site search methods), there has been no systematic effort to computationally annotate these features in sequenced genomes. (wikipedia.org)
  • Thus
  • Thus a consensus sequence is a model for a putative DNA binding site: it is obtained by aligning all known examples of a certain recognition site and defined as the idealized sequence that represents the predominant base at each position. (wikipedia.org)
  • Thus this PCR methodology using the consensus primer should be widely applicable for amplifying hemoglobin β chains from teleosts. (springer.com)
  • This protein was found to be binding to three regularly spaced repeats of the core sequence CCCTC and thus was named CCCTC binding factor. (wikipedia.org)
  • splice
  • Finally splice sites (sequences immediately surrounding the exon-intron boundaries) can also be considered as consensus sequences. (wikipedia.org)
  • A possible explanation of the in-frame skipping of exon 2 and of the neighboring exon 3 is the complete removal of the consensus sequence of the 5' splice site of exon 2/intron 2 (13) and splicing alterations circumventing the nonsense codon in exon 3 of the cDNA so that translation terminates normally (14). (thefreedictionary.com)
  • characterization
  • Here we report the discovery and characterization of retroviral sequences belonging to a new lentiviral subgroup from the European rabbit ( Oryctolagus cuniculus ). (pnas.org)
  • genetic
  • CSIRO Entomology 120 Meiers Road Indooroopilly, Qld 4068, Australia) for providing the consensus sequences in the genetic divergence analysis. (thefreedictionary.com)
  • Relatively recent dates for the emergence of the modern lentiviral subgroups have been suggested, but these estimates are based on extrapolations of genetic distances observed among contemporary viruses, which are likely to be unreliable for evolutionary comparison of distantly related sequences ( 12 - 15 ). (pnas.org)
  • promoters
  • Studies have shown that promoters with a functional Inr are more likely to lack a TATA box or to possess a degenerate TATA sequence. (wikipedia.org)
  • CTCF is thought to be a primary part of the activity of insulators, sequences that block the interaction between enhancers and promoters. (wikipedia.org)
  • Binding of targeting sequence elements by CTCF can block the interaction between enhancers and promoters, therefore limiting the activity of enhancers to certain functional domains. (wikipedia.org)
  • identical
  • The proposed active site of ADAM10 has been identified by sequence analysis, and is identical to enzymes in the Snake Venom metalloprotein domain family. (wikipedia.org)
  • annotation
  • Even though NCBI contemplates DNA binding site annotation in its reference sequences (RefSeq), most submissions omit this information. (wikipedia.org)
  • evolutionary
  • Evolutionary analyses of the genomic sequences of modern-day lentiviruses have suggested a relatively recent date for their emergence, but the failure to identify any endogenous, vertically transmitted examples has meant that their longer term evolutionary history and origin remain unknown. (pnas.org)
  • cysteine
  • In the CAAX box sequence, the C represents the cysteine that is prenylated, the A's represent any aliphatic amino acid and the X determines the type of prenylation that will occur. (wikipedia.org)
  • 1989
  • Inr in humans was first explained and sequenced by two MIT biologist, Stephen T. Smale and David Baltimore in 1989. (wikipedia.org)