CTGFCCN2FibrosisPlatelet deriveDiseasesSecretionEpidermal growth fAbnormalitiesExpressionPulmonaryDisruptsProteinsExtracellularGeneFibroblastsCytokinesMediatesDrug-inducedThyroidProliferation and differentiationPromotesPathwaysVascular endothWoundResiduesMesenchymalSerumTumor growthPrognosticFibroblastCellsAngiotensinAmniotic fluidTransforming growTherapeuticDiseasePathwaySoftLung developmentSpeciesRepairDiabetic nephropathy
CTGF22
- Angiotensin II has previously been shown to trigger fibrosis, an effect involving connective tissue growth factor (CTGF). (amrita.edu)
- This study was designed to improve our understanding of the role of miR-18a and its target (connective tissue growth factor (CTGF), which are mediators in HBX-induced hepatocellular carcinoma (HCC). (medscimonit.com)
- We also observed a clear increase in CTGF mRNA and protein expression levels in HBV-positive HCC human tissue samples in comparison with the HBV-negative controls, indicating a possible negatively associated relationship between miR-18a and CTGF. (medscimonit.com)
- The CCN family presently consists of six members in human also known as: Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), Nov (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). (neuromics.com)
- Pathologic changes in the TM are partially mediated by growth factors like connective tissue growth factor (CTGF). (uni-regensburg.de)
- CTGF orchestrates diverse multicellular processes including embryonic development, wound healing, and tissue repair. (bmj.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig Connective Tissue Growth Factor (CTGF) in serum, plasma, tissue homogenates and other biological fluids. (stemcellcharter.org)
- Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Pig Connective Tissue Growth Factor (CTGF) in serum, plasma and other biological fluids. (stemcellcharter.org)
- Description: Quantitativesandwich ELISA kit for measuring Rat connective tissue growth factor, CTGF in samples from serum, plasma, cell culture supernates, tissue homogenates. (jsce-ip.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Connective Tissue Growth Factor (CTGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (jsce-ip.com)
- Conclusions CTGF can promote proliferation, growth and metastasis of SKOV3, and that may contribute to the regulation of epithelium-mesenchymal transformation (EMT). (magtechjournal.com)
- 8] Chu CY, Chang CC, Prakash E, et al .Connective tissue growth factor(CTGF) and cancer progression[J]. J Biomed Sci,2008,15:675-685. (magtechjournal.com)
- Introduction: Connective tissue growth factor (CTGF)/CCN2 is a unique growth factor that stimulates the proliferation and differentiation, but not hypertrophy, of articular chondrocytes in vitro. (elsevierpure.com)
- Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Connective Tissue Growth Factor (CTGF) were tested 20 times on one plate, respectively. (bioprodhub.com)
- Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Connective Tissue Growth Factor (CTGF) were tested on 3 different plates, 8 replicates in each plate. (bioprodhub.com)
- Connective tissue growth factor (CTGF) a transforming growth factor (TGF)-β 1 downstream mediator, is a secreted cell matrix-inducing peptide involved in both tissue regeneration mechanisms, such as wound repair and also in aberrant deposition of extracellular matrix. (lih.lu)
- The deficiency in GFs such as connective tissue growth factor (CTGF) and insulin-like growth factor (IGF-I) disrupts and delays efficient and complete wound healing. (pharmaceuticsconference.com)
- It binds to the connective tissue growth factor (CTGF) protein. (wikipedia.org)
- Quantitative RT-PCR was used to asses mRNA levels of collagenase-1 (MMP-1), stromelysin (MMP-3), vascular endothelial growth factor (VEGF), connective tissue growth factor (CTGF), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), type III collagen (COL-III) and fibronectin (FBRN). (cdc.gov)
- CTGF is comprised of four distinct structural domains (modules), which are identified as IGF-Binding Protein (IGF-BP), von Willebrand Factor C (VWFC), Thrombospondin type I (TSP type I), and C-terminal cysteine knot-like (CTCK) domains. (peprotech.com)
- Full length CTGF can be proteolytically cleaved in certain tissues to yield N-terminal truncated isoforms, which, depending on the isoform, contain only the TSP type I and CTCK domains or contain only the CTCK domain. (peprotech.com)
- Connective tissue growth factors, CTGF and Cyr61 in drug-induced gingival overgrowth--an animal model]. (bvsalud.org)
CCN21
- Downregulation of CCN2 expression in these cells was associated with a growth arrest at the G1/S transition while over-expression of CCN2 induced a two-fold increase of the number of cells in the G1 phase. (neuromics.com)
Fibrosis11
- [ 5 ] Cohen and colleagues have found that in-utero overexpression of the cystic fibrosis transmembrane conductance regulator (CFTR) increased liquid secretion into the lung, accelerating lung growth in a rat model. (medscape.com)
- Pamrevlumab, an anti-connective tissue growth factor therapy, for idiopathic pulmonary fibrosis (PRAISE): a phase 2, randomised, double-blind, placebo-controlled trial. (nih.gov)
- Moreover, GATA2 was identified as a cardiac fibrosis-associated upstream positive transcription factor of miR-409-3p. (hindawi.com)
- Inflammation, oxidative stress, and aging have been proven to contribute to cardiac fibrosis, which is regulated by multiple factors [ 7 - 9 ]. (hindawi.com)
- For instance, miR-409-3p promotes epithelial to mesenchymal transition and tumor growth in prostate cancer and also accelerates osteoblastic differentiation through the Wnt/ β -catenin pathway [ 17 , 18 ], a crucial pathway in regulating cardiac fibrosis. (hindawi.com)
- Yang D, Yuan J, Liu G, Ling Z, Zeng H, Chen Y, Zhang Y, She Q, Zhou X. Angiotensin Receptor Blockers and Statins Could Alleviate Atrial Fibrosis via Regulating Platelet-Derived Growth Factor/Rac1 /Nuclear Factor-Kappa B Axis. (medsci.org)
- To investigate whether the administration of renin-angiotensin system (RAS) inhibitors and statins could alleviate atrial fibrosis via platelet-derived growth factor (PDGF)/Rac1 /nuclear factor-kappa B (NF-κB) axis. (medsci.org)
- In addition, other studies demonstrated that AngII activated platelet-derived growth factor-A (PDGF-A), a novel contributor to cardiac remodelling, to result in atrial fibrosis in pressure-overloaded mouse model [ 13 ] . (medsci.org)
- In addition, fascial fibroblasts express transforming growth factor-beta I and connective-tissue growth factor mRNA, which may account for the clinical fibrosis. (medscape.com)
- Hepatic fibrosis is overly exuberant wound healing in which excessive connective tissue builds up in the liver. (msdmanuals.com)
- Commonly, fibrosis progresses, disrupting hepatic architecture and eventually function, as regenerating hepatocytes attempt to replace and repair damaged tissue. (msdmanuals.com)
Platelet derive2
- Several growth factors such as fibroblast growth factor (FGF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF), promote cell proliferation and differentiation. (medscape.com)
- As a result, reactive oxygen species and inflammatory mediators (eg, platelet-derived growth factor, transforming growth factors, connective tissue growth factor) are released. (msdmanuals.com)
Diseases3
- Endothelial dysfunction is a critical initiating factor contributing to cardiovascular diseases, involving the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO). (nature.com)
- Connective tissue diseases, hypersensitivity pneumonitis, asbestosis and sarcoidosis may progress to cause the histological lesion of UIP 1 . (ersjournals.com)
- Prior to joining Surrey, her research centred around pulmonary hypertension and connective tissue diseases. (surrey.ac.uk)
Secretion1
- They demonstrated that moderate and high AjA concentrations significantly suppressed tumor necrosis factor (TNF)-alpha secretion, whereas all AjA doses significantly reduced interferon (IFN)-alpha and INF-beta production. (aad.org)
Epidermal growth f1
- Renal epidermal growth factor receptor (EGFR) signaling is activated in models of diabetic nephropathy (DN), and inhibition of the EGFR signaling pathway protects against the development of DN. (diabetesjournals.org)
Abnormalities1
- The resulting abnormalities of connective tissue underlie the signs and symptoms of congenital contractural arachnodactyly. (medlineplus.gov)
Expression9
- We found that the expression of miR-18a was abnormally reduced in the HBV-positive HCC tissue samples compared with HBV-negative HCC samples. (medscimonit.com)
- Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma[J]. Oncol Rep,2019,42:2323-2332. (magtechjournal.com)
- TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. (medscape.com)
- Kutasy B, Friemacher F, Duess JW, Puri P. Prenatal administration of retinoic acid increases the trophoblastic insulin-like-growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia. (medscape.com)
- Different regulatory mechanisms between mRNA and protein expression or localized changes missed due to homogenization of the tissue samples, may explain the discrepancy in findings. (cdc.gov)
- Aortic tissue samples were collected from normal donors and AAD patients, and the expression of ADAMTS-5 was analyzed in all aortic tissues. (frontiersin.org)
- Lung tissues were collected on day 21 to detect pathological changes and the expression of collagen content and regulator of G protein signaling 2(RGS2). (researchsquare.com)
- The incubation of DSS fibroblasts with a synthetic cannabinoid receptor agonist (WIN55, 212- 2) decreased their expression in a dose-dependent manner, together with a parallel reduction in collagen production and pro- fibrotic cytokines, including transforming growth factor-beta (TGF-beta), connective tissue growth factor and interleukin-6 (IL-6). (aad.org)
- Therefore, the expression of a number of growth factors and their receptors, all of which affect fetal lung development, is temporally and spatially regulated. (medscape.com)
Pulmonary6
- Pulmonary hypoplasia (PH) or aplasia is a rare condition that is characterized by incomplete development of lung tissue, which can be unilateral or bilateral. (medscape.com)
- Oligohydramnios is considered to be an independent risk factor for the development of pulmonary hypoplasia. (medscape.com)
- Thyroid transcription factor 1 (TTF-1) is thought to be the earliest embryologic marker associated with cells committed to pulmonary development. (medscape.com)
- Histologic assessment of patients with systemic sclerosis-associated PAH and the hypoxia/SU5416 mouse model identified the presence von Willebrand factor/α-smooth muscle actin-positive endothelial cells in up to 5% of pulmonary vessels. (surrey.ac.uk)
- Pulmonary hypoplasia or aplasia is part of the spectrum of malformations characterized by incomplete development of lung tissue. (medscape.com)
- Postnatal diagnosis of pulmonary hypoplasia can be made with specific criteria such as clinical and radiologic criteria, or pathologic criteria such as lung weight or lung weight-to-body weight ratio, mean radial alveolar count, and DNA estimation for growth assessment at autopsy. (medscape.com)
Disrupts1
- As a result, microfibril formation is reduced, which probably weakens the structure of connective tissue and disrupts regulation of growth factor activity. (medlineplus.gov)
Proteins9
- Connective Tissue Growth Factor belongs to the CCN family of proteins. (neuromics.com)
- The full length protein consists of four modulesModule I shares partial identity with the N-terminal part of the Insulin-like Growth Factor Binding Proteins (IGFBPs). (neuromics.com)
- Transforming growth factor family proteins like TGFß1 can oppose these effects. (medscape.com)
- Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
- These markers include a variety of proteins usually including growth factors, and hormones among others. (bvsalud.org)
- A complex extracellular matrix with collagenous and non-collagenous proteins composes mineralized tissue. (bvsalud.org)
- Three non-collagenous proteins, osteonectin, transforming growth factor β-1 (TGF-β1) and bone morphogenetic proteins (BMPs), have drawn much attention in the literature lately. (bvsalud.org)
- Bone morphogenetic proteins (BMPs) form a unique group of proteins within the transforming growth factor beta (TGF-β) superfamily. (bvsalud.org)
- The drug mediates interactions between these receptors, growth factors, and proteins within that pathway to reduce new abnormal bone formation. (medscape.com)
Extracellular4
- Module IV resembles the CT domain of several extracellular protein including, Von Willebrand's factor and mucins. (neuromics.com)
- DFUs are caused, in part, by the deficiency in growth factors (GFs) implicated in keratinocytes and fibroblasts proliferation, migration, and extracellular matrix deposition. (pharmaceuticsconference.com)
- The process of myelination is controlled in part by cell extrinsic factors derived from the extracellular matrix (ECM). (jneurosci.org)
- They are believed to play a role in modulating the effects of a variety of GROWTH FACTORS and PROTEASES at the cell membrane extracellular matrix. (bvsalud.org)
Gene1
- A gene highly expressed in fibrosing tissue is the serum- and glucocorticoid-inducible kinase SGK1. (amrita.edu)
Fibroblasts1
- We found that miR-409-3p was consistently increased in three fibrotic models, including heart tissues of postmyocardial infarction (MI) mice and neonatal rat cardiac fibroblasts treated with angiotensin II (Ang II) or transforming growth factor- β (TGF- β ). (hindawi.com)
Cytokines1
- Induced EndoMT in PAECs by inflammatory cytokines IL-1β, tumor necrosis factor α, and transforming growth factor β led to actin cytoskeleton reorganization and the development of a mesenchymal morphology. (surrey.ac.uk)
Mediates1
- Connective tissue growth factor mediates TGF-β1-induced low-grade serous ovarian tumor cell apoptosis[J]. Oncotarget, 2017,8:85224-85233. (magtechjournal.com)
Drug-induced1
- Connective tissue disease, hypersensitivity pneumonitis, drug-induced lung disease, resolved acute respiratory distress syndrome and some cases of cryptogenic organising pneumonia may all produce a histological picture of NSIP 1 , 3 . (ersjournals.com)
Thyroid1
- Lung development is regulated by several transcription factors, such as thyroid transcription factor 1 (TTF-1) family, hepatocyte nuclear family, and peptide growth factors. (medscape.com)
Proliferation and differentiation1
- Signals from these growth factors are integrated with environmental influences, such as lung fluid volume and hyperoxia, to cause cellular proliferation and differentiation. (medscape.com)
Promotes1
- Connective tissue growth factor promotes the proliferation and migration of human ovarian cancer cell line SKOV3[J]. Basic & Clinical Medicine, 2021, 41(2): 193-196. (magtechjournal.com)
Pathways1
- However, the KEGG signalling pathways namely "tumour necrosis factor (TNF)" and "cytokine-cytokine receptor interaction" were downregulated at 24H but activated at 48H. (nature.com)
Vascular endoth1
- Bedaiwy MA, Burlingame JM, Hussein M, Flyckt R, Assad R, Falcone T. Assessment of vascular endothelial growth factor, basic fibroblast growth factor and transforming growth factor levels in amniotic fluid. (medscape.com)
Wound2
- Commonly affecting those with skin of color, keloids are an aberrant wound response that leads to wound tissue expanding above and beyond the original cutaneous injury. (springer.com)
- Keloids are a pathologic response to cutaneous injury in which wound tissue grows beyond the inciting insult. (springer.com)
Residues1
- Module II includes a stretch of 70amino acid residues - which shares sequence identity with the Von Willebrand Factor Type C repeat (VWC). (neuromics.com)
Mesenchymal2
- Growth factors are produced by mesenchymal tissue and are present in amniotic fluid. (medscape.com)
- TGF-β1 is a multifunctional regulator of cell growth which will either stimulate or inhibit proliferation of mesenchymal cells depending on the presence of other growth factors 7,8,9 . (bvsalud.org)
Serum1
- Other studies have shown elevated serum levels of manganese superoxide dismutase and tissue inhibitor of metalloproteinase (TIMP-1). (medscape.com)
Tumor growth1
- The T category informs about tumor growth, depth and stage of adjacent tissues invasion. (biorxiv.org)
Prognostic3
- The present study aimed to identify differentially expressed tissue miRs associated with prognostic factors in CRC patients, through a systematic review of the Literature. (biorxiv.org)
- Using the PubMed database, Cochrane Library and Web of Science, studies published in English evaluating miRs differentially expressed in tumor tissue and significantly associated with the prognostic aspects of CRC were selected. (biorxiv.org)
- Specific tissue miRs are shown to be promising prognostic biomarkers in patients with CRC, given their strong association with the prognostic aspects of these tumors, however, new studies are necessary to establish the sensibility and specificity of the miRs in order to use them in clinical practice. (biorxiv.org)
Fibroblast1
- Enhances fibroblast growth factor-induced DNA synthesis. (joplink.net)
Cells1
- Major connective tissue mitoattractant secreted by vascular endothelial cells. (joplink.net)
Angiotensin1
- Angiotensin II (Ang II) and transforming growth factor- β (TGF- β ) are the most important among these factors. (hindawi.com)
Amniotic fluid2
- The presence of growth factors in amniotic fluid indicates that lung development is not solely a pressure phenomenon. (medscape.com)
- Fetal urine is an important component of amniotic fluid during late gestation and contributes to lung growth. (medscape.com)
Transforming grow1
- Further research into eosinophilic fasciitis has shown elevations of transforming growth factor-beta and interleukin 5, which normalize with corticosteroid therapy. (medscape.com)
Therapeutic1
- These factors have drawn considerable interest to finding optimal therapeutic regimens for this infection, as well as to identifying the pathogenesis, ecology, and the reservoirs of this microorganism. (cdc.gov)
Disease2
- Frequently, however, ILDs can also be associated with a specific environmental exposure or an underlying connective tissue disease. (ersjournals.com)
- Since then, many clinicians and researchers from Taiwan have reported risk factors and the clinical spectrum of this disease on the basis of an increasing number of reported cases ( 4 - 12 ). (cdc.gov)
Pathway1
- It has been postulated that the Rho-ROCK pathway can affect the growth of the lung epithelium. (medscape.com)
Soft2
- In contrast, only soft tissue repair occurred when the PBS-hydrogel collagen was implanted. (elsevierpure.com)
- Affecting roughly 400 people in the United States and 900 worldwide, FOP is an autosomal dominant condition in which bone develops in soft connective tissue areas of the body where it isn't normally present (heterotopic ossification), such as the ligaments, tendons, and skeletal muscles. (medscape.com)
Lung development1
- Effect of insulin-like growth factors on lung development in a nitrofen-induced CDH rat model. (medscape.com)
Species1
- Borrelia species were not identified by direct microscopic examination of tissue samples or by polymerase chain reaction amplification of tissue samples in any of these reported cases of eosinophilic fasciitis. (medscape.com)
Repair2
- Connective tissue growth factor in tumor pathogenesis[J]. Fibrogenesis Tissue Repair,2012.doi:10.1186/1755-1536-5-S1-S8. (magtechjournal.com)
- Growth factors enable the growth and repair of tissues throughout the body. (medlineplus.gov)
Diabetic nephropathy1
- Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). (hindawi.com)