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  • Systems Biology
  • Hofestädt, R., Kolchanov, N. eds: Computational Systems Biology: German/Russian Network of Computational Systems Biology. (uni-bielefeld.de)
  • Cancer systems biology encompasses the application of systems biology approaches to cancer research, in order to study the disease as a complex adaptive system with emerging properties at multiple biological scales. (wikipedia.org)
  • Cancer systems biology represents the application of systems biology approaches to the analysis of how the intracellular networks of normal cells are perturbed during carcinogenesis to develop effective predictive models that can assist scientists and clinicians in the validations of new therapies and drugs. (wikipedia.org)
  • Cancer systems biology approaches, therefore, are based on the use of computational and mathematical methods to decipher the complexity in tumorigenesis as well as cancer heterogeneity. (wikipedia.org)
  • Cancer systems biology encompasses concrete applications of systems biology approaches to cancer research, notably (a) the need for better methods to distill insights from large-scale networks, (b) the importance of integrating multiple data types in constructing more realistic models, (b) challenges in translating insights about tumorigenic mechanisms into therapeutic interventions, and (d) the role of the tumor microenvironment, at the physical, cellular, and molecular levels. (wikipedia.org)
  • Cancer systems biology therefore adopts a holistic view of cancer aimed at integrating its many biological scales, including genetics, signaling networks, epigenetics, cellular behavior, histology, (pre)clinical manifestations and epidemiology. (wikipedia.org)
  • Cancer systems biology merges traditional basic and clinical cancer research with "exact" sciences, such as applied mathematics, engineering, and physics. (wikipedia.org)
  • Cancer systems biology finds its roots in a number of events and realizations in biomedical research, as well as in technological advances. (wikipedia.org)
  • Cancer Systems Biology is steadily improving our ability to organize information on cancer, in order to fill these gaps. (wikipedia.org)
  • The Cancer Genome Atlas data collection Computational algorithms to extract drivers of cancer progression from existing datasets Statistical and mechanistic modeling of signaling networks Quantitative modeling of cancer evolutionary processes Mathematical modeling of cancer cell population growth Mathematical modeling of cellular responses to therapeutic intervention Mathematical modeling of cancer metabolism The practice of Cancer Systems Biology requires close physical integration between scientists with diverse backgrounds. (wikipedia.org)
  • At the translational level, Cancer Systems Biology should engender precision medicine application to cancer treatment. (wikipedia.org)
  • Wikipedia
  • All articles are open access and licensed under the Creative Commons Attribution License.The journal is known beyond its core field for its Ten Simple Rules series of articles that capture the essence of selected aspects of research in computational biology or in science more generally, e.g. how to present a poster, how to collaborate, or how to edit Wikipedia. (wikipedia.org)
  • research
  • Sponsored by the International Society for Computational Biology , the Computational Biology series publishes the very latest, high-quality research devoted to specific issues in computer-assisted analysis of biological data. (springer.com)
  • Our research groups address fundamental and applied questions in biology using big data approaches, and methods and tools from mathematics, statistics and computer science. (edu.au)
  • Combining mechanistic and clinical studies from multiple systems in a single resource, the Journal delivers authoritative, peer-reviewed reporting on the latest research in the field of molecular biology. (liebertpub.com)
  • WPI's Bioinformatics & Computational Biology (BCB) program comprises multiple disciplines, and the research focus areas of our program are similarly varied and diverse. (wpi.edu)
  • The BCB program provides opportunities for motivated high school students to work alongside WPI faculty members and students who are conducting exciting research at the intersection of biology, mathematics, and computer science. (wpi.edu)
  • In conclusion, computational approaches I have used have been successful in testing theories and highlighting potentially promising research directions, but much theoretical and experimental work is still needed to fully understand the evolution of sex in nature. (ens.fr)
  • Galaxy is a scientific workflow, data integration, and data and analysis persistence and publishing platform that aims to make computational biology accessible to research scientists that do not have computer programming or systems administration experience. (wikipedia.org)
  • The institute focuses its research on the interface between theoretical and experimental molecular and cell biology. (wikipedia.org)
  • sequence
  • Content: Dynamic Programming techniques as they apply to problems in Computational Biology, e.g., sequence alignment, prediction of RNA Secondary Structure, comparison of philogenetic trees, etc. (bio.net)
  • Analysis
  • Galaxy supports reproducibility by capturing sufficient information about every step in a computational analysis, so that the analysis can be repeated, exactly, at any point in the future. (wikipedia.org)
  • Workflows Workflows are computational analyses that specify all the steps (and parameters) in the analysis, but none of the data. (wikipedia.org)
  • systems
  • It is similar in spirit to the history of Computational linguistics, a discipline that focuses on the linguistic structures rather than the sensor acting as the transmission and communication medium(s).Due to the availability of dense 3D measurements via technologies such as magnetic resonance imaging (MRI), Computational anatomy has emerged as a subfield of medical imaging and bioengineering for extracting anatomical coordinate systems at the morphome scale in 3D. (wikipedia.org)
  • In computational anatomy, the diffeomorphism group is used to study different coordinate systems via coordinate transformations as generated via the Lagrangian and Eulerian velocities of flow from one anatomical configuration in R 3 {\displaystyle {\mathbb {R} }^{3}} to another. (wikipedia.org)
  • The metric structures in Computational anatomy are related in spirit to morphometrics, with the distinction that Computational anatomy focuses on an infinite-dimensional space of coordinate systems transformed by a diffeomorphism, hence the central use of the terminology diffeomorphometry, the metric space study of coordinate systems via diffeomorphisms. (wikipedia.org)
  • These systems provide a means to build multi-step computational analyses akin to a recipe. (wikipedia.org)
  • Students may choose a thesis advisor from any of the three institutions for the completion of their PhD. The focus of study is on the various forms of mathematical and computational modeling of biological systems, particularly as they are relevant to medicine. (wikipedia.org)
  • program
  • The Tri-Institutional Training Program in Computational Biology and Medicine or Tri-I CBM is a PhD program that exists as a partnership between the Cornell University in Ithaca (CU-I), Weill Cornell Medical College (WMC), Memorial Sloan-Kettering Cancer Center (MSKCC). (wikipedia.org)
  • Systems Biology
  • Hofestädt, R., Kolchanov, N. eds: Computational Systems Biology: German/Russian Network of Computational Systems Biology. (uni-bielefeld.de)
  • Cancer systems biology encompasses the application of systems biology approaches to cancer research, in order to study the disease as a complex adaptive system with emerging properties at multiple biological scales. (wikipedia.org)
  • Cancer systems biology represents the application of systems biology approaches to the analysis of how the intracellular networks of normal cells are perturbed during carcinogenesis to develop effective predictive models that can assist scientists and clinicians in the validations of new therapies and drugs. (wikipedia.org)
  • Cancer systems biology approaches, therefore, are based on the use of computational and mathematical methods to decipher the complexity in tumorigenesis as well as cancer heterogeneity. (wikipedia.org)
  • Cancer systems biology encompasses concrete applications of systems biology approaches to cancer research, notably (a) the need for better methods to distill insights from large-scale networks, (b) the importance of integrating multiple data types in constructing more realistic models, (b) challenges in translating insights about tumorigenic mechanisms into therapeutic interventions, and (d) the role of the tumor microenvironment, at the physical, cellular, and molecular levels. (wikipedia.org)
  • Cancer systems biology therefore adopts a holistic view of cancer aimed at integrating its many biological scales, including genetics, signaling networks, epigenetics, cellular behavior, histology, (pre)clinical manifestations and epidemiology. (wikipedia.org)
  • Cancer systems biology merges traditional basic and clinical cancer research with "exact" sciences, such as applied mathematics, engineering, and physics. (wikipedia.org)
  • Cancer systems biology finds its roots in a number of events and realizations in biomedical research, as well as in technological advances. (wikipedia.org)
  • Cancer Systems Biology is steadily improving our ability to organize information on cancer, in order to fill these gaps. (wikipedia.org)
  • The Cancer Genome Atlas data collection Computational algorithms to extract drivers of cancer progression from existing datasets Statistical and mechanistic modeling of signaling networks Quantitative modeling of cancer evolutionary processes Mathematical modeling of cancer cell population growth Mathematical modeling of cellular responses to therapeutic intervention Mathematical modeling of cancer metabolism The practice of Cancer Systems Biology requires close physical integration between scientists with diverse backgrounds. (wikipedia.org)
  • At the translational level, Cancer Systems Biology should engender precision medicine application to cancer treatment. (wikipedia.org)
  • 2016
  • Klaus Schulten (January 12, 1947 - October 31, 2016) was a German-American computational biophysicist and the Swanlund Professor of Physics at the University of Illinois at Urbana-Champaign. (wikipedia.org)
  • evolutionary
  • The link areas form a circle that encompasses the fundamental nature of biological information processing, computational modeling of complex biological systems, evolutionary models of computation, the application of biological principles to the design of novel computing systems, and the use of biomolecular materials to synthesize artificial systems that capture essential principles of natural biological information processing. (wikipedia.org)
  • Pardis C. Sabeti (Persian: پردیس ثابتی‎) (born December 25, 1975 in Tehran, Iran) is an Iranian-American computational biologist, medical geneticist and evolutionary geneticist, who developed a bioinformatic statistical method which identifies sections of the genome that have been subject to natural selection and an algorithm which explains the effects of genetics on the evolution of disease. (wikipedia.org)
  • research
  • The next speaker in the Virginia Tech Carilion Research Institute's Distinguished Public Lecture Series, Sriram Subramaniam, will present on, "Visualizing Biology in 3D: Why Does It Matter? (vt.edu)
  • This book highlights some important research directions that combine mechanical sciences with exciting new developments in biology. (springer.com)
  • It is a multidisciplinary research field, at the crossroad of Virology, Synthetic Biology and Computational Biology, and DNA Nanotechnology from which it borrows and integrates its concepts and methodologies. (wikipedia.org)
  • This technology was further developed and improved by groups at the Laboratory of Molecular Biology with Greg Winter and John McCafferty, The Scripps Research Institute with Lerner and Barbas and the German Cancer Research Center with Breitling and Dübel for display of proteins such as antibodies for therapeutic protein engineering. (wikipedia.org)
  • Initial work was done by laboratories at the MRC Laboratory of Molecular Biology (Greg Winter and John McCafferty), the Scripps Research Institute (Richard Lerner and Carlos F. Barbas) and the German Cancer Research Centre (Frank Breitling and Stefan Dübel). (wikipedia.org)
  • The institute is engaged in research in many areas of modern biological sciences and microbe-related biotechnology, with special emphasis on research that is interdisciplinary and of a collaborative nature, such as immunity and infectious diseases, protein design and engineering, fermentation science, microbial physiology and genetics, yeast biology, bioinformatics, microbial systematics, exploitation of microbial diversity for bioactives and enzymes for biotransformations. (wikipedia.org)
  • The School engages in research in the following areas: Artificial Intelligence Computational Biology Database Management Systems Media Systems and Networking Programming Languages and Software Engineering Electronic Commerce Economics of Information Systems Information Management Information Systems and Management Healthcare Service System Innovation Social Computing The NUS Students' Computing Club, also known as CompClub, is the faculty club for all undergraduates in NUS School of Computing. (wikipedia.org)
  • The Scholarly Publishing and Academic Resources Coalition, the Alliance for Taxpayer Access, the American Library Association, the International Society for Computational Biology, the Confederation of Open Access Repositories and prominent open science and open access advocates criticized the Research Works Act, some of them urging scholarly societies to resign from the AAP because of its support for the bill. (wikipedia.org)
  • methods
  • Here, we describe a technique that consists of a combination of biochemistry approaches, quantitative proteomics and computational methods using wild‐type and deletion strains to investigate the organization of proteins within macromolecular protein complexes. (embopress.org)
  • Using a series of computational methods, these raw quantitative values are next interpreted in order to determine the modular organization of the complex as well as the interrelationships between its subunits, which in turn can be used to predict a macromolecular model of the complex. (embopress.org)
  • study
  • In this study, we developed and applied a novel method utilizing biochemistry, quantitative proteomics and computational approaches in order to characterize the organization of proteins in a complex. (embopress.org)
  • Sabeti went on to study biology at the Massachusetts Institute of Technology where she was a member of the varsity tennis team and class president, graduating in 1997 with a major in biology and a "perfect 5.0 average. (wikipedia.org)
  • analysis
  • The computational analysis of an RNA-Seq experiment begins earlier: what we get from the sequencing machine is a set of FASTQ files that contain the nucleotide sequence of each read and a quality score at each position. (bioconductor.org)
  • Arteries in health and disease - analysis of residual stress and its development, modelling the constitutive properties of arterial walls, computational analysis of the effect of stenting on the arterial wall, studies of collagen fibre distributions in saccular aneurysms and the interaction between blood flow and aneurysm development. (springer.com)
  • Sciences
  • It includes: the critical investigation of the conceptual nature and basic principles of information, including its dynamics, utilisation and sciences the elaboration and application of information-theoretic and computational methodologies to philosophical problems. (wikipedia.org)