AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth Care
Cold IschemiaIschemiaOrgan PreservationCold TemperatureOrgan Preservation SolutionsReperfusion InjuryRaffinoseMyocardial IschemiaBrain IschemiaDelayed Graft FunctionGraft SurvivalTissue DonorsWarm IschemiaKidney TransplantationLiver TransplantationAllopurinolTissue and Organ ProcurementCadaverTime FactorsCommon ColdTransplantation, IsogeneicCryopreservationProcaineTissue and Organ HarvestingRats, Inbred LewTransplantsTrimetazidineBrain DeathDeathKidneyMyocardial Reperfusion InjuryMannitolPancreas TransplantationGraft RejectionAdenosineRats, WistarHypothermia, InducedRats, Sprague-DawleyTransplantation, HomologousLiverIschemic Attack, TransientReperfusionDisease Models, AnimalLiving DonorsPerfusionRetrospective StudiesLiver FailureTissue FixationIschemic PreconditioningGlutathioneCold ClimateModels, AnimalImmunohistochemistryHeart TransplantationGerbillinaeSpinal Cord IschemiaNephrectomyPostoperative ComplicationsMyocardiumLung TransplantationIschemic Preconditioning, MyocardialSwineTreatment OutcomeP-SelectinLiver DiseasesTransplantation ImmunologyApoptosisNeuroprotective AgentsPotassium ChlorideInfarction, Middle Cerebral ArteryMyocardial ReperfusionSpecimen HandlingIntercellular Adhesion Molecule-1Risk FactorsAdenosine TriphosphateHistocompatibility TestingMice, Inbred C57BLCerebrovascular CirculationPatient SelectionCoronary CirculationReoperationSurvival RateHindlimbBrain
TransplantationImpact of cold ischemiaHepaticMyocardial ischemiaExertionPreservationOxidative stressDonorNormothermicExtracellularUnderwentOxygenConcludeNecrosisComplicationsShamTimeProcurementClinicallyTissueExposureCoronaryOccurLiversOccursOrganSheepPhysicalTissuesSevereExerciseTypicallyProcedureHoursCause seriousReductionPartialPatientsModelHeartCommonTemperaturesIncludeGroup
Transplantation14
  • To study the impact of cold ischemia on tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) expression after liver transplantation, a stable model of partial liver transplantation in rats was established. (geneticsmr.com)
  • The experimental animals were divided into the following groups: a partial hepatectomy control group, a group that received partial liver transplantation after 30 min of cold ischemia (experimental group A), and a group that received a partial liver transplantation after 10 h of cold ischemia (experimental group B). The survival rate was observed in each group. (geneticsmr.com)
  • The survival rates of rats in the partial hepatectomy control group, in the group that received a partial liver transplantation after 30 min of cold ischemia, and the group that received a partial liver transplantation after 10 h of cold ischemia were 100, 70, and 33.3%, respectively. (geneticsmr.com)
  • We conclude that with the extension of cold ischemic time, liver regeneration and survival rate after liver transplantation decreased. (geneticsmr.com)
  • The experimental setup is a platform that can be used to conduct further studies on uterine ischemia- and reperfusion injury that may lead to improved human uterus transplantation protocols. (nih.gov)
  • Advantages of living donation for the recipient include shorter waiting times and shorter cold ischemic times for explanted organs, largely because transplantation can be scheduled to optimize the patient's condition. (msdmanuals.com)
  • 11-13] Although platelet is indispensable for liver tissue repair after liver transplantation, platelet can also contribute to graft injury through ischemia/ reperfusion injury. (researchsquare.com)
  • Ischemia/reperfusion (I/R) is a predominant cause of hepatic injury, which is of clinical significance following liver surgery, hemorrhagic shock and liver transplantation ( 1 ). (spandidos-publications.com)
  • The accumulation of intracellular calcium ([Ca 2+ ] i ) caused by ischemia-reperfusion during liver transplantation has been implicated as a factor leading to primary graft nonfunction. (psu.edu)
  • Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have made intermediate-term survival after lung transplantation an achievable goal. (ersjournals.com)
  • Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have contributed to increase the 1‐yr patient survival after lung transplantation (LTx) to 70-80% 1 . (ersjournals.com)
  • In liver transplantation, tissue damage at reperfusion is mostly correlated with warm and cold ischemia times and leads in turn to poor graft function [13] and biliary complications [14,15]. (123dok.net)
  • Novel approaches to preventing ischemia-reperfusion injury during liver transplantation. (ox.ac.uk)
  • Ischemia-reperfusion injury (IRI) results in profound allograft damage during liver transplantation. (ox.ac.uk)
Impact of cold ischemia2
  • The objective of the current study is to examine the impact of cold ischemia on tissue phosphorylation using statistical models based on the longitudinal data observed from ovarian cancer patients. (amstat.org)
  • Since a typical time series analysis method is not sufficient to model the short-term time course data, the current project uses a Bayesian approach and an algorithm order-restricted inference to examine the impact of cold ischemia on tissue phosphorylation. (amstat.org)
Hepatic6
  • Scholars@Duke publication: Bosentan, an endothelin antagonist, augments hepatic graft function by reducing graft circulatory impairment following ischemia/reperfusion injury. (duke.edu)
  • We evaluated the role of an endothelin antagonist in hepatic ischemia/reperfusion injury. (duke.edu)
  • These results indicate that administration of bosentan before and after ischemia/reperfusion reduces hepatic circulatory disturbances, diminishes endothelial cell damage, and augments hepatic graft function. (duke.edu)
  • However, the effect of GP on ischemia/reperfusion (I/R)-induced hepatic injury has, to the best of our knowledge, not previously been investigated. (spandidos-publications.com)
  • Cold preservation studies showed a significant decrease in porcine hepatic PM Ca 2+ -ATPase activity after 4 hours of storage and near-total inhibition after 12 hours. (psu.edu)
  • Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)
Myocardial ischemia14
Exertion2
  • Ischemia occurs most often during stress, exertion, exposure to cold or while eating. (marijuanadoctors.com)
  • Tulsi has been found to protect organs and tissues against chemical stress from industrial pollutants and heavy metals, and physical stress from prolonged physical exertion, ischemia, physical restraint and exposure to cold and excessive noise. (losethebackpain.com)
Preservation6
  • Objective We hypothesized that cold ischemia during partial orchiectomy Peramivir would lead to higher serum testosterone levels and preservation of testicular architecture than warm ischemia in a prepubescent rat model. (biopaqc.com)
  • Isolated sheep uteri were perfused with the preservation solution IGL-1 and were then exposed to cold ischemia for either 4 (n = 6) or 48 hours (n = 7). (nih.gov)
  • Histological evaluation revealed extensive diffuse evidence of necrosis in all controls (at 3 hours, cold static preservation) but flaps placed on hyperbaric ex-vivo perfusion support showed decreased histologic evidence of ischemic injury or necrosis ranging from rare to moderate. (sages.org)
  • Injuries secondary to ischemia and cold preservation are mitigated. (sages.org)
  • With this technique, cold, ischaemic preservation is completely eradicated, and ischemia-reperfusion injury is avoided. (perfusion.com)
  • We also hypothesized that cold preservation would depress Ca 2+ -ATPase activity in the porcine liver. (psu.edu)
Oxidative stress2
  • However, harmful stimuli (such as ischemia-reperfusion, oxidative stress, and toxic chemicals) can change the direction and efficiency of intercellular mitochondrial transfer. (frontiersin.org)
  • One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
Donor2
  • He told Renal & Urology News that "high discard rates for COVID-positive donors and greater cold ischemic times may suggest that such donor kidneys remain difficult to place. (renalandurologynews.com)
  • Broader sharing of deceased donor livers will not significantly increase cold ischemia time -- the time the liver is in a cooled state outside the donor suggesting that this is not a barrier to broader sharing of organs. (sciencedaily.com)
Normothermic2
  • In this study, we investigated the paracrine effects of human amnion-derived MSCs (hAMSCs) in an in vitro model of lung IRI that includes cold ischemia and normothermic EVLP. (xvivoperfusion.com)
  • Quantification of cell density indicated no significant edema in the myometrium or in the endometrium of uteri exposed to 4 hours cold ischemia and then a normothermic ex vivo reperfusion for 48 hours. (nih.gov)
Extracellular1
  • Within two minutes of ischemia, extracellular pH can drop from about 7.3 to about 6.7. (benbest.com)
Underwent4
  • 4 rats 8 testicles) Group 2 underwent bilateral partial orchiectomy with 30 min of cord compression and cold ischemia via ice slush (= 7 rats 14 testicles) and Group 3 underwent bilateral partial orchiectomy with 30 min of cord compression and warm ischemia (no ice slush = 7 rats 14 testicles). (biopaqc.com)
  • Of 97 such patients, about 44% underwent CAD/ischemia testing by invasive angiography, myocardial functional imaging, or both. (medscape.com)
  • A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
  • Sham group (n = 6), mice underwent same anesthetic and surgical procedures except for ischemia induction. (biomedcentral.com)
Oxygen2
  • Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
  • When your heart demands extra oxygen, this is when ischemia is likely to occur. (marijuanadoctors.com)
Conclude1
  • We conclude that cold ischemia at clinically relevant times depresses PM Ca 2+ -ATPase more than ER Ca 2+ -ATPase activity in pig liver homogenates. (psu.edu)
Necrosis1
  • Irreversible damage to teeth may vary from apical resorption to pulp involvement, resulting in ischemia and necrosis 1 . (bvsalud.org)
Complications1
  • A few livers come from deceased, non-heart-beating donors (called donation-after-cardiac-death [DCD] donors), but in such cases, bile duct complications develop in up to one third of recipients because the liver had been damaged by ischemia before donation. (msdmanuals.com)
Sham2
  • Results Mean serum testosterone levels were 1445 ± 590 pg/mL for the sham group 449 ± 268 pg/mL for the cold ischemia group and 879 ± 631 pg/mL for the warm ischemia group (= 0.12). (biopaqc.com)
  • Mean sperm counts were 2.1 × 107 for sham 4.4 × 106 for cold ischemia and 9.9 × 106 for the warm ischemia groups (= 0.48). (biopaqc.com)
Time4
  • After 30 min of ischemia time the vessel loop was removed. (biopaqc.com)
  • For liver transplants, the cold ischemia time can be up to 24 hours, although typically surgeons aim for a much shorter period of time. (wikipedia.org)
  • For kidney transplants, as the cold ischemia time increases, the risk of delayed function of the kidney increases. (wikipedia.org)
  • In that single context, the preanalytical steps of cold ischemia time, formalin fixation method, and total time in formalin are addressed in the guideline jointly developed by the American Society of Clinical Oncology (ASCO) and the College of American Pathologists (CAP) and are included in the Accreditation Checklist of the CAP Laboratory Accreditation Program (LAP). (cap.org)
Procurement2
  • The fragility of the lungs limits the procurement rate and can favor the occurrence of ischemia-reperfusion injury (IRI). (xvivoperfusion.com)
  • For example, freezing delay of sample procurement may lead to cold ischemia, which may result in inaccurate study results. (amstat.org)
Clinically1
  • The aim of this study was to clinically assess the incidence of negative pulp sensitivity to cold among maxillary canines in infraocclusion submitted to orthodontic traction. (bvsalud.org)
Tissue3
  • Histological evaluation revealed significant difference in tissue injury grading with more injury in the cold ischemia than in the warm ischemia group (= 0.01). (biopaqc.com)
  • Therapeutic cold has the primary effect of cooling tissue. (diagnose-me.com)
  • Cold is commonly used in the treatment of acute soft tissue injuries and has been shown to reduce pain effectively in the post-operative period after orthopedic surgery procedures. (diagnose-me.com)
Exposure1
  • The symptoms usually appear suddenly, and are precipitated by exposure to cold. (cdc.gov)
Coronary2
  • Patients with a severe form of ventricular arrhythmia who may be referred for catheter ablation are often first tested for coronary artery disease (CAD) or ischemia. (medscape.com)
  • The findings, they say, question such routine CAD/ischemia testing in patients like those studied, who had episodes of monomorphic ventricular tachycardia (VT) storm but not an acute coronary syndrome (ACS) and ultimately went to ablation. (medscape.com)
Occur3
  • For optimal results in cases of trauma, cold should be applied before significant edema and hemorrhage occur. (diagnose-me.com)
  • Like a heart attack, ischemia can occur without giving off any warning signs. (marijuanadoctors.com)
  • Workers tend to underreport the syndrome because symptoms are intermittent and occur most frequently under conditions not present in a doctor's office (e.g., early in the morning or when the hands are cold or wet). (cdc.gov)
Livers1
  • Bosentan, a novel endothelin receptor antagonist, was infused directly into the portal vein prior to cold ischemia and immediately on reperfusion, in five porcine livers. (duke.edu)
Occurs1
Organ2
  • While the organ is being transported, it is either stored in an icy cold solution to help preserve it or it is connected to a miniature organ perfusion system which pumps an icy solution (sometimes enriched with potassium) through the organ. (wikipedia.org)
  • Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)
Sheep1
  • Sheep are the intermediate limb ischaemia, or may lead to conges- embolism. (who.int)
Physical1
  • Cold physical plasmas are particularly effective in promoting wound closure, irrespective of its etiology. (mdpi.com)
Tissues1
  • The vasoconstriction effect of therapeutic cold is beneficial for reducing posttraumatic swelling and pain or for reducing hemorrhage into soft tissues. (diagnose-me.com)
Severe1
  • However, a much faster and severe reperfusion damage of all uterine layers were evident during the reperfusion experiment following 48 hours of cold ischemia. (nih.gov)
Exercise1
  • The most common methods of cold application include cold packs, cold immersion, ice massage, and cooling during exercise (cryokinetics). (diagnose-me.com)
Typically1
  • These issues are "not very controversial" among cardiac electrophysiologists, Hussein said, but it remains "common practice" for other specialists to order angiography or ischemia testing for patients with monomorphic VT storm, typically in the cardiac care unit (CCU), before considering ablation. (medscape.com)
Procedure1
  • It is still an experimental procedure with numerous critical details remaining to be established, including tolerance to warm and cold ischemic insults. (nih.gov)
Hours1
  • Group 1 (controls, n=5) flaps were perfused with cold UW at 4ºC for three hours prior to transplant. (sages.org)
Cause serious1
Reduction1
  • Pain reduction associated with application of cold relaxes muscle spasm and minimizes upper motor neuron spasticity. (diagnose-me.com)
Partial1
  • 0.05) in animals that received a partial liver transplant after 10 h of cold ischemia compared with that in the animals that received a partial liver transplant after 30 min of cold ischemia. (geneticsmr.com)
Patients2
  • It's "reasonable" to test for CAD or ischemia in patients with polymorphic VT storm, which is likely ischemia-driven, he observed. (medscape.com)
  • La réanimation agressive, la prise en charge nutritionnelle, l'excision chirur- gicale complète des plaies infectées, la fermeture rapide des plaies, les greffes et la mise au point d'une chimiothérapie locale et systémique efficace ont permis d'améliorer grandement le taux de morbidité et de mortalité chez les patients brûlés. (who.int)
Model1
  • Conclusions In our preclinical rat model we found no benefit for cold ischemia over warm ischemia at 30 min. (biopaqc.com)
Heart1
Common1
  • That said, the evidence base to support the common practice of superficial cold is limited and there is a need for future higher-quality randomized controlled trials. (diagnose-me.com)
Temperatures1
  • On Saturday after Labor Day chemo infusion, my husband had chills, extremely cold, low temperatures, and extremely wiped out. (cdc.gov)
Include1
  • The most useful local therapeutic cold applications include management of edema , muscle spasm , bleeding, and traumatic pain. (diagnose-me.com)
Group2