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  • gene
  • In 1996, the clusterin ( CLU ) gene was suggested to be a potential AD susceptibility gene ( 2 ). (spandidos-publications.com)
  • Clusterin, ubiquitously distributed in mammalians, was cloned and identified as the most potently induced gene during rat prostate involution following androgen deprivation. (biochemj.org)
  • These results suggest that a 45 kDa isoform of clusterin, when targeted to the nucleus, can decrease cell proliferation and promotes cell-detachment-induced apoptosis, suggesting a possible major role for clusterin as an anti-proliferative gene in human prostate epithelial cells. (biochemj.org)
  • study
  • The present study aimed to evaluate the association between rs11136000 in clusterin (CLU) and late‑onset Alzheimer's disease (LOAD) by meta‑analysis. (spandidos-publications.com)
  • We show in the present study that the accumulation of an intracellular 45 kDa clusterin isoform was an early event closely associated with death of PNT1A cells caused by cell detachment followed by apoptosis induction (anoikis). (biochemj.org)
  • plasma
  • Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment. (ox.ac.uk)
  • Our main aim was to examine associations between plasma clusterin concentration and longitudinal changes in brain volume in normal aging and mild cognitive impairment (MCI). (ox.ac.uk)
  • Clusterin concentration was assayed by ELISA in plasma samples collected within a year of the baseline MRI. (ox.ac.uk)
  • Mixed effects regression models investigated whether plasma clusterin concentration was associated with rates of brain atrophy for control and MCI groups and whether these associations differed between groups. (ox.ac.uk)
  • The associations of plasma clusterin concentration with rates of change in brain volume were significantly different between MCI and control groups in several volumes including whole brain, ventricular CSF, temporal gray matter as well as parahippocampal, superior temporal and cingulate gyri. (ox.ac.uk)
  • Within the MCI but not control group, higher baseline concentration of plasma clusterin was associated with slower rates of brain atrophy in these regions. (ox.ac.uk)
  • In the combined autopsy sample of AD and control cases, representing a range of severity in AD pathology, we observed a significant association between clusterin concentration in the plasma and that in the superior temporal gyrus. (ox.ac.uk)
  • Schrijvers EM, Koudstaal PJ, Hofman A, Breteler MM. Plasma clusterin and the risk of Alzheimer disease. (wikipedia.org)
  • cell
  • Clusterin is involved in photo-oxidative cell death pathway. (prospecbio.com)
  • N-terminal deletion of clusterin is vital for its alterations of biogenesis in esophageal squamous cell carcinoma. (prospecbio.com)
  • The role of cytoplasmic clusterin in modulating response to two antiestrogens (toremifene and tamoxifen) was studied in two ER+ anti-estrogen-sensitive cell lines (MCF-7, 734B) and one ER+ antiestrogen-resistant cell line (T47D) using siRNA strategy. (spandidos-publications.com)
  • They find that clusterin can accumulate in juxtanuclear aggregates that exhibit features characteristic of aggresomes (inclusion bodies thought to prevent misfolded proteins spreading throughout the cell). (biologists.org)
  • The clusterin (CLU) protein was first discovered more than 25 years ago in rat testis fluid because of its ability to facilitate clustering of a variety of cell types in culture[ 1 ]. (pubmedcentralcanada.ca)
  • Clusterin can be stained to help distinguish FDCS and is involved in the many important cancer hallmarks including resistance to cell death and evading growth suppressors. (wikipedia.org)
  • cells
  • Clusterin was first identified in ram rete testis fluid where it showed signs of clustering with rat sertoli cells and erythrocytes, hence its name. (wikipedia.org)
  • We have shown that clusterin directly interacts with TDP-43 in vitro and potently inhibits its aggregation, and observed that in ER stressed neuronal cells, clusterin co-localized with TDP-43 and specifically reduced the numbers of cytoplasmic inclusions. (edu.au)
  • Analysis of conditioned media from RPE cells cultured on permeable supports suggests that different forms of clusterin display alternative patterns of secretion. (edu.au)
  • These cells are best visualized with immunostaining using the FDC markers CD21, CD35, R4/23, clusterin, and KiM4p. (wikipedia.org)
  • examine
  • A secondary objective was to examine associations between peripheral concentration of clusterin and its concentration in the brain within regions that undergo neuropathological changes in AD. (ox.ac.uk)
  • found
  • We attempted to verify in an experimental model the role of cytoplasmic clusterin (CLU), a cytoprotective protein found to be up-regulated in antiestrogen-resistant patients, following neoadjuvant treatment with toremifene. (spandidos-publications.com)
  • analysis
  • We demonstrate for the first time that a diverse number of clusterin isoforms were observed in monkey eye tissues by western analysis. (edu.au)