• cell
  • The clusterin (CLU) protein was first discovered more than 25 years ago in rat testis fluid because of its ability to facilitate clustering of a variety of cell types in culture[ 1 ]. (pubmedcentralcanada.ca)
  • The role of cytoplasmic clusterin in modulating response to two antiestrogens (toremifene and tamoxifen) was studied in two ER+ anti-estrogen-sensitive cell lines (MCF-7, 734B) and one ER+ antiestrogen-resistant cell line (T47D) using siRNA strategy. (spandidos-publications.com)
  • A direct role for clusterin in programmed cell death in the rat CNS was subsequently disclosed in a study by Garden and coworkers32 using in situ hybridization. (mussenhealth.us)
  • They find that clusterin can accumulate in juxtanuclear aggregates that exhibit features characteristic of aggresomes (inclusion bodies thought to prevent misfolded proteins spreading throughout the cell). (biologists.org)
  • Debure and co-workers reconcile these seemingly conflicting effects on cell survival by suggesting that clusterin is an anti-apoptotic, aggresome-forming chaperone but can be cytotoxic if it accumulates. (biologists.org)
  • role
  • Consistent with these data and supportive of a role for clusterin in the maturation of the nervous tissue are the observations made by O'Bryan et al33 during neuronal development in the mouse. (mussenhealth.us)