• Clofazimine, sold under the brand name Lamprene, is a medication used together with rifampicin and dapsone to treat leprosy. (wikipedia.org)
  • Clofazimine is marketed under the trade name Lamprene by Novartis although its discontinued in some countries like the US. (wikipedia.org)
  • This study is testing the effectiveness of a medicine called clofazimine (Lamprene) to treat NTM. (nih.gov)
  • The primary use of clofazimine is for the treatment of leprosy. (wikipedia.org)
  • Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum (ENL). (wikipedia.org)
  • Clofazimine is taken to treat leprosy (Hansen disease). (genericonlinemeds.com)
  • When clofazimine is used to treat flare-ups of leprosy, it may be given with a cortisone-like medicine. (genericonlinemeds.com)
  • Objectives: Although clofazimine has been traditionally used to treat leprosy, there is recent interest in using clofazimine for the treatment of MDR-TB and drug-susceptible TB. (johnshopkins.edu)
  • Clofazimine (CFZ) is routinely used worldwide for the treatment of leprosy and TB. (bvsalud.org)
  • Sumit Chanda of the Sanford Burnham Prebys Medical Discovery Institute in La Jolla was the co-senior author of a study that indicated the leprosy drug clofazimine may treat COVID-19. (lajollalight.com)
  • Extemporaneously compounded liquid formulations of clofazimine. (bvsalud.org)
  • PK, safety and acceptability data and practical guidance on the optimal dosing of new more child-friendly formulations of moxifloxacin and clofazimine in children are urgently needed to inform their current and future use in children with Rifampicin-Resistant TB (RR-TB). (hopkinscidi.org)
  • This is an open-label multisite trial to study the PK, safety, tolerability, and acceptability of new child-friendly formulations of moxifloxacin and clofazimine (hereafter referred to as "study drugs") given at current WHO-recommend weight-based doses, where these drugs are included in an optimized RR-TB treatment regimen, in HIV-infected and -uninfected children treated for RR-TB. (hopkinscidi.org)
  • Clofazimine is an antibiotic used for the treatment of certain bacterial infections. (singhealth.com.sg)
  • It turns out all these images were taken by one lab and they all have a single antibiotic, clofazimine (CFZ). (bashthebug.net)
  • Clofazimine: A useful antibiotic for drug-resistant tuberculosis. (nih.gov)
  • Primarily, there has been a shortage of Linezolid, Clofazimine, and Cycloserine, which are used to treat drug-resistant TB. (mid-day.com)
  • On the 20th day of admission, therefore, rifampicin and ethambutol treatments of the girl were stopped, and anti-tuberculosis treatment was readjusted to high doses of isoniazid (15 mg/kg once daily), pyrazinamide (30 mg/kg/day), amikacin (15 mg/kg/day), levofloxacin (10 mg/kg twice daily), linezolid (10 mg/kg twice daily), cycloserine (15 mg/kg once daily) and clofazimine (5 mg/kg once daily) (8). (who.int)
  • Additionally, Delamanid (50 mg) and Clofazimine (100 mg) were procured in August and supplied to all states and UTs. (mid-day.com)
  • Current or past use of clofazimine, bedaquiline or delamanid. (who.int)
  • Methods: We isolated 96 mutants of Mycobacterium tuberculosis resistant to clofazimine and performed WGS and Sanger sequencing to identify possible mutations associated with clofazimine resistance. (johnshopkins.edu)
  • Chanda said another "interesting thing that we found is that [clofazimine] works very well with remdesivir," cutting the amount of the latter drug needed to 1/20 of the amount normally used, with "the same effect. (lajollalight.com)
  • Remdesivir costs somewhere around $1,500 to $2,500 per use," he said, while the clofazimine pills are about $1.50 each. (lajollalight.com)
  • Early research suggested clofazimine inhibits the replication of SARS-CoV-2 in vitro and reduce viral load and inflammation in the lung in animal models Clofazimine produces pink to brownish skin pigmentation in 75-100% of patients within a few weeks, as well as similar discoloration of most bodily fluids and secretions. (wikipedia.org)
  • Here, we investigated the molecular basis of clofazimine resistance using resistant mutants isolated in vitro. (johnshopkins.edu)
  • We're hoping that … people taking clofazimine should have a drastic reduction in ICU admittance and hospitalization, which is really what we're trying to treat here with COVID," he said. (lajollalight.com)
  • Some medications may affect how Clofazimine works or be affected by Clofazimine. (singhealth.com.sg)
  • These trials assessed: betamethasone (1 trial), thalidomide (5 trials), pentoxifylline (1 trial), clofazimine (3 trials), indomethacin (2 trials), and levamisole (1 trial). (cochrane.org)
  • Three small trials showed benefit for thalidomide and clofazimine treatment in terms of fewer further reactions, more treatment successes, and less relapses of ENL. (cochrane.org)
  • Chanda and his team are now gathering funding for Phase 2 trials of clofazimine, hoping to run human testing to determine the drug's efficacy and broader application as a go-to COVID treatment. (lajollalight.com)
  • Phase 2 trials would administer clofazimine to a few hundred to a thousand volunteers who have recently tested positive for the virus, along with a placebo group, Chanda said. (lajollalight.com)
  • The Phase 1 trials were "safety trials" held long ago, when clofazimine was first approved by the Food and Drug Administration, he said. (lajollalight.com)
  • Chanda said clofazimine, if successful in clinical trials, would be most beneficial in cases of "post-exposure prophylaxis," either when a person is exposed to someone with COVID-19 or tests positive but doesn't have symptoms severe enough to warrant a hospital stay. (lajollalight.com)
  • There are several treatments for ENL, including the oral drugs prednisolone, thalidomide, and clofazimine. (cochrane.org)
  • There is evidence in medical literature that as a result of clofazimine administration, several patients have developed depression which in some cases resulted in suicide. (wikipedia.org)
  • medical citation needed] Clofazimine works by binding to the guanine bases of bacterial DNA, thereby blocking the template function of the DNA and inhibiting bacterial proliferation. (wikipedia.org)
  • So far, clofazimine has shown that it "classically works against at least the four different coronaviruses that we've tested," Chanda said, meaning the drug has "broad spectrum activity" and would be applicable to future viruses. (lajollalight.com)
  • Clofazimine is a phenazine dye and is believed to work by interfering with DNA. (wikipedia.org)
  • The study - which tested clofazimine in hamsters infected with SARS-CoV-2, the coronavirus that causes COVID-19 - showed that clofazimine "blocks two critical steps of viral replication," Chanda said. (lajollalight.com)
  • However, in the United States, clofazimine is considered an orphan drug, is unavailable in pharmacies, and its use in the treatment of MAC is overseen by the Food and Drug Administration. (wikipedia.org)
  • Clofazimine was originally intended as an anti-tuberculosis drug but proved ineffective. (wikipedia.org)
  • citation needed] Novartis was granted FDA approval of clofazimine in December 1986 as an orphan drug. (wikipedia.org)
  • The drug is currently no longer commercially available in the United States as Novartis has discontinued production of clofazimine for the US market and no generic or other brand names are marketed in the US although it retains FDA approval. (wikipedia.org)
  • Clofazimine was discovered in the 1950s at Trinity College, Dublin, and approved for medical use in the United States in 1986. (wikipedia.org)
  • citation needed] The immunosuppressive effects of clofazimine were immediately noticed when applied in animal model. (wikipedia.org)
  • Results:We found that 97% (93/96) of clofazimine-resistant mutants had a mutation in rv0678 encoding a transcription repressor for efflux pump MmpL5. (johnshopkins.edu)
  • Autopsies performed on those who have died while on clofazimine show crystal-like aggregates in the intestinal mucosa, liver, spleen, and lymph nodes. (wikipedia.org)
  • There is some evidence of benefit for thalidomide and clofazimine, but generally we did not find clear evidence of benefit for interventions in the management of ENL. (cochrane.org)