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  • deficiency
  • Urea cycle disorders are a collection of 8 enzymes involved in waste nitrogen excretion as urea including N-acetylglutamate synthase deficiency (NAGS), carbamoylphosphate synthetase (CPS1), ornithine transcarbamylase deficiency (OTC), citrin deficiency (including citrullinemia type 2, CIT2), argininosuccinic acidemia (ASA), and argninase deficiency (ARG). (clinicaladvisor.com)
  • The disorder is characterized by bruising, fatigue, anemia, low blood platelet count and enlargement of the liver and spleen, and is caused by a hereditary deficiency of the enzyme glucocerebrosidase (also known as glucosylceramidase), which acts on glucocerebroside. (wikipedia.org)
  • Genzyme's business focused on enzyme deficiency diseases. (wikipedia.org)
  • Pseudocholinesterase deficiency results in delayed metabolism of only a few compounds of clinical significance, including the following: succinylcholine, mivacurium, procaine, heroin, and cocaine. (wikipedia.org)
  • Following the approval and success of Ceredase in 1991, Genzyme became devoted to finding drugs, involving recombinant human enzymes that would treat enzyme deficiency conditions that were essential to human survival and which usually afflict a very small percentage of the world's population. (wikipedia.org)
  • The version related to bradykinin may occur due to an inherited problem known as C1 esterase inhibitor deficiency, medications known as angiotensin converting enzyme inhibitors, or a lymphoproliferative disorder. (wikipedia.org)
  • immunoassay
  • Meet the Top Five Vendors in the U.S. Clinical Immunoassay Analyzer Market. (pearltrees.com)
  • With the increase in demand for these devices, there is intense competition among the large, medium, and small-sized manufacturers of clinical immunoassay analyzers. (pearltrees.com)
  • Technavio, a leading global technology research and advisory company, recently announced the top five vendors in its U.S. clinical immunoassay analyzer market report for 2016-2020. (pearltrees.com)
  • Technavio's report predicts that the U.S. clinical immunoassay analyzer market will grow at a healthy CAGR of around 6% during the forecast period. (pearltrees.com)
  • It is an immunoassay in which a drug or metabolite in the sample competes with an drug/metabolite labelled with an enzyme, to bind to an antibody. (wikipedia.org)
  • In the many decades since, other techniques have been applied as science and technology have advanced, including the use and measurement of enzyme activities, spectrophotometry, electrophoresis, and immunoassay. (wikipedia.org)
  • assay
  • ALBUQUERQUE, N.M., Sept. 2 /PRNewswire-FirstCall/ -- Clinical Lab Products magazine features Biomoda, Inc. (OTC Bulletin Board: BMOD) ( http://www.biomoda.com ) and its proprietary early lung cancer screening assay as one of the more promising advances in the cancer diagnostic technology. (bio-medicine.org)
  • The ease in use of the assay is apparent, as well as the benefit of a test that detects cancer at its earliest stage," said John Cousins, President of Biomoda. (bio-medicine.org)
  • a second phase will test more than 2000 veterans for lung cancer using Biomoda's non-invasive patented assay. (bio-medicine.org)
  • Assay of butyrylcholinesterase activity in plasma can be used as a liver function test as both hypercholinesterasemia and hypocholinesterasemia indicate pathological processes. (wikipedia.org)
  • In many endemic areas of tropical Africa, however, the quantitative assessment of parasitaemia is important, as a large percentage of the population will test positive in any qualitative assay. (wikipedia.org)
  • detection
  • Other examinations for the detection of an AV block include electrophysiologic testing, echocardiography, and exercise. (wikipedia.org)
  • The threshold of detection by these rapid diagnostic tests is in the range of 100 parasites/┬Ál of blood compared to 5 by thick film microscopy. (wikipedia.org)
  • It generally takes around two weeks after successful treatment for HRP2-based tests to turn negative, but may take as long as one month, which compromises their value in the detection of active infection. (wikipedia.org)
  • These include: Phenol red Tryptone broth Phenylalanine agar for detection of production of deaminase, which converts phenylalanine to phenylpyruvic acid Methyl red or Voges-Proskauer tests depend on the digestion of glucose. (wikipedia.org)
  • antigen
  • Clinical significance of tissue polypeptide antigen in colorectal cancer]. (naver.com)
  • The first malaria antigen suitable as target for such a test was a soluble glycolytic enzyme Glutamate dehydrogenase. (wikipedia.org)
  • Antigen-based rapid diagnostic tests (RDTs) have an important role at the periphery of health services capability because none of the rural clinics has the ability to diagnose malaria on-site due to a lack of microscopes and trained technicians to evaluate blood films. (wikipedia.org)
  • Presence of pGluDH is known to represent parasite viability and a rapid diagnostic test using pGluDH as antigen would have the ability to differentiate live from dead organisms. (wikipedia.org)
  • genetic
  • There may be genetic variability in the kinetics of this enzyme that can lead to prolonged muscle blockade and potentially dangerous respiratory depression that needs to be treated with assisted ventilation. (wikipedia.org)
  • concentration
  • EMIT therapeutic drug monitoring tests provide accurate information about the concentration of such drugs such as immunosuppressant drugs and some antibiotics. (wikipedia.org)
  • diagnostic tests
  • As the symptoms and diagnostic tests are almost indistinguishable from an acute abdomen (e.g. perforated appendicitis) it is possible for undiagnosed HAE patients to undergo laparotomy (operations on the abdomen) or laparoscopy (keyhole surgery) that turns out to have been unnecessary. (wikipedia.org)
  • drugs
  • The enzyme alpha-galactosidase now is allowed to be produced in moss bioreactors by the German Federal Institute for Drugs and Medical Devices. (wikipedia.org)
  • include
  • He was scheduled for a spleen removal but his mother pleaded with Roscoe Brady, MD, and expert in Gaucher's disease, to include Brian in the clinical trial of Ceredase along with the other seven patients who were all adults. (wikipedia.org)
  • known
  • Butyrylcholinesterase (HGNC symbol BCHE), also known as BChE, BuChE, pseudocholinesterase, or plasma (cholin)esterase, is a nonspecific cholinesterase enzyme that hydrolyses many different choline-based esters. (wikipedia.org)
  • If a person tests positive but has no symptoms it is known as C. difficile colonization rather than an infection. (wikipedia.org)
  • analysis
  • This bench top analyzer includes 104 programmable test channels, 72 cuvette capacity, and an analysis interval of 25 seconds. (pearltrees.com)
  • Treatment
  • Aniru Sahib Sahib Conteh (6 August 1942 - 4 April 2004) was a Sierra Leonean physician and expert on the clinical treatment of Lassa fever, a viral haemorrhagic fever endemic to West Africa caused by the Lassa virus. (wikipedia.org)
  • produce
  • People with these disorders either do not produce enough of one of the enzymes needed to metabolize and break down lipids or they produce enzymes that do not work properly. (wikipedia.org)
  • Oxidase test on nutrient agar tests for the production of the enzyme oxidase, which reacts with an aromatic amine to produce a purple color. (wikipedia.org)
  • Disease
  • Prenatal testing is also available to determine if the fetus will have the disease or is a carrier. (wikipedia.org)
  • He later returned to Sierra Leone where he joined the Centers for Disease Control and Prevention (CDC) Lassa fever program at Nixon Methodist Hospital in Segbwema, first as superintendent and then as clinical director. (wikipedia.org)
  • determine
  • The purpose of the study is to determine whether ipilimumab given with paclitaxel/carboplatin has clinical benefit when compared with paclitaxel/carboplatin alone in patients with previously untreated lung cancer. (clinicaltrials.gov)
  • present
  • Based on the P waves and QRS complexes that can be evaluated from these readings, that relationship will be the standardized test if an AV block is present or not. (wikipedia.org)
  • Drug
  • QuikScreen Multi 6, 11, 12 Drug Test Cup. (pearltrees.com)
  • In the U.S., the cutoff limits must be set in accordance with Mandatory Guidelines for Federal Workplace Drug Testing Programs that were developed by SAMHSA (The Substance Abuse and Mental Health Services Administration is a branch of the U.S. Department of Health and Human Services). (wikipedia.org)
  • Positive
  • Positive tests, however, may not mean there is a significant allergy to the substance in question. (wikipedia.org)
  • Because of the social and legal consequences, a positive test result must be confirmed by an alternative method, usually Gas Chromatography/Mass spectrometry. (wikipedia.org)
  • lead
  • These later onset presentations are often due to partial enzyme deficiencies and may not lead to severe, permanent brain damage and developmental delays often seen in early, more severe onset forms. (clinicaladvisor.com)
  • results
  • The results indicate that CK estimates of myocardial infarct size represent a valid clinical end point for assessing myocardial infarct size, and the effect of therapy thereon, in groups of treated and control patients. (biomedsearch.com)
  • research
  • however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane. (wikipedia.org)
  • small
  • Clinical findings in 22 patients with small hepatocellular carcinoma, without anti-cancer therapy for a long period]. (naver.com)
  • A microtiter plate (spelled Microtiter is a registered trade name in the United States) or microplate or microwell plate or multiwell, is a flat plate with multiple "wells" used as small test tubes. (wikipedia.org)
  • time
  • Henri Termeer joined Genzyme as its president in 1983 and worked to redirect the company, which by this time had reached a valuation of $100 million, from its focus on diagnostic enzymes to modified enzymes for use as human therapeutics. (wikipedia.org)