• mammalian
  • The information obtained from yeast studies can then be used to inform more directed studies in mammalian models, such as mice or human cell lines. (omrf.org)
  • syndrome
  • Our findings reveal fundamental processes that, when they fail in humans, might be responsible for infertility and birth defects, such as Down syndrome. (omrf.org)
  • pair
  • They then compared the number of mutations between the X form and the Y form of a pair of X-Y genes to come up with rough estimates of when they were last alike, giving them a 'geologic' snapshot of sex chromosomes. (abc.net.au)
  • appear
  • Most likely this suppression was the result of a series of chromosomal inversions on the Y chromosome, which would also explain why the genes appear to be in order on the X but scrambled on the Y," Page explains. (abc.net.au)
  • research
  • Research published in this week's Science reveals that the Y chromosome developed from an X-like ancestor around 300 million years ago. (abc.net.au)
  • system
  • However, in a ZW system one can separate the effect of the hemizygous chromosome from the male-biased mutations, providing an excellent system for understanding the evolution of SCD. (royalsocietypublishing.org)
  • We use yeast as a model for our studies, as yeast and humans use the same basic machinery, but the yeast system allows us to obtain data much more quickly. (omrf.org)
  • This system has allowed us to describe the cellular processes that are used to correctly partition the error-prone chromosomes in most meioses. (omrf.org)