Chromosomes human pair 7. Medical search. Frequent questions

CRISPR screening in human hematopoietic stem and progenitor cells reveals an enrichment for tumor suppressor genes within chromosome 7 commonly deleted regions. (nih.gov)
BACs can also be utilized to detect genes or large sequences of interest and then used to map them onto the human chromosome using BAC arrays. (wikipedia.org)
Identifying genes on each chromosome is an active area of genetic research. (medlineplus.gov)
Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. (medlineplus.gov)
Chromosome 7 likely contains 900 to 1,000 genes that provide instructions for making proteins. (medlineplus.gov)
The region, which is 1.5 to 1.8 million DNA base pairs (Mb) in length, includes 25 to 27 genes. (medlineplus.gov)
Some individuals with FOXP2 -related speech and language disorder have a deletion that removes a small segment of chromosome 7, including the FOXP2 gene and several neighboring genes. (medlineplus.gov)
Additional features that are sometimes associated with FOXP2 -related speech and language disorder, including delayed motor development and autism spectrum disorders, likely result from changes to other genes on chromosome 7. (medlineplus.gov)
For example, in affected individuals with a deletion involving chromosome 7, a loss of FOXP2 is thought to disrupt speech and language development, while the loss of nearby genes accounts for other signs and symptoms. (medlineplus.gov)
Although it is widely accepted that genes can influence complex behavioral traits such as human temperament, the underlying neurogenetic mechanisms remain unclear. (nih.gov)
Williams syndrome (WS), a rare disorder caused by a hemizygous deletion on chromosome 7q11.23, including genes important for neuronal migration and maturation (LIMK1 and CLIP2), is typified by a remarkable hypersocial but anxious personality and offers a unique opportunity to investigate this open issue. (nih.gov)
To better understand the impact of genes on disease and its implications for medicine and public health, researchers have pursued methods for determining the sequences of individual genes, then all genes, and now complete human genomes. (medscape.com)
Only 1% of these bases comprise the approximately 20,000 protein coding genes found in humans. (medscape.com)
1 Over three years ago, in May 2009, the American Civil Liberties Union ( ACLU ) and the Public Patent Foundation ( PPF ) filed a lawsuit in the Federal District Court for the Southern District of New York seeking to overturn the patents on DNA isolated from two human genes. (nybooks.com)
The DNA in the two BRCA genes, like that in other human genes, is a double helical molecule, each side of which is joined, like the rungs of a ladder, by two complementary chemicals called base pairs-adenine, which always links to thymine, and cytosine, which always links to guanine. (nybooks.com)
The average chromosome contains 3-5000 genes and they range from a size of 1 kilobase to 2 megabases. (standardofcare.com)
This state of having two different variants of the same gene on each chromosome is originally caused by a mutation in one of the genes, either new ( de novo ) or inherited . (wikipedia.org)
Mutations in various genes have been reported to be associated with various phenotypes and they include crystallins, connexins, aquaporin, beaded structural filament protein 2, transcription factors like paired-like homeodomain 3 ( PITX3 ) and heat shock transcription factor 4 ( HSF4 ), avian musculoaponeurotic fibrosarcoma ( MAF ) protein and chromosome modifying proteins. (molvis.org)
For the exams, it is important to know the relationship of chromosomes and genes. (educationquizzes.com)
Genes are small sections of the chromosomes. (educationquizzes.com)
Do you know the difference between genes, chromosomes and DNA? (educationquizzes.com)
In humans, genes are found in. (educationquizzes.com)
Genes are always found in pairs. (educationquizzes.com)
Genome-wide analysis of consistently RNA edited sites in human blood reveals interactions with mRNA processing genes and suggests correlations with cell types and biological variables. (ox.ac.uk)

Fluorescence in situ hybridization (FISH) is a powerful new technique that allows numerical chromosome aberrations (aneuploidy) to be detected in interphase cells. (nih.gov)
Chromosome painting in biological dosimetry: assessment of the ability to score stable chromosome aberrations using different pairs of paint probes. (nih.gov)
We exposed human peripheral lymphocytes in vitro to 0.3 and 1 Gy of 60Co gamma rays to evaluate whether the ability and sensitivity to detect chromosomal aberrations by chromosome painting is independent or not to the specific paint probes. (nih.gov)
Genomic analysis of the tumor revealed aberrations in chromosomes 1 and 7 and a CLIP2-MET fusion. (johnshopkins.edu)
The loss of HGPRT enzyme activity could arise from a variety of genetic insults at this locus, including frameshift mutations, base pair substitutions, chromosomal aberrations, and deletions. (cdc.gov)

NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
Journal of Human Genetics. (ncku.edu.tw)
In genetics , dominance is the phenomenon of one variant ( allele ) of a gene on a chromosome masking or overriding the effect of a different variant of the same gene on the other copy of the chromosome . (wikipedia.org)

Human telomerase RNA component (hTERC) gene expression and chromosome 7 ploidy correlate positively with histological grade of cervical intraepithelial neoplasia. (nih.gov)
Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome 7 . (nih.gov)
Only in CMT2E, linked to chromosome 8p21, disease-causing mutations in the gene for neurofilament light chain (NEFL) were identified. (nih.gov)
These changes involve a region of the long (q) arm of chromosome 7 containing the FOXP2 gene. (medlineplus.gov)
It remains unclear how having two maternal copies of chromosome 7 affects the activity of the FOXP2 gene. (medlineplus.gov)
These chromosomal changes involve a region of the short (p) arm of chromosome 7 that contains the GLI3 gene. (medlineplus.gov)
There are three different types of tests performed on embryos during IVF: preimplantation genetic testing for monogenic/single-gene diseases (PGT-M), preimplantation genetic testing for structural chromosome rearrangements (PGT-SR), and preimplantation genetic testing for aneuploidy (PGT-A). PGT should be offered for 3 major groups of disease: (1) sex-linked disorders, (2) single gene defects, and (3) chromosomal disorders. (medscape.com)
The coat color gene is carried on the X chromosome. (csbsju.edu)
We report a case of glioneuronal tumor (GNT) with a discovery of novel gene fusion of CLIP2-MET resulting from aberrant chromosome 7 abnormalities. (johnshopkins.edu)
We concluded that the chromosome 7 abnormalities prompted CLIP2-MET gene fusion which successively leads to MAPK pathway activation. (johnshopkins.edu)
Earlier results indicating increased sensitivity to formaldehyde in FANCB-deficient cells were validated by testing a human FA gene-deficient cell line (human B cell line NALM-6). (europa.eu)
Additionally, there are other forms of dominance, such as incomplete dominance , in which a gene variant has a partial effect compared to when it is present on both chromosomes, and co-dominance , in which different variants on each chromosome both show their associated traits. (wikipedia.org)
Different versions of the same gene found on a pair of chromosomes in the nucleus of a cell are called alleles. (educationquizzes.com)
Finally, we identified genetic loci associated with editing levels, including known ADAR eQTLs and a small region on chromosome 7, containing LOC730338, a lincRNA gene that appears to modulate ADARs mRNA expression. (ox.ac.uk)
Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32. (ox.ac.uk)
In this study, the BCP gene has been localised to chromosome 7q31.3-32 by fluorescent in situ hybridisation of cosmid clones containing the gene. (ox.ac.uk)
This is consistent with previous mapping of the BCP gene to chromosome 7q31-35. (ox.ac.uk)
Episodic memory performance predicted by the 2bp deletion in exon 6 of the 'alpha 7-like' nicotinic receptor subunit gene. (cdc.gov)
A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia. (cdc.gov)

Chromosome 7 spans about 159 million DNA building blocks (base pairs) and represents more than 5 percent of the total DNA in cells. (medlineplus.gov)
In previous studies, FISH has been used to demonstrate that the benzene metabolites hydroquinone and 1,2,4-benzenetriol induce aneuploidy of chromosomes 7 and 9 in cultures of human cells. (nih.gov)
However, the use of small chromosome probes is not recommended because of the high number of cells to be analyzed due to the small amount of genome painted and because it is more difficult to detect translocations in small chromosomes. (nih.gov)
In plants, polytene chromosomes have been observed in only a few species, and seemed to be restricted to ovary and immature seed tissues, e.g., in Phaseolus coccineus and P. vulgaris (Nagl, 1981), until relatively recently, when they were observed in the cells of the anther tapetum of Vigna unguiculata (Guerra and Carvalheira, 1994) and of some Phaseolus species (Carvalheira and Guerra, 1994). (scielo.br)
The endomitotic cycle (endomitosis) starts with a normal prophase (endoprophase), after which the chromosome contracts further (endometaphase), their sister chromatids separate from each other (endoanaphase) and decondense to assume the interphase nuclear structure, resulting in polyploid cells, with double the chromosome number (endopolyploidy) at the end of each cycle. (scielo.br)
The endoreduplication cycle differs from endomitosis because it results in polytene cells (cells with many identical paired chromatids). (scielo.br)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
Human cells contain 23 pairs of chromosomes. (standardofcare.com)
During cellular division chromosomes are replicated, divided, and passed successfully to their daughter cells so as to ensure the genetic diversity and survival of their progeny. (standardofcare.com)
Cells can tolerate imbalances of sex chromosomes better than imbalances of autosomes. (csbsju.edu)
Cells were exposed to formaldehyde and allowed to divide for 7 days. (europa.eu)
Thus cells of human origin showed similar hypersensitivity to formaldehyde. (europa.eu)
Diploid cells within either the human testes or ovaries produce haploid sperm or eggs by undergoing two divisions during the process of meiosis. (jove.com)
The first division during meiosis is meiosis I, which begins with diploid cells in which chromosomes have replicated, appearing x like in shape. (jove.com)
The end result is a novel pair of haploid cells. (jove.com)
This again yields haploid cells, with the key difference being that the chromosomes in them are no longer replicated and appears as I's when condensed. (jove.com)
In contrast, meiosis produces four cells that not only have half the number of chromosomes from their predecessor, but they also contain unique combinations of genetic material. (jove.com)
HepG2 is an immortalized cell line consisting of human liver carcinoma cells, derived from the liver tissue of a 15-year-old Caucasian male who had a well-differentiated hepatocellular carcinoma. (igem.org)
The morphology of HepG2 cells is epithelial and contains 55 chromosome pairs. (igem.org)
Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells. (igem.org)
The human lens is made up of elongated lens fiber cells, which are devoid of cell organelles. (molvis.org)
Sperm cells carry which of the following chromosomes? (educationquizzes.com)
In the firstdivision, the reduction division, homologous chromosomes areseparated randomly between two da ughter cells, giving the haploidchromosome number. (dokumen.tips)
A. Mitosis in the Onion Root-tip The onion root tip is one of the mo st widely used mate rials for thestudy of the cell cycle be cause it is readily av ailable, preparation ofthe dividing cells is easy, and the chromosomes are large and few innumber, hence, easier to study than the cells of many otherorganisms. (dokumen.tips)
A stain is then applied(toluidine blue in this case), wh ich penetrates the damaged cells andstains the chromosomes. (dokumen.tips)
The root-tip is finally squashed by hand inorder to spread out the cells and the ir chromosomes for easierviewing. (dokumen.tips)
Theimmature anthers of pla nts are of ten used to illustrate meiosisbecause the cells are lar ge, and relatively few chromosomes arepresent. (dokumen.tips)
Chromosome territory formation attenuates the translocation potential of cells. (nih.gov)
The induction of mutations at the hypoxanthine- guanine-phosphoribosyl-transferase (HGPRT) locus, situated on the X- chromosome, rendered the cells resistant to the nucleic acid analogue 6-thioguanine (thioguanine). (cdc.gov)
Thioguanine resistant P3 cells were activated with human BJ cells and incubated with benzo(e)pyrene (192972) (BeP), pyrene (129000), chrysene (218019), BaP, 3-methylcholanthrene (56495) (MCA), or 7,12- dimethylbenz(a)anthracene (57976) (DMBA) and assayed for the induction of thioguanine resistant mutants. (cdc.gov)

These analyses are fundamental in the design of control specimens present C-heterochromatic blocks in most of campaigns because their results will help determine the their 22 chromosomes, whereas non-Andean specimens have only 4-7 autosomes with C-banding. (cdc.gov)
pairs of autosomes and 1 pair of sex chromosomes (XY in Institut de Recherche pour le Développement, Montpellier, males, XX in females) (8). (cdc.gov)
The first 22 pairs of chromosomes, called autosomes,are numbered from 1 to 22, from largest to smallest. (standardofcare.com)
All other chromosomes are termed autosomes . (csbsju.edu)
H umans have 46 total chromosomes: 44 autosomes and 2 sex chromosomes. (csbsju.edu)
Or, 22 pairs (homologous chromosomes) of autosomes and 1 pair of sex chromosomes. (csbsju.edu)

These polytenics are characterized by numerous transverse bands along their linear axis, produced by the exact pairing of sister chromatids and the intimate association of their chromomeres (Ashburner, 1970). (scielo.br)
The original chromosome and the copy are called sister chromatids. (standardofcare.com)
Duplicated chromosomes contain two identical copies, called chromatids or sister chromatids, joined by a centromere. (standardofcare.com)
Importantly, although every x in these newly formed structures is individually termed a chromosome, each is actually composed of two copies of the same chromosome, termed sister chromatids. (jove.com)

Fertilization is the procession of events that begins when a spermatozoon makes contact with an oocyte or its investments and ends with the intermingling of maternal and paternal chromosomes at metaphase of the first mitotic division of the zygote (Brackett et al. (ehd.org)
Normally visible under a light microscope only when the cell is undergoing the metaphase of cell division, where all chromosomes are aligned in the center of the cell in their condensed form. (standardofcare.com)
The X-shape structure formed in metaphase is called a metaphase chromosome, and it is a highly condensed. (standardofcare.com)
Thus, cell division stops at metaphase, allowing a good view of the spread chromosomes. (csbsju.edu)

7q11.23 duplication syndrome, a condition that can cause a variety of neurological and behavioral problems as well as other abnormalities, results from an extra copy of a region on the long (q) arm of chromosome 7. (medlineplus.gov)
It is a genetic disorder, located on chromosome 7 (band 7q11.23), in 99% of cases. (unab.cl)

These analyses suggest evidence for a locus or loci mapping to chromosome 5q31-33 associated with this composite atopic phenotype. (nih.gov)

Polytene chromosomes are structures found in highly specialized tissues in some animal and plant species, which are amplified through successive cycles of endoreduplication, finally producing several copies of each chromosome. (scielo.br)
1985) described polytene chromosomes as giant chromosomes produced by changes in the mitotic cycle during the interphase stage. (scielo.br)

HuH-7 is a well differentiated hepatocyte derived cellular carcinoma cell line that was originally taken from a liver tumor in a 57-year-old Japanese male in 1982. (igem.org)
Human Teratoma Cell Culture System For The Presceening Of Environmental Chemicals That May Initiate Or Promote Tumor Formation. (cdc.gov)

In humans, each diploid cell contains 46 chromosomes, half from the mother and half from the father. (jove.com)

To compare the rate of chromosome translocations detected by the different pairs of chromosomes, data were normalized according to the fraction of genome painted and evaluated by unconditional logistic regression. (nih.gov)
We observed that the amounts of translocations are dose dependent and quite homogeneous within each dose of radiation, independently of chromosomes painted. (nih.gov)
and PGTsr, which involves specifically screening for a structural rearrangment of chromosomes such as balanced translocations. (medscape.com)

Every chromosome is copied once in S phase, and the copy is joined to the original by a centromere, resulting either in an X-shaped structure if the centromere is located in the middle of the chromosome or a two-arm structure if the centromere is located near one of the ends. (standardofcare.com)
Each chromosome has one centromere, with one or two arms projecting from the centromere, although, under most circumstances, these arms are not visible as such. (standardofcare.com)
Each chromosome is made up of two chromatids, chromosomal arms, which are joined to each other at a small constricted region called the centromere, the primary constriction. (standardofcare.com)
The centromere is also concerned with the anaphase movement of the chromosomes, by which the spindle fibers pull the chromatids to the two opposite poles by their contraction during anaphase. (standardofcare.com)
There are two sex chromosomes in mammals, X and Y. The X chromosome, which is much larger than the Y, has a centrally-positioned centromere. (csbsju.edu)

The sex chromosomes are homologous to one another. (csbsju.edu)

In the endoreduplication cycle, the chromatid number is duplicated, but they do not segregate, and after various endoreduplication cycles, larger and thicker chromosomes are produced, called polytenics. (scielo.br)
Nondisjunction is the failure of chromosomes to properly segregate during meiosis. (csbsju.edu)

Abnormalities of chromosome 7 are responsible for some cases of Greig cephalopolysyndactyly syndrome, a disorder that affects development of the limbs, head, and face. (medlineplus.gov)

Although it is not unusual for the second polar body to display a nucleus, the chromosomes of the first polar body are isolated and naked (Zamboni, 1971). (ehd.org)
The inactivated X chromosome forms a small dark staining spot in nucleus, called a Barr body. (csbsju.edu)

BACs are often used to sequence the genome of organisms in genome projects, for example the Human Genome Project. (wikipedia.org)
[ 3-5 ] Shortly thereafter, Sanger sequencing [ 6 ] became the primary approach for both small- and large-scale projects, including the Human Genome Project. (medscape.com)
[ 7 ] From this 13-year, $3 billion effort, we learned the sequence of the approximately 6.4 billion nucleotide bases spread across 23 pairs of chromosomes that make up the human genome. (medscape.com)
[ 8 ] The Human Genome Project also resulted in a critical advance for the field: a human reference genome to use in identifying and cataloging clinically meaningful variants. (medscape.com)
Because the reference genome is haploid, meaning that only 1 copy of each chromosome is represented, and because it is derived from the DNA of several anonymous donors (a majority from 1 African-American individual), the reference genome does not necessarily contain the most common alleles in the population, and it even includes some known disease risk alleles. (medscape.com)
Illumina Inc., San Diego, California) can sequence 18,000 human genomes every year at a cost of approximately $1,000 per genome. (medscape.com)
We used hybridization capture to obtain genome-wide nuclear data, as well as mitochondrial and Y-chromosome sequences. (nature.com)
The reference genome is rCRS and the accession numbers for the present-day humans are East Asian (AF346973), European (AF346981) and African (AF381988). (nature.com)
The recombination distance in the human genome is approximately 3000 centimorgans. (standardofcare.com)
Samples of mtDNA were amplified using 24 pairs of overlapping primers to analyze the entire mitochondrial genome to screen for variations and analyzed for both coding and non-coding regions. (molvis.org)
Each person inherits two copies of the approximately 3 billion chemical letters ('A', 'T', 'G' and 'C') of the human genome-one copy from each parent. (icr.org)

Loss of heterozygosity in malignant melanoma at loci on chromosome 11 and 17 implicated in the pathogenesis of other cancers. (ox.ac.uk)

Two, DNA replication begins at multiple places along each chromosome. (utah.edu)
WHA50.37, which states "the use of cloning for the replication of human individuals is ethically unacceptable and contrary to human integrity and morality. (who.int)

They further highlight the usefulness of interphase cytogenetics and FISH for the rapid and sensitive detection of aneuploidy in exposed human populations. (nih.gov)
Condensin II drives large-scale folding and spatial partitioning of interphase chromosomes in Drosophila nuclei. (nih.gov)

The NIH Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative Cell Census Network (BICCN) has unveiled an atlas of cell types and an anatomical neuronal wiring diagram for the mammalian primary motor cortex, derived from detailed studies of mice, monkeys, and humans. (nih.gov)
The first somatic mammalian hyaluronidase isolated to homogeneity from a mammalian source was Hyal-1, which was obtained from human plasma. (gr.jp)

The likelihood that alleles will recombine during meiosis varies with the linear distance of one chromosome to another in the chromosomal sequence, this distance is referred to in centimorgans. (standardofcare.com)

Less commonly, FOXP2 -related speech and language disorder results from a rearrangement of the structure of chromosome 7 (such as a translocation) or from inheriting two copies of chromosome 7 from the mother instead of one from each parent (a phenomenon called maternal uniparental disomy or maternal UPD, which is described in more detail with Russell-Silver syndrome, below). (medlineplus.gov)
People with maternal UPD for chromosome 7 have FOXP2 -related speech and language disorder as part of a larger condition called Russell-Silver syndrome (described below). (medlineplus.gov)

Two copies of chromosome 7, one copy inherited from each parent, form one of the pairs. (medlineplus.gov)
The following chromosomal conditions are associated with changes in the structure or number of copies of chromosome 7. (medlineplus.gov)

Thus, after meiosis, all female eggs will have one X chromosome, whereas, 50% of sperms will carry the X chromosome and 50% the Y chromosome (see diagram in class). (csbsju.edu)
Non-disjunction at meiosis (or mitosis) is one cause of unusual combinations of chromosomes (a cell/individual with odd numbers of chromosomes is termed aneuploid). (csbsju.edu)
Although meiosis shares similarities with mitosis-both rely on microtubules to partition chromosomes to opposite sides of a cell, which then divides to form a daughter cell pair-meiosis is only observed in the sex organs, while mitosis occurs in other tissue types of the body. (jove.com)
PDF) Mitosis, Meiosis and Chromosomes 171L/Lab 08 Mitosis. (dokumen.tips)
Mitosis, Meiosis and Chromosomes Laboratory 8. (dokumen.tips)
Mitosis, Meiosis and Chromosomes. (dokumen.tips)

Two recent studies published in the journal Science obtained the Y chromosome sequences of many more males, and these new data brought the formerly discordant results into general agreement at 120,000-200,000 years ago. (icr.org)

In addition, the Y-chromosome diversity is an order of magnitude lower than the mitochondrial diversity, a pattern that we found is best explained by female migration between communities. (nature.com)
1 Two new studies suggest that female 'mitochondrial Eve' lived at roughly the same time as 'Y-chromosome Adam. (icr.org)
Simply count the number of Y-chromosome differences among males and the number of mitochondrial differences among all females. (icr.org)

Clinical and molecular profiling of AML patients with chromosome 7 or 7q deletions in the context of TP53 alterations and venetoclax treatment. (nih.gov)

In this study we report a multigenerational Russian family with autosomal dominant CMT2 and assign the locus to chromosome 7q11-q21. (nih.gov)

Recently, germline mutations in the MET proto-oncogene on chromosome 7 have been identified in families with hereditary PRCC. (elsevierpure.com)
Hence, differences among modern males would represent mutations to Adam's created Y chromosome sequence. (icr.org)

In 1995, Myriad's scientists also identified and isolated BRCA 2, which resides on chromosome number 13. (nybooks.com)

Normal females have two XX chromosomes, normal males have an X and Y chromosome. (csbsju.edu)
At creation, the Y chromosome would have been present in a single copy in Adam since males have an XY chromosome pairing and females an XX pairing. (icr.org)
This DNA sequence of about 16,500 DNA letters exists in addition to the 46 chromosomes, and is found in both males and females in cellular energy factories known as mitochondria. (icr.org)
Dosage compensation in Bombyx mori is achieved by partial repression of both Z chromosomes in males. (nih.gov)

Denaturing high-performance liquid chromatography (DHPLC) followed by genomic sequencing was performed on eight exons of the MET proto-oncogene, including exons 5-7 of the extracellular domain, exon 14, and exons 16-19 of the tyrosine kinase domain. (elsevierpure.com)

In some cases, Greig cephalopolysyndactyly syndrome results from a rearrangement (translocation) of genetic material between chromosome 7 and another chromosome. (medlineplus.gov)

Single-point and multipoint nonparametric sib-pair analyses were performed to assess linkage to markers on chromosome 5q31-33. (nih.gov)

The distribution of identical genetic informationis brought about by the longitudinal splitting of the chromosomes. (dokumen.tips)
Acomplex spindle apparatus arranges the separation of one whole setof identical chromosomes to each daughter cell. (dokumen.tips)

Humans normally have 46 chromosomes in each cell, divided into 23 pairs. (medlineplus.gov)
6. Minimal residual disease values discriminate between low and high relapse risk in children with B-cell precursor acute lymphoblastic leukemia and an intrachromosomal amplification of chromosome 21: the Austrian and German acute lymphoblastic leukemia Berlin-Frankfurt-Munster (ALL-BFM) trials. (nih.gov)
14. Unrelated donor stem cell transplantation compared with chemotherapy for children with acute lymphoblastic leukemia in a second remission: a matched-pair analysis. (nih.gov)
Human spinal cord cell atlas provides foundation to study neurodegeneration, chronic pain, and other diseases. (nih.gov)
Jonnakuty C, Gragnoli C. Karyotype of the human insulinoma CM cell line--beta cell model in vitro? (jefferson.edu)
In a human cell, that's 6.2 billion nucleotides. (utah.edu)
During cell division chromatin increasingly condensed to form chromosomes. (standardofcare.com)
Each cell of a human body contains 46 chromosomes. (stackexchange.com)
If so then each cell of a kidney should have a pair of sex chromosomes. (stackexchange.com)
Other changes during this period result in a microtubule-based framework that separates the chromosomes so that they are randomly but evenly partitioned between opposite ends of the cell, which then splits. (jove.com)
HuH-7 cell is HBV negative，and can produce some cytoplasmic proteins, such as albumin, a antitrypsin, AFP, etc[6]. (igem.org)
A human teratoma cell culture system that can be used to detect a variety of chemical mutagens was described. (cdc.gov)
The system used an epithelial cell line, designated P3, which was cloned from a human teratoma cell line. (cdc.gov)
The authors conclude that the human P3 epithelial cell mutagenesis assay can detect genetic damage induced by physical agents and direct acting and proximate mutagens or carcinogens. (cdc.gov)

Robbins KM, Stabley DL, Holbrook J, Sahraoui R, Sadreameli A, Conard K, Baker L, Gripp KW, Sol-Church K. Paternal uniparental disomy with segmental loss of heterozygosity of chromosome 11 are hallmark characteristics of syndromic and sporadic embryonal rhabdomyosarcoma. (jefferson.edu)

Chromosomes, Human, Pair 16" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)

These results show that high benzene exposure induces aneuploidy of chromosome 9 in nondiseased individuals, with trisomy being the most prevalent form. (nih.gov)
Advancements in embryo culture, blastocyst biopsy techniques, 24-chromosome aneuploidy screening platforms, and improved genomic coverage of new sequencing platforms, such as next-generation sequencing, have made PGT safe and accessible for all patients who undergo in vitro fertilization. (medscape.com)

Nucleotide (NER), base pair excision repair (BER) and some other repair mechanisms were shown to not be involved in DPC repair. (europa.eu)

The tetraploid genomic (AABB) component could be extracted by hybridization between a natural hexaploid wheat (NHW, AABBDD) and a natural tetraploid wheat (NTW, AABB) with nine generations of backcrossing using NHW as the recurrent parent, followed by three generations of self-pollination to exclude D chromosome and stabilize the genotype [ 13 ] (Fig. 1 a). (biomedcentral.com)

This region of chromosome 11 is also commonly mutated in breast cancers and haematological malignancies. (ox.ac.uk)

Localization of tuberous sclerosis 2 mRNA and its protein product tuberin in normal human brain and in cerebral lesions of patients with tuberous sclerosis. (musc.edu)
Supported by venture capital and both funds and collaborators from the National Institutes of Health, Skolnick and his colleagues won the race in 1994, finding BRCA 1 and isolating it from the rest of the DNA and the tangle of protein that form chromosome 17. (nybooks.com)

Most eukaryotic chromosomes include packaging proteins which, bind to and condense the DNA molecule to prevent it from becoming an unmanageable tangle. (standardofcare.com)
Chromosomes are composed of chromatin fiber, which are made of nucleosomes, which are packaged by proteins into a condensed structure called chromatin. (standardofcare.com)

A bacterial artificial chromosome (BAC) is a DNA construct, based on a functional fertility plasmid (or F-plasmid), used for transforming and cloning in bacteria, usually E. coli. (wikipedia.org)
The development and applications of the bacterial artificial chromosome cloning system" (PDF). (wikipedia.org)

DNA sequence variants are responsible for much of the diversity in human appearances, traits, and disease status. (medscape.com)
More immediately, since only Noah and his biological sons boarded the Ark, all modern human Y chromosome diversity traces back to Noah's sons, who inherited their Y chromosome from Noah. (icr.org)

The two strands of a DNA molecule are held together through complementary base pairing: A pairs with T, and C pairs with G. (utah.edu)
A chromosome is a DNA molecule with part or all of the genetic material of an organism. (standardofcare.com)

While Sanger sequencing provided critical advances in the rise of genomics, it is prohibitively expensive and time-consuming to use for sequencing entire human genomes. (medscape.com)

To date, linkage of chromosome 20 (HPC20) to hereditary PC has been one of the strongest linkage signals, yet the efforts to replicate this linkage have been limited. (elsevierpure.com)

The chromosomes are stained, photographed and arranged from large to small, matching homologs ( see exercise) . (csbsju.edu)
Although, a few small linkage signals for chromosome 20 were found in various strata of this pooled analysis, this large study failed to replicate linkage to HPC20. (elsevierpure.com)
Naus compared the power of the scan test with that of the Ederer, Myers, and Mantel test and concluded that if the scanning interval is small and the data are continuous over the interval, the scan test is the more powerful of the two (7). (cdc.gov)

Cosmid End-sequence profiling Fosmid Human artificial chromosome Secondary chromosome Yeast artificial chromosome O'Connor M, Peifer M, Bender W (June 1989). (wikipedia.org)
1930). Good photomicrographs and electron micrographs of human secondary oocytes are available (e.g. (ehd.org)
In certain chromosomes there is a secondary constriction as well. (standardofcare.com)

Since there is only one copy of the Y chromosome , Y-linked traits cannot be dominant or recessive. (wikipedia.org)

7. Clinical features and outcome of children with first marrow relapse of acute lymphoblastic leukemia expressing BCR-ABL fusion transcripts. (nih.gov)
These should reflect both the complex pathophysiological and the immunological alterations induced by trauma, with the objective to translate the findings to the human situation, providing new clinical treatment approaches for patients affected by severe trauma. (biomedcentral.com)

WHA50.37 of 1997 argues that human cloning is ethically unacceptable and contrary to human integrity and morality. (who.int)

Anatomy66

Organisms8

Diseases26

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology1

Phenomena and Processes174

Disciplines and Occupations2

Technology, Industry, Agriculture2

Information Science4

Health Care1

Genes24

Aberrations5

Genetics3

Gene19

Cells30

Autosomes6

Sister chromatids4

Metaphase4

7q11.232

Mapping1

Polytene chromosomes2

Tumor2

Diploid1

Translocations3

Centromere5

Homologous1

Segregate2

Abnormalities1

Nucleus2

Genome11

Loci1

Replication2

Interphase2

Mammalian2

Alleles1

Maternal2

Copies2

Meiosis6

Sequences1

Mitochondrial3

Deletions1

Locus1

Mutations2

19951

Males4

Exon1

Translocation1

Analyses1

Identical2

Cell14

Paternal1

MeSH1

Aneuploidy2

Nucleotide1

Genomic1

Commonly1

Protein2

Proteins2

Bacterial2

Diversity2

Molecule2

Genomics1

Hereditary1

Small3

Secondary3

Dominant1

Clinical2

19971