Loading...
  • Homo
  • http://www.ensembl.org/Homo_sapiens/Transcript/Summary?db=vega;g=OTTHUMG00000170426;r=14:105491268-105499209;t=OTTHUMT00000074613 https://www.ncbi.nlm.nih.gov/nuccore/NM_001134875.1 http://bgee.unil.ch/bgee/bgee?page=gene&action=summary&gene_id=ENSG00000185347 https://www.ncbi.nlm.nih.gov/geoprofiles http://www.genecards.org/cgi-bin/carddisp.pl?gene=C14orf80 Altschul, S.F. (wikipedia.org)
  • While not functional, there are two pseudogenes found on chromosome 6 and 14 in Homo sapiens. (wikipedia.org)
  • genome
  • Disease genes and chromosomes: disease maps of the human genome. (wikipedia.org)
  • However, the smaller chromosome lost may carry so few genes (which are, in any case, also present elsewhere in the genome) that it can be lost without an ill effect to the individual. (wikipedia.org)
  • New genetic technologies are developing very rapidly: recent discoveries related to the human genome have opened the door to new opportunities and unprecedented ethical concerns. (coe.int)
  • 2. In particular, recent advances in genome editing are bound to result in germline interventions in human beings quite soon, for example with the birth of children whose genome has been altered with some unforeseeable consequences in such a way that their descendants are also affected. (coe.int)
  • 4. Numerous scientific and ethical bodies are starting to make recommendations to establish an appropriate regulatory framework for genome editing and germline interventions in human beings, including most recently the United States National Academy of Sciences and National Academy of Medicine, and the European Academies Science Advisory Council (EASAC). (coe.int)
  • The current prohibition on interventions aimed at modifying the germline in human beings in all European Union and many Council of Europe member States is not going to stop genome-edited babies from being born elsewhere. (coe.int)
  • The human genome is the sum total of all human genes. (slideshare.net)
  • An MSH4 hypomorphic (partially functional) mutant of S. cerevisiae showed a 30% genome wide reduction in crossover numbers, and a large number of meioses with non exchange chromosomes. (wikipedia.org)
  • mammalian
  • Human ALOX15 was initially named arachidonate 15-lipoxygenase or 15-lipoxygenase but subsequent studies uncovered a second human enzyme with 15-lipoxygenase activity as well as various non-human mammalian Alox15 enzymes that are closely related to and therefore orthologs of human ALOX15. (wikipedia.org)
  • Lymphoma
  • The mechanism of chromosome 14 inversion in a human T cell lymphoma. (ox.ac.uk)
  • Previous studies have shown that a hybrid gene (designated IgT) consisting of an immunoglobulin VH gene segment and T cell receptor J alpha C alpha segments encompasses the telomeric breakpoint in SUP-T1, a cell line derived from a human T cell lymphoma. (ox.ac.uk)
  • mutations
  • Mutations in the human gene may contribute to the condition of Klippel-Feil syndrome, which is the failure of the vertebrae to segment near the top of the spine and possibly further down with symptoms including a short, immovable neck and a low hairline on the back of the head. (wikipedia.org)
  • situ
  • Using in situ hybridization in human embryos, we demonstrate expression of BMP4 in optic vesicle, developing retina and lens, pituitary region, and digits strongly supporting BMP4 as a causative gene for AM, pituitary, and poly/syndactyly. (ox.ac.uk)
  • syndrome
  • The loss of these genes is likely responsible for several of the major features of ring chromosome 14 syndrome, including intellectual disability and delayed development. (nih.gov)
  • occur
  • Seizures may occur because certain genes on the ring chromosome 14 are less active than those on the normal chromosome 14. (nih.gov)
  • Up-regulation of ALOX5 may occur during the maturation of leukocytes and in human neutrophils treated with granulocyte macrophage colony-stimulating factor and then stimulated with physiological agents. (wikipedia.org)
  • 1999
  • Kelavkar and Badr (1999) described experiments yielding data that supported the hypothesis that loss of the TP53 gene, or gain-of-function activities resulting from the expression of its mutant forms, regulates ALOX15 promoter activity in human and in mouse, albeit in directionally opposite manners. (wikipedia.org)
  • enzyme
  • 15-LO is to be distinguished from another human 15-lipoxygenase enzyme, ALOX15B (also termed 15-lipoxygenase-2). (wikipedia.org)
  • and mouse, rat, and rabbit rodent orthologs of human ALOX15, which share 74-81% amino acid identity with the human enzyme, are commonly termed Alox15, 12/15-lipoxygenase, 12/15-LOX, or 12/15-LO). (wikipedia.org)
  • Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans is encoded by the ALOX5 gene. (wikipedia.org)
  • Carbohydrate sulfotransferase 14 is an enzyme that in humans is encoded by the CHST14 gene. (wikipedia.org)
  • found
  • The TMEM251 gene first appeared on the planet around 400 million years ago (MYA), since the most distant orthologs are found in fish which diverged from humans around the same time. (wikipedia.org)
  • species
  • Silene recently evolved sex chromosomes 5-10 million years ago and are widely used by geneticists and biologists to study the mechanisms of sex determination since they are one of only 39 species across 14 families of angiosperm that possess sex-determining genes. (wikipedia.org)
  • In most species, including humans, mtDNA is inherited solely from the mother. (wikipedia.org)
  • It is not threatened with extinction, but human activities, such as hunting, habitat destruction, and the introduction of foreign predatory species and parasites, have reduced its distribution in Australia. (wikipedia.org)
  • Assay
  • Leukocyte cell-derived chemotaxin-2 (LECT2) is a protein first described in 1996 as a chemotactic factor for neutrophils, i.e. it stimulated human neutrophils to move directionally in an in vitro assay system. (wikipedia.org)
  • The role of telomeres and telomerase in cell aging and cancer was established by scientists at biotechnology company Geron with the cloning of the RNA and catalytic components of human telomerase and the development of a polymerase chain reaction (PCR) based assay for telomerase activity called the TRAP assay, which surveys telomerase activity in multiple types of cancer. (wikipedia.org)
  • nucleotide
  • It is typically measured in terms of mass in picograms (trillionths (10−12) of a gram, abbreviated pg) or less frequently in Daltons or as the total number of nucleotide base pairs typically in megabases (millions of base pairs, abbreviated Mb or Mbp). (wikipedia.org)
  • organism
  • The aim of this study is to estimate the influence of general environmental conditions on human organism at the final stage of the Neolithic period - in the Corded Ware culture. (blogspot.com)
  • Different combinations of the genes present in a Silene Y chromosome affect the sexual expression in the organism. (wikipedia.org)
  • different
  • Human ALECT2 has several different transcriptional initiation sights and codes for a mRNA composed of 1,000 to 1,300 ribonucleotides. (wikipedia.org)
  • variants
  • There are sixteen variants of histone H2B found in humans, thirteen of which are expressed in regular body cells and three of which are only expressed in the testes. (wikipedia.org)
  • populations
  • So-called physiological stress markers are extremely valuable in assessing life conditions of old human populations. (blogspot.com)
  • Clonal populations of bacteria, each population maintaining a single artificial chromosome, are stored in various laboratories around the world. (wikipedia.org)
  • tissues
  • It is paired with keratin 6 in a number of epithelial tissues, including nail bed, esophagus, tongue, and hair follicles. (wikipedia.org)
  • single
  • It is important to know if the sequencing experiment was single-end or paired-end, as the alignment software will require the user to specify both FASTQ files for a paired-end experiment. (bioconductor.org)
  • some single cell organisms have much more DNA than humans (see Junk DNA and C-value enigma). (wikipedia.org)
  • Within 100 generations in humans (about 2100 years in ancient times) one expects a few hundred of these 'blending' events to have occurred across a single chromosome, the average size is 1 centiMorgan (or 1 cM). (wikipedia.org)
  • type
  • Human T-cell leukemia virus type I (HTLV-I) causes adult T-cell leukemia (ATL) after a long latent period. (biomedcentral.com)
  • long
  • It has 3 pointed (acuminate), green, between 7-14 cm (3-6 in) long and 1.8-2 cm wide, spathes (leaves of the flower bud). (wikipedia.org)
  • structure
  • Other changes in the number or structure of chromosome 7 can cause delayed growth and development, mental disorder, characteristic facial features, skeletal abnormalities, delayed speech, and other medical problems. (wikipedia.org)
  • A circular structure called ring chromosome 7 is also possible. (wikipedia.org)
  • cell
  • In the experiment, four primary human airway smooth muscle cell lines were treated with 1 micromolar dexamethasone for 18 hours. (bioconductor.org)
  • The protein was detected in and purified from cultures of Phytohaemagglutinin-activated human T-cell leukemia SKW-3 cells. (wikipedia.org)
  • molecules
  • Mechanisms for this include simple dilution (an egg contains on average 200,000 mtDNA molecules, whereas a healthy human sperm was reported to contain on average 5 molecules ), degradation of sperm mtDNA in the male genital tract, in the fertilized egg, and, at least in a few organisms, failure of sperm mtDNA to enter the egg. (wikipedia.org)
  • various
  • The various tarantula hawk wasps are of a similar size and can overpower a spider many times its own weight, and move it to its burrow, with a sting that is excruciatingly painful to humans. (wikipedia.org)
  • similar
  • Activity anorexia (AA) is a condition where rats begin to exercise excessively while simultaneously cutting down on their food intake, similar to human anorexia nervosa or hypergymnasia. (wikipedia.org)
  • studies
  • The common inference drawn from such studies is that the sex of the offspring is determined by the Y chromosome. (wikipedia.org)
  • Several studies concentrated on Silene latifolia have shown a correlation between loci on the Y chromosome and the sex that is expressed phenotypically in the flower. (wikipedia.org)
  • cause
  • Spiral wave breakup is believed to be a cause of ventricular fibrillation in human hearts(see movie). (blogspot.com)
  • certain
  • Some of these compounds had some antioxidant activity in certain cells and some effected yeast cells expressing human estrogen. (wikipedia.org)
  • example
  • For example, there are two genetic variations that can lead to male sterility in S. latifolia: if it possesses two Y chromosomes (YY) or if the Y chromosome possesses the female suppression and male promoting genes. (wikipedia.org)
  • study
  • Historically, there has been an anthropocentric tendency to emphasize the study of animal psychopathologies as models for human mental illnesses. (wikipedia.org)