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  • bone marro
  • The incidence of chromosome aberrations in bone marrow cells of 12-month-old SAMP-1 female mice characterized by accelerated aging was 1.8 times higher than in wild-type SAMR-1 females and 2.2 times higher than in SHR females of the same age. (semanticscholar.org)
  • aneuploidy
  • Inhibition of topo II activity may also predispose cells to aneuploidy because this enzyme is needed for removing regions of DNA catenation prior to chromosome segregation. (mysciencework.com)
  • 1985
  • In 1985 it was clearly established that the fusion gene on chromosome 22 produced an abnormal chimeric BCR/ABL1 protein with the capacity to induce chronic myeloid leukemia. (wikipedia.org)
  • peripheral blood
  • To examine the biological effect in the peripheral blood of the paediatric patients chromosome analysis was carried out in 10 children for whom the medical justifications for CT examinations were accidental injuries and not diseases as investigated in earlier studies. (radioprotection.org)
  • fragments
  • Deletion of certain fragments, including deletions that are a few hundred base pairs long, and hence gene segments is possible and consequently the production of double minute chromosomes. (wikipedia.org)
  • When multiple chromosomes are involved in chromothripsis, fragments of both chromosomes are joined together by paired end joining and the exchange of fragments between the original chromosomes. (wikipedia.org)
  • DISORDERS
  • Lonigan 's or is given the download chromosome aberrations figure( PI) for seven fully anti-abortion( IES, NICHD, NSF), infectious years of inoculations or purview patterns for legal disorders synthesis of Behavioral media or drawings. (windhover.org)
  • Together with Fredrik Mertens and Bertil Johansson he maintains a database of all published chromosome aberrations in neoplastic disorders, with clinical features, now numbering more than 65,000 cases (as of December 2016). (wikipedia.org)
  • mainly
  • By subdividing the children into two age groups, those with an age from 0.4 years to 9 years and from 10 years to 15 years, it became obvious that the observed increase in chromosome aberrations was mainly contributed by the younger age group. (radioprotection.org)
  • dose
  • The small but consistent differences between the two cities may be due either to different scoring efficiency of aberrations in the two laboratories or to differential errors in DS86 dose assignments. (rerf.jp)
  • Syndrome
  • In 2015, it was found that chromothripsis can also be curative: a woman who had WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome, an extremely rare autosomal dominant combined immunodeficiency disease, found her symptoms disappeared during her 30s after chromothripsis of chromosome 2 deleted the disease allele. (wikipedia.org)
  • Data
  • Ahmed does on the fine features of Ophthalmology, the Journal of Cataract and Refractive Surgery, and Techniques in Ophthalmology, among years, and he welcomes a download Chromosome for strong data as effortlessly. (leadroof.org.uk)
  • Effect
  • In addition to the anti-hyperglycemic action of mushrooms, the present study presents its effect on DNA damage, chromosome aberrations and sperm alternations in streptozotocin-induced diabetic rats. (scirp.org)
  • article{Rosenfeld2002EffectOE, title={Effect of Epithalon on the Incidence of Chromosome Aberrations in Senescence-Accelerated Mice}, author={Svetlana V. Rosenfeld and E. F. Togo and Vladimir Mikheev and Irina G. Popovich and M. A. Zabezhinskii and Vladimir Kh. (semanticscholar.org)
  • found
  • No increased risk for AML with complex CCA or with total or partial losses of chromosomes 5 or 7 were observed, but a higher risk was found for AML with trisomy 8 (OR 11, 95% CI 2.7-42) as the sole aberration. (sjweh.fi)
  • Loss of heterozygocity on chromosome arm 3p is found in more than 80% of SCLCs, including the loss of FHIT. (wikipedia.org)
  • centromere
  • By minimizing the amount of unnecessary genetic information on the chromosome and including the basic components necessary for replication (centromere, telomeres, replication sequence), scientists aim to construct a chromosomal platform which can be utilized to insert/present new genes into a host organism's cell. (wikipedia.org)
  • Chromosome 17 polysomy may not be present when the centromere is amplified, so it was later discovered that polysomy 17 is rare. (wikipedia.org)
  • sequences
  • It was developed by biomedical researchers in the early 1980s and is used to detect and localize the presence or absence of specific DNA sequences on chromosomes. (wikipedia.org)
  • Unlike traditional methods of genetic engineering, minichromosomes can be used to transfer and express multiple sets of genes onto one engineered chromosome package, Traditional methods which involve the insertion of novel genes into existing sequences may result in the disruption of endogenous genes and thus negatively affect the host cell. (wikipedia.org)
  • pathogenesis
  • The role of HAP1 in HD pathogenesis may involve aberration of cell cycle processes, as high immunostaining of HAP1 during the cell cycle has been observed. (wikipedia.org)
  • Several experimental and clinical studies have indicated that aberrations and deregulations of the UPS contribute to the pathogenesis of several neurodegenerative and myodegenerative disorders, including Alzheimer's disease, Parkinson's disease and Pick's disease, Amyotrophic lateral sclerosis (ALS), Huntington's disease, Creutzfeldt-Jakob disease, and motor neuron diseases, polyglutamine (PolyQ) diseases, Muscular dystrophies and several rare forms of neurodegenerative diseases associated with dementia. (wikipedia.org)
  • induce
  • In addition, the microwave can make normal bacteria growth and stable genetic breeding of nucleic acid (RNA) and deoxyribonucleic acid (DNA), is by the number of hydrogen bonding is flabby, faults and restructuring, and thus induce genetic mutations, or chromosome aberration and even rupture. (cityofalturas.org)
  • species
  • Polysomy is a condition found in many species, including fungi, plants, insects, and mammals, in which an organism has at least one more chromosome than normal, i.e., there may be three or more copies of the chromosome rather than the expected two copies. (wikipedia.org)
  • typically
  • Next, the desired contents of the minichromosome must be transformed into a host which is capable of assembling the components (typically yeast or mammalian cells) into a functional chromosome. (wikipedia.org)
  • newly
  • The newly synthesized truncated chromosome can then be altered through the insertion of new genes for desired traits. (wikipedia.org)
  • To distinguish the method of replication used by DNA experimentally, the team pulse-labeled newly replicated areas of Escherichia coli chromosomes, denatured, and extracted the DNA. (wikipedia.org)
  • cancer
  • Polysomy of chromosome 13 (Polysomy 13) is significant in the development of prostate cancer and is often caused by centric fusions. (wikipedia.org)
  • high
  • From 29 patients with non-classical cytogenetic aberrations, only 8 (28%) had been stratified to a high risk-arm on the first treatment protocol, suggesting that this subgroup might benefit from the identification of new prognostic markers in future studies. (uzh.ch)
  • thus
  • Minichromosome technology allows for the stacking of genes side-by-side on the same chromosome thus reducing likelihood of segregation of novel traits. (wikipedia.org)
  • patients
  • Higher degree of chromosome mosaicism in preimplantation embryos from carriers of robertsonian translocation t(13;14) in comparison with embryos from karyotypically normal IVF patients. (ac.be)
  • Terms
  • Other terms used to describe the arrays used for karyotyping include SOMA (SNP oligonucleotide microarrays) and CMA (chromosome microarray). (wikipedia.org)
  • structure
  • Conventional karyotypes can assess the entire genome for changes in chromosome structure and number, but the resolution is relatively coarse, with a detection limit of 5-10Mb. (wikipedia.org)