• radiation
  • A mouse study also confirmed that chromosome aberrations were not seen in offspring 20 weeks after in utero radiation exposure, although they were seen in mothers after exposure in adulthood. (rerf.jp)
  • Human fetuses do not register chromosome damage inflicted by radiation exposure in lymphoid precursor cells except for a small but significant effect at low doses. (rerf.jp)
  • In particular, unstable CA (dicentrics, rings and fragments) are generally considered as specific to radiation exposure, and these types of aberrations are referred to as unstable CA because of their persistence in the body decline with cell division cycles (Amaral, 2002). (scielo.br)
  • Furthermore, aberrations can be used for applications in biodosimetry and more generally as biomarkers of exposure and risk, that is the case for cancer patients monitored during Carbon-ion therapy and astronauts exposed to space radiation. (unipv.it)
  • Finally, two of the few available models of chromosome aberration induction by ionizing radiation (including heavy ions) will be described and compared, focusing on the different assumptions adopted by the authors and on how these models can deal with heavy ions. (unipv.it)
  • deletions
  • CGH does, however, allow for the exploration of all 46 human chromosomes in single test and the discovery of deletions and duplications, even on the microscopic scale which may lead to the identification of candidate genes to be further explored by other cytological techniques. (wikipedia.org)
  • Deletion of certain fragments, including deletions that are a few hundred base pairs long, and hence gene segments is possible and consequently the production of double minute chromosomes. (wikipedia.org)
  • bone marro
  • The incidence of chromosome aberrations in bone marrow cells of 12-month-old SAMP-1 female mice characterized by accelerated aging was 1.8 times higher than in wild-type SAMR-1 females and 2.2 times higher than in SHR females of the same age. (semanticscholar.org)
  • 1985
  • In 1985 it was clearly established that the fusion gene on chromosome 22 produced an abnormal chimeric BCR/ABL1 protein with the capacity to induce chronic myeloid leukemia. (wikipedia.org)
  • Genomic
  • The aim of this technique is to quickly and efficiently compare two genomic DNA samples arising from two sources, which are most often closely related, because it is suspected that they contain differences in terms of either gains or losses of either whole chromosomes or subchromosomal regions (a portion of a whole chromosome). (wikipedia.org)
  • The authors painted a series of individual human chromosomes from a DNA library with two different fluorophores in different proportions to test the technique, and also applied CGH to genomic DNA from patients affected with either Downs syndrome or T-cell prolymphocytic leukemia as well as cells of a renal papillary carcinoma cell line. (wikipedia.org)
  • dose
  • The small but consistent differences between the two cities may be due either to different scoring efficiency of aberrations in the two laboratories or to differential errors in DS86 dose assignments. (rerf.jp)
  • Syndrome
  • In 2015, it was found that chromothripsis can also be curative: a woman who had WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome, an extremely rare autosomal dominant combined immunodeficiency disease, found her symptoms disappeared during her 30s after chromothripsis of chromosome 2 deleted the disease allele. (wikipedia.org)
  • cell
  • However, dicentric frequency declines within a few years because the presence of two centromeres in one chromosome interferes with cell division. (rerf.jp)
  • Clonally expanded T-cell populations in atomic bomb survivors do not show excess levels of chromosome instability. (rerf.jp)
  • Chromosome aberrations are a particularly relevant endpoint in radiobiology, because they play a fundamental role in the pathways leading either to cell death, or to cell conversion to malignancy. (unipv.it)
  • If the cell senses extra chromosomes, the cell can attempt to remove the extra chromosome in another cell membrane, separate from the other normal chromosome. (wikipedia.org)
  • Mycoplasmae may induce cellular changes, including chromosome aberrations, changes in metabolism and cell growth. (wikipedia.org)
  • losses
  • No increased risk for AML with complex CCA or with total or partial losses of chromosomes 5 or 7 were observed, but a higher risk was found for AML with trisomy 8 (OR 11, 95% CI 2.7-42) as the sole aberration. (sjweh.fi)
  • distinct
  • The most widely accepted and straightforward model for chromothripsis is that within a single chromosome, distinct chromosomal regions become fragmented/shattered almost simultaneously and subsequently rejoined in an incorrect orientation. (wikipedia.org)
  • Data
  • Ahmed does on the fine features of Ophthalmology, the Journal of Cataract and Refractive Surgery, and Techniques in Ophthalmology, among years, and he welcomes a download Chromosome for strong data as effortlessly. (leadroof.org.uk)
  • Results
  • The results did not show an increased rate of later aberrations indicative of genetic instability. (rerf.jp)
  • But, the experimental results show that treatment with mushroom is better than treatment with amaryl in case of genetic changes (DNA fragmentation, disappear of some base pairs and chromosome aberrations. (scirp.org)
  • Results: The ratio of dicentric chromosome was found to be higher in the glioblastoma multiforme patients. (minervamedica.it)
  • This results in parts of the chromatids or chromosomes being broken off and enveloped as an extra nucleus in one of the daughter cells. (wikipedia.org)
  • test
  • Geraniol shows anti-clastogenic potential against MNNG induced chromosomal aberrations in both test-systems. (omicsonline.org)
  • A higher intensity of the test sample colour in a specific region of a chromosome indicates the gain of material of that region in the corresponding source sample, while a higher intensity of the reference sample colour indicates the loss of material in the test sample in that specific region. (wikipedia.org)
  • different
  • Based on these lines, 88 markers specific for chromosome 2R were physically mapped to 13 different blocks of 2R with three in arm 2RS and 10 in arm 2RL. (springer.com)
  • In anaphase, the microtubules are not attached properly to the chromosomes, which can cause pulling in a different direction. (wikipedia.org)
  • study
  • In addition to the anti-hyperglycemic action of mushrooms, the present study presents its effect on DNA damage, chromosome aberrations and sperm alternations in streptozotocin-induced diabetic rats. (scirp.org)