• Chromogranin A or parathyroid secretory protein 1 (gene name CHGA) is a member of the granin family of neuroendocrine secretory proteins. (wikipedia.org)
  • Human chromogranin A ELISA kit can be used for specifically detecting in vitro quantitative concentrations of chromogranin A (ChgA, parathyroid secretory protein 1) human serum and plasma. (elisakits.co.uk)
  • Chromogranin A (ChgA) is also called parathyroid secretory protein 1, consists of 439 amino acids that is a 49 kDa acidic protein encoded on chromosome 14. (elisakits.co.uk)
  • The minimum sensitivity detection limit of ChgA (chromogranin A, parathyroid secretory protein 1) using current chromogranin A ELISA kit was approximately 1.4 ng/ml. (elisakits.co.uk)
  • Chromogranin A is a secretory protein, composed of 439 amino acids, found in the large dense-core vesicles of the neuroendocrine cells. (medscape.com)
  • Chromogranin A (CgA) is a secretory protein, composed of 439 amino acids, found in the large dense-core vesicles of the neuroendocrine cells. (medscape.com)
  • PC-12 cells were subjected to SDS PAGE followed by western blot with 14968-1-AP (Chromogranin B antibody at dilution of 1:300 incubated at room temperature for 1.5 hours. (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 14968-1-AP (Chromogranin B antibody at dilution of 1:200 (under 10x lens). (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 14968-1-AP (Chromogranin B antibody at dilution of 1:200 (under 40x lens). (ptglab.com)
  • This antibody cocktail recognizes a protein of 68-75 kDa, identified as Chromogranin A antibody. (dbs-india.com)
  • Microtiter Plate - Coated with human chromogranin A antibody. (elisakits.co.uk)
  • Formalin-fixed, paraffin-embedded human Adrenal Gland stained with Chromogranin A Mouse Monoclonal Antibody (PHE5). (neobiotechnologies.com)
  • SDS-PAGE Analysis Purified Chromogranin A Mouse Monoclonal Antibody (PHE5). (neobiotechnologies.com)
  • Variations in Chromogranin A / CHGA antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. (enquirebio.com)
  • Tissues from cancer patients, for instance, have their own distinct pattern of Chromogranin A / CHGA expression as measured by anti-Chromogranin A / CHGA antibody immunohistochemical staining. (enquirebio.com)
  • Description: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. (postgenomeconsortium.com)
  • Aims: Inflammation has been linked to the development of diabetic retinopathy (DR). Chromogranins A, B (CgA, CgB) and secretogranin II (SgII), are prohormones overexpressed in inflammatory diseases. (unisr.it)
  • It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II. (medscape.com)
  • Chromogranin A is cleaved by an endogenous prohormone convertase to produce several peptide fragments. (wikipedia.org)
  • Chromogranin A is the precursor to several functional peptides including vasostatin-1, vasostatin-2, pancreastatin, catestatin and parastatin. (wikipedia.org)
  • The chromogranin A-derived peptides vasostatin-I and catestatin as regulatory peptides for cardiovascular functions. (elisakits.co.uk)
  • New biological aspects of chromogranin A-derived peptides: focus on vasostatins. (elisakits.co.uk)
  • Chromogranin A contains multiple cleavage sites, which undergo a tissue-specific proteolytic process, leading to the production of many biologically active peptides including vasostatin I, vasostatin II, pancreastatin, catestatin, parastatin, and serpinin. (medscape.com)
  • Adenocarcinoma ex-goblet cell carcinoid (AdexGCC) was considered a neuroendocrine adenocarcinoma, despite majority of tumor cells being negative for conventional neuroendocrine markers such as chromogranin and synaptophysin. (gastrores.org)
  • Recently, insulinoma-associated protein 1 (INSM1) has been identified as a novel neuroendocrine marker that is more sensitive than chromogranin, synaptophysin, and CD56 in pulmonary neuroendocrine tumors. (gastrores.org)
  • We studied this marker in conjunction with chromogranin, synaptophysin, and CD56 in 36 appendiceal AdexGCCs (21 primaries, 15 metastatic). (gastrores.org)
  • Primary and metastatic AdexGCCs showed no difference in INSM1, chromogranin, synaptophysin, or CD56 staining. (gastrores.org)
  • INSM1 exhibits low expression in AdexGCCs and is expressed by a lower proportion of tumor cells compared to chromogranin and synaptophysin. (gastrores.org)
  • Conventional neuroendocrine markers, such as chromogranin and synaptophysin, however, are often negative or focally positive in these tumors [ 2 , 3 ]. (gastrores.org)
  • Hristov et al previously demonstrated that chromogranin and synaptophysin were only expressed in 37% and 30% of AdexGCCs, respectively [ 2 ]. (gastrores.org)
  • In contrast, conventional carcinoids are often diffusely positive for chromogranin and synaptophysin, with abundant electron-dense granules on electron microscopy [ 4 ]. (gastrores.org)
  • The Chromogranin A Test Results High reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (postgenomeconsortium.com)
  • Chromogranin A can be either measured in the serum or detected by immunohistochemistry in a tissue specimen. (medscape.com)
  • Serum chromogranin A can be elevated in other situations and conditions, including chronic proton-pump inhibitors use, renal failure, liver failure, heart failure, rheumatoid arthritis, inflammatory bowel disease, and hypertension. (medscape.com)
  • Chromogranin A is a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumors but not for insulinomas. (medscape.com)
  • Clearance of an automated immunoassay allows practices to measure chromogranin A concentration in human serum, thereby tracking disease progression in those with gastroenteropancreatic neuroendocrine tumors. (cancernetwork.com)
  • Chromogranin A induces and promotes the generation of secretory granules such as those containing insulin in pancreatic islet beta cells. (wikipedia.org)
  • Description: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. (postgenomeconsortium.com)
  • It has been shown that Chromogranin A is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas and other neuroendocrine tumors. (dbs-india.com)
  • Chromogranin A may be a useful tumor marker to aid in predicting the extent of neuroendocrine differentiation and the time to recurrence in prostate cancer. (dbs-india.com)
  • Chromogranin A is a type of tumour marker. (humordiagnostica.co.za)
  • Click here for more information on the use of Chromogranin A as a tumour marker for prostate cancer. (humordiagnostica.co.za)
  • Determination of chromogranin A (marker of neuroendocrine tumors). (rezus.lt)
  • Chromogranin A (a marker of neuroendocrine tumors) is one of the most important indicators in the diagnosis of carcinoid tumors. (rezus.lt)
  • Therefore, the global deficiency of chromogranin A impairs recognition of the major diabetogenic antigen insulin, leading to broadly impaired autoimmune responses controlled by multiple regulatory mechanisms. (wustl.edu)
  • Immunoreactivity for chromogranin in a testicular well-differentiated neuroendocrine tumor (carcinoid). (webpathology.com)
  • The combination of LK2H10 and PHE5 is specifically designed for sensitive detection of Chromogranin A in formalin-fixed, paraffin-embedded (FFPE) tissues. (dbs-india.com)
  • OBJECTIVE: The aim of the study was to investigate whether chromogranin A (ChA) is tonically released in adrenal vein blood and might be used to assess the selectivity of AVS. (unipd.it)
  • chromogranin-A (CgA)+ Pulmonary neuroendocrine cells account for 0.41% of all epithelial cells in the conducting airway, but are absent from the alveoli. (wikipedia.org)
  • Chromogranin A is present in neuroendocrine cells throughout the body. (dbs-india.com)
  • By immunohistochemistry, the tumor cells are positive for inhibin and negative for chromogranin and S100. (cap.org)
  • Routine staining and immunohistochemistry for insulin-like growth factor 1 (IGF1), insulin-like growth factor 1 receptor (IGF IR), transforming growth factor beta (TGF-β), hepatocyte growth factor (HGF), chromogranin A (CgA) was applied. (utlib.ee)
  • He underwent an en bloc resection, and pathological findings concluded to a metastasis of a pulmonary combined small cell carcinoma and adenocarcinoma. (hindawi.com)
  • Chromogranin A: a useful biomarker in castration-resistant prostate cancer. (bvsalud.org)
  • Here we have further studied the role played by these proteins by generating mice lacking both chromogranins. (nih.gov)
  • Although chromogranins are thought to be essential for their biogenesis, LDCVs were evident in these mice. (nih.gov)
  • Relevant modifications of some enteroendocrine markers, such as Chromogranin A, and their correlation with disease activity have been reported in patients with inflammatory bowel diseases. (unimi.it)
  • Chromogranin A and other enteroendocrine markers in inflammatory bowel disease / S. Massironi, A. Zilli, F. Cavalcoli, D. Conte, M. Peracchi. (unimi.it)
  • We recently demonstrated that chromogranins A and B each regulate the concentration of adrenaline in chromaffin granules and its exocytosis. (nih.gov)
  • These data demonstrate that although chromogranins regulate the amine concentration in LDCVs, they are not completely essential, and other proteins unrelated to neurosecretion, such as fibrinogen, might compensate for their loss to ensure that vesicles are generated and the secretory pathway conserved. (nih.gov)
  • To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact chromagranin A. Other Chromogranin products are available in stock. (postgenomeconsortium.com)
  • Chromogranin A may be found in higher-than-normal amounts in patients with certain neuroendocrine tumours (NETs), small cell lung cancer, prostate cancer, and other conditions. (humordiagnostica.co.za)
  • Further data were obtained from PubMed and Embase databases by searches using keywords , including chromogranin A and prostate cancer . (bvsalud.org)
  • The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. (neobiotechnologies.com)
  • There are considerable differences in the amino acid composition between different species' chromogranin A . Commercial assays for measuring human CGA can usually not be used for measuring CGA in samples from other animals. (wikipedia.org)
  • Chromogranin A can be used, in conjunction with other testing modalities, as a diagnostic tool, but caution is advised since it is elevated in many other conditions. (medscape.com)
  • The nociceptive effects of i.p administration of a synthetic peptide (CgA4-16) derived from chromogranin A (CgA) were studied on a model of inflammatory (somato-visceral) pain. (nih.gov)
  • Inflammatory mediators participate in controlling the activity of enterochromaffin cells that store and release chromogranins. (nih.gov)