CellsExocytosisInsulin granuleSecretory granulesMembraneDense coreCatecholaminesEnkephalinSympatheticPlateletSerotoninEpinephrineCellSpecificFormFusionSystemPresenceCytoplasmic GranulesCytoplasmProteinBovine chromaffinSecretory granuleCatecholaminesMembranesZymogenSecretionTissuesConcentrationsIncrease
Cells19
- In Munc18-1 null chromaffin cells, vesicle docking is abolished and syntaxin levels are reduced. (jneurosci.org)
- Chromogranins are the main soluble proteins in the large dense core secretory vesicles (LDCVs) found in aminergic neurons and chromaffin cells. (nih.gov)
- Despite their increased size, single-cell amperometry recordings from chromaffin cells showed that the amine content in these vesicles is reduced by half. (nih.gov)
- Recently, miRNA exocytosis by vesicle fusion in response to stimulation was observed in chromaffin cells, which are neuroendocrine cells in the sympathetic nervous system ( 24 ). (frontiersin.org)
- Chromaffin Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
- This graph shows the total number of publications written about "Chromaffin Cells" by people in this website by year, and whether "Chromaffin Cells" was a major or minor topic of these publications. (jefferson.edu)
- Below are the most recent publications written about "Chromaffin Cells" by people in Profiles. (jefferson.edu)
- Organelles in CHROMAFFIN CELLS located in the adrenal glands and various other organs. (lookformedical.com)
- In adrenal chromaffin cells, leakage of norepinephrine and epinephrine from storage granules leads to substantial intracellular production of the O-methylated metabolite metanephrine. (hmdb.ca)
- In humans, about 93 percent of circulating metanephrine is derived from catecholamines metabolized within adrenal chromaffin cells. (hmdb.ca)
- The diversification of neural-crest-derived sympathoadrenal (SA) progenitor cells into sympathetic neurons and neuroendocrine adrenal chromaffin cells was thought to be largely understood. (silverchair.com)
- In-vitro studies with isolated SA progenitor cells had suggested that chromaffin cell differentiation depends crucially on glucocorticoids provided by adrenal cortical cells. (silverchair.com)
- However, analysis of mice lacking the glucocorticoid receptor gene had revealed that adrenal chromaffin cells develop mostly normally in these mice. (silverchair.com)
- 2000). and other molecules with estrogen activity have been widely The sites of action responsible for the rapid action of ste- studied in a variety of tissues including chromaffin cells roids are a source of controversy. (drugstodaypdf.com)
- These mast cells contain many granules, themselves containing histamine, serotonin and heparin, a naturally occurring anticoagulant. (epiphanyasd.com)
- the chromaffin cells settle near the sympathetic ganglia, the vagus nerve, paraganglia, and carotid arteries. (medscape.com)
- These cells are popular because they are able to synthesize and release catecholamines in a similar manner as dopaminergic neurons and adrenal medullary chromaffin cells [ 4 ]. (biomedcentral.com)
- The granules of certain cells, such as natural killer cells , contain components which can lead to the lysis of neighboring cells. (cloudfront.net)
- These granules, unique to the platelets, are a subtype of lysosome-related organelles (LROs), a group that also includes melanosomes, lamellar bodies of the type II alveolar cells, and lytic granules of cytotoxic T cells. (cloudfront.net)
Exocytosis5
- We recently demonstrated that chromogranins A and B each regulate the concentration of adrenaline in chromaffin granules and its exocytosis. (nih.gov)
- echolamine secretion and exocytosis kinetics was studied in perfused rat adrenals and in cultured bovine chromaffin echolamines. (drugstodaypdf.com)
- ADP-ribosylation factor6 has been shown to regulate chromaffin granule exocytosis through PLD activation. (tcu.edu)
- α-Granule exocytosis is evaluated primarily by plasma membrane expression of P-selectin (CD62P) by flow cytometry or estimation of the release of PF4, VWF, or other granule cargos. (cloudfront.net)
- Dense granule exocytosis is typically evaluated by ADP/ATP release by using luciferase-based luminescence techniques, release of preloaded [ 3H] serotonin, or membrane expression of lysosome-associated membrane protein 2 (LAMP2) or CD63 by flow cytometry. (cloudfront.net)
Insulin granule1
- A specific type of granule found in the pancreas is an insulin granule. (cloudfront.net)
Secretory granules1
- Insulin granules are secretory granules, which can release their contents from the cell into the bloodstream. (cloudfront.net)
Membrane2
- V-ATPase is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane. (nih.gov)
- The classic representation of α-granules as spherical organelles with a peripheral limiting membrane, a dense nucleoid, and progressively lucent peripheral zones on transmission electron microscopy is probably simplistic and may be in part a preparation artifact. (cloudfront.net)
Dense core1
- In this research, the role of PI4,5P 2 in neurotransmitter release from both dense-core granules (DCVs) and synaptic vesicles (SVs) was studied by using SLO-perforated synaptosomes. (tcu.edu)
Catecholamines1
- The biosynthesis and storage of catecholamines in chromaffin cell tumors may differ from the biosynthesis and storage in the normal medulla. (medscape.com)
Enkephalin2
- Incubation of radioactively labeled enkephalin with serum components or chromaffin granule components in vitro provided evidence that there are specific constituents which bind enkephalins and may affect their degradation. (elsevierpure.com)
- Hogue-Angeletti, R & Roda, LG 1980, ' In vitro interaction of enkephalin with serum and chromaffin granule components ', Experientia , vol. 36, no. 12, pp. 1420-1421. (elsevierpure.com)
Sympathetic1
- Characteristically, they are located in the adrenal medulla and paraganglia (PARAGANGLIA, CHROMAFFIN) of the sympathetic nervous system. (jefferson.edu)
Platelet4
- α-Granules are unique to platelets and are the most abundant of the platelet granules, numbering 50-80 per platelet 2. (cloudfront.net)
- These granules measure 200-500 nm in diameter and account for about 10% of platelet volume. (cloudfront.net)
- Dense granules (also known as δ-granules) are the second most abundant platelet granules, with 3-8 per platelet. (cloudfront.net)
- Other platelet granules have been described. (cloudfront.net)
Serotonin2
- In chromaffin granules, IC(50)'s for serotonin accumulation were 112+/-8.0 microM for methcathinone and 166+/-12 microM for methylone, 10-fold higher than the respective values for methamphetamine and MDMA. (mdma.net)
- Dense granules mainly contain bioactive amines (for example, serotonin and histamine), adenine nucleotides, polyphosphates, and pyrophosphates as well as high concentrations of cations, particularly calcium. (cloudfront.net)
Epinephrine1
- These granules are the site of the synthesis, storage, metabolism, and secretion of EPINEPHRINE and NOREPINEPHRINE. (lookformedical.com)
Cell2
- In cell biology , a granule is a small particle. (cloudfront.net)
- Beta cell with insulin granules, which are the dark black spots surrounded by a white area called a halo. (cloudfront.net)
Specific1
- The granules of leukocytes are classified as azurophilic granules or specific granules . (cloudfront.net)
Form1
- More recent work using transmission electron microscopy and freeze substitution dehydration of resting platelets shows that α-granules are ovoid with a generally homogeneous matrix and that tubes form from α-granules upon activation 5. (cloudfront.net)
Fusion2
- Interference of zippering of SNARE complexes by alpha-snap arrest fusion of chromaffin granule. (mpg.de)
- Annexin A7 is a Ca 2+ - and phospholipid-binding protein, which was isolated as the agent that mediated aggregation of chromaffin granules and fusion of phospholipid membranes in the presence of Ca 2+ . (biomedcentral.com)
System1
- The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. (scijournal.org)
Presence1
- An electron-dense granule defined by the presence of Toll-like receptor 9 (TLR9) and protein disulfide isomerase (PDI), termed the T granule, has also been described, although its existence remains controversial. (cloudfront.net)
Cytoplasmic Granules2
- Amino acids 1 to 14 of pp60°* are sufficient to mediate both myristylation and the attachment of pyruvate kinase to cytoplasmic granules. (nih.gov)
- Enterochromaffin cells consists of cytoplasmic granules that able to decrease silver compounds and these cell located in gastrointestinal tract. (geneandcells.com)
Cytoplasm1
- On electron microscopy ,the cells in tumors are found to contain membrane -bound secretory granules with dense-core granules in the cytoplasm . (wikidoc.org)
Protein5
- Despite the redistribution of monovalent ions, granule Ca2+, granule P, being in the form of ATP, and granule S, being in the form of protein, were not significantly changed. (nih.gov)
- Chromogranin A is a protein found in the same chromaffin granule core as the catecholamines. (medscape.com)
- Chromaffin granule amine transporter is a protein that in humans is encoded by the SLC18A1 gene. (immunologicalsciences.com)
- For example, CGA comprises at least 40% of the soluble protein of the adrenal chromaffin granule, and it appears to be the major secretory protein in the parathyroid secretory granules. (johnshopkins.edu)
- We have examined its presence at the subcellular level and characterized this protein on both secretory granule membranes and intragranular matrix. (hal.science)
Bovine chromaffin3
- In VMAT2-containing bovine chromaffin granules, the IC50's for [3H]5-HT uptake were 103 ± 15 mM for methcathinone and 125 ± 16 mM for methylone. (erowid.org)
- In the present report, using biochemistry and cell biology techniques, we report for the first time the presence of PEBP in bovine chromaffin cell, a well described secretion model. (hal.science)
- In addition, its presence in bovine chromaffin cell and platelet exocytotic medium, as well as in serum, was reported showing that it is secreted. (hal.science)
Secretory granule1
- Dopaminergic regulation of secretory granule-associated proteins in rat intermediate pituitary. (utoledo.edu)
Catecholamines2
- Chromaffin tissue secretes two hormones, epinephrine and norepinephrine , which are members of a class of compounds called catecholamines . (britannica.com)
- The biosynthesis and storage of catecholamines in chromaffin cell tumors may differ from the biosynthesis and storage in the normal medulla. (medscape.com)
Membranes1
- Channels and Transporters in Zymogen Granule Membranes and their Role in Granule Function: Recent Progress and a Critical Assessment. (pancreapedia.org)
Zymogen1
- A review on the topic of pancreatic zymogen granule (ZG) channels and transporters and their function is timely as the last exhaustive review appeared in 2002 (107) and is manageable because of the limited number of publications that had been published in the 12 years since then. (pancreapedia.org)
Secretion2
- These granules are the site of the synthesis, storage, metabolism, and secretion of EPINEPHRINE and NOREPINEPHRINE . (bvsalud.org)
- Both exocytic release of neurotransmitters from small clear vesicles and secretion of peptide hormones and neuropeptides from dense core granules are Ca 2+ -dependent processes that are subject to potentiation and inhibition from various cellular signaling pathways. (rupress.org)
Tissues1
- Both chromaffin and adrenocortical tissues are present in gnathostomes and probably in agnathans (although the evidence on the latter point is not yet decisive), but the tissues vary in the degree to which they are associated, being completely separated in elasmobranch fishes. (britannica.com)
Concentrations1
- Granule Na+ and K+ concentrations ranged from 43 to 12 mmol/kg and 28 to 60 mmol/kg dry weight, respectively, depending on the Na+ and K+ content of the buffer. (nih.gov)
Increase1
- Furthermore, SMase does not increase the size of chromaffin granules . (bvsalud.org)