Chondroitin sulfates. Medical search. Frequent questions

Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid). (texasnaturalsupply.com)
Placental malaria infection is mediated by the binding of the malarial VAR2CSA protein to the placental glycosaminoglycan, chondroitin sulfate. (lu.se)
Glycosaminoglycan (GAG) assembly initiates through the formation of a linkage tetrasaccharide region serving as a primer for both chondroitin sulfate (CS) and heparan sulfate (HS) chain polymerization. (dundee.ac.uk)
Chondroitin Sulfate is a glycosaminoglycan extracted from shark cartilage. (sodiumhyaluronate-powder.com)
Chondroitin Sulfate by NOW Foods Joint Mobility and Comfort* Tissue Elasticity* Chondroitin Sulfate is a glycosaminoglycan (GAG) naturally present in many body tissues, and is an especially important component of joint cartilage and synovial tissue. (mynutritiondepot.com)
Chondroitin Sulfate is a glycosaminoglycan (GAG) naturally present in many body tissues, and is an especially important component of joint cartilage and synovial tissue. (mynutritiondepot.com)

The following CSPGs have been identified: Aggrecan (CSPG1) Versican (CSPG2) Neurocan (CSPG3) CSPG4 (melanoma-associated chondroitin sulfate proteoglycan, NG2) CSPG5 SMC3 (CSPG6, structural maintenance of chromosomes 3) Brevican (CSPG7) CD44 (CSPG8, cluster of differentiation 44) Phosphacan Neurocan, brevican, versican, and aggrecan all share similar N-terminal and C-terminal domains. (wikipedia.org)
The 9.2.27 monoclonal antibody specifically binds to CSPG4 (chondroitin sulfate proteoglycan 4). (bdbiosciences.com)
CSPG4 is also known as MCSP (melanoma chondroitin sulfate proteoglycan) and NG2 (neural/glial antigen 2). (bdbiosciences.com)
Immunoablation of cells expressing the NG2 chondroitin sulphate proteoglycan. (atsbio.com)
Leoni G, Rattray M, Fulton D, Rivera A, Butt AM (2014) Immunoablation of cells expressing the NG2 chondroitin sulphate proteoglycan. (atsbio.com)
Summary: In this work the authors use an antibody against the NG2-glia marker chondroitin sulphate proteoglycan (CSPG) along with Mab-ZAP (Cat. (atsbio.com)
Recently, we discovered that targeted enzymatic removal of the inhibitory chondroitin sulfate proteoglycan (CSPG) component of the extracellular and perineuronal net (PNN) matrix via Chondroitinase ABC (ChABC) rapidly restored robust respiratory function to the previously paralyzed hemi-diaphragm after remarkably long times post-injury (up to 1.5 years) following a cervical level 2 lateral hemi-transection. (kcl.ac.uk)
An associated change with the cervical ripening process is an increase in cervical decorin (dermatan sulfate proteoglycan 2), leading to collagen fiber separation. (medscape.com)

The purpose of the present study was to determine relationship between disease activity, systemic markers of cartilage degradation, urinary C-terminal cross-linking telopeptides of type II collagen (uCTX-II), and bone degradation, urinary C-terminal cross-linking telopeptides of type I collagen (uCTX-I), structural progression of osteoarthritis (OA) and potential therapeutic efficacy of type II collagen (COLLII) in combination with glucosamine and chondroitin sulfate (GC). (springer.com)
Glucosamine and Chondroitin Sulfate by Natural Factors contains naturally sourced ingredients that proactively fight the root cause of joint pain and reduce the need for non-steroidal anti-inflammatory drugs (NSAIDs) which simply mask pain. (goodnessme.ca)
Glucosamine and chondroitin sulfate are not only cartilage building blocks, but they can have anti-inflammatory properties of their own, making them excellent additions to any joint support protocol. (vin.com)
Glucosamine and chondroitin sulfate are considered nutritional supplements. (vin.com)

Chondroitin sulfate proteoglycans (CSPGs) are proteoglycans consisting of a protein core and a chondroitin sulfate side chain. (wikipedia.org)
Proteoglycans including chondroitin sulfate, keratan sulfate, dermatan sulfate and heparan sulfate are major components of the extracellular matrices of many animal cell types. (bdbiosciences.com)
Chondroitin sulfate has been found to stimulate the production of proteoglycans, essential molecules that make up the cartilage matrix. (optiwizehealth.com)
Cartilage Protection and Repair: Chondroitin sulfate promotes the synthesis of proteoglycans and GAGs, which are vital components of cartilage. (optiwizehealth.com)
Intercalated among the collagen molecules are glycosaminoglycans and proteoglycans, predominantly dermatan sulfate, hyaluronic acid, and heparin sulfate. (medscape.com)

Conte A, Volpi N, Palmieri L, Bahous I, Ronca G. Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulfate. (meschinohealth.com)

We have investigated the effect of chondroitin sulfate (CS) on brain response to knee painful stimulation in patients with knee osteoarthritis using fMRI. (upf.edu)
Conrozier T, Vignon E. The effect of chondroitin sulfate treatment in coxarthritis. (meschinohealth.com)

Chondroitin sulfate is possibly safe when used together with other ingredients in an eye drop. (medlineplus.gov)
The move reflects an increasing trend towards certification as a means of lending credibility within competitive ingredients markets such as that for chondroitin sulfate. (nutraingredients-usa.com)
Along with glucosamine, chondroitin is one of the leading ingredients in joint health supplements. (nutraingredients-usa.com)
Liquid Glucosamine & Chondroitin with MSM combines three well-known joint support ingredients with nutritional components in an easy-to-swallow liquid. (vitaliving.com)
2. Combined shipment of all joint care ingredients: We are able to supply almost all joint care ingredients including: shark cartilage powder, Chondroitin Sulfate, Glucosamine, MSM, Hyaluronic Acid. (chondroitinpowder.com)

Pure Chondroitin Sulfate is derived from Bovine Cartilage. (bulkfoods.com)
And we're a big fan of potency and purity at Doctor's Best, so we chose a 90%+ pure chondroitin sulfate (a chemical found in our cartilage around our joints) in this formula. (ieproduce.com)

However, until more is known, do not take chondroitin sulfate if you have prostate cancer or are at high risk for developing it (you have a brother or father with prostate cancer). (medlineplus.gov)

Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate. (lu.se)
Dive into the research topics of 'Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate. (lu.se)
abstract = "The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the polysaccharides, as it generates a more flexible chain with increased binding potentials. (lu.se)
Iduronic acid in chondroitin/dermatan sulfate influences multiple cellular properties such as migration, proliferation, differentiation, angiogenesis and regulation of cytokine/growth factor activities. (lu.se)
The role of IdoA in chondroitin/dermatan sulfate is underlined by the vast changes of connective tissue features in patients with a new type of Ehler-Danlos syndrome, adducted thumb-clubfoot syndrome. (lu.se)
Further, a better definition of chondroitin/dermatan sulfate functions using different knock-out models is needed. (lu.se)
We offer a series of chondroitin sulphates (CS) and dermatan sulphates (DS) that cover the principal isomers found in mammalian tissues. (iduron.co.uk)
Mizumoto, S., Yamada, S. & Sugahara, K. (2015) Molecular interactions between chondroitin-dermatan sulfate and growth factors/receptors/matrix proteins. (iduron.co.uk)
Chondroitin Sulphate (CS) and Dermatan Sulphate (DS) are common constituents of the pericellular environment of most mammalian organs and tissues. (iduron.co.uk)
The amount of dermatan sulfate decreases, leading to reduced bridging among the collagen fibers and a corresponding decrease in cervical firmness. (medscape.com)

An observational retrospective study, 1-year follow-up, on 104 patients with OA (nodular osteoarthritis of the hand, erosive osteoarthritis of the hand, EOA, osteoarthritis of the knee or hip) who were treated with GC or glucosamine, chondroitin sulfate and collagen type II (GCC). (springer.com)
Each serving contains 1000 mg of BioCell Collagen®, which includes 600 mg of hydrolyzed collagen type II, 200 mg of chondroitin sulfate and 100 mg of hyaluronic acid. (ieproduce.com)
Chondroitin sulfate (CSA) is a mucopolysaccharide found in cartilage, tendons, and ligaments, where it is bound to proteins such as collagen and elastin. (ayurvedicherbsdirect.com)

J-Flex is pure, high-grade chondroitin sulfate - a natural ingredient for healthy joint lubrication and a normal inflammatory response. (springtimeinc.com)

Objectives Chondroitin sulfate 800 mg/day (CS) pharmaceutical-grade in the management of symptomatic knee osteoarthritis consistent with the European Medicines Agency guideline. (bmj.com)

Glucosamine and chondroitin sulfates are components of cartilage, and the theory is that by taking these precursors orally (by mouth), a body can use them to repair and rebuild damaged cartilage. (vin.com)
Both glucosamine and chondroitin are structural components of cartilage that cushions the ends of bones within the joints. (biolife.com.my)

Meitek chondroitin sulfate is the white powder made from animal cartilage, through the extraction and enzymolysis process. (meitek-inc.com)
China chondroitin sulfate powder Supplier. (sodiumhyaluronate-powder.com)
5. Other certificates we have: NSF-GMP, ISO Certificates, Halal Certificates, MSC Certificates for shark cartilage powder and shark chondroitin sulfate. (chondroitinpowder.com)

This effect has not been shown with chondroitin sulfate supplements. (medlineplus.gov)
The chondroitin used in dietary supplements is extracted from the cartilage and connective tissues of animals. (springtimeinc.com)
Manufacturers of foods and supplements will demand more chondroitin sulfate in the upcoming years. (precedenceresearch.com)
Chondroitin sulfate is utilized more frequently in joint health supplements to lessen joint pain as the population ages and becomes more health conscious. (precedenceresearch.com)
Manganese is a co-factor in joint fluid synthesis and is often included in glucosamine/chondroitin sulfate supplements as are numerous other supplements such as omega-3 fatty acids, creatine, and more. (vin.com)

An injectable solution containing chondroitin sulfate and sodium hyaluronate is approved by the FDA to protect the eye during cataract surgery. (medlineplus.gov)
Most of the positive studies using Chondroitin Sulfate with arthritic patients have used injectable forms. (meschinohealth.com)
1. Injectable chondroitin sulfate is the chondroitin puritied into a high substance of assay,with a lower substance of protein. (chondroitinpowder.com)
2. Injectable chondroitin sulfate is the chondroitin sulfate utilized for the creation of intra-articular application infusions, particularly for the joints. (chondroitinpowder.com)

Chondroitin is the substance that enables cartilage to provide cushion to healthy joints, and it is what the body uses to make new cartilage. (springtimeinc.com)
Glucosamine sulfate is used to make the cartilage needed for repairing joints, while chondroitin actively fights the enzymes that breakdown joint tissue and helps maintain the nutrients and fluid within joints that allows for smooth and cushioned movement. (goodnessme.ca)
ChondroCare is designed to provide broad support for healthy joints by featuring high quality glucosamine sulfate and chondroitin sulfate, nutritional factors known to help support cartilage health and soft tissue formation. (vitaliving.com)
Protocol For Life Balance Glucosamine & Chondroitin with MSM combines three of the best known nutrients available for the support of healthy joints in one dietary supplement. (vitaliving.com)
The cartilage between joints such as those in the hip, knee, finger, and other joints must contain chondroitin sulfate as a structural component. (precedenceresearch.com)
Glucosamine and chondroitin sulfates are not likely to be helpful with diseases involving other types of joints (i.e. the vertebrae and intervertebral discs). (vin.com)
The chondroitin sulfate infusion is utilized to alleviation the agony in the joints experienced osteoarthritis. (chondroitinpowder.com)
2. Ponders recommends that Chondroitin sulfate may keeps the separating of ligaments in joints. (chondroitinpowder.com)

The results after six months of treatment proved that the combination of chondroitin and glucosamine reduces pain, functional disability, stiffness, inflammation and joint liquid effusion in a clinically relevant way, and that this combination, unlike anti-inflammatory drugs, has a high safety profile. (bioiberica.com)
Morreale P, Manopulo R, Galati M, Boccanera L, Saponati G, Bocchi L. Comparison of the anti-inflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. (meschinohealth.com)
Research suggests that chondroitin sulfate exhibits anti-inflammatory properties. (optiwizehealth.com)
Anti-Inflammatory Effects: Chondroitin sulfate possesses anti-inflammatory properties, which can help reduce joint inflammation and associated pain. (optiwizehealth.com)
Glucosamine and chondroitin are able to protect joint cartilage and anti-inflammatory effect, thus help in pain-relieving. (biolife.com.my)

The Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT) was a large, placebo-controlled study of glucosamine , chondroitin sulfate, and the 2 in combination to treat osteoarthritis of the knee. (msdmanuals.com)

For Mega BiO-LiFE Glucosamine 500mg with Chondroitin Sulphate 400mg, glucosamine is harvested from shells of shellfishes, and chondroitin is harvested from a bovine source. (biolife.com.my)

In line with this, CHPF and CHPF2, which encode proteins required for chondroitin polymerization, are significantly upregulated in most cancer types. (lu.se)
Sequestration of malaria parasite in the human placenta is mediated by interactions between chondroitin sulphate A (CSA) on the syncytiotrophoblasts and proteins expressed on the surface of infected human erythrocytes. (biomedcentral.com)

To investigate this, we determined whether sulfate substitution of galactose (Gal) residues of the linkage region or of N-acetylgalactosamine (GalNAc) of the disaccharide unit influences activity and specificity of chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1), a key glycosyltransferase of CS biosynthesis. (dundee.ac.uk)
Intriguingly, a crucial loop from A4 DBL 3X which provides the important Gly and Lys residues that chelate the bound sulphate is missing or significantly altered in all other DBL domains that interact with CSA. (biomedcentral.com)
Further analysis of the proposed sulphate and predicted CSA-binding site indicates either none or very low level of conservation among the critical interacting residues. (biomedcentral.com)
Degradation kinetics models and chemical composition data of LMCS showed the GlcA residues of chondroitin -4- sulfate (CSA) may be preferentially attacked. (bvsalud.org)

We synthesized a series of sulfated and unsulfated analogs of the linkage oligosaccharide and of the constitutive unit of CS and tested these molecules as potential acceptor substrates for the recombinant human CSGalNAcT-1. (dundee.ac.uk)
Derbal, I., Lortat-Jacob, H. & Kwok, J. (2017) Chondroitin sulfates and their binding molecules in the central nervous system. (iduron.co.uk)
Generally speaking, Chondroitin Sulfate molecules are at least fifty to three hundred times larger than glucosamine sulfate molecules and are usually too large to pass through the normal intact intestinal barrier. (meschinohealth.com)
Any clinical benefit derived from taking Chondroitin Sulfate is probably due to the absorption of sulfur (which supports cartilage structure), or smaller GAG molecules broken down by the digestive tract. (meschinohealth.com)
By stimulating the production of these molecules, chondroitin sulfate aids in the protection and repair of cartilage tissue. (optiwizehealth.com)
Joint Lubrication: Chondroitin sulfate attracts water molecules into the cartilage, improving hydration and lubrication. (optiwizehealth.com)

The biological products involve Glucosamine, MethylSulfonylMethane, and Chondroitin Sulfate. (titanbiotechltd.com)
Chondroitin Sulfate, Glucosamine, and MSM (Methylsulfonylmethane) play vital roles in skin anti-aging. (titanbiotechltd.com)

Along with glucosamine, chondroitin sulfate has become a widely used dietary supplement for treatment of osteoarthritis. (texasnaturalsupply.com)
The food and dietary supplement industries' rising demand for chondroitin sulfate, consumers' awareness of the supplement's advantages, and a growing emphasis on preventive healthcare are driving this market's expansion. (precedenceresearch.com)

What drug interactions occur with chondroitin sulfate? (msdmanuals.com)

Recombinant subfragments of VAR2CSA (rVAR2) have also been shown to bind specifically and with high affinity to cancer cells and tissues, suggesting the presence of a shared type of oncofetal chondroitin sulfate (ofCS) in the placenta and in tumors. (lu.se)
Here, we show that both placenta and tumors contain significantly more chondroitin sulfate moieties of higher molecular weight than other tissues. (lu.se)
The basis for the amassing of parasitized erythrocytes (PEs) in the placenta was unknown until it was shown that PEs from placenta primarily bind to chondroitin sulfate A (CSA) [ 3 ]. (biomedcentral.com)
Two days before admission she had re- questration of infected red blood cells in ceived 5 injections of chloroquine after the placenta through binding to chondroitin confirmation of P. falciparum infection sulfate [ 3,4 ]. (who.int)

No GalNAcT activity was detected toward sulfated and unsulfated analogs of the CS constitutive disaccharide (GlcA-beta 1,3-GalNAc), indicating that CSGalNAcT-1 was involved in initiation but not in elongation of CS chains. (dundee.ac.uk)

Osteoarthritis: Oral supplementation with Chondroitin Sulfate has typically used 400 mg, three times per day in most studies. (meschinohealth.com)
1. Chondroitin sulfate is typically considered as could be expected under the circumstances treament for the joint deformity, for example, the osteoarthritis. (chondroitinpowder.com)

More precisely, the data of the MOVES study recently published by the Annals of the Rheumatic Diseases journal confirmed that the combination of chondroitin sulfate and glucosamine has an efficacy comparable to that of Celecoxib in the treatment of severe knee osteoarthritis. (bioiberica.com)
Effects of chondroitin sulfate on brain response to painful stimulation in knee osteoarthritis patients. (upf.edu)
Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulfate in the management of osteoarthrosis of the knee in out patients. (meschinohealth.com)

The finest chondroitin sulfate promotes joint and cartilage health. (springtimeinc.com)

Chondroitin sulfate is one of six related substances called glycosaminoglycans (gags), which are also referred to as mucopolysaccharides. (springtimeinc.com)

Chondroitin Sulfate contains a mixture of intact or partially hydrolysed glycosaminoglycans (GAG), of molecular weights ranging from 14,000 to over 30,000 Daltons. (meschinohealth.com)
Analysis of glycosaminoglycans in human sera after oral administration of chondroitin sulfate. (meschinohealth.com)

Chondroitin promotes water retention. (mynutritiondepot.com)
Chondroitin promotes water retention within the joint, giving it resiliency by acting as a lubricant and a means to absorb shock. (mynutritiondepot.com)

Cross-reactive surface epitopes on chondroitin sulfate A-adherent Plasmodium falciparum-infected erythrocytes are associated with transcription of var2csa. (edu.au)

Bioavailability of oral chondroitin sulfate. (meschinohealth.com)
Low molecular weight chondroitin sulfate (LMCS) has attention for enhanced bioavailability and bioactivity compared to native CS. (bvsalud.org)

Glucosamine and chondroitin sulfates are extracted from sea mollusks (such as Perna canaliculus, also known as the New Zealand green-lipped mussel), from shark skeleton, as well as from cattle and chicken bones. (vin.com)

Cross-reactive surface epitopes on chondroitin sulfate A-adherent Plasmodium falciparum-infected ery. (edu.au)
Malaria in pregnancy is associated with placental accumulation of Plasmodium falciparum-infected erythrocytes (IE) that adhere to chondroitin sulfate A (CSA). (edu.au)

CRISPR/Cas9 targeting of CHPF and CHPF2 in tumor cells reduced the average molecular weight of cell-surface chondroitin sulfate and resulted in a marked reduction of rVAR2 binding. (lu.se)
Preparation of low molecular weight chondroitin sulfate from different sources by H 2 O 2 /ascorbic acid degradation and its degradation mechanism. (bvsalud.org)

Chondroitin sulfate is a naturally occurring molecule found in the cartilage and connective tissues of people and animals. (springtimeinc.com)

There is concern that some chondroitin sulfate products are not labeled accurately. (medlineplus.gov)
Some products might contain no chondroitin, while other products might contain more than the amount stated on the product's label. (medlineplus.gov)
Because of these issues, the effects of different chondroitin products may vary. (medlineplus.gov)
Conversely, some products on the market are labeled as 100% chondroitin but contain little to no chondroitin-a, rendering them woefully ineffective. (springtimeinc.com)
A recent report in the Lancet (January 2001), indicated that the addition of Chondroitin Sulfate to glucosamine products has not been shown to provide a further benefit to the use of glucosamine sulfate alone. (meschinohealth.com)
The Chondroitin Sulfate can also be used as additive in the foodstuff and the healthy products. (sodiumhyaluronate-powder.com)

Chondroitin sulfate is a chemical found in human and animal cartilage. (medlineplus.gov)

Early research suggests that chondroitin might cause the spread or recurrence of prostate cancer. (medlineplus.gov)

In this blog post, we aim to shed light on the science behind Chondroitin Sulfate, explore its various applications, and highlight the compelling evidence supporting its efficacy. (optiwizehealth.com)

Chondroitin sulfate is an important structural component of cartilage and provides much of its resistance to compression. (texasnaturalsupply.com)

Chondroitin can stimulate the synthesis of GAGs. (optiwizehealth.com)

The global chondroitin sulfate market size surpassed USD 1.22 billion in 2022 and is projected to rise to USD 1.65 billion by 2032, anticipated to grow at a CAGR of 3.1 percent during the projection period from 2023 to 2032. (precedenceresearch.com)

Regular use of chondroitin sulfate may help slow down the progression of joint degeneration and improve the quality of life for individuals with osteoarthritis. (optiwizehealth.com)

Anatomy1

Organisms2

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes3

Information Science1

Glycosaminoglycan6

Proteoglycan8

Glucosamine and chondroitin sulfate4

Proteoglycans5

Oral treatment with chondroitin sulfate1

Effect of chondroitin sulfate2

Ingredients5

Pure Chondroitin Sulfate2

Take chondroitin sulfate1

Dermatan10

Collagen3

Grade chondroitin1

Pharmaceutical-grade1

Components of cartilage2

Powder3

Supplements5

Injectable4

Joints8

Anti-inflammatory5

Osteoarthritis of the knee1

Bovine source1

Proteins2

Residues4

Molecules6

Methylsulfonylmethane2

Dietary supplement2

Interactions1

Placenta4

Analogs1

Typically2

Knee3

Cartilage health1

Substances1

Glycosaminoglycans2

Promotes2

VAR2CSA1

Bioavailability2

Shark1

Falciparum2

Molecular weight2

Connective1

Products6

Animal cartilage1

Suggests1

Efficacy1

Structural component1

Stimulate1

20231

Progression1