• neocortex
  • From recent discoveries in the mouse, rat, monkey and human brain, a picture emerges in which the basal forebrain (BF) cholinergic system targets the neocortex with much more spatial and temporal detail than previously considered. (frontiersin.org)
  • Due to the strong impact of cholinergic modulation of the neocortex and its role in neuropsychiatric disorders, it is imperative that we understand the neuronal and synaptic mechanisms underlying ACh's role in cognition and neocortical microcircuit function. (frontiersin.org)
  • Moreover, recent exciting discoveries show that the basal forebrain (BF) cholinergic system may be innervating the neocortex at a spatially more refined scale than previously considered, raising the possibility that a more fine-scaled control by ACh exists that does not only confer specificity on a brain area scale, but even on that of cortical lamina. (frontiersin.org)
  • hippocampal
  • It consists of fibers that are said to arise in the parolfactory area, the gyrus subcallosus and the anterior perforated substance, and course backward in the longitudinal striae to the dentate gyrus and the hippocampal region. (wikipedia.org)
  • mechanisms
  • These findings support the involvement of cholinergic mechanisms in the axon-Schwann cell relationship previously described. (springer.com)
  • Despite the fact that we know for instance that cholinergic signaling in the prefrontal cortex (PFC) is involved in attention, very little is known about the neuronal circuit mechanisms involved. (frontiersin.org)
  • Finally, recent findings on cholinergic modulation of human neocortical microcircuits suggest that also in the human brain these mechanisms exist, which may prompt us to change our view on the cholinergic system as being merely a slow acting arousal system to one that includes a fast acting manipulation of cortical information flow important for sub-second cognitive operations. (frontiersin.org)
  • lateral
  • These fibers run between the most lateral (toward the side of the head) segment of the lentiform nucleus and the claustrum. (wikipedia.org)
  • The medial RF is large and has long ascending and descending fibers, and is surrounded by the lateral reticular formation. (wikipedia.org)
  • mice
  • Indeed, mice with a spontaneous GC-B loss of function mutation ( Npr2 cn/cn ) display an impaired bifurcation of auditory nerve (AN) fibers. (frontiersin.org)
  • However, efferent cholinergic feedback to inner and outer hair cells was reduced in GC-B KO mice, linked to very likely reduced rapid efferent feedback. (frontiersin.org)
  • further
  • Once too many are involved, the mAChRs will reduce or block further cholinergic input, which protects these cells and the networks from additional cholinergic input that could disrupt the signal. (wikipedia.org)