• serine
  • These include transferrin receptor, choline-phosphate cytidylyltransferase A, RNF168, serine/threonine-protein kinase, nuclear cap-binding protein complex, melanotransferrin, DLG1 and D-beta-hydroxybutyrate dehydrogenase Research on the risk for developing schizophrenia in Ashkenazi Jews and other populations showed that 3q29 microdeletion syndrome leads to a significant higher rate of schizophrenia. (wikipedia.org)
  • gene
  • A new form of congenital muscular dystrophy with multisystem involvement and characteristic mitochondrial structural changes, due to choline kinase beta gene defects has been characterized. (nih.gov)
  • homozygous or compound heterozygous mutations in the gene encoding choline kinase beta were identified in individulas with congenital muscular dystrophy. (nih.gov)
  • Clinical characteristics of megaconial congenital muscular dystrophy due to choline kinase beta gene defects in a series of 15 patients. (nih.gov)
  • Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and choline kinase activity . (genecards.org)
  • Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene. (wikipedia.org)
  • vivo
  • Introduction: In many human cancers, including prostate cancer, malignant transformation and disease progression are associated with changes in the choline containing phospholipids that can be visualized using magnetic resonance spectra (MRS). Using current MRI/MRS technologies, the choline resonance that can be measured in vivo appears a single peak in the proton spectral array. (aacrjournals.org)
  • Moreover, the specific ratios of choline metabolites that make up the in vivo choline peak are different in different cancers. (aacrjournals.org)
  • Activation
  • It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. (wikipedia.org)
  • Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. (wikipedia.org)
  • uptake
  • The uptake of choline is accomplished predominantly by the high-affinity, sodium dependent choline transporter (CHT) and requires ATP as an energy source. (wikipedia.org)