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  • Chlorzoxazone (INN) is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. (wikipedia.org)
  • Chlorzoxazone is a skeletal muscle relaxant. (drugs.com)
  • Aceclofenac + Paracetamol + Chlorzoxazone is a combination of two pain relieving medicines (Aceclofenac and Paracetamol ) and a muscle relaxant ( Chlorzoxazone). (genericaadhaar.com)
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  • It is sold under the brand names Lorzone, Paraflex and Muscol and in combination form as Parafon Forte, a combination of chlorzoxazone and acetaminophen (paracetamol). (wikipedia.org)
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  • talk to your doctor about the risks and benefits of taking chlorzoxazone if you are 65 years of age or older. (epnet.com)
  • Chlorzoxazone may cause side effects. (epnet.com)
  • medical citation needed] The mechanism of action of chlorzoxazone is thought[by whom? (wikipedia.org)
  • Nursing Central , nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/51151/all/chlorzoxazone. (unboundmedicine.com)
  • The aim of the study was to prepare Gastro retentive floating microspheres of chlorzoxazone by solvent evaporation method using ethyl cellulose and HPMCK15 as polymers to provide the drug release in sustained manner and to increase the bioavailability of drug. (repository-tnmgrmu.ac.in)
  • The solubility studies of pure drug showed, that the chlorzoxazone was not soluble in water. (repository-tnmgrmu.ac.in)
  • CONCLUSION: Gastro retentive floating microspheres of chlorzoxazone were prepared by emulsion solvent evaporation technique, using ethyl cellulose and HPMC K15 in order to retain drug in body for longer period of time to increase bioavailability. (repository-tnmgrmu.ac.in)
  • On the basis of data obtained from in-vitro dissolution studies, it can be concluded that formulation F9 was promising formulation suitable for the sustained release of chlorzoxazone for gastro retention purpose that may be giving rise to enhance the bioavailability of the drug. (repository-tnmgrmu.ac.in)
  • Chlorzoxazone floating drug delivery system promises to be a potential approach for gastric retention used in the treatment of muscular pain by its muscle relaxing property. (repository-tnmgrmu.ac.in)
  • Chlorzoxazone is used to relieve pain and stiffness caused by muscle strains and sprains. (epnet.com)
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  • If you become pregnant while taking chlorzoxazone, call your doctor. (epnet.com)
  • The λmax of chlorzoxazone was found to be 282nm using acid buffer pH 1.2 at concentration 10μg/ml. (repository-tnmgrmu.ac.in)
  • No information is available on the relationship of age to the effects of chlorzoxazone in the pediatric population. (drugs.com)
  • Here we studied effects of the SK channels modulator chlorzoxazone (CHZ) on the motor behavior of YAC128 HD mice and also on the electrophysiological activity and neuroanatomy of the cerebellar PCs from these mice. (elsevierpure.com)
  • tell your doctor and pharmacist if you are allergic to chlorzoxazone or any other medications. (epnet.com)
  • ask your doctor about the safe use of alcohol during your treatment with chlorzoxazone. (epnet.com)
  • Chlorzoxazone floating microspheres were prepared by solvent evaporation method, by changing polymer concentration, rpm, and surfactant concentration. (repository-tnmgrmu.ac.in)
  • Dicoliv-MR (Diclofenac Potassium/Paracetamol/Chlorzoxazone) tablets contain 50mg of diclofenac, 325mg of paracetamol and 250mg of chlorzoxazone. (unitedpharmacies.com)
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  • There is very limited or inconsistent data regarding the effectiveness of metaxalone, methocarbamol, chlorzoxazone, baclofen, or dantrolene compared to placebo in patients with musculoskeletal conditions. (nih.gov)
  • Dantrolene, and to a lesser degree chlorzoxazone, have been associated with rare serious hepatotoxicity. (nih.gov)
  • Dicoliv-MR (Diclofenac Potassium/Paracetamol/Chlorzoxazone) works by relieving pain and decreasing inflammation. (unitedpharmacies.com)
  • Treatment of any medical conditions with the combination medicine Dicoliv-MR (Diclofenac Potassium/Paracetamol/Chlorzoxazone) might lead to side effects, which you will need to report to the physician treating you. (unitedpharmacies.com)
  • Dicoliv-MR (Diclofenac Potassium/Paracetamol/Chlorzoxazone) might increase the risk of serious cardiovascular events or intestinal bleeding. (unitedpharmacies.com)
  • It is sold under the brand names Lorzone, Paraflex and Muscol and in combination form as Parafon Forte, a combination of chlorzoxazone and acetaminophen (paracetamol). (wikipedia.org)
  • A 77 year old woman was treated with a combination of chlorzoxazone, dextropropoxyphene and aspirin ("Paraflex Compound") for acute neck pains and developed fever and rash four days later. (nih.gov)
  • Chlorzoxazone (klor zox' a zone) acts centrally rather than directly on muscles to relieve muscle spasms, either through its sedative effects or other unknown mechanisms. (nih.gov)
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  • Chlorzoxazone (INN) is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. (wikipedia.org)
  • Chlorzoxazone is a centrally-acting agent for painful musculoskeletal conditions. (nih.gov)
  • Chlorzoxazone is a centrally acting muscle relaxant commonly used for low back pain. (nih.gov)
  • Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells. (nih.gov)
  • Chlorzoxazone is a benzoxazolone derivative with mild sedative effects and centrally acting muscle relaxant activities. (affygility.com)
  • On the other hand, Chlorzoxazone is a muscle relaxant that works by centrally acting on the spinal cord by depressing reflexes, thereby relieving pain and stiffness caused due to muscle strains and sprains. (apollopharmacy.in)
  • To determine whether the probe drugs caffeine, chlorzoxazone, dapsone, debrisoquin (INN, debrisoquine), and mephenytoin can be simultaneously administered as a metabolic cocktail to estimate in vivo cytochrome P450 (CYP) and N-acetyltransferase enzyme activities. (nih.gov)
  • Fourteen healthy nonsmoking male volunteers (mean age +/- SD, 21.6 +/- 2.2 years) received 100 mg caffeine, 250 mg chlorzoxazone, 100 mg dapsone, 10 mg debrisoquin, and 100 mg mephenytoin individually and in four and five-drug combinations in a randomized manner using a 7 x 7 Latin square. (nih.gov)
  • The phenotypic indexes determined for caffeine, chlorzoxazone, dapsone, debrisoquin, and mephenytoin were not significantly different when given alone than when given in combination. (nih.gov)
  • The results of this study show that caffeine, chlorzoxazone, dapsone, debrisoquin, and mephenytoin in low doses can be simultaneously administered without metabolic interaction. (nih.gov)
  • Chlorzoxazone is used in the treatment of Muscle Spasm and belongs to the drug class skeletal muscle relaxants . (drugs.com)
  • Chlorzoxazone is rapidly metabolized and is excreted in the urine, primarily in a conjugated form as the glucuronide. (nih.gov)
  • Less than one percent of a dose of chlorzoxazone is excreted unchanged in the urine in 24 hours. (nih.gov)
  • Rarely, a patient may note discoloration of the urine resulting from a phenolic metabolite of chlorzoxazone. (nih.gov)
  • tell your doctor and pharmacist if you are allergic to chlorzoxazone or any other medications. (medlineplus.gov)
  • Older adults should not usually take chlorzoxazone because it is not as safe or effective as other medications) that can be used to treat the same condition. (medlineplus.gov)
  • The idiosyncratic liver injury due to chlorzoxazone ranges from mild, self-limited hepatitis to severe, protracted liver injury leading to death or need for liver transplantation. (nih.gov)
  • Chlorzoxazone should be used with caution in patients with known allergies or with a history of allergic reactions to drugs. (nih.gov)
  • Chlorzoxazone use should also be discontinued if a patient develops abnormal liver enzymes (e.g. (nih.gov)
  • Chlorzoxazone has been linked to rare instances of acute liver injury, a few of which have been fatal. (nih.gov)
  • Rare instances of clinical apparent liver disease possibly attributable to chlorzoxazone have appeared, including fatal cases. (nih.gov)
  • Cytochrome P-450 2E1 is not the sole catalyst of chlorzoxazone hydroxylation in rat liver microsomes. (nih.gov)
  • The cause of acute hepatic injury from chlorzoxazone is unknown, but is clearly idiosyncratic and likely due to hypersensitivity. (nih.gov)
  • It is possible in rare instances that chlorzoxazone may have been associated with gastrointestinal bleeding. (nih.gov)
  • Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. (nih.gov)
  • The effect of chlorzoxazone on acute pain after spine surgery. (nih.gov)
  • Cholestatic enzyme elevations after exposure to chlorzoxazone have also been described. (nih.gov)
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  • Chlorzoxazone is indicated for therapy of low back pain and muscle spasms, although its overall efficacy is considered only fair. (nih.gov)
  • medical citation needed] The mechanism of action of chlorzoxazone is thought[by whom? (wikipedia.org)
  • ask your doctor about the safe use of alcohol during your treatment with chlorzoxazone. (medlineplus.gov)
  • Pill with imprint 1 2 is White, Capsule/Oblong and has been identified as Chlorzoxazone 500 mg. (drugs.com)
  • Data available from animal experiments as well as human study indicate that chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex arcs involved in producing and maintaining skeletal muscle spasm of varied etiology. (nih.gov)
  • Chlorzoxazone is widely used for muscle spasms, so as to relieve the soreness they cause. (unitedpharmacies.com)
  • Blood levels of chlorzoxazone can be detected in people during the first 30 minutes and peak levels may be reached, in the majority of the subjects, in about 1 to 2 hours after oral administration of chlorzoxazone. (nih.gov)
  • Chlorzoxazone containing products are usually well tolerated. (nih.gov)
  • Chlorzoxazone is contraindicated in patients with known intolerance to the drug. (nih.gov)