They are represented as a family of four closely bound GAPs1 (GTPase-activating proteins). (wikipedia.org)
α1-Chimerin is a GTPase-activating protein in the brain that effects the ras related p21rac. (wikipedia.org)
Beta-chimerin (Rho GTPase-activating protein 3, 468aa) is mainly found in the brain and pancreas and the expression is in the form of reduced malignant gliomas. (wikipedia.org)
It is also an SH2 containing GTPase activating protein and bears many similarities in function. (wikipedia.org)
The normal rate of Ras catalytic GTPase (GTP hydrolysis) activity can be increased by proteins of the RasGAP family, which bind to Ras and increase its catalytic rate by a factor of one thousand - in effect, increasing the rate at which Ras is inactivated. (bionity.com)
This may be explained because the SOS1 protein adopts an auto-inhibited conformation dependent on multiple domain-to-domain interactions that cooperate to block access of the SOS1 catalytic core to its Ras-GTPase targets [7] . (bionity.com)
GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. (embl-heidelberg.de)
The active conformation is promoted by guanine-nucleotide exchange factors, and the inactive state by GTPase-activating proteins (GAPs) which stimulate the intrinsic GTPase activity of small G proteins. (embl-heidelberg.de)
This gene is highly expressed in fetal brain and encodes a protein of relative molecular mass 91K, named oligophrenin-1, which contains a domain typical of a Rho-GTPase-activating protein (rhoGAP). (embl-heidelberg.de)
By enhancing their GTPase activity, GAP proteins inactivate small Rho and Ras proteins, so inactivation of rhoGAP proteins might cause constitutive activation of their GTPase targets. (embl-heidelberg.de)
In particular, we propose that Arg 85 and Asn 194 are involved in binding G proteins and enhancing GTPase activity. (embl-heidelberg.de)
A structural feature that distinguishes the Rho proteins from other small GTPases is the so-called Rho insert domain located between a β strand and an α helix within the small GTPase domain [ 1 - 3 ]. (biomedcentral.com)
Typically Rho proteins are 190-250 residues long and consist only of the GTPase domain and short terminal C-terminal extensions. (biomedcentral.com)
Within their GTPase domains, they share approximately 30% amino acid identity with the Ras proteins and 40-95% identity within the family. (biomedcentral.com)
Rho GTPase effectors are a large group of proteins and include actin nucleation promoting molecules, adaptors, as well as kinases. (biomedcentral.com)
Intracellular calcium-1
A family of intracellular calcium-sensing proteins found predominately in NEURONS and PHOTORECEPTOR CELLS . (nih.gov)
Duane Retracti1
Mutations in α2-chimerin can cause disorders such as Duane Retraction Syndrome as it changes the signals on how the eye moves. (wikipedia.org)
CHN11
Studying families with a variant form of the disorder (DURS2-DRS), we have identified causative heterozygous missense mutations in CHN1, a gene on chromosome 2q31 that encodes alpha2-chimaerin, a Rac guanosine triphosphatase-activating protein (RacGAP) signaling protein previously implicated in the pathfinding of corticospinal axons in mice. (elsevierpure.com)
Kinase9
Chimerins are a family of non-protein kinase C phorbol ester receptors. (wikipedia.org)
Ras-GTPases act as molecular switches that bind to downstream effectors, such as the protein kinase c-Raf , and localizes them to the membrane resulting in their activation. (bionity.com)
FN2 is followed by a transmembrane (TM) helix, and an intracellular part consisting of a juxtamembrane (JM) region with several conserved tyrosine (Y) residues, a tyrosine kinase domain, a sterile-α motif (SAM) protein-protein interaction domain, and a C-terminal Psd-95, Dlg and ZO1 domain (PDZ)-binding motif ( Pasquale, 2008 ). (silverchair.com)
Taxonomy and function of C1 protein kinase C homology domains. (embl-heidelberg.de)
These domains were first discovered as the loci of phorbol ester and diacylglycerol binding to conventional protein kinase C isozymes, which contain 2 C1 domains (C1A and C1B) in their N-terminal regulatory regions. (embl-heidelberg.de)
NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions. (embl-heidelberg.de)
Classical protein kinase C (PKC) family members are activated by the binding of various ligands to one of several cysteine-rich domains of the enzyme. (embl-heidelberg.de)
A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). (bvsalud.org)
GTPases3
Like all other GTPases, Rho proteins act as molecular switches, with an active GTP-bound form and an inactive GDP-bound form. (embl-heidelberg.de)
Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. (biomedcentral.com)
In turn, GTP-bound active GTPases can interact with a plethora of different effectors which mediate the different cellular functions of this family of proteins. (biomedcentral.com)
Bind4
They exclusively bind membrane-tethered ligands known as ephrin proteins. (silverchair.com)
Typically, EphA receptors bind to glycosylphosphatidylinositol anchor (GPI)-linked ephrin A proteins and EphB receptors bind to transmembrane ephrin B proteins. (silverchair.com)
Many C1 domains and C1 domain-containing proteins bind phorbol esters, but many others do not. (embl-heidelberg.de)
All members contain the sequence motifs characteristic of all GTP-binding proteins, bind to GDP and GTP with high affinity. (biomedcentral.com)
α1-Chimerin is also able to regulate dendritic spinal density by binding to NMDA receptors at the NR2A subunit. (wikipedia.org)
Members of the Rho family of small G proteins transduce signals from plasma-membrane receptors and control cell adhesion, motility and shape by actin cytoskeleton formation. (embl-heidelberg.de)
Neuronal2
Neuronal calcium-sensor proteins interact with other regulatory proteins to mediate physiological responses to a change in intracellular calcium concentration. (nih.gov)
A subfamily of MARVEL domain-containing proteins that are found in SYNAPTIC VESICLES, where they may play a role in modulating neuronal signaling. (ouhsc.edu)
Predominately1
A family of homologous proteins of low MOLECULAR WEIGHT that are predominately expressed in the BRAIN and that have been implicated in a variety of human diseases. (nih.gov)
Receptor3
β2-Chimerin can be linked to a fusion gene that is associated with a key insulin receptor that causes people to have decreased levels of insulin. (wikipedia.org)
Eph and ephrin proteins interact with a number of other ligand/receptor systems to influence how cells translate environmental signals to orchestrate morphogenetic events. (silverchair.com)
juega un papel crítico en la PLASTICIDAD SINÁPTICA mediada por el receptor NMDA. (bvsalud.org)
Interaction2
Residues conserved across the rhoGAP family are largely confined to one face of this bundle, which may be an interaction site for target G proteins. (embl-heidelberg.de)
The observed behavior indicates conformational exchange between bound and free states upon protein-micelle interaction. (embl-heidelberg.de)
Encodes1
Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation. (embl-heidelberg.de)
Found3
α2-Chimerin acts in a similar manner to α1-chimerin, but is primarily found in the brain and testes. (wikipedia.org)
Rho-specific GAP domains are found in a wide variety of large, multi-functional proteins. (embl-heidelberg.de)
Proteins found in the myelin sheath. (harvard.edu)
Domains4
There are 47093 RhoGAP domains in 46979 proteins in SMART's nrdb database. (embl-heidelberg.de)
There are 58922 C1 domains in 42393 proteins in SMART's nrdb database. (embl-heidelberg.de)
We present a comprehensive list of 54 C1 domains occurring singly or doubly in 34 different proteins. (embl-heidelberg.de)
Proteins containing typical C1 domains are predicted to be regulated by diacylglycerol, whereas those containing only atypical domains are not. (embl-heidelberg.de)
Dependent1
The retraction is dependent on the contractile protein thrombosthenin. (lookformedical.com)
Domain5
Taxonomic distribution of proteins containing RhoGAP domain. (embl-heidelberg.de)
The complete taxonomic breakdown of all proteins with RhoGAP domain is also avaliable . (embl-heidelberg.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing RhoGAP domain in the selected taxonomic class. (embl-heidelberg.de)
Taxonomic distribution of proteins containing C1 domain. (embl-heidelberg.de)
The complete taxonomic breakdown of all proteins with C1 domain is also avaliable . (embl-heidelberg.de)
Cell2
When introduced to the cancerous cells β2-chimerin then causes the G1 cell cycle to stop and therefore it stops the cells from multiplying. (wikipedia.org)
Expression of circular RNA CDR1-AS in colon cancer cells increases cell surface PD-L1 protein levels. (harvard.edu)
Include1
Types include: Chimerin 1 Chimerin 2 There are four known isoforms of the chimerin protein. (wikipedia.org)
Expression4
Over expression of this protein in hippocampus tissue can inhibit the formation of new spines and remove existing spines. (wikipedia.org)
The expression of α2-chimerin is present in development so α2-chimerin is essential for cognitive function as it directly leads to functioning cognitive ability in adulthood. (wikipedia.org)
Intriguingly, distinct phenotypes in DINE protein localization and mRNA expression were identified in these knock-in mouse lines. (biomedcentral.com)
For G607S, DINE mRNA and protein expression was decreased or almost absent in motor neurons. (biomedcentral.com)
People2
This graph shows the total number of publications written about "Myelin Proteins" by people in Harvard Catalyst Profiles by year, and whether "Myelin Proteins" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Myelin Proteins" by people in Profiles. (harvard.edu)
Motor1
α2-Chimerin also plays a role in the ocular motor system. (wikipedia.org)
Cells1
In breast cancer cells the amount of β2-chimerin messengers are extremely low. (wikipedia.org)
Role1
β2-Chimerin has been shown to play a role in breast cancer. (wikipedia.org)
Brain1
α1-Chimerin was the first protein to be isolated from the brain. (wikipedia.org)