Loading...
  • 1954
  • Chédiak, a Cuban hematologist, reported another case in 1952, and, in 1954, Higashi, a Japanese pediatrician, described a series of cases characterized by misdistribution of myeloperoxidase in the neutrophilic granules of affected patients. (medscape.com)
  • neurologic
  • A low hairline and eyebrows that meet in the middle (synophrys) Patches of white skin pigmentation, in some cases Abnormalities of the arms, associated with Type III neurologic manifestations, associated with Type IV Cleft lip, mostly associated with Type I Waardenburg syndrome has also been associated with a variety of other congenital disorders, such as intestinal and spinal defects, elevation of the scapula and cleft lip and palate. (wikipedia.org)
  • 1952
  • Van der Hoeve-Halbertsma-Waardenburg Syndrome is named after Jan Van der Hoeve (1878-1952), a Dutch ophthalmologist, Nicolaas Adolf Halbertsma (1889-1968), Dutch physician and Petrus Johannes Waardenburg (1886-1979). (wikipedia.org)
  • bone
  • Myelodysplastic syndromes (MDS) are a group of cancers in which immature blood cells in the bone marrow do not mature and therefore do not become healthy blood cells. (wikipedia.org)
  • Phase
  • Most children with Chédiak-Higashi syndrome ultimately reach a stage known as the "accelerated phase", or the "lymphoma-like syndrome", in which defective white blood cells divide uncontrollably and invade many of the body's organs. (wikipedia.org)