Chalcones. Medical search. Frequent questions

Chalcones have been used as intermediates in heterocyclic synthesis, especially in the synthesis of pyrazoles and aurones. (wikipedia.org)
reported the synthesis of thio-phene-chalcones containing two thio-phene rings and their anti-microbial and anti-cancer activities. (iucr.org)
Hence, a series of chalcone analogues is synthesized and used as precursor for the synthesis of novel series of pyrimidines. (afpm.org.my)
Precursor chalcones were prepared by reacting aldehydes and ketones in presence of sodium hydroxide followed by synthesis of corresponding pyrimidines by reaction with urea in presence of potassium hydroxide. (afpm.org.my)

Chalcones and their derivatives demonstrate a wide range of biological activities including anti-inflammation. (wikipedia.org)
Herein, a set of 26 synthetic chalcone derivatives with alkyl substituted pyrazine heterocycle A and four types of the monophenolic ring B, were evaluated for the potential radical scavenging and antioxidant cellular capacity influencing the growth of cells exposed to H2O2. (irb.hr)
The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives. (planteome.org)
In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with 5-(aryl)furfural derivatives. (anadolu.edu.tr)
To test this, we set up a two-tiered screening strategy, (1) for directed differentiation of hPSCs with commercially available chalcones (4'-hydroxychalcone [4'HC] and Isoliquiritigen) and 24 newly synthesized chalcone derivatives, and (2) a functional screen to assess the propensity of the obtained cardiomyocytes to self-organize into contractile engineered human myocardium (EHM). (mbexc.de)
The current research emphasized on exploring the Protein-Tyrosine Phosphatase-1 B (PTP-1B) inhibitory potentials of hydroxylated chalcone derivatives against PDB ID: 4I8N (PTP-1B in complex with an inhibitor [(4-{(2s)-2-(1,3-benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl}phenyl)amino](oxo)acetic acid) by molecular docking approach using the iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. (stmjournals.in)
The current molecular docking analysis of some hydroxylated chalcone derivatives have presented a profound inhibition of the antidiabetic target PTP-1B by interacting with the amino acid residues such as TYR46, ASP48, ASP181, ASP182, GLY200, CYS215, SER216, ALA217, ARG221, and GLN262 through hydrogen bonding. (stmjournals.in)
Mahapatra DK, Bharti SK, Asati V. Chalcone derivatives: Anti-inflammatory potential and molecular targets perspectives. (stmjournals.in)

Best Hesperidin Methyl Chalcone, sourced from Spain, is a flavonoid derived from citrus fruits that many experts believe has synergistic activity with vitamin C. Hesperidin may also increase vein and capillary strength. (priceplow.com)
While hesperidin in its original form is not very water soluble, hesperidin methyl chalcone (HMC) is highly water soluble for greater absorption in the gastrointestinal tract. (priceplow.com)

The enzyme chalcone synthase, a type III polyketide synthase, is responsible for the biosynthesis of these compounds. (wikipedia.org)
The activity of the enzyme chalcone synthase (CHS, EC 2.3.1.74) was measured, as it is a key enzyme for flavonoid production. (unboundmedicine.com)
Analysis of chalcone synthase gene in chemically induced male sterility (CIMS) in wheat (Triticum aestivum L. (org.in)
The expression of chalcone synthase (CHS) gene was assessed in anthers to determine its role in fertility/sterility in wheat. (org.in)

An In Silico study was carried to know on a series of chalcone ligands to understand their binding pattern with various molecular targets and to evaluate the possible pharmacological potency with relevance to their literature reports. (caribjscitech.com)
Chalcones and their role in management of diabetes mellitus: Structural and pharmacological perspectives. (stmjournals.in)

Abstract A series of eleven ethoxysubstituted chalcones (E1-E11) were synthesized and investigated for their inhibitory potential towards human recombinant monoamine oxidase A and B (hMAO−A and hMAO−B, respectively) and acetylcholinesterase (AChE). (amrita.edu)
Abstract- We synthesized photo cross linkable side chain photopolymer with a chalcone derivative in the side chain. (ijetch.org)

Stereoselective Photochemistry of Methoxy Chalcones in Solution and Th" by NURETTİN YAYLI, OSMAN ÜÇÜNCÜ et al. (tubitak.gov.tr)
Dimethylcardamonin (DMC) or (E)-2',4'-dihydroxy-6'-methoxy-3',5'-dimethyl chalcone was isolated from Syzygium samarangense (Blume) Merr. (edu.ph)
The results depicted that pyrimidines were more active than chalcones with methoxy (C5 and P5) substitution showing best results to inhibit ACE. (afpm.org.my)
A series of eleven hydroxy and methoxy substituted new chalcone oximes ( 2a-2k ) were synthesized by the condensation of chalcone ( 1a-1k ) with hydroxylamine hydrochloride in pyridine. (acgpubs.org)

Chalcones and chalconoids are synthesized in plants as secondary metabolites. (wikipedia.org)
Chalcones are polyphenolic secondary metabolites of plants, many of which have antioxidant activity. (irb.hr)

We investigated the inhibitory effects of dihydroartemisinin (DHA), methoxyamino chalcone (C3), and iron chelators including deferiprone (DFP), 1-( N -acety1-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and deferiprone-resveratrol hybrid (DFP-RVT) against the growth of wild-type (WT) P. falciparum parasites and those with k13 and fd mutations. (biorxiv.org)
A geranylated chalcone was isolated from leaves of Artocarpus incisus and it showed potent 5α-reductase inhibitory activity. (elsevierpure.com)

Chalcones have shown antihypertensive activity through inhibition of Angiotensin Converting Enzyme (ACE). (afpm.org.my)

A variety of important biological compounds are known collectively as chalcones or chalconoids. (wikipedia.org)
1-(1-Methyl-1H-pyrrol-2-yl)-3-(5-(4-chlorophenyl)furan-2-yl)prop-2-en-1-one (7) and 1-(1-methyl-1H-pyrrol-2-yl)-3-(5-(2,5-dichlorophenyl)furan-2-yl)prop-2-en-1-one (9) were found to be the most potent antifungal agents against Candida krusei and therefore these compounds were chosen for flow cytometry analysis and Ames MPF assay. (anadolu.edu.tr)

Precursor chalcones showed high superoxide radical scavenging activity although the dimers were inactive. (tubitak.gov.tr)

Given that chalcone analogues and pyrimidines show a potential as the angiotensin converting enzyme inhibitors. (afpm.org.my)

One of their reported structures is ( E )-1-(5-chloro-thio-phen-2-yl)-3-(3-methyl-thio-phen-2-yl)prop-2-en-1-one. (iucr.org)
MTT assay indicated that 1-(1-methyl-1H-pyrrol-2-yl)-3-(5-(2-nitrophenyl)furan-2-yl)prop-2-en-1-one (3) showed more selective anticancer activity than cisplatin against the HepG2 cell line. (anadolu.edu.tr)
On the other hand, 1-(1-methyl-1H-pyrrol-2-yl)-3-(5-(4-nitrophenyl)furan-2-yl)prop-2-en-1-one (1) was found to be more effective and selective on the A549 cell line than cisplatin. (anadolu.edu.tr)

Chalcones are of interest in medicinal chemistry and have been described as a privileged scaffold. (wikipedia.org)
In medicinal chemistry, chalcones have been used as: antioxidants Anticancer agents antidiabetic drugs antiviral drugs antimalarial drugs and more. (wikipedia.org)

Based on observations that chalcones can stimulate BMP4 signaling pathways, we hypothesized their utility in cardiac mesoderm induction. (mbexc.de)

Chalcone is a potent antioxidant that can help reduce inflammation in the body and protect cells from damage. (lovetofeel.com)

Mahapatra DK, Bharti SK, Asati V. Recent perspectives of chalcone based molecules as protein tyrosine phosphatase 1B (PTP-1B) inhibitors. (stmjournals.in)
Anti-inflammatory Perspectives of Chalcone based NF-κB inhibitors. (stmjournals.in)

Chalcone is usually prepared by an aldol condensation between benzaldehyde and acetophenone. (wikipedia.org)
Solvent free microwave assisted aldol condensation method was used for synthesising 3,4-dimethoxyphenyl chalcones. (qscience.com)
Conclusion Easy handling, non-hazardous and environmentally benign aldol condensation method had been adopted for synthesising chalcones with better yields. (qscience.com)

In the extended structure of the major chalcone component, mol-ecules are linked by a combination of C-H⋯O/S, Cl⋯Cl, Cl⋯ π and π - π inter-actions, leading to a compact three-dimensional supra-molecular assembly. (iucr.org)
Mahapatra DK, Bharti SK, Asati V. Anti-cancer Chalcones: Structural and molecular targets perspectives. (stmjournals.in)
Mahapatra DK, Bharti SK, Asati V. Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives. (stmjournals.in)

Chalcone is a type of flavonoid found in many plants where it acts as a natural pigment. (lovetofeel.com)

Chalcones have two absorption maxima at 280 nm and 340 nm. (wikipedia.org)

A new chalcone glycoside, chalcone-2′,4-dihydroxy-4′-O-β-D-glucoside was isolated from Rhamnus nipalensis together with sitosterol, lupeol, di-O-methyldaidzein, kaempferol-4′-methylether, quercetin, physcion, sitosterol glucoside, emodin and their structures established by spectroscopic data. (tcgls.com)

The Bauer-Kirby method was used for evaluation of antimicrobial activities of the synthesised chalcones. (qscience.com)
Few chalcones gave excellent antimicrobial activities, whereas others gave poor antimicrobial activities. (qscience.com)

Bioefficacy evaluation of ferrocenyl chalcones against Meloidogyne incognita and Sclerotium rolfsii infestation in tomato. (bvsalud.org)

Some 2′-amino chalcones have been studied as potential antitumor agents. (wikipedia.org)
Therapeutic Potential of chalcones as cardiovascular agents. (stmjournals.in)

However, the crystal structure of this thio-phene-based chalcone has not yet been determined. (iucr.org)

Synergism studies were performed by topically applying chalcones to adult female Ae. (ogu.edu.tr)

Fourteen chalcone analogs had LC50 values in the range of 0.4-38ppm against first-instar Ae. (ogu.edu.tr)

Anatomy1

Organisms3

Chemicals and Drugs6

Phenomena and Processes2

Synthesis4

Derivatives8

Hesperidin Methyl Chalcone2

Synthase4

Pharmacological2

Abstract2

Methoxy4

Secondary metabolites2

Inhibitory2

Inhibition1

Compounds2

Precursor1

Pyrimidines1

Methyl3

Medicinal Chemistry2

Pathways1

Potent1

Inhibitors2

Aldol condensation3

Molecular3

Flavonoid1

Absorption1

Structures1

Antimicrobial2

Evaluation1

Agents2

Crystal1

Studies1

Range1