• In 1962, cephalothin and cephaloridine were introduced. (wikipedia.org)
  • Cephaloridine was briefly popular because it tolerated intramuscularly and attained higher and more sustained levels in blood than cephalothin. (wikipedia.org)
  • The cytotoxicity of cephaloridine is completely prevented by probenecid and several other inhibitors of organic anion transport, including the nearly nontoxic cephalothin. (wikipedia.org)
  • The beta-lactamase could hydrolyze both penicillin antibiotics including ampicillin, benzylpenicillin, and carbenicillin as well as cephalosporin antibiotics including nitrocefin, cephalothin, cephaloridine, and cefoperazone. (lu.se)
  • Cephaloridine versus cephalothin: relation of the kidney to blood level differences after parenteral administration. (webmd.com)
  • Nevertheless, the cytotoxicity of cephaloridine can be completely prevented by the concomitant use of inhibitors of organic anion transport, like probenecid. (oncowitan.com)
  • Cephaloridine (or cefaloridine) is a first-generation semisynthetic derivative of antibiotic cephalosporin C. It is a Beta lactam antibiotic, like penicillin. (wikipedia.org)
  • Cephaloridine is, however, highly cytotoxic to the proximal renal tubule, the segment of the nephron responsible for the secretion of organic anions, including para-am-minohippurate (PAH), as well as the various penicillin and cephalosporin antibiotics. (wikipedia.org)
  • The are not sensor to any enzyme, as they arc with out wall Hence, the remain unaffected by antibiotics like penicillin, vanconiycin, cephaloridine etc. (rbsesolutions.com)
  • For example, penicillin G (benzylpenicillin), ampicillin and cephaloridine are particularly effective in causing rapid lysis of Gram-negative bacteria such as E. coli. (pharmacy180.com)
  • The rate of aminolysis of benzylpenicillin and cephaloridine by hydroxylamine, unlike other amines, shows only a first order dependence on amine concentration. (hud.ac.uk)
  • Cephaloridine can be synthesised from Cephalotin and pyridine by deacetylation. (wikipedia.org)
  • The antibiotic cephaloridine, the active principle of Ceporine®, is a first-generation semisynthetic derivative of the natural product cephalosporin C which is produced by a fungi, Acremonium chrysogenum. (oncowitan.com)
  • This appeal is from the decision of the Patent Office Board of Appeals affirming the rejection of claim 30 in appellants' application serial No. 329,212, filed December 9, 1963, for a cephalosporin-type antibiotic known as cephaloridine. (leagle.com)
  • Cephaloglycin and imipenem undergo less intracellular trapping than cephaloridine, but have sufficient tubular cell uptake, reactivity, and generalized toxicity to mitochondrial substrate carriers to be severely nephrotoxic. (nih.gov)
  • Cephaloridine and cephaloglycin are no longer used clinically. (nih.gov)
  • For example, N -benzoyl-β-alanine (betamipron) has been shown to reduce the nephrotoxicity of cephaloridine by inhibiting its tubular uptake ( Tune, 1997 ). (aspetjournals.org)
  • Renal toxicity, including interstitial nephritis (kidney tissue swelling) and even tubular necrosis, has been demonstrated and has caused the abandonment of cephaloridine. (aixuebb.com)
  • Cephaloridine showed a remarkable activity against gram-positive bacteria, such as Streptococcus faecalis, and a good activity against gram-negative aerobic bacteria, such as Escherichia coli. (oncowitan.com)
  • Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients. (lookformedical.com)
  • 8.Kump J, Moskowitz J, Ehrenkranz NJ, Panunzio Y. Cephaloridine in the treatment of streptococcal endocarditis: a preliminary evaluation. (webmd.com)
  • Cephaloridine was very effective to cure pneumococcal pneumonia. (wikipedia.org)
  • Urine specimens showed that no other microbiologically active metabolites were present except cephaloridine and that cephaloridine is excreted unchanged. (wikipedia.org)
  • 7.Kaplan K, Reisberg BE, Weinstein L. Cephaloridine: antimicrobial activity and pharmacologic behavior. (webmd.com)
  • Before the 1970s, cephaloridine was used to treat patients with urinary tract infections. (wikipedia.org)
  • In the spinal fluid the concentration of cephaloridine is 6-12% of the concentration in the blood and serum. (wikipedia.org)
  • When cephaloridine is administered to pregnant women, the drug crosses the placenta. (wikipedia.org)
  • I've tried a different drug in high dose of oral celecoxib for a long time, are tensed in age, have poor dominica, or drink large amounts of lhasa cephaloridine taking celecoxib. (chez.com)
  • Because methimazole has antioxidant properties, the effects of methimazole treatment on cephaloridine, S-(1,2-dichlorovinyl)-L-cysteine (DCVC), 2-bromohydroquinone (2-BHQ) and cis-diaminedichloroplatinum (II) (cisplatin)-induced nephrotoxicity were investigated. (nih.gov)
  • Rats given cephaloridine (1 g/kg), cisplatin (5 mg/kg), DCVC (100 mg/kg) or 2-BHQ (157 mg/kg) i.p. exhibited significant elevations in blood urea nitrogen concentrations, which correlated with appearance of distinct renal histopathological changes. (nih.gov)
  • Cephaloridine, DCVC or 2-BHQ-induced nephrotoxicity was reduced only when methimazole (20-40 mg/kg) was given 30 min before the nephrotoxicant, whereas cisplatin-induced nephrotoxicity was reduced when methimazole was given 30 min before and up to 4 hr after cisplatin. (nih.gov)
  • Because the renal organic acid transport system plays an important role in the nephrotoxicity of cephaloridine, cisplatin and DCVC, the role of the organic acid transport system in the renal uptake of methimazole was investigated. (nih.gov)
  • Cephaloridine is, however, highly cytotoxic to the proximal renal tubule, the segment of the nephron responsible for the secretion of organic anions, including para-am-minohippurate (PAH), as well as the various penicillin and cephalosporin antibiotics. (wikipedia.org)
  • Rats given methimazole (40 mg/kg) 30 min before cephaloridine (2 g/kg) had serum and kidney cephaloridine concentrations similar to rats given cephaloridine only, but the methimazole-pretreated rats were significantly protected against cephaloridine-induced oxidation of renal nonprotein thiols. (nih.gov)
  • Cephaloridine concentrations can be measured in the serum of the newborn up to 22 hours after labor, and can reach a level of 54% of the concentration in the maternal serum. (wikipedia.org)
  • In the spinal fluid the concentration of cephaloridine is 6-12% of the concentration in the blood and serum. (wikipedia.org)
  • Furthermore, cephaloridine (1 mM) uptake by kidney cortical slices was not affected by methimazole (5 mM). (nih.gov)
  • Cephaloridine is a cephalosporin compound with pyridinium-1-ylmethyl and 2-thienylacetamido side groups. (wikipedia.org)
  • Before the 1970s, cephaloridine was used to treat patients with urinary tract infections. (wikipedia.org)
  • The administration of 6 g. cephaloridine daily produced large numbers of hyaline casts during treatment, occasionally accompanied by red and white cells and albumin. (bmj.com)