• histone
  • Scientists from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg have succeeded in demonstrating that the position, function and inheritance of the centromere are determined by the histone CenH3, a DNA packaging protein. (redorbit.com)
  • A particularly promising candidate for this kind of epigenetic centromere marking is a variant form of the H3 histone known as CenH3. (redorbit.com)
  • For their experiments, the researchers equipped the CenH3 histone with an artificially attached DNA binding domain so that the protein could bind to a DNA region where a centromere does not normally form. (redorbit.com)
  • formation
  • Patrick Heun's research group at the Max Planck Institute of Immunobiology and Epigenetics and colleagues from the Helmholtz Research Center in Munich have now discovered that CenH3 alone is sufficient to trigger the formation of the centromere. (redorbit.com)
  • function
  • It is becoming increasingly clear that the key factors for assembly and function of the centromere structure are the specialized histories and modified histones which are present in the centromeric heterochromatin and in the chromatin of the central core. (diva-portal.org)
  • change
  • The step from a DNA-identified centromere in baker's yeast, in which the position "is set in stone", to a protein-defined centromere position which is easier to change may also play a role in evolution. (redorbit.com)