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  • histone
  • Scientists from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg have succeeded in demonstrating that the position, function and inheritance of the centromere are determined by the histone CenH3, a DNA packaging protein. (redorbit.com)
  • A particularly promising candidate for this kind of epigenetic centromere marking is a variant form of the H3 histone known as CenH3. (redorbit.com)
  • For their experiments, the researchers equipped the CenH3 histone with an artificially attached DNA binding domain so that the protein could bind to a DNA region where a centromere does not normally form. (redorbit.com)
  • formation
  • Patrick Heun's research group at the Max Planck Institute of Immunobiology and Epigenetics and colleagues from the Helmholtz Research Center in Munich have now discovered that CenH3 alone is sufficient to trigger the formation of the centromere. (redorbit.com)
  • function
  • It is becoming increasingly clear that the key factors for assembly and function of the centromere structure are the specialized histories and modified histones which are present in the centromeric heterochromatin and in the chromatin of the central core. (diva-portal.org)
  • change
  • The step from a DNA-identified centromere in baker's yeast, in which the position "is set in stone", to a protein-defined centromere position which is easier to change may also play a role in evolution. (redorbit.com)
  • autoimmune
  • okay so in addition to having this rare form of autoimmune epilepsy and muscle twitching caused by anti voltage gate potassium antibodies i have antibodies to centromere. (healingwell.com)
  • Species
  • Chapters cover the structure of centromeres from several plant species including Arabidopsis thaliana, rice, maize, wheat and beet, while other sections cover several unique characteristics associated with plant centromeres, including classical and modern neocentromeres, centromere drive and centromere misdivision. (wiley.com)
  • Consequently, in rare cases, a new centromere can arise as it has already occurred in a closely-related ape species. (redorbit.com)
  • Therefore neo-centromeres might contribute to the emergence of new species. (redorbit.com)
  • Any piece of DNA with the point centromere DNA sequence on it will typically form a centromere if present in the appropriate species. (wikipedia.org)
  • genome
  • Written by an international group of experts in the field, Plant Centromere Biology is a valuable handbook for all plant scientists working on plant genome research. (wiley.com)
  • This makes it difficult to determine centromere positions in the genome sequence assembly. (wur.nl)
  • clones
  • Immunostaining for cohesin followed by FISH with 23 BAC clones, covering the region from 0 to 23 Mb on chicken chromosome 3 (GGA3), allowed us to map the GGA3 centromere between BAC clones WAG38P15 and WAG54M22 located at position 2.3 and 2.5 Mb, respectively. (wur.nl)
  • Disease
  • Anti-centromere antibodies present early in the course of disease and are notably predictive of limited cutaneous involvement and a decreased likelihood of aggressive internal organ involvement, such as fibrosis in the lungs. (wikipedia.org)
  • https
  • Taber's Medical Dictionary, Taber's Online, https://www.unboundmedicine.com/medline/view/Tabers-Dictionary/734661/all/centromere. (tabers.com)
  • human cells
  • To find out, Hiroshi Masumoto and co-workers have investigated the reactivation of a functionally inactive centromere in human cells (see p. 4021 ). (biologists.org)