Cell derived microparticles. Medical search. Frequent questions

Several aspects of MSC function have been attributed to the paracrine effects of MSC derived extracellular vesicles (EVs). (frontiersin.org)
In the present work, we have isolated and characterized the extracellular vesicles from human AD-MSC to investigate their role in the chondroprotective actions of these cells. (karger.com)
Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. (nature.com)
Figure 1: Biogenesis of extracellular vesicles and their interactions with recipient cells. (nature.com)
Various cells release lipid-enclosed particles known as extracellular vesicles (EVs), which are rich in bioactive substances. (biomedcentral.com)
Similar to other cell types, neutrophilic granulocytes also release extracellular vesicles (EVs), mainly medium-sized microvesicles/microparticles. (stanford.edu)
Vesicle flow cytometry using fluorescence-based detection of EVs has the potential to realize the potential of cell-derived membrane vesicles as functional biomarkers for a variety of applications. (nih.gov)
Extracellular vesicles generated by the shedding of CELL MEMBRANE blebs. (nih.gov)
Extracellular vesicles act as a cell's transfer signals - these nanoparticles, which contain protein, sugars, and other biological materials, communicate with adjacent cells and tissues to transmit messages, such as whether a cell is healthy or in distress. (corning.com)
In conclusion, we provide evidence that proinflammatory polarization of macrophages does not lead to enhanced procoagulatory function, whereas alternative polarization of macrophages leads to an increased expression of TF and increased production of TF bearing extracellular vesicles by these cells suggesting a procoagulatory phenotype of alternatively polarized macrophages. (haematologica.org)
Background: Microparticles (MPs) are small vesicles (0.1-1 micron) deriving from plasma membrane budding during homeostasis and cell activation. (unibo.it)
Microparticles (MPs) are submicron vesicles shed from a variety of cells that are considered to have proinflammatory and prothrombotic properties. (biomedcentral.com)

The accumulation of band 3-derived neoantigens and phosphatidylserine on microvesicles induces their fast disappearance from the circulation, prevents inflammation and thrombosis. (frontiersin.org)
Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. (nature.com)
Cell-derived MPs are microvesicles of 0.05 to 1 micrometers, released through exocytic budding of the plasma membrane, following stimulation of different cell types. (sfari.org)
that may contrast with the procoagulatory part of platelet-derived larger microvesicles is definitely envisaged. (bioskinrevive.com)
Direct effects of high inorganic phosphate (Pi) concentrations have previously been demonstrated on endothelial cells (ECs), including generation of procoagulant endothelial microvesicles (MVs). (herts.ac.uk)

Many if not all of these processes depend on the organization of the RBC membrane that enables the complex, dynamic interactions between the cell membrane and various intracellular and extracellular molecules. (frontiersin.org)
Decellularized bone extracellular matrix and human dental pulp stem cells as a construct for bone regeneration. (open.ac.uk)
Extracellular matrix-derived hydrogels for dental stem cell delivery. (open.ac.uk)

Exosomes derived from HP‑HUVECs promoted the calcification of VSMCs, as assessed by Alizarin Red S staining, alkaline phosphatase activity assays, Ca content measurements and the increased expression of runt‑related transcription factor 2 and osteopontin. (spandidos-publications.com)
In conclusion, the present results indicated that exosomal STAT1 derived from HP‑treated HUVECs could promote VSMC calcification, and activation of the Wnt/β‑catenin pathway may be a potential mechanism of the VSMC calcification promoted by exosomes. (spandidos-publications.com)
Mast cell-derived exosomes activate endothelial cells to secrete plasminogen activator inhibitor type 1. (bioskinrevive.com)
ICAM-1 on exosomes from older dendritic cells is crucial for effective naive T-cell priming. (bioskinrevive.com)
Chen J, Wang S, Jia S, Ding G, Jiang G, Cao L. Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profile in Pancreatic Cancer Derived Exosomes Treated Dendritic Cells by Microarray Analysis. (jcancer.org)
However, few studies have investigated the role of pancreatic cancer-derived exosomes (PEXs) in DC-meditated immune escape. (jcancer.org)
For example, exosomes and nanovesicles secreted by living cells serve as intercellular couriers of mRNA, microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and proteins and have thus garnered considerable interest [ 3 ]. (jcancer.org)

In 57 patients with minimally symptomatic OSA, and 15 closely matched control subjects without OSA, AnnexinV-positive, platelet-, leukocyte- and endothelial cell-derived microparticles were measured by flow cytometry. (ox.ac.uk)
Levels of platelet-derived and leukocyte-derived microparticles were also significantly higher in patients with OSA (2,267 (1,102-3,592) microL(-1) and 20 (14-31) microL(-1), respectively) compared with control subjects (925 (328-2,068) microL(-1) and 15 (5-23) microL(-1), respectively). (ox.ac.uk)
In patients with minimally symptomatic obstructive sleep apnoea, levels of AnnexinV-positive, platelet- and leukocyte-derived microparticles are elevated when compared with closely matched control subjects without obstructive sleep apnoea. (ox.ac.uk)
Case-control and experimental studies indicate that platelet-, endothelium- and leukocyte-derived MP levels are increased in SDB and induce increased expression of proinflammatory molecules. (sfari.org)
The authors evaluated blood cell parameters and markers of platelet activation in mice exposed to concentrated ambient particulate matter (CAPs) from the San Joaquin Valley of California, a region with severe particulate matter (PM) pollution episodes. (cdc.gov)
These findings demonstrate a systemic proinflammatory and procoagulant response to inhalation of environmentally derived fine and ultrafine PM and suggests a role for platelet activation in the cardiovascular and respiratory effects of particulate air pollution. (cdc.gov)
Vascular endothelial cells serve a key role in the pathogenesis of atherosclerosis by regulating vascular tension, platelet adhesion, inflammation and fibrinolysis ( 5 ). (spandidos-publications.com)
Myelofibrosis (MF) is a clonal neoplasia of the hematopoietic stem/progenitor cells characterized by distinctive abnormalities in megakaryocyte (MKC) development and platelet (PLT) activation. (unibo.it)
No correlation was observed at baseline between the percentages of MK/PLT-derived MPs and platelet number, allele burden, splenomegaly and constitutional symptoms. (unibo.it)
Although platelet- derived MPs (PDMPs) are the main form of MPs, the role of PDMPs in critically ill patients remains unclear [ 1 ]. (biomedcentral.com)
The aim of this study was to determine if resuscitation with lactated Ringer's (LR), whole blood (WB), packed red blood cells (RBCs), platelet-rich plasma (PRP), platelet poor plasma, balanced RBC:PRP (1:1), or day 14 (d14) RBC would best minimize endothelial damage following shock. (bvsalud.org)

The uptake of labeled MPs in the presence of protein S and Gas6 in human aortic endothelial cells (HAEC) and human umbilical vein endothelial cells (HUVEC) was monitored by flow cytometry, western blotting and confocal/electron microscopy. (lu.se)
Flow cytometry was conducted to detect the apoptotic rate of cells. (spandidos-publications.com)
Flow cytometry is a popular tool for characterizing heterogeneous mixtures of particles such as cell types within blood, but the small size of EVs makes them difficult to measure using conventional flow cytometry. (nih.gov)
Flow cytometry enables the detection and enumeration of specific cellular and sub-cellular elements in complex mixture of cells, such as whole peripheral blood. (europeanpharmaceuticalreview.com)
Single cell analysis by flow cytometry can be described as a three step-process: 1) Preparation of the cells, 2) Data acquisition and 3) Data analysis (Figure 2). (europeanpharmaceuticalreview.com)
PLT (CD61+CD62P+) and MK (CD61+CD62P-)-derived MPs were analysed in PLT poor plasma samples by flow cytometry (CytoFLEX, Flow Cytometer-Beckman Coulter). (unibo.it)

Phagocytosis (from Ancient Greek φαγεῖν (phagein) 'to eat', and κύτος (kytos) 'cell') is the process by which a cell uses its plasma membrane to engulf a large particle (≥ 0.5 μm), giving rise to an internal compartment called the phagosome. (wikipedia.org)
The molecular organization of the membrane of the red blood cell controls cell morphology and function and is thereby a main determinant of red blood cell homeostasis in the circulation. (frontiersin.org)
The role of membrane organization is prominently reflected in red blood cell deformation and aggregation. (frontiersin.org)
Also, we found that most of these correlations were absent in misshapen red blood cells that have an inborn defect in the interaction between the membrane and the cytoskeleton. (frontiersin.org)
Studies of inborn errors of metabolism and membrane protein composition, in combination with the structural and functional changes that occur during RBC aging, have led to a membrane-centered molecular understanding of red blood cell function and survival, and of the role of membrane molecules in cell morphology and membrane organization. (frontiersin.org)
Upon activation, platelets release plasma-membrane derived microparticles (PMPs) exposing phosphatidylserine (PS) on their surface. (lu.se)
These findings identify emperipolesis as a new cell-in-cell interaction that enables neutrophils and potentially other cells passing through the megakaryocyte cytoplasm to modulate the production and membrane content of platelets. (elifesciences.org)

Platelets were the only peripheral blood cells that were significantly elevated in number in CAPs-exposed mice. (cdc.gov)
Stimulation of platelets by thrombin resulted in up-regulation of LAMP-1 expression in CAPs-exposed animals and an increased microparticle population relative to control animals. (cdc.gov)

The mechanism of how the calcification signal from endothelial cells is transmitted to vascular smooth muscle cells (VSMCs) remains unknown. (spandidos-publications.com)
Similarly, sEng is a truncated form of receptor for two subtypes of transforming growth factor beta (TGF β ) specifically, TGF β 1 and TGF β 2 which are highly expressed by vascular endothelial cells and syncytiotrophoblasts. (hindawi.com)
Great glucose condition boosts NADPH oxidase activity in endothelial microparticles that promote vascular irritation. (bioskinrevive.com)
Vascular even muscles cell calcification is normally mediated Heparin sodium by governed exosome secretion. (bioskinrevive.com)
A nitric oxide (NO) detection kit was used to determine the concentration of NO. Western blotting analysis was performed to determine the levels of intercellular cell adhesion molecule (ICAM)‑1, vascular cell adhesion molecule (VCAM)‑1, endothelin‑1, caspase‑3, Bax, Bcl‑2, Toll‑like receptor 4 (TLR4), p65 and p‑p65. (spandidos-publications.com)
At the onset of atherosclerosis, LDL is deposited on vascular endothelial cells to be oxidized to form ox-LDL, which is then absorbed by macrophages to form foam cells. (spandidos-publications.com)
TBI-induced microglial activation and the release of inflammatory factors, such as tumor necrosis factor (TNF), interleukin (IL), and interferon (IFN), cause direct neuronal cell death and also induce vascular endothelial cells to express a variety of cell adhesion molecules and cell chemotaxis. (biomedcentral.com)

Dendritic cells also reside in tissues and ingest pathogens by phagocytosis. (wikipedia.org)
The tyrosine kinase receptors Tyro3, Axl and Mer (TAMs) and their ligands protein S and Gas6 are involved in the uptake of PS-exposing apoptotic cells in macrophages and dendritic cells. (lu.se)
Dendritic cells (DCs), which are the most potent antigen-presenting cells in the human body, play a pivotal role in the immune response. (jcancer.org)
The expression profiles of long noncoding RNAs (lncRNAs) and mRNAs of PEX-treated dendritic cells are unknown. (jcancer.org)

Additionally, for many other engineered or synthetic advanced therapies, the amount of therapeutic agent required to elicit an efficacious response is high, necessitating their conveyance in a larger nanoparticle or a microparticle much larger than an EV. (corning.com)

Endothelial cell-derived microparticles induce plasmacytoid dendritic cell maturation: potential implications in inflammatory illnesses. (bioskinrevive.com)

Phenotype switching: plasticity and/or differentiation of stromal cells and their progenitors within the tumour microenvironment regulate tumour fate. (europa.eu)
Elevated ratio of Compact disc31+/Compact disc42- microparticles to endothelial progenitors being a book marker of atherosclerosis in hypercholesterolemia. (bioskinrevive.com)

Many existing tissue-engineering approaches focus on delivery of selected proteins (growth factors, transcription factors etc.) or nucleic acids to host or implanted stem cells to achieve lineage specific differentiation. (frontiersin.org)
At this time I also began working with mouse and human embryonic stem cells resulting in the publication of some of the first papers describing the osteogenic differentiation of mouse ES and human cells in vitro and in vivo . (nottingham.ac.uk)
However, when employing MSC transplantation to treat tissue defects, the research found that: less than one percent of MSCs could home and colonize in the tissue defect area, continuously promoting tissue regeneration, and the paracrine mechanism of MSCs plays a more important role than the replacement of damaged cells by differentiation [ 13 ]. (biomedcentral.com)
Specifically, the employment of BC-Ppy compositesdrives partial H9c2 differentiation toward a cardiomyocyte-like phenotype.The scaffolds increase the expression of functional cardiac markersin H9c2 cells, indicative of a higher differentiation efficiency,which is not observed with plain BC. (ibecbarcelona.eu)

Circulating cell-derived microparticles have been shown to have pro-inflammatory, pro-coagulant and endothelial function-impairing effects, as well as to predict subclinical atherosclerosis and cardiovascular risk. (ox.ac.uk)
The partnership between circulating endothelial microparticles and arterial atherosclerosis and stiffness in children with chronic kidney disease. (bioskinrevive.com)
Notch activation induces endothelial cell senescence and pro-inflammatory response: implication of Notch signaling in atherosclerosis. (bioskinrevive.com)
Atherosclerosis 2012 225 [PMC free of charge content] [PubMed] 56 Quillard T Devalliere J Coupel S Charreau B. Irritation dysregulates Notch signaling in endothelial cells: implication of Notch2 and Notch4 to endothelial dysfunction. (bioskinrevive.com)
Therefore, the study of ox-LDL-mediated endothelial cell dysfunction can further clarify the pathogenesis of atherosclerosis and provide a more theoretical basis for the treatment and prevention of atherosclerosis. (spandidos-publications.com)
Antigen-presenting cells (APCs) produce and release a broad spectrum of EVs involved in the pathogenesis of atherosclerosis. (bmrat.org)
Numerous animal studies as well as observational and clinical trials have shown that atherosclerosis arises from immune activation, with several cell-type specific pathways involved. (bmrat.org)

Macrophages are versatile cells that can be polarized by the tissue environment to fulfill required needs. (haematologica.org)
To understand if polarization of macrophages can lead to a procoagulant macrophage subset we polarized human monocyte derived macrophages to a proinflammatory and an alternative activation state. (haematologica.org)
Macrophages are cells of the innate immune system which play numerous and vastly different functions within the body. (haematologica.org)
2 Upon inflammation, the pool of resident macrophages gets quickly replaced by macrophages derived from circulating monocytes. (haematologica.org)
6 In addition, these cells are present during early wound healing and proinflammatory macrophages are characterized by a pronounced ability to degrade tissue. (haematologica.org)

Reductions in uteroplacental flow initiate a cascade of molecular effects leading to hypoxia, thrombosis, inflammation, and endothelial cell dysfunction resulting in untoward pregnancy outcomes. (hindawi.com)
The degree of skin tightening is associated with changed levels of proteins implicated in inflammation and cell death among systemic sclerosis (SSc) patients with pulmonary involvement, a study in India reports. (scleroderma.org.au)
The present study aimed to investigate the effects of S/V on the expression of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs) induced by oxidized low‑density lipoprotein (ox‑LDL) and to elucidate its possible mechanism. (spandidos-publications.com)
APC-derived EVs act as triggers of angiogenesis, neovascularization and inflammation through their participation in microvascular inflammation, angiogenesis, development of atherosclerotic plaques, and modulation of their instability. (bmrat.org)

Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
However, the most recent data from our laboratory prove that the same population of neutrophils is able to generate EVs with different functional properties, transmitting pro-inflammatory or anti-inflammatory effects on neighboring cells. (stanford.edu)
MPs express antigens and contain constituents from cell of origin and are increased in conditions that are characterized by high cell turnover or death, particularly inflammatory, autoimmune and neoplastic diseases. (unibo.it)
These include macrophage and smooth muscle cell (SMC) phenotypic switching and various inflammatory signaling, such as IL-33/suppression of tumorigenesis 2 (ST2), Ras-Raf-MEK-ERK pathways, and JAK-STAT signaling pathways 14 , 15 , 16 , 17 . (bmrat.org)

Among these are receptors that recognise the Fc part of bound IgG antibodies, deposited complement or receptors, that recognise other opsonins of cell or plasma origin. (wikipedia.org)

Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate. (open.ac.uk)
By combining sensitive detection with fluidics that allowed for single cell interrogation and subsequent conversion of the signals generated to digital format, the platforms we use today were born, and cell surface, intracellular protein or nucleic acids could be detected by fluorescent probes specific for the target. (europeanpharmaceuticalreview.com)
5 Functionally, proinflammatory polarization leads to potent effector cells that kill intracellular micro-organisms and tumor cells. (haematologica.org)
However, no mechanism directly sensing elevated intracellular Pi has ever been described in mammalian cells. (herts.ac.uk)

Apoptosis was measured by Hoechst 33258/propidium iodide double staining of nuclear chromatin and the formation of gaps into the lymphendothelial barrier in a three-dimensional co-culture model consisting of MCF-7 tumour cell spheroids and human lymphendothelial monolayers. (nature.com)
In HL-60 leukaemia cells, di-GA activated caspase 3 and dose-dependently induced apoptosis. (nature.com)
These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)
Also implicated in the disease are proteins associated with apoptosis - programmed cell death (as opposed to cell death caused by injury), which can alter immune responses. (scleroderma.org.au)
STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. (thermofisher.com)
The review focuses on the role of APC-derived EVs in regulating the transformation of macrophage phenotype, shaping foam cells, driving autophagy and/or inhibiting apoptosis of Th4 + cells, T regulatory cells, endothelial and smooth muscle cells (SMCs), as well as in facilitating oxidative stress in vasculature. (bmrat.org)

Targeting the H3K4 Demethylase KDM5B Reprograms the Metabolome and Phenotype of Melanoma Cells. (uni-due.de)

PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy. (open.ac.uk)

Thus, the secretion of gall wasps stimulates plant cell growth and overrules homeostasis of the affected leaf area - this is similar to tumour outgrowth. (nature.com)
As a first step, we correlated a number of deformability and aggregation parameters in red blood cells from healthy donors, which we obtained in the course of our studies on red blood cell homeostasis in health and disease. (frontiersin.org)

Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)

During the 3rd incubation, streptavidin-coated microparticles and vitamin B12 labeled with biotin are added and the still-vacant sites of the ruthenium labeled intrinsic factor become occupied. (cdc.gov)

J. Cell Biol. (nature.com)
Arterioscler Thromb Vasc Biol 2005 25 [PubMed] 48 Dignat-George F Boulanger CM. The countless encounters of endothelial microparticles. (bioskinrevive.com)

Almost 50 years ago, it was observed that MKs can engulf other hematopoietic cells, most commonly neutrophils ( Larsen, 1970 ). (elifesciences.org)

By performing local transplants, other non-periodontal-derived MSCs such as dental pulp stem cells (DPSCs), bone marrow stem cells (BMSCs), and adipose tissue-derived stem cells (ADSCs) also aid in the regeneration of periodontal tissue [ 12 ]. (biomedcentral.com)

According to published data, authors have reached a consensus on the physical parameters (size, density) and chemical composition (surface proteins, proteomics) of neutrophil-derived EVs. (stanford.edu)

In patients with OSA, median (interquartile range) levels of AnnexinV-positive microparticles were significantly elevated compared with control subjects: 2,586 (1,566-3,964) microL(-1) versus 1,206 (474-2,501) microL(-1), respectively. (ox.ac.uk)
Compared with the ox‑LDL group, S/V treatment significantly increased the cell viability, NO concentration and Bcl‑2 expression, decreased the levels of IL‑1β, IL‑6 and TNF‑α and reduced the expressions of MALAT1, ICAM‑1, VCAM‑1, cleaved‑caspase‑3, Bax, TLR4 and p‑p65. (spandidos-publications.com)
At 3 and 6 months, RUX did not significantly modify the mean percentages of MK- and PLT-derived MPs compared to baseline values. (unibo.it)

Part of the discrepancy may be ascribed to differences in the viability of the starting cells, in eliciting factors, in separation techniques and in storage conditions. (stanford.edu)
BC-Ppy scaffolds improved cell viability andattachment, promoting a desirable cardiomyoblast morphology. (ibecbarcelona.eu)
Cell Counting Kit‑8 assay was used to detect cell viability. (spandidos-publications.com)
Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. (thermofisher.com)

My research interests focus mainly on stem cells (embryonic, 'adult' and fetal origins) and their applications in tissue engineering, particularly the osteoblast and bone tissue. (nottingham.ac.uk)
Noninvasive detection and imaging of molecular markers in live cardiomyocytes derived from human embryonic stem cells Biophysical Journal. (nottingham.ac.uk)

They are secreted by a wide array of cells, including cardiac myocytes, mature and progenitor endothelial cells, mesenchymal stem cells, immune cells like antigen-presenting cells (APCs), and malignant cells 5 , 6 . (bmrat.org)

Lai, R. C., Chen, T. S. & Lim, S. K. Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. (nature.com)
Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. (nature.com)
Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. (nature.com)

Human mesenchymal stem cells (HMSCs) are multipotent somatic stem cells that can be isolated from a variety of tissues such as the bone marrow, adipose tissue, and dental pulp. (frontiersin.org)

Improved delivery of PLGA microparticles and microparticle-cell scaffolds in clinical needle gauges using modified viscosity formulations. (open.ac.uk)
All aspects of a biological process from biochemical, genetic and cellular to clinical and environmental can be integrated using computational models to derive unique signatures from vast amounts of data. (europeanpharmaceuticalreview.com)
While genomics, proteomics and metabolomics are familiar to most investigators, and even clinicians, cytomics, facilitated by high dimensional, single cell analysis is becoming a technology of choice for the elucidation of relevant phenotypic patterns that can be directly utilised in the clinical arena (Figure 1). (europeanpharmaceuticalreview.com)
A survey produced by HTStec Ltd in June 2012 2 , derived from responses from 202 respondents worldwide, from research to Pharma to clinical laboratories, indicated that most respondents highly rated the specificity that could be provided by singlecell analysis versus the population analysis that is the basis of genomic and proteomic studies. (europeanpharmaceuticalreview.com)

Further transfusion should be delayed until the cause of the reaction is known, unless the need is urgent, in which case type O Rh-negative red blood cells (RBCs) should be used. (msdmanuals.com)

The first demonstration of phagocytosis as a property of leucocytes, the immune cells, was from the German zoologist Ernst Haeckel. (wikipedia.org)
It was the first direct evidence of phagocytosis by immune cells. (wikipedia.org)
The disease is thought to develop from the combination of immune dysfunction - meaning the activation and recruitment of immune cells and the production of self-targeting antibodies (fibrosis) - and damage to small blood vessels. (scleroderma.org.au)
In periodontitis, EVs play a pivotal role in regulating the biological functions of both periodontal tissue cells and immune cells, as well as the local microenvironment, thereby promoting periodontal injury repair and tissue regeneration. (biomedcentral.com)

So far we have only made small amounts [of the nanomedicine], but we can access a tumour cell and reverse and fix it. (irishtimes.com)

Protein activation and expression were analysed by western blotting, deoxyribonucleoside triphosphate levels by HPLC, ribonucleotide reductase activity by 14 C-cytidine incorporation into nascent DNA and cell-cycle distribution by FACS. (nature.com)

Tissue oxygenation depends on hemoglobin as much as on red blood cell (RBC) characteristics such as metabolism, communication with the immune system, deformability and aggregation behavior. (frontiersin.org)

I cover mainly cell biology and physiology. (nottingham.ac.uk)
Biology of Metastasis - Adhesion Molecules and Cell-Cell/Matrix Interactions 1 (Migration) ( MSc Oncology , A34C02/L/05 Tumour Physiology) (2015-present). (nottingham.ac.uk)
Biology of Metastasis - Adhesion Molecules and Cell-Cell/Matrix Interactions 2 (Invasion) ( MSc Oncology , A34C02/L/05 Tumour Physiology) (2015-present). (nottingham.ac.uk)

I returned full time to Imperial College in 1999 to take up a lectureship in cell biology and tissue engineering and was also actively involved in establishing the Tissue Engineering Centre. (nottingham.ac.uk)
Character cell biology 2012 14 [PubMed] 62 Peterson MF Otoc N Sethi JK et al. (bioskinrevive.com)
The molecular biology and genetics of brain tumour cells grown as 3D cultures better resembles the biology of the patients' tumour, when compared to traditional 2D cultures. (nottingham.ac.uk)

Mesenchymal stem cells (MSCs) are multipotent cells with regenerative and immunomodulatory properties. (frontiersin.org)

The surface molecules of EVs enable them to target recipient cells. (biomedcentral.com)

Stem Cell Res. (nature.com)
A biomaterials approach to influence stem cell fate in injectable cell-based therapies. (open.ac.uk)
Stem Cell Research & Therapy , 9(1), article no. 39. (open.ac.uk)

Our first important observation is that, MSC EVs possess a common mechanism of endocytosis across multiple cell types. (frontiersin.org)
Overall, the results presented in this study show a common mechanism of endocytosis for MSC EVs across different cell types and the feasibility to generate functionally enhanced EVs by modifications to parental MSCs. (frontiersin.org)

Although MSC EVs show great promise for regenerative medicine applications, insights into their uptake mechanisms by different target cells and the ability to control MSC EV properties for defined function in vivo have remained elusive knowledge gaps. (frontiersin.org)
The primary goal of this study is to elucidate how the basic properties of MSC derived EVs can be exploited for function-specific activity in regenerative medicine. (frontiersin.org)
Kim and Park, 2017 ) and make HMSCs attractive cells for regenerative therapies. (frontiersin.org)
Her research interests include the preparation and design of materials and scaffolds for in vitro and in vivo fundamental studies, and a further focus is the provision of useful tools to assess mechanisms that govern cell behavior in regenerative medicine. (ibecbarcelona.eu)

thus, due to the unique characteristics of mesenchymal stem cells (MSCs), they have become the focus of attention and may be the most promising new therapy for periodontitis. (biomedcentral.com)
MSCs are multipotent stem cells with the ability to self-renew and differentiate in multiple directions [ 3 ]. (biomedcentral.com)

Unlike whole cell therapies, EVs are acellular products, the equivalent of text messages sent back and forth in order to elicit reactions. (corning.com)
Their small size confers other benefits, as well - too small to convey pathogens such as bacteria or viruses, EVs are also incapable of the unwanted replication or tumor formation that whole cell therapies can occasionally provoke. (corning.com)
The potential EVs possess for the field of acellular therapies - treatments derived from acellular products that achieve the same therapeutic response without delivering entire cells - is an exciting one. (corning.com)

We used integrated lncRNA and mRNA microarrays to determine the expression profiles of PEX-treated DCs and normal DCs derived from five healthy donors. (jcancer.org)

Anatomy17

Organisms1

Diseases5

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes13

Disciplines and Occupations6

Technology, Industry, Agriculture19

Health Care2

Vesicles12

Microvesicles5

Extracellular3

Exosomes7

Platelet11

Flow cytometry6

Membrane7

Platelets2

Vascular7

Dendritic cells4

Nanoparticle1

Induce1

Progenitors2

Differentiation4

Atherosclerosis7

Macrophages5

Inflammation4

Inflammatory4

Plasma1

Intracellular4

Apoptosis6

Phenotype1

Nanoparticles1

Homeostasis2

Concentrations1

Incubation1

Biol2

Hematopoietic1

Dental pulp stem cells1

Proteins1

Significantly3

Viability4

Embryonic2

Antigen-prese1

Mesenchymal stem3

Adipose1

Clinical4

RBCs1

Immune cells4

Tumour cell1

Protein1

Metabolism1

Physiology3

Biology3

Multipotent cells1

Molecules1

Stem cell3

Endocytosis2

Regenerative4

MSCs2

Therapies3

Healthy donors1