Cell migration inhibition. Medical search. Frequent questions

1. Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch‑1‑dependent manner. (nih.gov)
12. An increased expression of long non-coding RNA PANDAR promotes cell proliferation and inhibits cell apoptosis in pancreatic ductal adenocarcinoma. (nih.gov)
In the last years, a wide spectrum of phytochemicals have been found to be beneficial to health interacting with molecular signaling pathways underlying critical functions such as cell growth and differentiation, apoptosis, autophagy, inflammation, redox balance, cell volume regulation, metabolic homeostasis, and energy balance. (frontiersin.org)
In summary, our results showed that enhanced apoptosis, induced by Qu, might be caused in part by its DNA demethylating activity, by HDAC inhibition, and by the enrichment of H3ac and H4ac in the promoter regions of genes involved in the apoptosis pathway, leading to their transcription activation. (cancerindex.org)
Moreover, activation of Wnt/β-catenin signaling via Wnt3a/R-Spo1 treatment protects these cells from regorafenib induced apoptosis. (frontiersin.org)
AZD4547 markedly inhibited the proliferation and elevated the apoptosis of ovarian most cancers cells. (immpact-international.org)
These are involved in fundamental cellular processes, such as nerve impulse transmission, cell proliferation, apoptosis, hormone secretion and sensory transduction ( 11 , 12 ). (spandidos-publications.com)
Additionally, CF had no impact on apoptosis susceptibility while TF caused increased apoptosis in MET-5A cells and its inhibition in BEAS-2B cells. (cdc.gov)

Collective cell migration is an essential process in the lives of multicellular organisms, e.g. embryonic development, wound healing and cancer spreading (metastasis). (wikipedia.org)
9. MicroRNA-323-3p inhibits cell invasion and metastasis in pancreatic ductal adenocarcinoma via direct suppression of SMAD2 and SMAD3. (nih.gov)
Cancer stem cells (CSCs), a small population of cancer cells, have been considered to be the origin of cancer initiation, recurrence, and metastasis. (nature.com)
Noncanonical Wnt5-Frizzled2 pathway also regulates epithelial-mesenchymal transition (EMT), a characteristic of CSCs, and promotes metastasis in hepatocellular carcinoma (HCC) and colon cancer cells through the activation of STAT3 10 . (nature.com)
Female BALB/C mice were used in a TNBC brain metastasis model by intracardiac injection of the 4T1-Br3-Luc cell line. (bmj.com)
MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells. (biomedcentral.com)
Silencing or pharmacologic inhibition of the two-pore channel TPC2 reduced lung metastasis of mammary mouse cancer cells. (cipsm.de)
Intro The procedure of tumor metastasis contains detachment from the principal tumor, migration, Rabbit Polyclonal to OR5B3 invasion, transportation in the bloodstream or lymphatic vessels, and connection at the supplementary site. (tsfaq.info)
Migration is mixed up in system of most types of tumor metastasis especially. (tsfaq.info)
Mixed exposures to AZD4547 (FGFR1 inhibitor) and GANT61 (GLI1 inhibitor) considerably lowered cell proliferation, cell motility, and invasion, suggesting molecular crosstalk in breast most cancers development and metastasis. (immpact-international.org)
A robust optimistic suggestions mechanism between FGFR1-GLI1 axis was noticed, which considerably elevated cell proliferation and metastasis. (immpact-international.org)
My research focuses on understanding the molecular mechanisms underlining cell migration, which are fundamental to a variety of physiological and pathological processes, including embryonic development, tissue repair, immune responses, and cancer cell metastasis. (exeter.ac.uk)
Previous studies have confirmed that ion channels fulfill an important role in the development and progression of cancer, including the infinite proliferation of cells and their invasion and metastasis ( 14 - 16 ), and ion channels have been approved as effective drug targets for cancer therapy ( 17 , 18 ). (spandidos-publications.com)

Two very distinct migration scenarios are crawling motion (most commonly studied) and blebbing motility. (wikipedia.org)

Directional microvascular endothelial cell migration was shown to increase with increasing gradient slope with no significant change in cellular persistence time or random cell speed. (duke.edu)

Confinement is also observed in vivo, where the optimal width is a function of the number of migrating cells in different streams of different species. (wikipedia.org)
Cell-cell communication mechanisms are widely studied experimentally (in vivo and in vitro), and computationally (in silico). (wikipedia.org)
Ewing sarcoma cells in porous electrospun polycaprolactone scaffolds exhibited the expression signaling patterns similar to tumors in vivo 18 . (nature.com)
This study was performed in vivo in two human xenograft acute myeloid leukemia (AML) models and in vitro using HL60 and U937 cell lines. (cancerindex.org)
RNA sequencing revealed increased mesenchymal gene expression in attached HGSC cells both in vivo and in vitro, hinting to an epithelial-mesenchymal-transition. (uni-marburg.de)
Moreover, regorafenib resistant cells also exhibit significantly augmented in vitro and in vivo migration capacity which could be reversed by TGF-β type 1 receptor (TGFb -R1) inhibition. (frontiersin.org)
To this end, average linkage hierarchical clustering, pathway and gene ontology (GO) analyses of transcriptomes from cultured and ex vivo-isolated myelin basic protein-reactive T cells (TMBP cells) were performed. (uni-muenchen.de)
A novel tetraspan membrane protein called epithelial membrane protein (EMP1), was found to be up regulated in ex vivo-isolated effector T cells. (uni-muenchen.de)
Overexpression of EMP1 in encephalitogenic T cells influenced the migratory behaviour of effector T cells both in vitro and in vivo. (uni-muenchen.de)
EMP1 enhanced T cell motility within the extracellular matrix milieu in vitro and promoted T cell migration from the connective tissue to lymph nodes in vivo resulting in an accelerated onset of EAE. (uni-muenchen.de)
The zebrafish embryo is an ideal model system for studying PGC migration due to 1) the transparency of the embryo, allowing in vivo analyses of cell migration and development, 2) the availability of various mutant stocks and the morpholino antisense oligo nucleotide gene knockdown system, and 3) the availability of PGC marker genes, for which localisation and functions are well characterised. (exeter.ac.uk)
A major limitation of C3 Transferase for use in in vivo applications is that this protein is only slightly cell permeable. (cytoskeleton.com)
ArfGAP1 regulates the endosomal sorting of guidance receptors to promote directed collective cell migration in vivo . (iric.ca)
The aim of this work was to compare the in vitro and in vivo migration capacity between BM-MSCs and human umbilical cord perivascular cells (HUCPVCs) towards HCC and to analyze the mechanisms involved. (conicet.gov.ar)
As a result, we observed that HUCPVCs presented higher in vitro and in vivo migration towards factors released by HCC. (conicet.gov.ar)

KIR2.1 plays crucial roles in regulating cell proliferation and migration, and vascular remodeling. (nih.gov)
However, researchers have not yet clearly determined whether KIR2.1 participates in the proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) and its role in pulmonary vascular remodeling (PVR) also remains elusive. (nih.gov)
The present study aimed to examine whether KIR2.1 alters PASMC proliferation and migration, and participates in PVR, as well as to explore its mechanisms of action. (nih.gov)
It inhibits endothelial cell proliferation and migration [5]. (who.int)

The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes. (cancerindex.org)
In this study, we show that regorafenib treatment activates Wnt/β-catenin signaling only in hepatoblast-like HCC cell lines and induces enrichment of markers associated with hepatic stem/progenitor cells. (frontiersin.org)
When expressed in the mesoderm of wild-type embryos, activated Htl induces the formation of additional Eve founder cells but has no effect on mesoderm migration. (sdbonline.org)
Together, these results demonstrate that endogenous CIB1 is required for regulated adhesion-induced PAK1 activation and preferentially induces a PAK1-dependent pathway that can negatively regulate cell migration. (rupress.org)

Tissue formation during embryonic development , wound healing and immune responses all require the orchestrated movement of cells in particular directions to specific locations. (wikipedia.org)
The leptin modulation of the immune system is also mediated by the regulation of hematopoiesis and lymphopoiesis [ 7 , 11 ] Thus, seven days of provision of recombinant leptin promoted substantial lymphopoiesis, with a twofold increase of the numbers of B cells in the marrow of obese mice while doubling and tripling, respectively, the numbers of pre-B and immature B cells. (hindawi.com)
By detecting the expression level of multiple chemokines and performing the tumor-immune cell co-culture assay, they found that Arf1 inhibition mainly influenced T cell migration through upregulating the level of chemokine CCL5 in tumor cells. (news-medical.net)
Conclusions These data suggest that SIRPα blockade modulates immune and TNBC cells to limit metastatic spread. (bmj.com)
We will examine whether the inhibition of certain CXCR4 complexes and/or the activation of the immune system is the most effective way of deactivating CXCR4-positive tumour cells. (uu.nl)
It is worth noting that the treatment of HCC is complex and several years of study have demonstrated that treatment of patients with HCC depends on the clinical manifestation, liver function and tumor staging, although multidisciplinary treatments exist, which mainly include surgical resection and liver transplantation, radiofrequency ablation, chemical drug targeting inhibition and immune suppression ( 3 , 7 , 8 ). (spandidos-publications.com)

A recently developed technique for the measurement of cell migration on surface bound gradients was used to assay the behavior of microvascular endothelial cells on a range of fibronectin gradient slopes in the presence of soluble promoters and inhibitors of chemotaxis. (duke.edu)
Methods: We generated NC cells from human embryonic stem cells, and after establishing a migration assay of NC cells (MINC assay), we tested environmental toxicants as well as inhibitors of physiological signal transduction pathways. (nih.gov)
Using the MINC assay and applying classic pharmacologic inhibitors and large-scale microarray gene expression profiling, we found several signaling pathways that are relevant for the migration of NC cells. (nih.gov)
Conclusions: The MINC assay faithfully models human NC cell migration, and it reveals impairment of this function by developmental toxicants with good sensitivity and specificity. (nih.gov)
Cell viability and death were tested by MTT assay and LDH release assay, respectively. (karger.com)
A Real-Time Cell Analysis (RTCA) impedance assay was used to determine migration, proliferation, and microglia-mediated cancer cell clearance changes. (bmj.com)
Migration was assessed by wound curing assay. (tsfaq.info)
After JPYZ treatment, TAM conditioned medium (TAM-CM)/TAM-exos were co-cultured with gastric cancer cells and were detected by wound healing and transwell assay. (bvsalud.org)

The leptin receptor Ob-Rb is expressed by B and T lymphocytes, suggesting that leptin regulates directly the B and T cell responses [ 10 ]. (hindawi.com)
There is passive diffusion of the glucocorticoids through the cell membrane, followed by binding to soluble receptor proteins in the cytoplasm. (slideshare.net)
Right here, we exhibit that AZD4547, a extremely potent and selective inhibitor of fibroblast development issue receptor (FGFR), shows anti-tumor exercise towards KM12(Luc) harboring the TPM3-NTRK1 fusion gene related to its direct inhibition of TRKs. (immpact-international.org)
Expression of the chemokine receptor protein CXCR4 is raised in leukaemic cells, and this plays an important role in their cell division and migration to the lymph glands where, through interactions with other cells, they promote cell division and are less susceptible to cell death. (uu.nl)
In contrast, T cells isolated from spleen 3 days post transfer, downregulated activation markers such as interleukin 2 receptor (IL2R) and interferon γ (IFNγ), and at the same time upregulated migration specific genes such as CC-chemokine receptor 1 (CCR1), CC-chemokine receptor 2 (CCR2) and CC-chemokine receptor 5 (CCR5). (uni-muenchen.de)
T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue. (exeter.ac.uk)
In addition, genes related with the availability of the receptor on the cell surface (caveolin-1 and -2) and metalloproteinase 3, which is induced by the receptor activation and important for cell migration, were also overexpressed in HUCPVCs. (conicet.gov.ar)

ROCK inhibition decreases nocodazole-induced membrane blebbing and stabilizes MTs. (exeter.ac.uk)
CIB1 overexpression significantly decreases cell migration on fibronectin as a result of a PAK1-and LIM kinase-dependent increase in cofilin phosphorylation. (rupress.org)

We performed in utero electroporation at E14.5, and examined neuronal migration and morphology after 48 h. (mendeley.com)

The epithelial healing process begins when basal epithelial cells undergo mitosis, producing new cells that occupy fresh wounds. (medscape.com)
Cells can migrate as a cohesive group (e.g. epithelial cells) or have transient cell-cell adhesion sites (e.g. mesenchymal cells). (wikipedia.org)
Methods: To test this hypothesis, we cultured primary tracheal epithelial cells in monolayers from both wild type and dimethylarginine dimethylaminohydrolase (DDAH) overexpressing C57Bl/6 mice and measured wound repair using the electric cell impedance sensing (ECIS) system. (cdc.gov)

Further analysis of isolated cardiac tissue by RT-qPCR revealed cardiomyocyte-specific inhibition of sox9b function significantly decreased the expression of the critical cardiac development genes nkx2.5 , nkx2.7 , and myl7 , as well as c-fos , an immediate early gene necessary for cardiomyocyte progenitor differentiation. (nature.com)
In addition, Qu treatment significantly increased the mRNA levels of all these genes, when compared to cells treated with vehicle only (control cells) (*p (cancerindex.org)
Further results showed that LPE indeed increased the expression of downstream genes in the PPARγ signaling pathway, suggesting that inhibition of Arf1 may affect the activation of PPARγ through the unsaturated fatty acid LPE. (news-medical.net)
Regorafenib resistant cells (RRCs) also show increased expression of several mesenchymal genes along with an induction of CD24 and CD133 cancer stem cell markers. (frontiersin.org)
The medical relevance of mRNA and protein expression of FGFR1 and its related genes have been additionally evaluated in mouse embryonic fibroblasts (MEFs) and breast most cancers cell line (MDA-MB-231). (immpact-international.org)
Moreover, MDA-MB-231 cell line was handled with AZD4547 and GANT61 to determine the possible function of FGFR1 and its related genes on cells motility and invasion. (immpact-international.org)
At the time of transfer, encephalitogenic T cells in vitro are maximally activated, i.e. they exhibit a prominent upregulation of cell cycle genes such as cyclin A2 (CCNA2) and cyclin B2 (CCNB2) among others. (uni-muenchen.de)
Hierarchical cluster analysis revealed that several transcription regulators known for inhibiting cell cycle progression such as krüppel-like factor 4 (KLF4), B-cell translocation gene 2 (BTG2) and transducer of ERBB2, 1 (TOB1) were clustered together with cell cycle and migration genes. (uni-muenchen.de)
Therefore, new therapeutic strategies are urgently needed and the use of mesenchymal stromal cells (MSCs) as carrier of therapeutic genes is emerging as a promising option. (conicet.gov.ar)

Pharmacological inhibition or genetic depletion of AKT induced BRD4 downregulation, sensitizing AZD5153-induced cytotoxicity in PC-3 cells. (karger.com)
LPA-induced cell motility and cell-in-cell invasion (entosis) were sensitive to pharmacological inhibition of ROCK, ERK or PKC. (uni-marburg.de)

4. ProNGF siRNA inhibits cell proliferation and invasion of pancreatic cancer cells and promotes anoikis. (nih.gov)
5. Antibiotic tigecycline inhibits cell proliferation, migration and invasion via down-regulating CCNE2 in pancreatic ductal adenocarcinoma. (nih.gov)

The present thesis focused on the early metastatic dissemination of HGSC cells and the underlying molecular mechanisms. (uni-marburg.de)
Therefore, we appeared for mobile migration inhibitors of low molecular pounds from microbial tradition filtrates. (tsfaq.info)
The objectives of this study were to examine the molecular mechanisms by which resveratrol inhibits stem cell characteristics of pancreatic CSCs derived from human primary tumors and Kras(G12D) transgenic mice. (greenmedinfo.com)
My scientific expertise includes biochemistry, molecular biology, pharmacology, immunology and mouse genetics in combination with cell biology techniques. (exeter.ac.uk)
My recent research greatly focuses on the study of molecular mechanisms underlining cell movement. (exeter.ac.uk)

Different ECM proteins (such as collagen, elastin, fibronectin, laminin, and others) allow cells to adhere and migrate, while forming focal adhesions in the front and disassembling them in the back. (wikipedia.org)
Cells can be guided by a gradient of those proteins (haptotaxis) or a gradient of soluble substrates in the liquid phase surrounding the cell (chemotaxis). (wikipedia.org)
The contacts (cell-junctions) are created by transmembrane glycoproteins named cadherins (E-cadherin, N-cadherin or cadherin 11) and other proteins. (wikipedia.org)
How extracellular guidance factors regulate cytoskeletal proteins to influence interneuron migration is an area of active investigation. (jneurosci.org)
Cancer stem cells (CSCs) can proliferate and self-renew extensively due to their ability to express anti-apoptotic and drug resistant proteins, thus sustaining tumor growth. (greenmedinfo.com)
However, uropod-localized receptors and ezrin/radixin/moesin proteins still cluster in nocodazole-treated cells, indicating that MTs are required specifically for uropod stability. (exeter.ac.uk)
Consequently, overnight incubations with C3 Transferase at concentrations as high as 100 µg/ml are often necessary to inactivate Rho proteins in cultured cells. (cytoskeleton.com)
Cytoskeleton, Inc. has overcome these problems by providing a cell permeable form or C3 Transferase that can efficiently inactivate cellular Rho proteins in as little as 2 h. (cytoskeleton.com)
CT04 has been used to inactive Rho proteins to an efficiency of 75-95% in fibroblasts, neurons, epithelial, endothelial, and hematopoietic cells as well as other primary and immortalized cell lines (see Table 1 for recommended conditions of use for different cells types). (cytoskeleton.com)
Ion channels are specialized proteins found in cell membranes, which facilitate the movement of specific ions across the plasma membrane. (spandidos-publications.com)

Additional studies indicated that this combination resulted in a significant inhibition in mammary cancer cell migration. (aacrjournals.org)

3. Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1. (nih.gov)
Wiskott-Aldrich syndrome protein family verprolin-homologous protein2 (WAVE2) is a member within the Wiskott-Aldrich syndrome protein (WASP) family displays a significant role in actin polymerization and cytoskeletal organization which, are essential for cellular migration and invasion. (aacrjournals.org)
Studies were conducted to examine the effects of combined γ-tocotrienol and pterostilbene on Rac1/WAVE 2 signaling in mouse +SA and human MDA-MB231 breast cancer cells and cellular migration. (aacrjournals.org)
Open up in another home window Fig 1 Inhibition of cellular invasion and migration by migracin A.A. Constructions of migracin B and A. B. Aftereffect of migracin A for the viability of Sera-2 cells. (tsfaq.info)
p21-activated kinases (PAKs) regulate many cellular processes, including cytoskeletal rearrangement and cell migration. (rupress.org)

15. BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion. (nih.gov)
18. Kif20a inhibition reduces migration and invasion of pancreatic cancer cells. (nih.gov)
Human pancreatic CSCs expressing high levels of CD133, CD24, CD44, ESA, and aldehyde dehydrogenase also express significantly more Nanog, Oct-4, Notch1, MDR1 and ABCG2 than normal pancreatic tissues and primary pancreatic cancer cells. (greenmedinfo.com)

Nishioka, K. Migration enhancement by tuftsin of human mononuclear cells and its effect on the migration inhibition factor test with tumor antigens. (webmd.com)
T cells directed against brain antigens are generally held to play a crucial role in the initiation of multiple sclerosis (MS). This was deduced from experimental autoimmune encephalomyelitis (EAE). (uni-muenchen.de)
In this model for MS, T cells reactive for myelin antigens induced a severe paralytic disease upon transfer to healthy syngeneic recipients. (uni-muenchen.de)
An increased reactivity to specific antigens mediated not by antibodies but by cells. (bvsalud.org)

The lateral line in zebrafish: collective cell migration from head to tails is essential to the development of the sensory system of the fish. (wikipedia.org)
Neural crest cells in mice, Leghorn chicks, amphibians (Xenopus laevis), and fish (zebrafish): collective migration of neural crest cells occurs during embryo development of vertebrates. (wikipedia.org)
Interactions between primordium cells and their environment determines the self-organization of the zebrafish posterior Lateral Line primordium as it migrates under the skin from the ear to the tip of the tail forming and depositing neuromasts to spearhead formation of the posterior Lateral Line sensory system. (nih.gov)
In particular, I am currently working on primordial germ cell (PGC) migration using the zebrafish embryo as a model organism. (exeter.ac.uk)

Inhibition of the channel abrogated migration of metastatic cancer cells in vitro . (cipsm.de)
Our findings link TPC to cancer cell migration and provide a preclinical proof of concept for their candidacy as targets to treat metastatic cancers. (cipsm.de)

The aim of the project was to characterize the functional properties of these migrating encephalitogenic T cells during the course of EAE and to identify biological pathways which determine their migratory behaviour and pathogenic potential. (uni-muenchen.de)

This study entitled 'Blockade of Arf1-mediated lipid metabolism in cancers promotes tumor infiltration of cytotoxic T cells via the LPE-PPARγ-NF-κB-CCL5 pathway' was published online in Life Metabolism on 6 September 2023. (news-medical.net)
Le Docteur Coley élabora dès lors une mixture composée de bactéries mortes, donc moins dangereuses, qui une fois administrée à des patients souffrant de cancers même métastasés, en provoquant de la fièvre, permettait à la maladie de régresser et de repousser parfois considérablement l'échéance de la mort. (come4news.com)
In this study, we introduce two-pore channels (TPC), a recently described class of NAADP- and PI(3,5)P2-sensitive Ca 2+ -permeable cation channels in the endolysosomal system of cells, as candidate targets for the treatment of invasive cancers. (cipsm.de)
The outcomes of profiling, utilizing a 64-member in-house most cancers cell panel, present that AZD4547 shows anti-proliferation exercise towards KM12(Luc) with a GI 50 of 100 nM. (immpact-international.org)
This examine was carried out to analyze the antitumor results and decide the mechanistic particulars of AZD4547 in ovarian most cancers cells. (immpact-international.org)
AZD4547 additionally suppressed the migration and invasion of ovarian most cancers cells underneath unhazardous circumstances. (immpact-international.org)

When combined with regorafenib treatment, TGFβ-R1 inhibition also significantly decreased colony formation ability and augmented cell death in resistant spheroids. (frontiersin.org)

That inhibition had the potential to reduce cell proliferation, impair survival signals, and prevent the migration and invasion of tumor cells, Amgen reasoned. (genengnews.com)
High grade serous ovarian carcinoma (HGSC) is characterized by an early dissemination of tumor cells and the accumulation of ascites, which provides a unique tumor-supportive microenvironment. (uni-marburg.de)

Genetic analysis of tumor cell spheroids and corresponding solid tumor masses (primary lesions and metastases) showed that HGSC cells acquire few new mutations during progression, except for mutated FAT3 and RAD51A/C, which were enriched in metastases. (uni-marburg.de)
Genetic enhancers of partial PLK1 inhibition reveal hypersensitivity to kinetochore perturbations. (iric.ca)

An understanding of the mechanism by which cells migrate may lead to the development of novel therapeutic strategies for controlling, for example, invasive tumour cells. (wikipedia.org)
CTC (circulating tumour cells)-positive had significantly higher levels of miR-141 than CTC-negative MBC and controls. (biomedcentral.com)

The high mobility group transcription factor SOX9 is expressed in stem cells, progenitor cells, and differentiated cell-types in developing and mature organs. (nature.com)
SOX9 is a high mobility group (HMG) domain containing transcription factor necessary for establishing and maintaining pools of stem and progenitor cells, and is expressed in multiple cell types in developing and mature organs 5 . (nature.com)
CD133 expression in circulating hematopoietic progenitor cells. (buffalo.edu)

13. ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells. (nih.gov)
Furthermore, we demonstrated that chitosan might activate canonical Wnt/β-catenin-CD44 axis signaling in CD44 positive colon cancer cells and noncanonical Wnt-STAT3 signaling in CD44 negative HCC cells. (nature.com)
Emerging evidences indicate that certain subpopulations of cancer cells in a tumor could be the origin of the tumor. (nature.com)
CSCs can self-renew to maintain CSC pools and differentiate into heterogeneous progeny cancer cells 7 . (nature.com)
Stimulation of the Wnt/β-catenin signaling on differentiated colon cancer cells can restore CSC properties 9 . (nature.com)
For example, ovarian cancer cells embedded within gelatin-methacrylamide hydrogels displayed a higher drug resistance 17 . (nature.com)
People use spleen extract for conditions such low white blood cell counts, cancer, autoimmune diseases , infections, and many others, but there is no good scientific evidence to support these uses. (webmd.com)
GAS6 expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance. (mpg.de)
Combined inhibition of AXL, Lyn and p130Cas kinases block migration of triple negative breast cancer cells. (mpg.de)
γ-Tocotrienol is a natural isoform within the vitamin E family that displays anticancer activity against a variety of cancer cell types. (aacrjournals.org)
Results show that combined treatment of γ-tocotrienol and pterostilbene caused a synergistic inhibition of both mouse +SA and human MDA-MB231 breast cancer cells growth, and corresponding reduction in Rac1/WAVE2 signaling as characterized by a significant inhibition in the levels of phospho-Rac1/cdc42, WAVE2, Arp2, and Arp3 expression. (aacrjournals.org)
Regulates beta-tubulin isotypes in MCF7 breast cancer cells. (biomedcentral.com)
Sans doute était-il plus proche d'elle que de ses autres malades, en tout cas décida-t-il de se rendre plutôt qu'au New-York Cancer Hospital où il exerce, dans les locaux de l'université de Yale, mondialement réputée pour les archives sur nombre de maladies, conservées au sein de sa faculté de médecine. (come4news.com)
As a consequence, invasive cancer cells were no longer able to form leading edges, which are required for adequate migration. (cipsm.de)
Chronic lymphatic leukaemia is the most common form of blood cancer (the uncontrolled proliferation of certain white blood cells). (uu.nl)
Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. (greenmedinfo.com)
These data suggest that resveratrol inhibits pancreatic cancer stem cell characteristics in human and Kras(G12D) transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. (greenmedinfo.com)
I have had small cell colorectal cancer twice-initially in 2/03 and then a return of cancer in 2/05 to the outside of the rectal wall. (cancer.org)
Cell Cycle and Beyond: Exploiting New RB1 Controlled Mechanisms for Cancer Therapy. (buffalo.edu)
The aberrant expression and function of ion channels leads to impairment of these processes, allowing normal cells to transform into malignant derivatives that exhibit uncontrolled proliferation and spread, which are hallmarks of cancer ( 13 ). (spandidos-publications.com)
miRNA mimic and inhibitor were used to verify the effect of miRNA in exosomes on gastric cancer cells. (bvsalud.org)
Sub-chronic exposures of human epithelial (BEAS-2B) and mesothelial (MET-5A) cells - both target cells of the respective lung cancer and malignant mesothelioma - to TF and CF were employed in the current study. (cdc.gov)
Cells were evaluated for the presence of several cancer hallmarks indicating the neoplastic transformation following continuous exposure to the sub-toxic concentration of TF and CF for 5 weeks. (cdc.gov)

Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy? (wjgnet.com)
Mesenchymal stromal cells (MSCs) are currently being investigated for use in a wide variety of clinical applications. (wjgnet.com)
Finally, resveratrol inhibits CSC's migration and invasion and markers of epithelial-mesenchymal transition (Zeb-1, Slug and Snail). (greenmedinfo.com)

Journal Article] 5-Lipoxygenase and CysLT1 regulate EGF‐induced cell migration through Tiam1 upregulation and Rac1 activation. (nii.ac.jp)
In conclusion, our data suggest that HCC tumors with aberrant activation in the Wnt/β-catenin pathway, might have higher intrinsic regorafenib resistance and the inhibition of this pathway along with regorafenib administration might increase regorafenib-induced cell death in combinational therapies. (frontiersin.org)
Conversely, the RNA interference-mediated depletion of CIB1 increases cell migration and reduces normal adhesion-induced PAK1 activation and cofilin phosphorylation. (rupress.org)

These cell-cell communication mechanisms are the main reasons for the difference between efficient migration of the collective and random walk movements of the isolated cell. (wikipedia.org)
Cells achieve active movement by very different mechanisms. (wikipedia.org)
Eukaryotic cell migration typically is far more complex and can consist of combinations of different migration mechanisms. (wikipedia.org)
Human tumor-derived cell lines recapitulate HCC diversity and are widely used for studying mechanisms that drive drug resistance in HCC. (frontiersin.org)

These data provide mechanistic insight into the regulation of interneuron leading process dynamics during neuronal migration in mice and provides insight into how cortactin and DCX , a known human neuronal migration disorder gene, participate in this process. (jneurosci.org)

Head and neck tumors are the sixth most common malignant tumors in the world, in which Squamous Cell Carcinoma (SCC)[ 1 ] predominantly, accounting for approximately 90 % of cases. (ijpsonline.com)

Microtubules (MTs) are required for persistent migration and chemotaxis, but how they affect cell polarity is not known. (exeter.ac.uk)

Although Eph-ephrin signaling has been implicated in the migration of cranial neural crest (CNC) cells, it is still unclear how ephrinB transduces signals affecting this event. (nih.gov)
Because impaired neural crest (NC) function is one of the known causes for teratologic effects, testing of toxicant effects on NC cells is desirable for a DT test battery. (nih.gov)
citation needed] Collective cell migration is enhanced by geometrical confinement of an extracellular matrix molecule (e.g. the proteoglycan versican in neural crest cells), that acts as a barrier, to promote the emergence of organized migration in separated streams. (wikipedia.org)
C3a in neural crest cells), that stimulates other cells in the group that have the receptors to that chemo-attractant. (wikipedia.org)

Conclusions: These data suggest that preserving the NO signal through endogenous inhibition of asymmetric dimethylarginine (the endogenous nitric oxide inhibitor) enhances wound repair even in the presence of swine dust exposure. (cdc.gov)
Inhibition of Nanog by shRNA enhances the inhibitory effects of resveratrol on self-renewal capacity of CSCs. (greenmedinfo.com)

J Cell Biol (2005) 170 (3): 465-476. (rupress.org)
Trends Cell Biol. (buffalo.edu)

Although there are effective drugs used to treat melanoma, some cell lines have proven resistant to chemotherapy. (intechopen.com)
Flavonoids have shown to play an important role in chemoprevention and inhibition of the proliferation, migration, and invasion of melanoma cells. (intechopen.com)

Researchers from the Department of Cell and Developmental Biology at School of Life Sciences of Fudan University developed two designed Arf1 inhibitors and elucidated their anti-tumor mechanism. (news-medical.net)

Mutations have been described in the Drosophila heartless gene that eliminate development of the single somatic muscle and the subset of pericardial cells that express Even-skipped (Eve) in the dorsal region of the embryonic mesoderm. (sdbonline.org)
The potential of AZD4547 to inhibit TRKA, TRKB and clinically related mutants (TRKA G595R, G667S, G667C and G667A) was additionally evaluated utilizing Ba/F3 cells harboring the ETV6-NTRKs fusion gene. (immpact-international.org)
In conclusion, gene expression profiling of encephalitogenic T cells revealed interesting genome wide transcriptomic changes and established a correlation between cell cycle progression and cell migration. (uni-muenchen.de)

Potassium (K + ) channels have an important role in HCC, including regulating the proliferation, migration, invasion and drug resistance of HCC cells. (spandidos-publications.com)

In this study, the effect of therapeutic whole lung lavage (WLL) on AM migration in four patients with PAP was determined. (nih.gov)
Migracin B and A inhibited mobile migration in human being breasts carcinoma MDA-MB-231, fibrosarcoma HT1080, and lung carcinoma A549 cells without displaying any cytotoxicity. (tsfaq.info)

Decreased calretinin expression resulted in loss of adherence in all tested primary as well as established HGSC cell lines, revealing calretinin as a potential therapeutic target for interfering with the early adhesion and invasion process. (uni-marburg.de)
These findings suggest that MYPT1 may represent a new promising candidate for therapeutic intervention with HGSC cell migration and invasion. (uni-marburg.de)

Cell migration is a central process in the development and maintenance of multicellular organisms . (wikipedia.org)

However, this requires the homing and migration of MSCs to a target tissue. (wjgnet.com)
Although MSC homing has been described, this process does not appear to be highly efficacious because only a few cells reach the target tissue and remain there after systemic administration. (wjgnet.com)
Tissue RNA sequencing data revealed a strong association between chemokines and T cells. (news-medical.net)
Localization of primed T cells to antigenic tissue is essential for the development of effective immunity. (exeter.ac.uk)

Furthermore, treatment of the cell lines with the proteasome inhibitor, MG132, together with Qu prevented degradation of class I HDACs compared to cells treated with Qu alone, indicating increased proteasome degradation of class I HDACS by Qu. (cancerindex.org)
Moreover, the combination of programmed cell death ligand 1 (PD-L1) inhibitor atezolizumab and VEGFR inhibitor bevacizumab was also recently approved for first-line treatment for advanced HCC. (frontiersin.org)
as an inhibitor of capillary pipe formation in human being umbilical vein endothelial cells (HUVEC) [2]. (tsfaq.info)

Nocodazole stimulates RhoA activity, and inhibition of the RhoA target ROCK allows nocodazole-treated cells to re-establish lamellipodia and uropods and persistent migratory polarity. (exeter.ac.uk)

In coherence with these findings, downregulation of MYPT1 via siRNA interference hampered cell migration and entosis. (uni-marburg.de)
METHODOLOGY/PRINCIPAL FINDINGS: Here we report that T cells treated with nocodazole to disrupt MTs are unable to form a stable uropod or lamellipodium, and instead often move by membrane blebbing with reduced migratory persistence. (exeter.ac.uk)

Microtubules regulate migratory polarity through Rho/ROCK signaling in T cells. (exeter.ac.uk)

The extracellular matrix (ECM) provides not only the structural and biochemical support, but also plays a major role in regulating cell behavior. (wikipedia.org)

Our results indicate that TBC1d24 is a critical player in ephrinB2 control of CNC cell migration via CIL. (nih.gov)
CONCLUSIONS/SIGNIFICANCE: Our results indicate that RhoA/ROCK signaling normally contributes to migration by affecting both actomyosin contractility and MT stability. (exeter.ac.uk)

Scholars@Duke publication: Haptotactic gradients for directed cell migration: stimulation and inhibition using soluble factors. (duke.edu)
Cells sense the secreted substrate and respond to the stimulation by moving towards each other's and maintain high cell density. (wikipedia.org)

Furthermore, it inhibited capillary pipe formation of Ibuprofen piconol human being umbilical vein endothelial cells also. (tsfaq.info)

Previously, we have reported that bronchial epithelial cell exposure to swine CAFO dust significantly blunts normative cell migration and wound repair via a PKC-dependent mechanism. (cdc.gov)
We propose that regulation of MT stability and RhoA/ROCK activity is a mechanism to alter T-cell migratory behavior from lamellipodium-based persistent migration to bleb-based migration with frequent turning. (exeter.ac.uk)

The cells had been Ibuprofen piconol incubated with migracin A for 24 h, and viability was evaluated by MTT. (tsfaq.info)

In this study, we grew colon and hepatocellular carcinoma (HCC) cells on chitosan membranes and evaluated the tumor progression and the CSC properties. (nature.com)

Wound healing: collective cell migration is an essential part in this healing process, wound area is closed by the migrating cells. (wikipedia.org)
Wound healing is commonly studied in vitro using cell lines such as Madin-Darby Canine Kidney cells. (wikipedia.org)
Results: Migration of epithelial cell monolayers from wild type mice significantly promoted repair of the ECIS-standardized wound as determined by resistance. (cdc.gov)
Importantly, a significant enhancement of wound repair (25% increase in resistance) was observed in DDAH cells vs. wild type cells treated with swine CAFO dust for 24 hr. (cdc.gov)

Overall, our data are compatible with the interpretation that tremolite asbestos fibers demonstrated higher neoplastic transformation potential compared to CF (at the same mass dose) in both epithelial and mesothelial cells. (cdc.gov)

Anatomy9

Organisms1

Diseases3

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Psychiatry and Psychology1

Phenomena and Processes9

Health Care1

Apoptosis8

Metastasis13

Blebbing motility1

Endothelial cell migration1

Vivo15

Proliferation and migration4

Induces4

Immune6

Assay8

Receptor7

Decreases2

Morphology1

Epithelial cells3

Genes9

Pharmacological2

Inhibits cell proliferation2

Molecular5

Proteins10

Mammary1

Cellular5

Pancreatic cancer cells3

Antigens4

Zebrafish4

Metastatic2

Pathways1

Cancers6

Significantly decreased1

Tumor cells2

Genetic2

Tumour cells2

Progenitor cells3

Cancer23

Mesenchymal3

Activation3

Mechanisms4

Neuronal migration1

Malignant1

Chemotaxis1

Neural4

Enhances2

Biol2

Melanoma2

Department of Cell and Developmental Biology1

Gene3

Drug resistance1

Lung2

Therapeutic2

Multicellular organisms1

Tissue4

Inhibitor3

Stimulates1

Findings2

Regulate1

Extracellular1

Results indicate2

Stimulation2

Human being umb1

Mechanism2

Viability1

Hepatocellular carcinoma1

Wound4

Mesothelial cells1