• spindle
  • In animal cells, the mitotic spindle plays a pivotal role in the formation and placement of the cleavage furrow. (bl.uk)
  • The coupling of cytokinesis and chromosome segregation to the mitotic spindle ensures that nuclear and cytoplasmic division are tightly coordinated. (bl.uk)
  • How the mitotic spindle controls cytokinetic events at the cell envelope is a key challenge in cell division research. (bl.uk)
  • Using live-cell time-lapse microscopy, I found that Ect2 concentrates not only at the spindle midzone but also accumulates at equatorial plasma membrane during cytokinesis. (bl.uk)
  • Exit from mitosis in animal cells is substantially delayed when spindle assembly is inhibited, spindle bipolarity is disrupted, or when a monopolar spindle is formed. (biologists.org)
  • Thus, neither of these cell types can detect the presence of gross aberrations in spindle architecture that inevitably lead to aneuploidy. (biologists.org)
  • animal cells
  • Formation of the cytokinetic furrow in animal cells requires activation of the GTPase RhoA by the conserved guanine nucleotide exchange factor Ect2. (bl.uk)
  • cycle
  • Cytokinesis is the final stage of the cell cycle. (bl.uk)
  • The stress-regulated mitogen activated protein kinase: MAPK) p38 also phosphorylates Rb, but it does so in a cell cycle-independent manner that is associated with apoptosis rather than with cell division. (wustl.edu)
  • p38 bypasses the cell cycle-associated hierarchical phosphorylation and directly phosphorylates Rb on Ser567, which is not phosphorylated during the normal cell cycle. (wustl.edu)
  • human
  • I further demonstrated that both guanine nucleotide exchange activity and the membrane targeting domains of Ect2 are essential for RhoA activation, contractile ring formation and cleavage furrow ingression in human cells. (bl.uk)
  • Phosphorylation by p38, but not Cdks, triggers an interaction between Rb and the human homologue of murine double minute 2: Hdm2), leading to degradation of Rb, release of E2F1 and cell death. (wustl.edu)
  • normal
  • Observation of untreated PtK1 cells that formed tripolar or tetrapolar spindles revealed that they progressed through mitosis, on average, at the normal rate. (biologists.org)
  • different
  • These findings provide a mechanistic explanation for how Rb regulates cell division and apoptosis through different kinases, and reveal how Hdm2 may functionally link the tumor suppressors Rb and p53. (wustl.edu)
  • Inter-sex variation in synaptonemal complex lengths largely determine the different recombination rates in male and female germ cells. (warwick.ac.uk)