• immune
  • Because the recruitment of mast cell progenitors started early after influenza infection, the role of innate immune signals in inducing the recruitment of mast cell progenitors was addressed. (diva-portal.org)
  • Cutaneous mast cells are a type of innate immune cell that resides in the dermis. (asahq.org)
  • Immunization of age‐matched apoE −/− mice with the apoB‐100 peptide altered the immune‐dominant epitope of CD 8+ T cells and reduced atherosclerosis. (ahajournals.org)
  • Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing, angiogenesis, immune tolerance, defense against pathogens, and blood-brain barrier function. (wikipedia.org)
  • As a result, mast cells are coated with IgE, which is produced by plasma cells (the antibody-producing cells of the immune system). (wikipedia.org)
  • Immune complexes (a type III reaction) and inflammatory cells are deposited within the mucous membranes of the airways, leading to necrosis (tissue death) and eosinophilic infiltration. (wikipedia.org)
  • It is a major mediator of endotoxin shock and acts on several immune cells to trigger inflammatory responses as a DAMP. (wikipedia.org)
  • It is used by several different cells involved in the immune system, including granulocytes (neutrophils, basophils, and eosinophils) and mast cells. (wikipedia.org)
  • An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses. (wikipedia.org)
  • Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize its target directly (for example, by blocking a part of a microbe that is essential for its invasion and survival). (wikipedia.org)
  • Antibodies are secreted by B cells of the adaptive immune system, mostly by differentiated B cells called plasma cells. (wikipedia.org)
  • intravenous injection is contraindicated as this can result in non-immune mast-cell degranulation and resulting anaphylactoid reaction. (wikipedia.org)
  • membrane
  • Our results demonstrate a nonredundant function for the p101 and p84 PI3Kγ adaptor proteins and show that distinct pools of PtdIns(3,4,5)P 3 at the plasma membrane can elicit specific cell responses. (sciencemag.org)
  • Other membrane activation events can either prime mast cells for subsequent degranulation or act in synergy with FcεRI signal transduction. (wikipedia.org)
  • Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. (wikipedia.org)
  • Although more common in plasma membrane, lipid rafts have also been reported in other parts of the cell, such as the Golgi apparatus and lysosomes. (wikipedia.org)
  • The extraction would take advantage of lipid raft resistance to non-ionic detergents, such as Triton X-100 or Brij-98 at low temperatures (e.g., 4 °C). When such a detergent is added to cells, the fluid membrane will dissolve while the lipid rafts may remain intact and could be extracted. (wikipedia.org)
  • Until 1982, it was widely accepted that phospholipids and membrane proteins were randomly distributed in cell membranes, according to the Singer-Nicolson fluid mosaic model, published in 1972. (wikipedia.org)
  • Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate. (wikipedia.org)
  • secretion
  • Thus, coronin proteins, and in turn the actin cytoskeleton, exhibit a functional dichotomy as differential regulators of degranulation versus cytokine secretion in MC biology. (rupress.org)
  • Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence. (semanticscholar.org)
  • triggers
  • Physical factors such as exercise (known as exercise-induced anaphylaxis) or temperature (either hot or cold) may also act as triggers through their direct effects on mast cells. (wikipedia.org)
  • hematopoietic
  • Although mast cells were once thought to be tissue resident basophils, it has been shown that the two cells develop from different hematopoietic lineages and thus cannot be the same cells. (wikipedia.org)
  • The chromatin-associated protein high-mobility group box 1 (HMGB1) is a prototypical leaderless secreted protein [LSP] secreted by hematopoietic cells through a lysosome-mediated pathway. (wikipedia.org)
  • vitro
  • The first in vitro differentiation and growth of a pure population of mouse mast cells has been carried out using conditioned medium derived from concanavalin A-stimulated splenocytes. (wikipedia.org)
  • citation needed
  • Mast cell stabilizer medications include: β2-adrenergic agonists Cromoglicic acid Ketotifen Methylxanthines[citation needed] Olopatadine Mepolizumab Omalizumab Pemirolast Quercetin Nedocromil Azelastine Allergy medications: Know your options Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (2015). (wikipedia.org)
  • pathway
  • White blood cells are activated by upregulation of integrin avidity, the lipoxygenase pathway and arachidonic acid metabolism. (wikipedia.org)
  • inflammation
  • However, whether other types of lung inflammation stimulate the recruitment of mast cell progenitors to the lung was unknown until now. (diva-portal.org)
  • However, upon the resolution of inflammation, the mast cells that accumulated in the lung upon influenza infection were gradually lost. (diva-portal.org)
  • localization
  • Functional reconstitution assays revealed that the inhibitory effect of Coro1a on MC degranulation strictly correlates with cortical localization of Coro1a, requires its filamentous actin-binding activity, and is regulated by phosphorylation of Ser2 of Coro1a. (rupress.org)
  • accumulation
  • C5a is also an effective chemoattractant, initiating accumulation of complement and phagocytic cells at sites of infection or recruitment of antigen-presenting cells to lymph nodes. (wikipedia.org)
  • myeloid
  • Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. (wikipedia.org)
  • endogenous
  • The current study was undertaken to identify and characterize endogenous, antigen‐specific CD 8+ T cells in atherosclerosis. (ahajournals.org)
  • RT-PCR showed that cystathionine-γ-lyase is the main enzyme to produce endogenous H(2)S in As4.1 cells. (biomedsearch.com)
  • Uric acid is also an endogenous danger signal released by injured cells. (wikipedia.org)
  • epithelial
  • Smears and conjunctival scrapings should be examined microscopically and stained with Gram stain to identify bacteria and stained with Giemsa stain to identify the characteristic epithelial cell basophilic cytoplasmic inclusion bodies of chlamydial conjunctivitis. (merckmanuals.com)
  • DAMPs vary greatly depending on the type of cell (epithelial or mesenchymal) and injured tissue. (wikipedia.org)
  • immature mast
  • I definitely showed autoimmune issues in my blood tests there, but the tryptase levels (used to measure the leakiness of the immature mast cells) were in normal range. (blogspot.com)
  • The site an immature mast cell settles in probably determines its precise characteristics. (wikipedia.org)
  • whereas
  • Basophils leave the bone marrow already mature, whereas the mast cell circulates in an immature form, only maturing once in a tissue site. (wikipedia.org)
  • subsequent
  • The BCR is found only on the surface of B cells and facilitates the activation of these cells and their subsequent differentiation into either antibody factories called plasma cells or memory B cells that will survive in the body and remember that same antigen so the B cells can respond faster upon future exposure. (wikipedia.org)
  • Conclusions
  • Conclusions Our study provides evidence of a self‐reactive, antigen‐specific CD 8+ T‐cell population in apoE −/− mice. (ahajournals.org)
  • macrophages
  • Concomitantly, CPT-11 enhanced tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels and inducible nitric oxide synthase (iNOS) gene expression, associated with an increase in the total number macrophages (positive cells for ionized calcium-binding adapter molecule, Iba-1) and degranulated mast cells in the small intestine segments and caused significant weight loss. (nih.gov)
  • Our data suggests the participation of mast cells on the CPT-11-induced intestinal mucositis, macrophages activation, enteric reactive gliosis, and neuron loss. (nih.gov)