• Jia L, Gu W, Zhang Y, Jiang B, Qiao X, Wen Y. Activated Yes-Associated Protein Accelerates Cell Cycle, Inhibits Apoptosis, and Delays Senescence in Human Periodontal Ligament Stem Cells. (medsci.org)
  • To provide insight into the biological effects of activated Yes-associated protein (YAP) on the proliferation, apoptosis, and senescence of human periodontal ligament stem cells (h-PDLSCs). (medsci.org)
  • Discussion This study provides evidence that cell cycle-related and apoptosis-inhibitor survivin is related to prostate cancer biochemical recurrence. (nih.gov)
  • The types of cell death induced by honokiol were primarily autophagy and apoptosis. (nature.com)
  • In contrast, reducing production of intracellular ROS using N -acetylcysteine, a scavenger of ROS, concurrently suppressed honokiol-induced cellular apoptosis, autophagy, and cell cycle arrest. (nature.com)
  • Furthermore, pretreatment of osteosarcoma cells with PD98059, an inhibitor of ERK1/2, inhibited honokiol-induced apoptosis and autophagy. (nature.com)
  • Taken together, our results revealed that honokiol caused G0/G1 phase arrest, induced apoptosis, and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells. (nature.com)
  • In particular, autophagy has been found to closely related to apoptosis, which is a kind of programmed cell death. (nature.com)
  • In our work , myeloma cells were treated with FABP inhibitors (BMS3094013 and SBFI-26) and examined in vivo and in vitro for cell cycle state , proliferation, apoptosis , mitochondrial membrane potential , cellular metabolism ( oxygen consumption rates and fatty acid oxidation ), and DNA methylation properties. (bvsalud.org)
  • We found that myeloma cells treated with FABPi or with FABP5 knockout (generated via CRISPR /Cas9 editing) exhibited diminished proliferation, increased apoptosis , and metabolic changes in vitro . (bvsalud.org)
  • It is usually understood that carcinogenesis is a multistep process that involves defects of the genetic pathways including cell proliferation, cell adhesion, cell death and apoptosis [ 2 ]. (biomedcentral.com)
  • Specific inhibition of BRAF by RNAi in cells with BRAF V600E mutation had no effect on apoptosis. (biomedcentral.com)
  • In the case of sorafenib treatment, cells harbouring BRAF V600E mutation showed increase levels of apoptosis due to a balance of the anti-apoptotic proteins Mcl-1 and Bcl-2. (biomedcentral.com)
  • We have shown that in thyroid cancer cells sorafenib induces apoptosis by affecting Mcl-1 and Bcl-2 in BRAF V600E mutated cells which was independent of BRAF. (biomedcentral.com)
  • In colon cancer suppression of BRAF in cell lines with BRAF V600E showed significant decreased proliferation through cyclin D1 and p27 Kip1 and induces apoptosis by a significant decrease in the levels of anti-apoptotic protein Bcl-2 [ 14 ]. (biomedcentral.com)
  • Therefore, Cdc48/VCP is involved in numerous cellular pathways such as membranes associated degradation, cell cycle regulation, genome stability, vesicular trafficking, autophagy and apoptosis. (inrae.fr)
  • 4. Loss of p21 expression is associated with p53 mutations and increased cell proliferation and p27 expression is associated with apoptosis in maxillary sinus squamous cell carcinoma. (nih.gov)
  • 17. Immunohistochemical analysis of cell cycle-related molecules in gastric carcinoma: prognostic significance, correlation with clinicopathological parameters, proliferation and apoptosis. (nih.gov)
  • Changes in cell viability, apoptosis, lactate dehydrogenase release, and cell cycle analysis were measured by cell counting kit-8 assay, annexin V/ propidium iodide staining, and enzyme-linked immunosorbent assay, respectively. (medsci.org)
  • Apoptosis and cellular senescence-related proteins were measured by Western blotting. (medsci.org)
  • These changes were markedly reversed by EPA administration, and the expressions of apoptosis and cellular senescence-related proteins were reversed by EPA treatment. (medsci.org)
  • In conclusion, these results indicate that Manu A is a potential to treat human OSCC via cell apoptosis through the downregulation of Sp1. (spandidos-publications.com)
  • Many studies have demonstrated that Manu A inhibits cell viability and induces cell apoptosis in many cancers, such as prostate cancer, multiple myeloma, anaplastic thyroid cancer and colon cancer ( 14 - 17 ). (spandidos-publications.com)
  • To induce apoptosis of cancer cells by targeting the specific signal-transduction pathway could be an effective anticancer therapy. (spandidos-publications.com)
  • Therefore, we investigated whether the Manu A-induced cell apoptosis is related to Specificity protein 1 (Sp1), a transcription factor that binds to a specific DNA sequence, overexpressed in many cancer cells, such as bladder cancer ( 19 ), breast cancer ( 20 , 21 ), pancreatic cancer ( 22 ), gastric cancer ( 23 ) and oral cancer ( 24 ). (spandidos-publications.com)
  • Specificity protein 1 (Sp1) has already been examined and plays important physiological roles such as cell cycle regulation, cell proliferation, and cell apoptosis ( 25 ). (spandidos-publications.com)
  • 2 Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China. (jci.org)
  • In mouse embryonic stem cells (ESCs), Cdc7 is needed for proliferation. (wikipedia.org)
  • Gain-of-function experiments showed that upregulation of miR-501-3p expression significantly decreased cell proliferation and colony formation, and induced cell cycle arrest in the G0/G1 phase. (nih.gov)
  • To address the effect of deficient RPS19 expression on cell proliferation, RPS19 was downregulated by siRNA. (nih.gov)
  • The proliferation activity was detected by cell counting kit-8 (CCK-8) and 5-ethynyl-2'-deoxyuridine (EdU), and the cell cycle was determined by flow cytometry. (medsci.org)
  • In this study, we found Msi1 was highly expressed in cervical cancer tissues, and over-expressing Msi1 in cervical cancer cells enhanced tumor formation and cell proliferation and accelerated cells into the S phase. (oncotarget.com)
  • Whereas, down-regulating Msi1 by shRNA in cervical cancer cells inhibited tumor formation and cell proliferation and slowed cell into the S phase, suggesting that Msi1 might act as cell cycle regulator. (oncotarget.com)
  • Our findings provide new evidence that Msi1 might promote cell proliferation by accelerating the cell cycle by directly targeting p21, p27 and p53. (oncotarget.com)
  • Nibrin's role in regulating cell division and cell growth (proliferation) is thought to lead to the problems with the immune system that are seen in affected individuals. (medlineplus.gov)
  • A lack of functional nibrin results in less immune cell proliferation. (medlineplus.gov)
  • In order to fill this lack of knowledge we studied the proliferation and survival pathways and associated molecules induced by BRAF inhibition in thyroid carcinoma cell lines harbouring distinct genetic backgrounds. (biomedcentral.com)
  • Both BRAF RNAi and sorafenib inhibited proliferation in all the cell lines independently of the genetic background, mostly in cells with BRAF V600E mutation. (biomedcentral.com)
  • Our results in thyroid cancer cells, namely those harbouring BRAF V600E mutation showed that BRAF signalling pathway provides important proliferation signals. (biomedcentral.com)
  • The CCAAT displacement protein (CDP-cut/CUTL1/cux) performs a key proliferation-related function as the DNA binding subunit of the cell cycle controlled HiNF-D complex. (elsevierpure.com)
  • Mutations in these genes can result in abnormal versions of the proteins that fail to prevent the growth and proliferation of cancer cells. (news-medical.net)
  • In addition, estrogen receptor alpha (ESR1)-mediated stimulation of proliferation of the epithelial cells contributes to conversion of DNA damage into mutations (i.e., tumor initiation) as well as tumor promotion and progression (Yager 2015 ). (springer.com)
  • ESR1-mediated proliferation involves complex intercellular signaling between epithelial and stromal cells (Lanigan et al. (springer.com)
  • The activity of AD against vascular smooth muscle cell (VSMC) proliferation remains unclear. (hindawi.com)
  • Moreover, in adults, Merkel cells undergo slow turnover and are replaced by cells originating from epidermal stem cells, not through the proliferation of differentiated Merkel cells. (medscape.com)
  • It has been suggested that the protein is essential for initiation of DNA replication and that it plays a role in regulating cell cycle progression. (wikipedia.org)
  • Much effort has been expended in attempts to clarify the role of cell cycle regulators in the progression of squamous intraepithelial lesions (SILs) to cervical cancer. (medscape.com)
  • Deregulation of this balance may contribute to anomalous segregation of chromosomes during mitotic progression of cancer cells. (nih.gov)
  • Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signaling. (bvsalud.org)
  • Clinical data demonstrated worse overall and progression-free survival in patients with high FABP5 expression in tumor cells . (bvsalud.org)
  • In MM cells , FABPs have a multitude of actions and cellular roles that result in the support of myeloma progression. (bvsalud.org)
  • Yes-associated protein, a downstream effector of the Hippo signaling pathway, has been linked to progression of non-small-cell lung carcinoma. (elsevierpure.com)
  • 8. Loss of p21WAF1/CIP1 expression in invasive fronts of oral tongue squamous cell carcinomas is correlated with tumor progression and poor prognosis. (nih.gov)
  • Cumulative evidence indicates that cell-cycle progression is mediated by cell-cycle regulatory proteins, such as cyclin D1, cyclin E, and cyclin-dependent kinase inhibitor 1B (p27), which are associated with G0/G1 phase cell-cycle arrest [ 5 ]. (hindawi.com)
  • Introduction: CDKN1B gene, which encodes a cyclin-dependent kinase (Cdk) inhibitor, regulates the progression throughout G1 to S cell cycle progression. (endocrine-abstracts.org)
  • In this study, we aimed to investigate the regulatory effect and mechanism of miR-501-3p on cell growth of prostate cancer cells. (nih.gov)
  • The cell-cycle map provides a guide for further defining important regulatory networks in Drosophila and other organisms. (wayne.edu)
  • The aim of our study was to evaluate survival outcomes in malignant mixed Mullerian tumors (MMMT) of the uterus with respect to the role of cell cycle and apoptotic regulatory proteins in the carcinomatous and sarcomatous components. (biomedcentral.com)
  • Our study supports that a) cell cycle and apoptotic regulatory protein dysregulation is an important pathway for tumorigenesis and b) p53 is an important immunoprognostic marker in MMMT of the uterus. (biomedcentral.com)
  • Cell survival and apoptotic regulatory proteins such as the Bcl-2 family of genes, PCNA, p16, p21, p27, and cyclin D1 are of vital importance to malignant neoplasms in prolonging cell survival. (biomedcentral.com)
  • Despite the understanding that cell cycle regulatory protein dysregulation may be involved in numerous malignant tumors [ 2 ], there is limited data that explores the role of these oncoproteins with survival data in MMMTs. (biomedcentral.com)
  • The aim of this study is to evaluate the role of cell cycle and apoptotic regulatory proteins in the carcinomatous and sarcomatous components of uterine MMMT in relation to clinico-pathological data including survival outcomes. (biomedcentral.com)
  • Specific ROS affect different MAPK family members and cell growth regulatory proteins with different potencies. (cdc.gov)
  • However, the molecular interactions that enable CDP and pRB to form a complex and thus convey cell growth regulatory information onto histone gene promoters must be further defined. (elsevierpure.com)
  • correlation with cell cycle regulatory proteins. (nih.gov)
  • In addition, more research is encouraged to understand the genetic and biochemical regulatory mechanisms that control the self-renewal phenotype, asymmetric cell division, and the stem cell microenvironment (or niche). (nih.gov)
  • A Capping Protein Regulatory Cycle Driven by CARMIL and V-1 May Promote Actin Network Assembly at Protruding Edges. (nih.gov)
  • The serine/threonine protein phosphatase 1 (PP1) dephosphorylates hundreds of key biological targets by associating with nearly 200 regulatory proteins to form highly specific holoenzymes. (rcsb.org)
  • The 2001 Nobel Prize in Physiology and Medicine was awarded to Dr. Paul Nurse and others who identified the chemical regulatory mechanisms of the cell cycle. (angelfire.com)
  • The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. (wikipedia.org)
  • The gene, CDC7, is involved in the regulation of cell cycle because of the gene product Cdc7 kinase. (wikipedia.org)
  • Because the two proteins, Cdc7 and Dbf4, must form a complex before activating the MCM complex, the regulation of one protein is sufficient for both. (wikipedia.org)
  • Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. (nih.gov)
  • Our results suggest that a feedback regulation through phosphorylation/dephosphorylation events between STK15 kinase and PP1 phosphatase operates through the cell cycle. (nih.gov)
  • Coptis Japonica makino extract suppresses angiogenesis through regulation of cell cycle-related proteins. (logosbio.com.cn)
  • This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI), and the National Institute on Aging (NIA), encourages research in all aspects of tumor stem cell biology, including the molecular and biochemical regulation of embryonic and adult stem cell behavior relevant to tumor formation. (nih.gov)
  • These proteins mainly maintain genomic integrity through DNA repair and the regulation of transcription processes. (news-medical.net)
  • One key example, given their potential etiopathogenic and therapeutic relevance, is a set of genes that encode proteins that regulate excitatory glutamatergic synapses in brain. (nih.gov)
  • Mutations in genes that encode proteins of the FA pathway fail to orchestrate the repair of DNA damage caused by DNA interstrand crosslinks. (cancerindex.org)
  • The protein is also evolutionarily related to many cell cycle control proteins, which mediate cellular pathways that are activated by environmental changes or cellular injury, resulting in a protective response. (nih.gov)
  • Proteins in ERK, Bcl-2, and p53 signaling pathways were detected by Western blotting. (medsci.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • FABPi negatively impacted mitochondrial respiration and reduced expression of MYC and other key signaling pathways in MM cells in vitro . (bvsalud.org)
  • The differential effects of Yes-associated protein expression patterns in adenocarcinomas and squamous cell carcinomas suggest that Yes-associated protein may play important roles in different pathways in distinct tumor subtypes. (elsevierpure.com)
  • Telomeres and cancer, Cancer Stem Cell Hypothesis, Tumour Angiogenesis, additional signalling pathways disrupted in Cancers. (manchester.ac.uk)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Even as the nature of the exact cell in which Merkel cell carcinoma oncogenesis occurs is controversial, there is strong support for the notion that Merkel cell carcinoma results from of one of two distinct pathways. (medscape.com)
  • [ 1 ] Through the expression of E7 and E6 viral oncoproteins, certain HPV genotypes (high-risk HPV) block pRb and p53 cellular proteins and, thus, generate a state of unscheduled activation of the cell cycle and create a permissive state for the appearance of nonrepairing novel mutations and genomic instability. (medscape.com)
  • The NBN gene mutations that cause Nijmegen breakage syndrome typically lead to the production of an abnormally short version of the nibrin protein. (medlineplus.gov)
  • Studies in Eastern European populations reported that people with mutations in one copy of the NBN gene in each cell may be more likely to develop breast cancer than people who do not carry NBN mutations. (medlineplus.gov)
  • Cells with a mutation in one copy of the NBN gene do not repair DNA as effectively as cells without these mutations. (medlineplus.gov)
  • Retroviruses expressing a fluorescent protein, Cas9 and a small guide RNA are used to mimic nonsense PTEN mutations from autism patients in developing mouse neurons. (nature.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Interestingly, 4 of the indel mutations led to aberrant splicing, which may produce a different protein than predicted from the genomic sequence. (cancerindex.org)
  • Moreover, miR-501-3p was shown to negatively regulate CREPT expression in prostate cancer cells. (nih.gov)
  • Immunohistochemistry assay showed the negative correlation between Msi1 and p21, p27 and p53, suggesting that Msi1 might regulate these cycle regulators in cervical cancer. (oncotarget.com)
  • BRCA1 interacts with several proteins that regulate the cell cycle. (news-medical.net)
  • Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells. (rochester.edu)
  • We propose that GIT1 regulates the phosphorylation of a network of synaptic proteins and other critical regulators of neuroplasticity, and that perturbation of these networks may contribute specifically to cognitive deficits observed in schizophrenia and neurodevelopmental disorders. (nih.gov)
  • In BRAF V600E mutated cells inhibition of BRAF pathway lead to a decrease in ERK1/2 phosphorylation and cyclin D1 levels and an increase in p27 Kip1 . (biomedcentral.com)
  • Vanadate stimulated mitogen-activated protein kinases (MAPKs) family members, as determined by the phosphorylation of ERK and p38. (cdc.gov)
  • The level of phosphorylation is cell cycle dependent, and may also be cell type dependent (not all forms are seen in all cell types that express Rb). (bdbiosciences.com)
  • The expressions of matrix metalloproteinases-2/9 (MMP-2/9), cyclin D1/E, cyclin-dependent kinase inhibitor 1B (p27), extracellular regulated protein kinases 1/2 (ERK1/2), and ERK1/2 phosphorylation were examined by western blotting or quantitative reverse transcription PCR. (hindawi.com)
  • PP1 nuclear targeting subunit (PNUTS) is a PP1 targeting protein that, with PP1, plays a central role in the nucleus, where it regulates chromatin decondensation, RNA processing, and the phosphorylation state of fundamental cell cycle proteins, including the retinoblastoma protein (Rb), p53, and MDM2. (rcsb.org)
  • As to the role of the cytoskeleton, what does this tell us about the membrane itself, or the behavior of membrane proteins as individual molecules in their interplay with the membrane? (biophysics.org)
  • In thyroid cancer cells the target molecules, implicated on the cellular effects, mediated by inhibition of BRAF are not well established. (biomedcentral.com)
  • These wide ranging consequences of the loss of BRCA1 function are explained by the proteins numerous interactions with several molecules, including the products of tumor suppressor genes and cancer-causing genes or oncogenes. (news-medical.net)
  • As members of the Kingdom Fungi, which also includes mushrooms , molds , and mildews, yeasts are eukaryotes ( organisms with a distinct, membrane-bound nucleus) that digest their food externally and absorb the nutrient molecules into their cells . (newworldencyclopedia.org)
  • CHROMOSOMES are molecules of DNA wrapped around histone proteins and contain the hereditary information within the sequence of nitrogen bases of the DNA molecule. (angelfire.com)
  • During this G1 phase the cell is accumulating materials such as water and the building blocks of organic molecules and building new parts. (angelfire.com)
  • Our data showed that the expression of myogenic genes as well as cell cycle exit genes was increased after FGF21 overexpression, and FGF21 overexpression induces cell cycle arrest. (hindawi.com)
  • Additionally, the inhibitory effect of miR-501-3p on prostate cancer cell growth was partially reversed by CREPT overexpression. (nih.gov)
  • These results indicate that nuclear overexpression of Yes-associated protein contributes to pulmonary adenocarcinoma growth and that high cytoplasmic expression of Yes-associated protein is an independent predictor of low pathologic TNM staging and histologic grading. (elsevierpure.com)
  • 18. Deregulated p21(WAF1) overexpression impacts survival of surgically resected esophageal squamous cell carcinoma patients. (nih.gov)
  • Moreover, cell cycle genes were decreased in FGF21 overexpression cells while they were increased in FGF21 knockdown cells. (hindawi.com)
  • The ubiquitin proteasome system (UPS) is a major actor in the selective degradation of misfolded proteins to preserve proteome balance. (inrae.fr)
  • Plaza JA, Suster S. The Toker tumor: spectrum of morphologic features in primary neuroendocrine carcinomas of the skin (Merkel cell carcinoma). (medscape.com)
  • Cell lines - 8505C, and C643 derived from anaplastic thyroid carcinomas and TPC1 derived from papillary thyroid carcinoma - were grown in RPMI 1640 medium (with L-glutamine and HEPES) supplemented with 10% fetal bovine serum (FBS) and 1% penicillin-streptomycin (GIBCO, Invitrogen). (biomedcentral.com)
  • For the 102 squamous cell carcinomas, univariate analysis revealed that high cytoplasmic expression of Yes-associated protein was correlated with the low pathologic TNM staging (stage I) and histologic grading. (elsevierpure.com)
  • 1. Cell cycle regulating proteins p21 and p27 in prognosis of oral squamous cell carcinomas. (nih.gov)
  • 5. High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas. (nih.gov)
  • [ 2 ] As neuroendocrine carcinomas were thought to be of neural crest origin, in 1978 Tang and Toker proposed that this carcinoma might be derived from Merkel cells. (medscape.com)
  • [ 6 ] As they are primarily postmitotic, Merkel cells putatively have low sensitivity to oncogenic stimuli, and they are found in the basal epidermis, whereas cutaneous neuroendocrine carcinomas arise in the dermis. (medscape.com)
  • Feng et al established in 2008 that approximately 80% of Merkel cell carcinomas in the Northern hemisphere occur after genomic integration by a ubiquitous skin commensal virus, Merkel cell polyoma virus (MCPyV). (medscape.com)
  • In addition to p53 and pRb as targets of E6 and E7 HPV oncoproteins, cyclins such as cyclin D1 and cyclin inhibitors such as p16 are key proteins in the study of the molecular alterations that characterize cervical carcinoma. (medscape.com)
  • p16 is a tumor suppressor protein belonging to the family of INK4 cyclin-dependent-kinase inhibitors whose increased expression has been associated with HPV-infected dysplastic and neoplastic epithelium of the cervix. (medscape.com)
  • 7. Expression patterns of cyclins D1, E and cyclin-dependent kinase inhibitors p21waf1/cip1, p27kip1 in colorectal carcinoma: correlation with other cell cycle regulators (pRb, p53 and Ki-67 and PCNA) and clinicopathological features. (nih.gov)
  • However, the mechanisms underlying this phenomenon have not been fully clarified.Aim: The aim of our study is to investigate the mechanisms of resistance to mTOR inhibitors in BC cells. (endocrine-abstracts.org)
  • These cell cycle proteins are overexpressed in premalignant and malignant lung lesions in patients. (cancer.org)
  • A family of proteins homologous to the cdc25 gene product of the fission yeast bear specific protein tyrosine phosphatase activity involved in the activation of the p34cdc2-cyclin B kinase. (rupress.org)
  • These results suggest that abnormal ribosomal biogenesis causes inadequate cell cycle arrest in haematopoietic progenitors, and that, subsequently, erythroid progenitors are specifically hampered. (nih.gov)
  • Furthermore, honokiol induced G0/G1 phase arrest, elevated the levels of glucose-regulated protein (GRP)−78, an endoplasmic reticular stress (ERS)-associated protein, and increased the production of intracellular reactive oxygen species (ROS). (nature.com)
  • We show that B-cyclin translation is specifically inhibited upon nitrogen starvation of wild-type cells, when B-cyclin/Cdc2 inactivation is a prerequisite for G(1) arrest and subsequent mating. (ox.ac.uk)
  • ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest. (nih.gov)
  • Cell growth arrest is an important mechanism in maintaining genomic stability and integrity in response to environmental stress. (cdc.gov)
  • Using the human lung alveolar epithelial cancer cell line A549, we investigated the role of reactive oxygen species (ROS), extracellular signal-regulated protein kinase (ERK), and p38 protein kinase in vanadate-induced cell growth arrest. (cdc.gov)
  • Exposure of cells to vanadate led to cell growth arrest at the G2/M phase and caused upregulation of p21 and phospho-cdc2 and degradation of cdc25C in a time- and dose-dependent manner. (cdc.gov)
  • PD98059, an inhibitor of ERK, and SB202190, an inhibitor of p38, inhibited vanadate-induced cell growth arrest, upregulation of p21 and cdc2, and degradation of cdc25C. (cdc.gov)
  • ROS activate ERK and p38, which in turn upregulate p21 and cdc2 and cause degradation of cdc25C, leading to cell growth arrest at the G2/M phase. (cdc.gov)
  • It has been previously demonstrated that the atypical BC human cell line NCI-H720 is sensitive to everolimus (E), an m-TOR inhibitor, in terms of cell viability reduction, with a G0 cell-cycle arrest and a Cyclin D1 protein reduction. (endocrine-abstracts.org)
  • Cell Biology Unit, Centre National de la Recherche Scientifique-Institut National de la Santé Et de la Recherche Médicale, Montpellier, France. (rupress.org)
  • The biology and treatment of Merkel cell carcinoma: current understanding and research priorities. (medscape.com)
  • The primary research interests of the Molecular Cell Biology Laboratory, led by Dr. John A. Hammer, revolve around the roles played by motor proteins and cytoskeletal protein dynamics in driving the motility of organelles and cells. (nih.gov)
  • Yeasts also are important as model organisms in modern cell biology research. (newworldencyclopedia.org)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • The tumor suppressor p53, among its many functions, exerts its control on the cell cycle through the activation of p21, an inhibitor of cyclin and cyclin-dependent-kinase complexes. (medscape.com)
  • At this time, the US Food and Drug Administration (FDA) has approved two checkpoint inhibitor immunotherapies for the treatment of Merkel cell carcinoma, avelumab and pembrolizumab. (medscape.com)
  • Suppression of BRAF pathway in thyroid cancer cell lines (8505C, TPC1 and C643) was achieved using RNA interference (RNAi) for BRAF and the kinase inhibitor, sorafenib. (biomedcentral.com)
  • Many organs form by invaginating and rolling flat epithelial cell sheets into tubes. (biologists.com)
  • Oral squamous cell carcinoma (OSCC) which occurs in the lining of the epithelial cell represents approximately 95% of head and neck cancer and is the sixth most common malignant neoplasm worldwide ( 3 - 5 ). (spandidos-publications.com)
  • With the advent of improved immunohistochemical profiling, the tumor was reclassified as Merkel cell carcinoma because shared epithelial and neuroendocrine markers, along with ultrastructural features suggestive of neural crest origin, were observed in both the constituent tumor cell and the physiologic Merkel cell of the skin. (medscape.com)
  • Within skin, Merkel cells have also been shown to cluster in the basal layers of the interfollicular epidermis in specialized epithelial structures called touch domes, where they are juxtaposed with epidermal keratinocytes. (medscape.com)
  • [ 5 , 6 ] Furthermore, experiments have demonstrated that epidermal progenitors in the touch domes are capable of producing Merkel cell lines and that epithelial progenitor populations in adults have the capacity to give rise to both neuroendocrine and squamous lineages. (medscape.com)
  • Other suggested cells of origin include the neural crest‒derived cell of amine precursor uptake and decarboxylation (APUD) system, dermal fibroblasts, pre or pro B cells, residual epidermal stem cells, and epithelial, non-Merkel cell progenitors. (medscape.com)
  • Avelumab is an IgG monoclonal antibody against PD-L1, which was approved by the FDA for treatment of advanced Merkel cell carcinoma on March 23, 2017. (medscape.com)
  • It is indicated for metastatic Merkel cell carcinoma in adults and pediatric patients aged 12 years or older. (medscape.com)
  • The FDA approved pembrolizumab for treatment of adults and children with recurrent, locally advanced, or metastatic Merkel cell carcinoma on December 19, 2018. (medscape.com)
  • Merkel cell carcinoma: An update and review: Pathogenesis, diagnosis, and staging. (medscape.com)
  • Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review. (medscape.com)
  • Sunshine JC, Jahchan NS, Sage J, Choi J. Are there multiple cells of origin of Merkel cell carcinoma? (medscape.com)
  • Merkel cell carcinoma: histologic features and prognosis. (medscape.com)
  • Clonal integration of a polyomavirus in human Merkel cell carcinoma. (medscape.com)
  • Merkel Cell Carcinoma: Updates on Staging and Management. (medscape.com)
  • Merkel cell carcinoma: An update and review: Current and future therapy. (medscape.com)
  • Recent advances in Merkel cell carcinoma. (medscape.com)
  • Paul Nghiem, MD, PhD of the University of Washington in Seattle will use data from over 6,000 patients diagnosed with a type of skin cancer called Merkel cell carcinoma to develop a staging system for this disease that will better define prognosis and standardize future clinical trials for Merkel cell carcinoma as his laboratory studies specific genes involved in this disease. (cancer.org)
  • Merkel cell carcinoma is a rare primary cutaneous neuroendocrine carcinoma with growing incidence and high metastatic potential. (medscape.com)
  • Ultimately, it is unclear whether the eponymous Merkel cell is truly a histiogenic precursor of Merkel cell carcinoma. (medscape.com)
  • [ 7 , 8 ] Sunshine et al offer that perhaps there are multiple cell-line precursors of Merkel cell carcinoma. (medscape.com)
  • [ 9 ] Since our understanding of the histogenesis is still evolving, some authors choose to refer to Merkel cell carcinoma as neuroendocrine carcinoma of the skin or cutaneous neuroendocrine carcinoma. (medscape.com)
  • Also see Merkel Cell Tumors of the Head and Neck and Merkel Cell Carcinoma and Rare Appendageal Tumors . (medscape.com)
  • When these 12 mutants were expressed in the erythro-leukaemic cell lines K562 and human bone marrow CD34(+) cells, almost all of the mutant proteins (except for G120R) were unstable, and the levels of mutated RPS19 protein were significantly low. (nih.gov)
  • Most mammalian cells function on an approximate 24-hour cell cycle, and the circadian clock has been implicated in regulating the phases of cell division. (nih.gov)
  • STK15 is an Aurora/Ipl-1 related serine/threonine kinase that is associated with centrosomes and induces aneuploidy when overexpressed in mammalian cells. (nih.gov)
  • cdc25 is a nuclear protein expressed constitutively throughout the cell cycle in nontransformed mammalian cells. (rupress.org)
  • Using affinity-purified antibodies raised against a synthetic peptide corresponding to the catalytic site of the cdc25 phosphatase, we show that cdc25 protein is constitutively expressed throughout the cell cycle of nontransformed mammalian fibroblasts and does not undergo major changes in protein level. (rupress.org)
  • Furthermore, interactions between these proteins were established by yeast and mammalian two-hybrid experiments and co-immunoprecipitation assays. (elsevierpure.com)
  • The product encoded by this gene is predominantly localized in the nucleus and is a cell division cycle protein with kinase activity. (wikipedia.org)
  • By indirect immunofluorescence, cdc25 protein is found essentially localized in the nucleus throughout interphase and during early prophase. (rupress.org)
  • HiNF-D interacts with all five classes (H1, H2A, H2B, H3, and H4) of the cell-cycle dependent histone genes, which are transcriptionally and coordinately activated at the G 1 /S phase transition independent of E2F. (elsevierpure.com)
  • Thus, several converging lines of evidence indicate that complexes between CDP and pRB repress cell cycle regulated histone gene promoters. (elsevierpure.com)
  • The C-terminal end of BRCA1 interacts directly or indirectly with p53, RNA Polymerase II, RNA helicaseA, p300 and CBP (CREB binding protein), BRCA2, histone-deacetylase complex, RB and CtIP. (news-medical.net)
  • Nibrin interacts with two other proteins, produced from the MRE11A and RAD50 genes, as part of a larger protein complex. (medlineplus.gov)
  • The MRE11A/RAD50/NBN complex interacts with the protein produced from the ATM gene, which plays an essential role in recognizing broken strands of DNA and coordinating their repair. (medlineplus.gov)
  • Immunohistochemical assessment of cell cycle proteins may help to distinguish normal and benign conditions of the cervix from precursor lesions of CC. (medscape.com)
  • A Drosophila protein-interaction map centered on cell-cycle regulators " by Clement A. Stanyon, Guozhen Liu et al. (wayne.edu)
  • In the most extensive screen to date, a Gal4-based two-hybrid system was used recently to detect over 20,000 interactions among Drosophila proteins. (wayne.edu)
  • Kaufmann and colleagues found that the human Timeless protein interacted with both Cry2 (a confirmed circadian clock protein) and Chk1 kinase (a cell cycle checkpoint protein). (nih.gov)
  • Timeless also appeared to play a role in the DNA damage checkpoint response, a process that arrests cell division and activates DNA repair mechanisms. (nih.gov)
  • Other experiments demonstrated that inhibiting production of Timeless protein seriously compromised checkpoint-regulated coordination of cell division, "indicating an intimate connection between the circadian cycle and DNA damage checkpoints. (nih.gov)
  • Functional alteration of cell cycle regulators in cervical cancer is, therefore, paradigmatic and seems to have a major role in cervical cancer pathogenesis. (medscape.com)
  • this means that most eukaryotic cells have the Cdc7 kinase protein. (wikipedia.org)
  • SOX2 has been reported to be a potential nuclear marker of stem cells in cervical cancer [ 3 ]. (oncotarget.com)
  • High ALDH1 activity might be a cytoplasmic marker for cervical cancer stem cells (CCSCs) [ 4 ]. (oncotarget.com)
  • ITGA6 (CD49f) might be a possible surface marker of cervical cancer stem cells [ 5 ]. (oncotarget.com)
  • T umor stem cells are a rare population of cells that can recapitulate all the cell types represented in the original tumor. (nih.gov)
  • Tumor stem cells are capable of self-renewal and asymmetric cell division. (nih.gov)
  • This FOA intends to stimulate efforts on isolation and characterization of tumor stem cells from a large spectrum of tumors. (nih.gov)
  • They may also inspire the development of new therapeutic strategies based on specific targeting of tumor stem cells. (nih.gov)
  • 6. Expression of p27, p21(WAF/Cip1), and p16(INK4a) in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma. (nih.gov)
  • 13. p21WAF1/CIP1 expression is a marker of poor prognosis in oral squamous cell carcinoma. (nih.gov)
  • However, the anticancer effects of Manu A on oral squamous cell carcinoma (OSCC) have not been reported. (spandidos-publications.com)
  • Cells transfected with these non-binding mutants manifest aberrant chromosome alignment during mitosis. (nih.gov)
  • Just before the complete nuclear envelope breakdown at the prophase-prometaphase boundary, cdc25 proteins are redistributed throughout the cytoplasm. (rupress.org)
  • During metaphase and anaphase, cdc25 staining remains distributed throughout the cell and excludes the condensed chromosomes. (rupress.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Cell Division Cycle Protein 25 (CDC25) in Tissue homogenates, cell lysates and other biological fluids. (isogem.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Cell Division Cycle Protein 25 (CDC25) in samples from serum, plasma, tissue homogenates or other biological fluids. (isogem.org)
  • A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls. (ox.ac.uk)
  • 2004). In binary fission, the parent cell divides into two equal cells. (newworldencyclopedia.org)
  • Nibrin regulates the activity of this complex by carrying the MRE11A and RAD50 proteins into the cell's nucleus and guiding them to sites of DNA damage. (medlineplus.gov)
  • The MRE11A/RAD50/NBN complex helps maintain the stability of a cell's genetic information through its roles in repairing damaged DNA and regulating cell division. (medlineplus.gov)
  • The creation of this synapse requires rapid, large-scale polarizations of the T cell's actin cytoskeleton, its microtubule cytoskeleton, and multiple proteins in the T cell's plasma membrane. (nih.gov)
  • Biomarker discovery is challenged by many clinical and analytical factors including, but not limited to, the complexity of urine and the wide dynamic range of endogenous proteins in the sample. (nih.gov)
  • Cdc48/VCP is a cytosolic and nuclear protein which segregates misfolded proteins from subcellular structures or protein complexes, and brings them to the proteasome to facilitate their recycling or degradation. (inrae.fr)
  • In this project, we aimed to characterize the nuclear function(s) of the Cdc48 protein during the plant immune response triggered by cryptogein (an elicitor produced by Phytophthora cryptogea) in tobacco cells. (inrae.fr)
  • This comparison has shown that during plant immune response, (i) the nuclear mobility of Cdc48 increased and (ii) Cdc48 interacted more quickly with more proteins. (inrae.fr)
  • In a univariate analysis of the 66 adenocarcinomas, high nuclear expression of Yes-associated protein was significantly correlated with expression of cyclin A and mitogen-activated protein kinase. (elsevierpure.com)
  • Multivariate analysis, including age and sex, showed that cyclin A expression was independently correlated with nuclear expression of Yes-associated protein in adenocarcinomas. (elsevierpure.com)
  • they are related by their assembly into a common nuclear protein complex. (cancerindex.org)
  • Phosphorylated pRb causes the release of the active E2F transcriptional factor, which then can induce the expression of genes whose protein products are required for cells to enter the DNA synthesis phase (S phase) of the cell cycle. (medscape.com)
  • The control of protein homeostasis, a balance between their synthesis and degradation, also called proteostasis, is essential for cell survival. (inrae.fr)
  • During the S (synthesis) PHASE, an exact copy of the DNA is synthesized so that at the end of the phase there will actually be 46 pairs of chromosomes in the cell. (angelfire.com)
  • Overall, these results suggest that miR-501-3p restricts prostate cancer cell growth by targeting CREPT to inhibit the expression of cyclin D1. (nih.gov)
  • Associations of Yes-associated protein expression with clinicopathologic parameters, expression of cell cycle-specific markers, and epidermal growth factor receptor gene amplification were also analyzed. (elsevierpure.com)
  • Fibroblast growth factor 21 (FGF21), a secretion protein, functions as a pivotal regulator of energy metabolism and is being considered as a therapeutic candidate in metabolic syndromes. (hindawi.com)
  • Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. (rochester.edu)
  • We observed that Manu A reduced cell growth and Sp1 protein levels in OSCC cell lines (HN22 and HSC4) in a dose- and time-dependent manner. (spandidos-publications.com)
  • Both the cell cycle and the life cycle of organisms involve growth periods. (angelfire.com)
  • A cell undergoes growth and usually doubles in size during interphase. (angelfire.com)
  • When fed to laboratory animals that had cancer cells implanted in them, amygdalin did not reduce the tumor size or slow their growth. (mskcc.org)
  • Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis. (medscape.com)
  • Identification of epidermal progenitors for the Merkel cell lineage. (medscape.com)
  • Towards this goal, here we study the roles of GPCR-kinase interacting protein 1 (GIT1), a synaptic scaffolding and signaling protein with damaging coding variants found in schizophrenia patients, as well as copy number variants found in patients with neurodevelopmental disorders. (nih.gov)
  • However, the roles of FGF21 in myogenic differentiation and cell cycle remain obscure. (hindawi.com)
  • Multiple myeloma is an incurable plasma cell malignancy with only a 53% 5-year survival rate . (bvsalud.org)
  • The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells. (babraham.ac.uk)
  • Ki-67 is a nonhistone protein expressed in the nucleus during the whole cell cycle, except in the G 0 and G 1 early phases. (medscape.com)
  • After YAP was activated by lentiviral vector, the mRNA and protein of YAP were highly expressed, and more YAP translocated into the nucleus. (medsci.org)
  • The nucleus of the parent cell splits into a daughter nucleus and migrates into the daughter cell. (newworldencyclopedia.org)
  • MITOSIS is the division of the nucleus of body (somatic) cells into genetically identical daughter cells. (angelfire.com)
  • MEIOSIS is division of the nucleus of cells in the reproductive organs and leads to the development of sex cells or GAMETES. (angelfire.com)
  • The nucleus of all eukaryotic cells is the central storehouse of information for the construction of the cell. (angelfire.com)
  • Maps depicting binary interactions between proteins can be powerful starting points for understanding biological systems. (wayne.edu)
  • Although these data are a valuable resource for insights into protein networks, they cover only a fraction of the expected number of interactions. (wayne.edu)
  • We detected 1,814 reproducible interactions among 488 proteins. (wayne.edu)
  • Informative regions of the map could be highlighted by searching for paralogous interactions and by clustering proteins on the basis of their interaction profiles. (wayne.edu)
  • Dr. Hammer's lab uses cell biological, genetic, biochemical, and biophysical approaches, coupled with advanced imaging techniques, to study the molecular interactions that give rise to cellular and intracellular movements, and to define the functional significance of these movements in the context of whole organisms. (nih.gov)
  • Here, we show that cell-cycle-dependent BMP and TGFβ antagonism elicits MHP formation by dynamically regulating interactions between apical (PAR complex) and basolateral (LGL) polarity proteins. (biologists.com)
  • Thus, the interactions of BMP and TGFβ with polarity proteins dynamically modulate MHP formation by regulating r-SMAD competition for tight junctions and r-SMAD sequestration by LGL. (biologists.com)
  • Unscheduled cell cycle activation constitutes a crucial process in virtually all human cancers. (medscape.com)
  • Coupling of human circadian and cell cycles by the Timeless protein. (nih.gov)
  • In the current study, NIEHS grantee William K. Kaufmann and colleagues at the University of North Carolina-Chapel Hill set out to determine whether the Timeless protein may itself function as a core component of the human cell cycle. (nih.gov)
  • Repressive expression of RPS19 in human CD34(+) cells produced an elevated number of cells at G0 and induced erythroid progenitor-specific defects in BM cells. (nih.gov)
  • h-PDLSCs were isolated successfully and were positive for human mesenchymal stem cell surface markers. (medsci.org)
  • In the present study, we investigated the anticancer effect of honokiol (HNK), an active component isolated and purified from the magnolia officinalis on human osteosarcoma cells. (nature.com)
  • Our results showed that honokiol caused dose-dependent and time-dependent cell death in human osteosarcoma cells. (nature.com)
  • Moreover, the ability to overcome chemoresistance in human multiple myeloma cells has been demonstrated 9 . (nature.com)
  • Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (nih.gov)
  • 14. [Expression of key cell cycle markers in squamous cell carcinoma of the cervix positive in human papillomavirus: a comparative study between Chinese and Australian populations]. (nih.gov)
  • MOLT-4 cells (ATCC CRL-1582, Human T lymphoblast) were labeled with [32P]-orthophosphate and immunoprecipitated with either clone G99-549 (lanes 1 & 3) or clone G3-245 (lanes 2 & 4). (bdbiosciences.com)
  • Given the extensive similarities between yeast cells and human cells, yeast homologues (or counterparts) of human genes , particularly those associated with specific diseases , may provide insights that aid in medical diagnosis and treatment. (newworldencyclopedia.org)
  • Cultured human umbilical vein endothelial cells (HUVECs) were exposed to H 2 O 2 as oxidative stress and a high glucose concentration with palmitate as a glucolipotoxic condition. (medsci.org)
  • We previously demonstrated that the typical BC human cell line NCI-H727 is sensitive to Everolimus, in terms of cell viability reduction, while the atypical human BC cell line NCI-H720 is not. (endocrine-abstracts.org)
  • On the contrary, the typical human BC cell line NCI-H727 is not sensitive to E, despite the Cyclin D1 reduction. (endocrine-abstracts.org)
  • Thus all body cells such as skin cells, muscle cells, bone cells in the human have 46 chromosomes. (angelfire.com)
  • TGFβ and BMP-activated receptor (r)-SMADs [phosphorylated SMAD2 or SMAD3 (pSMAD2,3), or phosphorylated SMAD1, SMAD5 or SMAD8 (pSMAD1,5,8)] undergo cell-cycle-dependent modulations and nucleo-cytosolic shuttling along the apicobasal axis of the neural plate. (biologists.com)
  • For T cells to perform their duties, they must form an "immunological synapse" with an antigen-presenting cell (APC). (nih.gov)
  • Other cells, such as the B lymphocytes which will eventually produce Antibodies, will return to the G1 phase when stimulated by an antigen. (angelfire.com)