AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceNamed GroupsHealth Care
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BiochemistryImmunologyDevelopmentalGeneticsDifferentiationPhysiologyMetabolismProkaryotic and eukaryotic cellsReproductive biologyVirologyMechanismsBiologicalNeuroscienceFundamentalPathwaysApoptosisCancerTranslational researchOrganismsContentAssaysEukaryoticProteinsOrganellesMoleculesPancreatic Beta CellRegulationProcessesOrganelleInterdisciplinaryPlasma membraneDynamics2020NIDDKMesenchymal stemCellular and molecularAnatomyMembranes2022Tumor-initGeneticBiol CellMammalian cellsEpithelialBeta Cell BiologyResearchProteinExperimentsDepartmentEmbryonic stemMutagenesisLipidBacteria
Biochemistry11
  • Cell biology encompasses both prokaryotic and eukaryotic cells and has many subtopics which may include the study of cell metabolism, cell communication, cell cycle, biochemistry, and cell composition. (wikipedia.org)
  • Cell culture is one of the major tools used in cellular and molecular biology, providing excellent model systems for studying the normal physiology and biochemistry of cells (e.g., metabolic studies, aging), the effects of drugs and toxic compounds on the cells, and mutagenesis and carcinogenesis. (wikipedia.org)
  • Find out more about research in the Department of Biology & Biochemistry. (bath.ac.uk)
  • Expertise in cell biology, molecular biology/biochemistry, pathogen-host interactions, and confocal or high-resolution imaging is desirable. (nih.gov)
  • Scientists at the Max Planck Institute of Biochemistry and Ludwig-Maximilians-Universitaet (LMU) in Munich report that, even in normal cells, aberrant aggregation-prone proteins are continually produced due to partial failure of the respiratory system. (sciencedaily.com)
  • To determine how aggregates can arise in mitochondria and cause damage to cells, they cooperated with the team led by F.-Ulrich Hartl at the Max Planck Institute of Biochemistry. (sciencedaily.com)
  • Together with Dr. Deborah Brown in the Dept. Of Biochemistry and Cell Biology we have been studying the structure and function of lipid domains enriched in cholesterol and sphingolipid. (stonybrook.edu)
  • Although their earlier studies focused on in vitro biochemistry and conventional molecular genetics approaches, their recent research is directed at the more challenging task of integrating specific molecular transactions with in vivo mechanisms in cells and organisms under physiological conditions. (berkeley.edu)
  • Single Cell Biochemistry, Structural Biology and Single Molecule Measuremen ts: In order to address mechanisms of transcriptional control they use a combination of structural biological methods such as cryo EM/3D particle reconstruction, X-ray crystallography and single molecule measurements. (berkeley.edu)
  • BIOCHEM 2504 uses the knowledge and understanding gained in the prerequisite level 1 courses (see below) to provide students with an appreciation and an understanding of key biochemistry and molecular biology concepts. (edu.au)
  • Philip Jordan is an Associate Professor in the Biochemistry and Molecular Biology Department, Johns Hopkins University Bloomberg School of Public Health in Baltimore, Maryland. (hopkinsmedicine.org)
Immunology1
  • Aiming to serve as a bridge between basic biomedical research and clinical medicine, the journal welcomes articles from scientific areas such as pathology, oncology, anatomy, virology, internal medicine, surgery, cell and molecular biology, and immunology. (karger.com)
Developmental12
Genetics4
  • NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
  • As it turned out, studies of the frog and sea urchin cell cycle coupled with yeast genetics gave us the mechanism. (the-scientist.com)
  • Because of its mutated aggressive genetics, this cell has a selective growth advantage over its neighbors. (medscape.com)
  • We combine cutting-edge microscopy, advanced genetics, next-generation bulk and single-cell sequencing, and bioinformatic analysis to understand how cells accomplish specific steps in metastasis, define the molecular tool-kit they utilize, and identify targets for new anti-metastatic drugs. (hopkinsmedicine.org)
Differentiation2
  • We found that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and affects their differentiation into osteoblasts. (nih.gov)
  • LSD1 and Sin3A, to examine their critical roles in development using a number of ES cell differentiation systems. (le.ac.uk)
Physiology3
  • Cell biology research looks at different ways to culture and manipulate cells outside of a living body to further research in human anatomy and physiology, and to derive medications.The techniques by which cells are studied have evolved. (wikipedia.org)
  • Using this novel method we are studying domain formation in the plasma membrane of cells, and how its lipid composition influences the function of membrane proteins such as the insulin receptor (in collaboration with the lab of Dr. Todd Miller, Physiology and Biophysics). (stonybrook.edu)
  • Since retiring, I have focused on teaching in Bio1AL (Intro Biol lab) and MCB136 (Advanced Human Physiology) but have also remained involved in research through collaborations: (i) Chi Li (U. Louisville) and his group are determining how the quorum-sensing molecule N-(3-oxo-acyl)-homoserine lactone (C12) secreted by P. aeruginosa triggers apoptosis (cell suicide) in airway epithelial cells. (berkeley.edu)
Metabolism3
  • ATP production, calcium signalling, fatty acid metabolism, and programmed cell death are all regulated by a mitochondrial proteome that is largely encoded in the nucleus and imported into the organelle. (stonybrook.edu)
  • Although some few prokaryotic cells use internal membranes as a site of metabolism, prokaryotic cells characteristically lack internal membrane-bound compartments, while eukaryotic cells have a highly specialized endomembrane system, characterized by regulated traffic and transport vesicles. (newworldencyclopedia.org)
  • In this context, we will look at the processes of cell metabolism. (edx.org)
Prokaryotic and eukaryotic cells1
Reproductive biology1
Virology2
  • Viruses are not considered in cell biology - they lack the characteristics of a living cell and instead are studied in the microbiology subclass of virology. (wikipedia.org)
  • Convergence of virology and cell biology / sponsored by the Foundation for the National Institutes of Health and the NIH Virology Interest Group. (nih.gov)
Mechanisms11
  • The Epigenetics and Stem Cell Biology Laboratory investigates fundamental mechanisms by which epigenetics - non-genetic modulation and alterations - influences chromatin architecture, transcription and gene expression in normal, cancer and embryonic stem cells and provides insights into biological processes that modulate the effects of environmental exposures. (nih.gov)
  • The Cell Biology Branch focuses on the basic molecular mechanisms believed to underlie age-related dysfunction and deficit accumulation, with a focus on molecular studies, performed primarily in cell culture, model organisms, and humans. (nih.gov)
  • The Cell Biology Branch has a broad array of programs that support research on the basic molecular mechanisms believed to underlie age-related dysfunction. (nih.gov)
  • The laboratory of Structural Cell Biology aims to understand the molecular mechanisms governing specialized cell shapes, such as those of neurons, activated immune cells or platelets and certain cancer cells. (nih.gov)
  • The underlying molecular mechanisms and the signaling processes governing cell shape formation are challenging to elucidate within a cell due to their complexity and diverse crosstalk with other pathways. (nih.gov)
  • Therefore, cells have internal quality control mechanisms that detect and rapidly destroy faulty proteins. (sciencedaily.com)
  • What are the underlying genetic and molecular mechanisms of the cells that are influenced by gravitational changes and the space environment? (nasa.gov)
  • [ 6 ] These events lead the cancer cell to escape normal cell growth and control mechanisms, to avoid system control mechanisms (ie, immunologic surveillance), and to establish a nutrient supply. (medscape.com)
  • Using techniques such as ChIP-sequence, ATAC and Micro-C analysis, systematic RNAi mutagenesis, transgenic animals or cells, and in vitro transcription assays, they have developed complimentary experimental strategies to dissect in vivo mechanisms of transcriptional regulation and tease out how these various protein/DNA and protein/protein transactions influence gene expression. (berkeley.edu)
  • Viral infection has long been a powerful experimental system for fundamental discoveries in biology, ranging from molecular mechanisms of gene expression at the cellular level to cell-to-cell communication at the organismal level. (apsnet.org)
  • Our research focuses on understanding the molecular mechanisms regulating DNA repair, chromosome segregation and cell cycle progression. (hopkinsmedicine.org)
Biological10
  • Dr. Hammer's lab uses cell biological, genetic, biochemical, and biophysical approaches, coupled with advanced imaging techniques, to study the molecular interactions that give rise to cellular and intracellular movements, and to define the functional significance of these movements in the context of whole organisms. (nih.gov)
  • Knowing the components of cells and how cells work is fundamental to all biological sciences while also being essential for research in biomedical fields such as cancer, and other diseases. (wikipedia.org)
  • Research supported by this branch includes genetic, cell biological, and metabolic changes that affect the length and/or quality of life in human and animal models. (nih.gov)
  • Multidisciplinary approaches and advanced technologies are encouraged to achieve a more comprehensive understanding of the molecular determinants of aging and longevity across the full arc of biological systems - from molecules, genes, signal pathways, organelles to cells and organisms. (nih.gov)
  • Cell death is an important biological process whose experimental detection and measurement can be difficult, especially when examining many conditions in parallel. (nature.com)
  • To precisely understand the molecular functions of key components, we are taking a bottom-up approach to reconstitute and investigate the macromolecular machinery that can mimic cell shape formation processes using biophysical and structural biological methods. (nih.gov)
  • PLOS Biology provides an Open Access platform to showcase your best research and commentary across all areas of biological science. (plos.org)
  • Together, faculty and students in Cell Biology and Neuroscience study biological processes that span the continuum from single cells to the entire human body. (montana.edu)
  • The research discoveries themselves and the cutting-edge multidisciplinary research tools that were developed have firmly established the cell biology of plant-virus interactions as a vibrant field of current biological research. (apsnet.org)
  • The research council responsible for funding Cell Biology PhDs in the UK is the Biotechnology and Biological Sciences Research Council (BBSRC). (findaphd.com)
Neuroscience2
  • Cell Biology and Neuroscience at Montana State University offers an innovative and exciting approach to undergraduate education. (montana.edu)
  • Cell Biology and Neuroscience offers an undergraduate B.S. in Cell Biology and Neuroscience, with Biomedical and Neuroscience options, as well as M.S. and a Ph.D. graduate degrees in Cell Biology and Neuroscience. (montana.edu)
Fundamental4
  • There are two fundamental classifications of cells: prokaryotic and eukaryotic. (wikipedia.org)
  • Deciphering the molecular basis of pluripotency is fundamental to our understanding of development and embryonic stem (ES) cell function. (berkeley.edu)
  • There is a compelling motivation to understand the fundamental biology of HDAC enzymes and to exploit this knowledge to improve their use as drug targets. (le.ac.uk)
  • Cells are the fundamental component of life itself. (karger.com)
Pathways6
  • It also focuses on the molecular basis of self-renewal and pluripotency in embryonic stem (ES) cells and induced pluripotency stem (iPS) cells, as well as gene regulatory pathways using genomic, molecular, biochemical, computational and structural approaches. (nih.gov)
  • Use of emerging genomic and proteomic methods to elucidate beta cell specific trafficking events, signaling pathways, and novel components of the islet microenvironment required for proper beta cell function is strongly encouraged. (nih.gov)
  • We have linked membrane proteins known for their roles in muscular dystrophies to signaling pathways understood best for their roles during tumor cell growth and migration. (umassmed.edu)
  • We are finding both similarities and differences between these pathways in tumor and other nonmuscle cells versus skeletal muscle and heart cells. (umassmed.edu)
  • Consequently the topics covered include DNA structure, synthesis and repair, RNA and protein synthesis, and the control of gene expression, recombinant DNA technology, cell structure and organisation and signal transduction pathways. (edu.au)
  • We also use mouse and human pluripotent stem cells to help define the function of these proteins within essential molecular pathways of the cell. (hopkinsmedicine.org)
Apoptosis2
  • Oppositely, expression of mutated myocilin sensitizes cells to apoptosis induced by oxidative stress. (nih.gov)
  • Paraoxonase 2 (a lactonase in airway epithelial cells) cleaves C12 to smaller molecules that activate a novel form of apoptosis that involves mitochondria but not the pro-apoptotic molecules Bax and Bak. (berkeley.edu)
Cancer18
  • The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. (medscape.com)
  • Here, the authors review the novel insights that these studies have provided and present a comprehensive strategy for the use of proteomics in studying cancer SC biology. (medscape.com)
  • According to the cancer stem cell (CSC) concept, the cellular hierarchy in normal tissues is preserved in a number of hematological and solid malignancies. (medscape.com)
  • The CSC is defined as a cancer cell with self-renewing capacity that can regenerate the original tumor in all its differentiated heterogeneity. (medscape.com)
  • Cancer stem cell-associated proteins revealed by proteomics. (medscape.com)
  • Influence of a self-assembling peptide, RADA16, compared with collagen I and Matrigel on the malignant phenotype of human breast-cancer cells in 3D cultures and in vivo. (nih.gov)
  • The significance of this paper as well as the accompanying papers in the same issue of Cell, by Erich Nigg's group at the Swiss Institute for Experimental Cancer Research (pages 591-60) and Frank McKeon's group at Harvard University (pages 579-89), must be considered in relation to the rapid progress that has occurred in the cell cycle field. (the-scientist.com)
  • In turn, as a result of research into the abnormal cancer cell, the basic understanding of the cell has greatly improved. (medscape.com)
  • Cancer is characterized by uncontrolled growth and division of a cell, with extension beyond the normally limiting basement membrane and through the boundaries of normal cells. (medscape.com)
  • This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)
  • We recently published the first PROTACs to target HDAC1/2 specifically in cancer cells and are currently optimising additional molecules that target specific complexes. (le.ac.uk)
  • focus on how clusters of cancer cells disseminate from the tumor, traverse the systemic circulation, and cooperate with resident stromal cells to colonize distant organs. (hopkinsmedicine.org)
  • Dr. Andrew Ewald seeks to understand how cells build organs and how these same cellular processes can contribute to cancer metastasis. (hopkinsmedicine.org)
  • Dr. Ewald's research lab recently identified a unique class of breast cancer cells that lead the process of invasion into surrounding tissues-a first step in cancer metastasis. (hopkinsmedicine.org)
  • He completed postdoctoral work with Zena Werb in mammary biology and cancer at the University of California, San Francisco. (hopkinsmedicine.org)
  • He is the director of the department of Cell Biology, director of the Giovanis Institute for Translational Cell Biology and holds the Virginia De Acetis Professorship in Basic Cancer Research. (hopkinsmedicine.org)
  • Metastasis is the multistep process by which cancer cells acquire the ability to leave the primary tumor, travel through the circulation, evade the immune system, and establish new tumors in distant vital organs. (hopkinsmedicine.org)
  • We grow cancer cells in three-dimensional (3D) environments customized to model specific stages in cancer progression, including tumor initiation, tumor growth, cancer invasion, entry into blood vessels, immune evasion, and growth of metastases in distant organs. (hopkinsmedicine.org)
Translational research1
  • We invite applications from driven scientists to contribute to our cutting-edge, translational research programme on hepatocyte biology. (jobs.ac.uk)
Organisms12
  • All living organisms are made of cells. (wikipedia.org)
  • A cell is the basic unit of life that is responsible for the living and functioning of organisms. (wikipedia.org)
  • These have allowed for and are currently being used for discoveries and research pertaining to how cells function, ultimately giving insight into understanding larger organisms. (wikipedia.org)
  • All of this preceded the cell theory which states that all living things are made up of cells and that cells are organisms' functional and structural units. (wikipedia.org)
  • Cell and molecular biology research cuts across all science disciplines in Space Biology, from understanding how single-celled organisms, such as protozoa, bacteria, and fungi respond to the conditions of spaceflight, to how all of the various cells in a complex tissue or organ work together to help an organism as a whole acclimate to such a foreign environment. (nasa.gov)
  • The cell is a membrane-enclosed body that is the structural and functional unit of living organisms , being the smallest unit that can carry on all life processes, including maintenance, growth, replication, and self-repair. (newworldencyclopedia.org)
  • All living organisms, with the exception of viruses (and there is debate whether or not they can be considered living organisms), consist of cells, demonstrating the unity, harmony, and interconnectedness of life. (newworldencyclopedia.org)
  • The specialization of cells in multicellular organisms to form many different organs and bodily systems all integrated into a harmonious, hierarchically arrayed collective, with each component of equal value and essential to the function of the whole, demonstrates a principle and pattern of organization that provides an analogue for systems of higher order, like ecosystems, families, and nations. (newworldencyclopedia.org)
  • Prokaryotic cells are usually single, while eukaryotic cells are usually found in multicellular organisms. (newworldencyclopedia.org)
  • All organisms, from single-celled algae to complex multicellular organisms like us, are made up of cells. (edx.org)
  • The overarching goal is for learners to understand, from a human-centered perspective, that cells are evolving ensembles of macromolecules that in turn form complex communities in tissues, organs, and multicellular organisms. (edx.org)
  • Our cells are not so different from those of other organisms. (futurelearn.com)
Content2
  • Cytometry: The cells are placed in the machine which uses a beam to scatter the cells based on different aspects and can therefore separate them based on size and content. (wikipedia.org)
  • The course combines lectures, special tutorial sessions that reinforce the lecture content and research aspects in molecular biology, and the practicals offered by the school of Molecular and Biomedical Science to complement this material. (edu.au)
Assays1
  • we can examine the cells, either visually with a microscope, or with biochemical assays. (futurelearn.com)
Eukaryotic4
Proteins10
Organelles5
  • From the motor protein-dependent transport of organelles inside the cell, to the changes in overall cell shape driven by cytoskeletal dynamics, normal cell function is highly dependent on movement. (nih.gov)
  • Regarding the coat color defect, myosin Va is required to generate the correct intracellular distribution of pigment granules (melanosomes) inside melanocytes, which in turn is required for the intercellular transfer of these organelles to keratinocytes, the principal cell type in hair and skin. (nih.gov)
  • These domains have been proposed to have a functional role in processes such as viral and toxin entry into cells, protein sorting among organelles, signal transduction, prion formation and amyloid formation. (stonybrook.edu)
  • Given this conceptual basis and the advances in genetic analysis and visualization of cells and their organelles, cell biology is poised to be transformed by embracing the approaches of Evo-Devo - cells provide the link between genotype and phenotype, both during development and in evolution. (routledge.com)
  • This collection focuses on the essential components and functions of cells, including organelles and membranes, cellular transport, and cell energetics. (jove.com)
Molecules4
  • The functioning of a cell depends upon its ability to extract and use chemical energy stored in organic molecules. (newworldencyclopedia.org)
  • Cell contents are enclosed by a cell surface membrane , a lipid bilayer within which are floating up to thousands of protein molecules. (newworldencyclopedia.org)
  • Invertebrates use relatively simple defense strategies that rely chiefly on protective barriers, toxic molecules, and phagocytic cells that ingest and destroy invading microorganisms (microbes) and larger parasites (such as worms). (nih.gov)
  • If the regulatory picture of the genome was not complicated enough, now scientists have discovered yet one more amazing level of bio-complexity that involves a whole new class of molecules in the form of RNA hoops, or circles-the results just published in several new Nature papers. (icr.org)
Pancreatic Beta Cell3
  • An NIDDK/Juvenile Diabetes Foundation (JDF) workshop entitled, "Imaging the Pancreatic Beta Cell" held in April, 1999, further recommended the development of imaging techniques that could be used to assess beta cell mass in the pancreas. (nih.gov)
  • A recent RFA entitled, "Imaging Pancreatic Beta Cell Mass, Function, or Inflammation" addressed recommendations from that workshop, as does this solicitation. (nih.gov)
  • An important goal of this workshop is to identify areas of research opportunity in the adult pancreatic beta cell. (nih.gov)
Regulation3
  • I would have imagined that the cell cycle would be figured out by going from the understanding of particular processes, such as mitosis and DNA replication, to a reconstruction of their regulation. (the-scientist.com)
  • Their studies indicate that large co-activator complexes play a critical role in mediating both universal as well as cell type specific networks of gene transcription and can serve as the interface between transcription and chromatin regulation. (berkeley.edu)
  • The Ewald Lab seeks to elucidate the molecular regulation of collective cell migration during normal mammary development and during the invasion and metastatic spread of mammary tumors. (hopkinsmedicine.org)
Processes5
  • ATP is the universal "energy carrier" and is essential for all processes in living cells. (sciencedaily.com)
  • A cell is the basic unit of life, being the smallest unit of life that can carry on all life processes (see life ). (newworldencyclopedia.org)
  • These and related findings using "Fast SPT" are forcing us and the field to rethink many traditional and accepted models for how various processes and reactions such as transcription control actually take place in living cells. (berkeley.edu)
  • JoVE Core Cell Biology illustrates complex cellular processes in easy-to-understand yet comprehensive animated video lessons. (jove.com)
  • His research program encompasses using mouse and human stem cells and germ cells to discover the molecular processes that ensure genome stability during gametogenesis and early development. (hopkinsmedicine.org)
Organelle1
  • We will focus, in particular, on the mitochondrion, the organelle that powers the cell. (edx.org)
Interdisciplinary3
  • and to foster interdisciplinary approaches to the study of beta cell biology. (nih.gov)
  • We visualize the key factors determining different cell morphologies using in situ cellular cryo-electron tomography in combination with interdisciplinary techniques such as single-particle cryo-EM, X-ray crystallography, in vitro reconstitution and light microscopy. (nih.gov)
  • This course is ideal if you want an interdisciplinary approach to Molecular Cell Biology. (york.ac.uk)
Plasma membrane1
  • Dr. Hammer and his colleagues have shown that actin polymerization-driven retrograde flow and myosin II-dependent actin arc contraction coordinately drive the movements of T cell receptor and integrin clusters in the plasma membrane to form the mature immunological synapse. (nih.gov)
Dynamics1
  • The Laboratory of Cell Structure and Dynamics (LCSD) seeks an integrated molecular understanding of the architecture, dynamics, function, and renewal of specialized cellular structures-in particular, those underlying the mechanosensory function of auditory and vestibular sensory cells. (nih.gov)
20202
NIDDK4
  • In response to the DRWG report, a NIDDK/American Diabetes Association (ADA)/JDF sponsored workshop, "Stem Cells and Pancreatic Development" was held in April, 2000. (nih.gov)
  • FUNDS AVAILABLE The NIDDK plans to commit up to $7.25 million in FY 2001 to fund approximately five new awards for Beta Cell Biology Programs. (nih.gov)
  • In further support of this initiative, the NIDDK will hold a workshop, "Beta Cell Biology in the 21st Century: Engineering a Pathway to Greater Understanding", on November 26-28. (nih.gov)
  • In this initiative, the NIDDK is encouraging the formation of collaborations among scientists with a variety of different expertise and ideas, so that multifaceted approaches, diverse skills, unique tools, and special resources can be used to investigate the biology of the adult beta cell. (nih.gov)
Mesenchymal stem1
  • Researchers have developed a new method for preparing mesenchymal stem cells (MSCs) that not only leads to the production of more native stem cells, but also labels them with a FDA approved iron-oxide nanoparticle (Ferumoxytol). (nih.gov)
Cellular and molecular2
  • Abstract: DESCRIPTION (provided by applicant): This is a competitive renewal application for a long-standing predoctoral training grant in Cellular and Molecular Biology (CMB). (nih.gov)
  • The overarching goal of Space Biology Cell and Molecular Biology research at NASA is to determine how the stresses of the spaceflight environment affect living systems at the basic cellular and molecular levels, using contemporary cell and molecular biology techniques and measures. (nasa.gov)
Anatomy1
Membranes2
  • We invented a method to prepare asymmetric artificial vesicles that more closely mimic natural membranes using cyclodextrins, and are applying this methodology: to analyze the rules for domain formation in natural membranes, to examine how asymmetry affects amyloid formation (in collaboration with the lab of Dr. Daniel Raleigh), and to determine how asymmetric lipid vesicles (asymmetric liposomes) may have improved properties for delivery of drugs into cells. (stonybrook.edu)
  • The lab also has developed a method to efficiently replace the natural lipid composition of the outer leaflet of cell plasma membranes with other lipids using cyclodextrins. (stonybrook.edu)
20221
  • Cell (2022 Mar 31) 185:1143-1156.e13. (nih.gov)
Tumor-init1
  • [ 2 ] In addition, some tumor types do not appear to adhere to the CSC concept at all [ 3 , 4 ] or may have multiple independent tumor-initiating cell populations. (medscape.com)
Genetic2
  • Particular attention is given to genetic and epigenetic programming, cell signalling and whole organism biology. (bath.ac.uk)
  • The general goal of our research since about 1995 has been to determine how lung airway epithelial cells respond to and prevent bacterial infections, particularly in the genetic disease cystic fibrosis. (berkeley.edu)
Biol Cell2
Mammalian cells2
  • We are also carrying out studies on these domains in mammalian cells (see below). (stonybrook.edu)
  • There are 18 HDAC enzymes in mammalian cells that can be sub-divided according to the presence of Zn2+-dependent (Class I, II and IV) or NAD+-dependent (Class III/Sirtuins) catalytic domains. (le.ac.uk)
Epithelial4
  • Hepatocytes maintain their function on basement membrane formed by epithelial cells. (nih.gov)
  • The Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is an anion channel located in the apical membrane of trachea and other secretory and absorptive epithelial cells. (berkeley.edu)
  • ii) With Christian Schwarzer (UCB) and Horst Fischer (Children's Hospital Oakland Research Institute) we showed that amino acids released from wounded or damaged airway epithelial cells are strong chemoattractants for P. aeruginosa to locate and bind to the cells. (berkeley.edu)
  • Chemotaxis and binding of Pseudomonas aeruginosa to scratch-wounded human cystic fibrosis airway epithelial cells. (berkeley.edu)
Beta Cell Biology3
  • Through the Consortium, individual Beta Cell Biology Programs will have access to information, resources, technologies, expertise, and reagents that are beyond the scope of any single research effort. (nih.gov)
  • The award for each Beta Cell Biology Program will be limited to $1 million in direct costs/year. (nih.gov)
  • This Request for Applications (RFA), COMPREHENSIVE PROGRAMS IN BETA CELL BIOLOGY, is related to one or more of the priority areas. (nih.gov)
Research11
  • We've discovered new details about a basic process used in all sorts of ways by every cell in the body," said co-author Joshua Zimmerberg, M.D., Ph.D., head of the Program in Physical Biology at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), where the research was conducted. (nih.gov)
  • The Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Division of Intramural Research, NIAID, seeks a staff scientist to study the cell biology of virus-host interactions following infection with emerging RNA viruses including flaviviruses, coronaviruses, and alphaviruses. (nih.gov)
  • One area of research in the lab is the identification of additional GEFs that activate Arf6 and studies aimed at identifying factors that regulate GEF activity in cells. (nih.gov)
  • It is complemented by scientist-in-action videos that demonstrate the application of cell biology in real-world research experiments. (jove.com)
  • Further research is planned to examine if these cells are viable targets for therapy. (hopkinsmedicine.org)
  • A postdoctoral research opportunity is available in the Rashid laboratory, focusing on the investigation of human liver biology and pathology using induced pluripotent stem cell-derived (iPSC) hepatocytes. (jobs.ac.uk)
  • Situated at the Hammersmith Campus, the successful candidate will join a collaborative research team investigating both intracellular and extracellular liver cell biology using iPSC-derived hepatocytes in context of cell therapy and disease modelling. (jobs.ac.uk)
  • A Cell Biology PhD would give you the opportunity to take on a three to four-year research project into the inner workings of cells. (findaphd.com)
  • Your research may involve investigating cell-to-cell communication, the potential use of stem cells, or researching the difference between cells from a healthy individual compared to those with a certain disease. (findaphd.com)
  • Writing a research proposal and suggesting your own research topic is uncommon in Cell Biology. (findaphd.com)
  • During Dr. Jordan's training he developed a keen focus on research that encompasses maintenance of genome integrity and cell cycle progression. (hopkinsmedicine.org)
Protein4
  • Step 3: Coils of dynamin protein (orange) seal the cargo into a compartment within the cell. (nih.gov)
  • In order to get rid of these toxic aggregates, cells have developed an elaborate protein quality control system, which the researchers now describe in the journal Cell . (sciencedaily.com)
  • This includes characterizing and identifying changes in gene and protein expression, DNA function and structure, cellular structure and morphology, and cell-to-cell communication. (nasa.gov)
  • Delta singlet oxygen (D 1 O 2 ) is an extensively studied type II photodynamic action involving excited state molecular oxygen, and it is responsible for modulating numerous cellular functions, including cell secretion, muscle contraction, cellular signaling, cell death and senescence, autophagy, gene transcription and translation, development, and protein oxidation. (mdpi.com)
Experiments2
  • Here, we offer tips to help interpret cell death experiments. (nature.com)
  • Currently, we are performing transcriptomic experiments in 'gastruloids', an organoid system formed from aggregating ES cells that closely mimics the gastrulating embryo. (le.ac.uk)
Department3
  • This is why the mitochondria are also referred to as the 'Achilles' heel' of the cell," says Walter Neupert from the Department of Cell Biology at the LMU Biomedical Center. (sciencedaily.com)
  • The Department of Biology will provide you with the opportunity to learn in new, spacious and modern teaching laboratories which provide excellent facilities for practicals and small group project work, alongside our state-of-the-art computing facilities. (york.ac.uk)
  • One of my favourite things about the Department of Biology is it contains several dedicated study spaces, including computer rooms and the creative lounge. (york.ac.uk)
Embryonic stem1
  • We have therefore used gene editing methods, such as CRISPR, to generate embryonic stem (ES) cell lines in which we can specifically 'switch off' HDAC1 and HDAC2, or components of specific complexes e.g. (le.ac.uk)
Mutagenesis1
  • The functional relevance learned from the in vitro reconstitution analysis is then validated inside cells by mutagenesis and in situ analysis. (nih.gov)
Lipid1
  • In this case, we have stained cells with a dye that colors lipids in red: so we can count lipid droplets in the microscope. (futurelearn.com)
Bacteria1