• researchers
  • In a small study involving 35 men in their 50s and 60s, researchers at the Preventive Medicine Research Institute and the University of California, San Francisco found that the 10 participants who adopted several healthful lifestyle changes for five years experienced a 10 percent lengthening of their cell's telomeres, indicating that the cells would have a longer lifespan. (bostonglobe.com)
  • For this study, the researchers used several techniques, including a process called transcriptome analysis, to determine the extent to which genes are on or off depending on the age of the HSCs. (nih.gov)
  • Often researchers can count the number of different types of transcripts in the transcriptome to determine the level of activity of different genes, also called gene expression, in a certain cell or tissue type. (nih.gov)
  • Researchers found, for instance, that genes regulated by a growth factor called TGF-β showed differences in expression between young and old HSC cells. (nih.gov)
  • In addition, the researchers confirmed and extended previous studies by identifying epigenetic changes in young versus old HSCs that are consistent with the aging HSCs' inability to develop into other types of blood cells. (nih.gov)
  • Cells have evolved ways to defend themselves, but in a new study, Brown University researchers describe how cells lose this ability as they age, possibly resulting in a decline in their function and health. (scoop.it)
  • A team of researchers, led by scientists at the University of North Carolina, Chapel Hill, with support from the National Institute on Aging at the NIH, has developed an innovative approach to study aging cells in living mice. (nih.gov)
  • Researchers conclude that findings from this work support p16 as a potential indicator of aging and this new strain of mice may be helpful in determining the effects of compounds on aging cells. (nih.gov)
  • 13 January Man-made carbon emissions have delayed the next ice age by 50,000 years, according to researchers at the Potsdam Institute for Climate Impact Research. (wikipedia.org)
  • 25 January Researchers at the University of Washington announce a new handheld, pen-sized microscope that could identify cancer cells in doctor's offices and operating rooms. (wikipedia.org)
  • Researchers at the University of Iowa use real-time 3D videos of cellular movement to show how cancer cells extend "cables" and grab other cells, leading to tumour growth. (wikipedia.org)
  • 29 January Researchers demonstrate that graphene can be successfully interfaced with neurons, while maintaining the integrity of these vital nerve cells. (wikipedia.org)
  • However, Olovnikov's prediction was not widely known except by a handful of researchers studying cellular aging and immortalization. (wikipedia.org)
  • genes
  • New research has provided insight into the HSC's aging process by systematically evaluating the gene expression (whether genes are turned "off" or "on") in cells from both young and old male mice. (nih.gov)
  • The genome is made up of DNA, a long, winding molecule that contains the instructions, in the form of genes, needed to build and maintain cells. (nih.gov)
  • In humans and other multi-cell creatures, nearly every cell contains the same genes, but different cells show different patterns of gene expression. (nih.gov)
  • mentioned a suggested common mechanism between the Sgs1 and WRN genes since they both had age related effects on yeast and human aging respectively. (wikipedia.org)
  • It remained for a privately funded collaboration from biotechnology company Geron to isolate the genes for the RNA and protein component of human telomerase in order to establish the role of telomere shortening in cellular aging and telomerase reactivation in cell immortalization. (wikipedia.org)
  • Gene therapy agents/strategies intended to edit the genes of the cells of an organism in order to increase their resistance to aging, senile diseases and to prolong the life of the organism Childs BG, Durik M, Baker DJ, van Deursen JM (2015). (wikipedia.org)
  • In the cells of extant organisms, the vast majority of the proteins present in the mitochondria (numbering approximately 1500 different types in mammals) are coded for by nuclear DNA, but the genes for some, if not most, of them are thought to have originally been of bacterial origin, having since been transferred to the eukaryotic nucleus during evolution. (wikipedia.org)
  • Guarente's lab has studied the function of genes involved in aging. (wikipedia.org)
  • antigen-prese
  • CD28 and cytotoxic T-lymphocyte antigen (CTLA)-4 play a crucial role in regulating the activation of T cells after engagement by CD80/CD86 on antigen-presenting cells . (natap.org)
  • The age-associated impairment of dendritic Antigen Presenting Cells (APCs) has profound implications as this translates into a deficiency in cell-mediated immunity and thus, the inability for effector T-lymphocytes to modulate an adaptive immune response (see below). (wikipedia.org)
  • telomerase
  • A single in vitro study on human CD4 and CD8 T cells led to claims that cycloastragenol may activate telomerase, leading to controversial claims for its role in reducing the effects of aging. (wikipedia.org)
  • The small study (using T-cells taken from 6 participants) found that TA-65 activated telomerase in cultured cells in all samples, while another Astragalus extract did not. (wikipedia.org)
  • gene expression
  • Global gene expression analyses uncovered an induction of p16INK4a in satellite cells of physiologically aged geriatric and progeric mice that inhibits satellite cell-dependent muscle regeneration. (fightaging.org)
  • Heat shock is used to induce Flp recombinase marker gene expression is activated in dividing cells due to recombination. (wikipedia.org)
  • decline
  • Aging is the inevitable decline in the body's resiliency, which ultimately leads to dwindling powers, both mental and physical. (howstuffworks.com)
  • There is a notable decline in the total number of phagocytes in aged hosts, coupled with an intrinsic reduction of their bactericidal activity. (wikipedia.org)
  • A decline in humoral immunity caused by a reduction in the population of antibody producing B-cells along with a smaller immunoglobulin diversity and affinity. (wikipedia.org)
  • As age advances, there is decline in both the production of new naive lymphocytes and the functional competence of memory cell populations. (wikipedia.org)
  • Although myeloid cell production does not seem to decline with age, macrophages become dysregulated as a consequence of environmental changes. (wikipedia.org)
  • adult
  • In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. (karger.com)
  • The HSC, a type of adult stem cell, holds great promise for future biomedical applications because of its ability to self-renew and develop into any kind of blood cell. (nih.gov)
  • replicates
  • protective caps that keep DNA in order as the cell replicates. (nutritionexpress.com)
  • Building on this, and to accommodate Leonard Hayflick's idea of limited somatic cell division, Olovnikov suggested that DNA sequences are lost every time a cell/DNA replicates until the loss reaches a critical level, at which point cell division ends. (wikipedia.org)
  • mice
  • On the one hand, some muscle cells - including, it appears, some cells that would otherwise be satellite cells (skeletal muscle stem cells) - become senescent over the course of life, at least in mice (no studies in humans of which I'm aware). (fightaging.org)
  • Sirt7 mutant mice show phenotypic and molecular features of accelerated aging. (wikipedia.org)
  • Overexpression of SIRT1 (mammalian sir2 homolog) in mice improved their health and retarded numerous age-associated diseases. (wikipedia.org)
  • humans
  • In humans cells, SIRT7 has only been shown to interact with two other molecules: RNA polymerase I (RNA Pol I) and upstream binding factor (UBF). (wikipedia.org)
  • mechanism
  • As they report in the European Respiratory Journal , they have already successfully counteracted this mechanism in the cell culture with the help of drugs. (eurekalert.org)
  • The number of stem cells in young people is very much higher than older people and this cause a better and more efficient replacement mechanism in the young contrary to the old. (wikipedia.org)
  • tissue
  • It is an open question as to how this interacts with other signaling mechanisms also recently shown to influence the suppression of stem cell tissue maintenance. (fightaging.org)
  • cycle progression
  • This effect is due to cell cycle progression from G 1 to the more sensitive S-G 2 phase during the interval between the split doses. (aacrjournals.org)
  • On one end, the hypermethylation, mutation, or deletion of p16 leads to downregulation of the gene and can lead to cancer through the dysregulation of cell cycle progression. (wikipedia.org)
  • Biology
  • Aging Biology: How do cells age? (howstuffworks.com)
  • It was established in 2002 and the editors-in-chief are Peter Adams (University of Glasgow), Adam Antebi (Max Planck Institute for Biology of Ageing), Ana Maria Cuervo (Albert Einstein College of Medicine), Brian Kennedy (Buck Institute for Research on Aging), and John Sedivy (Brown University). (wikipedia.org)
  • Nature Cell Biology. (wikipedia.org)
  • The International Journal of Biochemistry & Cell Biology. (wikipedia.org)
  • niche
  • If the niche can be rejuvenated it can return Stem cells into service and that is something I understand she is working on. (fightaging.org)
  • These can be woken up and returned to work if the niche environment is de-aged. (fightaging.org)
  • vitro
  • Mukherjee, Asit B. "Culture media variation as related to in vitro aging of human fibroblasts: II. (wikipedia.org)
  • umdnj.edu
  • NIA AGING CELL REPOSITORY WWW CATALOG To ensure that investigators have access to the most up-to-date information and complete listings of cell cultures, a World Wide Web version of the NIA Aging Cell Repository catalog is now available ( http://locus.umdnj.edu/nia ). (bio.net)
  • Regulation
  • p16 plays an important role in cell cycle regulation by decelerating cells progression from G1 phase to S phase, and therefore acts as a tumor suppressor that is implicated in the prevention of cancers, notably melanoma, oropharyngeal squamous cell carcinoma, cervical cancer, and esophageal cancer. (wikipedia.org)
  • regeneration
  • It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery. (karger.com)
  • Regeneration of skeletal muscle relies on a population of quiescent stem cells ( satellite cells ) and is impaired in very old (geriatric) individuals undergoing sarcopenia . (fightaging.org)
  • p16INK4a silencing rejuvenated satellite cells, restoring regeneration in geriatric and progeric muscles. (fightaging.org)
  • function
  • Chronic untreated HIV infection results in decreased expression of CD28 and increased expression of CTLA-4 by CD4 T cells , where both may contribute to impaired T-cell function. (natap.org)
  • Although they have protective mechanisms, they still age and lose function. (wikipedia.org)
  • This age-associated immune deficiency is ubiquitous and found in both long- and short-living species as a function of their age relative to life expectancy rather than chronological time. (wikipedia.org)
  • The cytotoxicity of Natural Killer (NK) cells and the antigen-presenting function of dendritic cells is known to diminish with old age. (wikipedia.org)
  • involves
  • This damage response involves the proteolysis of type XVII collagen by neutrophil elastase in response to the DNA damage in the hair follicle stem cells. (wikipedia.org)
  • slows
  • p16 is a cyclin-dependent kinase (CDK) inhibitor that slows down the cell cycle by prohibiting progression from G1 phase to S phase. (wikipedia.org)
  • That same year, David Sinclair joined the Guarente lab, and they developed the hypothesis that caloric restriction slows aging by activation of sirtuins. (wikipedia.org)
  • myeloid
  • Stem cells decrease in number and tend to lose the ability to differentiate into progenies or lymphoid lineages and myeloid lineages. (wikipedia.org)
  • chronological
  • We defined beta-cell age as chronological age of a person with the same predicted risk but all risk factors at the normal levels (i.e. (hindawi.com)
  • Hereby, we have made it also possible to estimate wide ranges of "beta-cell age" for most chronological ages to assist clinician with risk communication. (hindawi.com)
  • primarily
  • Some maintain that aging is preprogrammed into our cells, while others contend that aging is primarily the result of environmental damage to our cells. (howstuffworks.com)
  • On May 28, 2015, the FDA approved sirolimus to treat lymphangioleiomyomatosis (LAM), a rare, progressive lung disease that primarily affects women of childbearing age. (wikipedia.org)
  • lifespan
  • as well as Maria Blasco in the journal Aging Cell, finding no increase in murine median or mean lifespan but some physiological anti-aging effects without augmenting cancer incidence. (wikipedia.org)
  • cancerous
  • We become more susceptible to infections and less proficient at seeking out and destroying mutant cells that could cause cancerous tumors . (howstuffworks.com)
  • As little as five percent of cancerous cells are needed for tumour formation, they suggest. (wikipedia.org)
  • alterations
  • In fact, age-related alterations are evident in all stages of T-cell development, making them a significant factor in the development of immunosenescence. (wikipedia.org)
  • diseases
  • Diseases such as Alzheimer's disease, end-stage renal failure and heart disease are caused by different mechanisms that are not related to stem cells. (wikipedia.org)
  • Together with the age-related thymic involution, and the consequent age-related decrease of thymic output of new T cells, this situation leaves the body practically devoid of virgin T cells, which makes the body more prone to a variety of infectious and non-infectious diseases. (wikipedia.org)
  • rDNA
  • Extrachromosomal rDNA circles (aka ERC) are extrachromosomal circular DNA (eccDNA), are self replicating sequences of ribosomal DNA (rDNA) found in a strain of yeast, Saccharomyces cerevisiae, and are suggested to contribute to their aging and found in their aged cells. (wikipedia.org)
  • disorders
  • This research provides new insight into the aging process and may be the basis for future treatments for aging-related disorders. (nih.gov)
  • These include disorders of accelerated aging (e.g., progeria, Werner syndrome, Cockayne syndrome, Rothmund-Thomson syndrome, and Down syndrome) and cell cultures from familial Alzheimer disease extended pedigrees. (bio.net)
  • Advancement
  • Immunosenescence refers to the gradual deterioration of the immune system brought on by natural age advancement. (wikipedia.org)