A functional single-nucleotide polymorphism (a common normal variant) of the gene for catechol-O-methyltransferase results in a valine to methioninemutation at position 158 (Val158Met) rs4680. (wikipedia.org)
Background: The catechol-O-methyltransferase (COMT) enzyme plays a crucial role in dopamine degradation, and the COMT Val158Met polymorphism (rs4680) is associated with significant differences in enzymatic activity and consequently dopamine concentrations in the prefrontal cortex. (umn.edu)
Most studies have focused on the effects of a particular common variation (polymorphism) in catechol-O-methyltransferase. (medlineplus.gov)
Catechol-o-methyltransferase (COMT) alters extracellular dopamine levels in PFC, and its gene contains a functional polymorphism (Val(158)Met) that has been associated with variation in PFC function. (ox.ac.uk)
The catechol- O -methyltransferase ( COMT ) gene contains a functional polymorphism, Val158Met which has been related to common diseases like cancer, psychiatric illness and myocardial infarction. (biomedcentral.com)
The catechol- O -methyltransferase ( COMT ) gene located at chromosome 22q11.2 contains a functional polymorphism at codon 158 that has been the subject of several molecular epidemiological studies because of the important role of the COMT enzyme in the metabolism of catecholamines and catechol estrogens. (biomedcentral.com)
The thiopurine methyltransferase genetic polymorphism is responsible for clinically significant individual variations in the toxicity and therapeutic efficacy of thiopurine drugs such as 6-mercaptopurine. (scienceopen.com)
Phenotyping for the thiopurine methyltransferase genetic polymorphism represents one of the first examples in which testing for a pharmacogenetic variant has entered standard clinical practice. (scienceopen.com)
Val158Met1
Our objectives were (1) to examine how baseline stress and change in stress is associated with course of geriatric depression and (2) to test whether polymorphisms of serotonin transporter (5-HTTLPR) and catechol-O-methyltransferase (COMT Val158Met) genes moderate this relation. (nih.gov)
Gene8
In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. (wikipedia.org)
The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. (medlineplus.gov)
A loss of one copy of the COMT gene in each cell leads to abnormal regulation of catechol-O-methyltransferase levels in the brain. (medlineplus.gov)
Aims: The catechol-O-methyltransferase (COMT) gene codes for synaptic enzyme degrading catecholamines, including dopamine, and has been extensively studied in mental health research. (frontiersin.org)
PMID 15124004 ] Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families. (snpedia.com)
PMID 17482701 ] No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population. (snpedia.com)
The catechol-o-methyltransferase (COMT) gene has repeatedly been shown to change amygdala activity and amygdala-prefrontal connectivity during face processing. (frontiersin.org)
Variations in catechol-o-methyltransferase gene interact with parenting to influence attention in early development. (bvsalud.org)
Inhibitor2
Stalevo, a combination drug consisting of levodopa (aromatic amino acid), carbidopa (aromatic amino acid decarboxylation inhibitor), and entacapone (catechol-O-methyltransferase (COMT) inhibitor) is indicated for the treatment of Parkinson's disease. (nih.gov)
Description: A sandwich ELISA for quantitative measurement of Rat Catechol O methyltransferase domain containing protein 1(COMTD1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (worldcarecouncil.org)
Description: A sandwich ELISA for quantitative measurement of Human Catechol O methyltransferase domain containing protein 1(COMTD1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (worldcarecouncil.org)
Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan. (ox.ac.uk)
Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. (snpedia.com)
Norepinephrine2
EC 2.1.1.6) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. (wikipedia.org)
Catechol-O-methyltransferase is involved in the inactivation of the catecholamine neurotransmitters (dopamine, epinephrine, and norepinephrine). (wikipedia.org)
The principal routes of metabolism are methylation of the catechol and conjugation. (drugs.com)
Parkinson's1
TY - JOUR T1 - Catechol-O-methyltransferase inhibitors for levodopa-induced complications in Parkinson's disease. (unboundmedicine.com)
Genotype2
An analysis by researchers showed that early signs of liver damage were somewhat more common than normal in women with one variation in the catechol-O-methyltransferase (COMT) genotype and strongly predicted by a variation in the uridine 5'-diphospho-glucuronosyltransferase 1A4 (UGT1A4) genotype. (sciencedaily.com)
Catechol-O-methyltransferase (COMT) genotype affects cognitive control during total sleep deprivation. (cdc.gov)
Variation2
Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls. (snpedia.com)
The change affects the stability and activity of catechol-O-methyltransferase, which alters the enzyme's ability to break down neurotransmitters in the prefrontal cortex. (medlineplus.gov)
Polymorphisms4
PMID 17006672 ] Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia. (snpedia.com)
PMID 17363961 ] Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment. (snpedia.com)
In recent years, characterization of these genetic polymorphisms has been extended to include the cloning of cDNAs and genes, as well as a determination of the molecular basis for the effects of inheritance on these methyltransferase enzymes. (scienceopen.com)
Enzymes1
LD is extensively and rapidly metabolized by peripheral enzymes, namely, aromatic amino acid decarboxylase and catechol- O -methyltransferase (COMT). (scienceopen.com)
Antipsychotic drugs target primarily dopaminergic system which makes catechol-O-methyltransferase (COMT) an interesting target in studies searching for treatment response predictors in schizophrenia. (srce.hr)
Levodopa1
Current strategies include concomitant treatment with inhibitors of dopa decarboxylase (DDC) and catechol- O -methyltransferase (COMT) to prolong the peripheral levodopa half-life and increase CNS bioavailability. (scienceopen.com)
Dopamine degradation1
Catechol-O-Methyltransferase (COMT) is responsible for most dopamine degradation in the frontal cortex. (ismrm.org)
Abstract1
Abstract: The cellular localization of the two forms of catechol‐O‐methyltransferase (COMT) was investigated by measuring their activities in rat striatum following unilateral stereotaxic injection of kainic acid, which causes degeneration of striatal neurons followed by proliferation of astroglial cells. (psu.edu)
Emotional1
Little is known, however, about the relationship between catechol-O-methyltransferase activity and the specific mental and emotional problems characteristic of this condition. (medlineplus.gov)
Brain7
Rivett, AJ , Francis, A & Roth, JA 1983, ' Distinct Cellular Localization of Membrane‐Bound and Soluble Forms of Catechol‐O‐Methyltransferase in Brain ', Journal of neurochemistry , vol. 40, no. 1, pp. 215-219. (psu.edu)
The longer form, called membrane-bound catechol-O-methyltransferase (MB-COMT), is chiefly produced by nerve cells in the brain. (medlineplus.gov)
In the brain, catechol-O-methyltransferase helps break down certain chemical messengers called neurotransmitters. (medlineplus.gov)
Catechol-O-methyltransferase is particularly important in an area at the front of the brain called the prefrontal cortex, which organizes and coordinates information from other parts of the brain. (medlineplus.gov)
Catechol-O-methyltransferase helps maintain appropriate levels of these neurotransmitters in this part of the brain. (medlineplus.gov)
Catechol-O-methyl transferase (COMT) inhibitors (COMT-i) are used as first-line adjuvant therapy to L-dopa for end-of-dose (EoD) motor fluctuations, since they increase L-dopa availability in the brain by inhibiting its peripheral metabolism. (dovepress.com)
Catechol-O-methyl transferase (COMT) inhibitors are currently used as add-on therapy to L-Dopa for the treatment of end-of-dose motor fluctuations, as they inhibit peripheral L-Dopa metabolism and increase its delivery to the brain. (dovepress.com)
Effects1
PMID 15505638 ] Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia. (snpedia.com)
Structure1
Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT. (wikipedia.org)
Results1
These results indicate that the K m membrane‐bound catechol‐O‐methyltransferase may be localized predominantly in neurons, whereas the high‐K m soluble enzyme is found in glial cells. (psu.edu)
Shown1
Catechol-O-methyltransferase is shown in green boxes. (en-academic.com)
Attention1
PMID 15635644 ] A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD). (snpedia.com)
Activities1
Chemical Profiles of Korean Bee Pollens and Their Catechol-O-methyltransferase Inhibitory Activities. (acs.org)