• The acyl carrier protein (ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. (wikipedia.org)
  • The structures of a number of acyl carrier proteins have been solved using various NMR and crystallography techniques. (wikipedia.org)
  • This coupling is mediated by acyl carrier protein synthase (ACPS), a 4'-phosphopantetheinyl transferase. (wikipedia.org)
  • 4'-Phosphopantetheine is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). (wikipedia.org)
  • Here, the structure of the third enzyme in the FAS pathway, 3-ketoacyl-(acyl-carrier-protein) reductase, is reported at a resolution of 2.25 Å. (rcsb.org)
  • β-Ketoacyl-(acyl carrier protein) reductase (FabG) catalyzes the key reductive reaction in the elongation cycle of fatty acid synthesis (FAS), which is a vital metabolic pathway in bacteria and a promising target for new antibiotic development. (rcsb.org)
  • Acyl carrier proteins are critical components of fatty acid and polyketide biosynthesis. (rsc.org)
  • Selectivity for the holo over apo -form of acyl carrier proteins is demonstrated indicating that only the phosphopantetheine - thiol is modified. (rsc.org)
  • beta-Ketoacyl-acyl carrier protein synthetase. (brenda-enzymes.org)
  • Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • An enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein] in the fatty acid biosynthesis pathway. (umassmed.edu)
  • This graph shows the total number of publications written about "Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" by people in this website by year, and whether "Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" was a major or minor topic of these publications. (umassmed.edu)
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  • The ivy enzyme can also act on oleoyl-[acyl-carrier protein] and palmitoleoyl-[acyl-carrier protein], generating the corresponding 4,9-diene. (expasy.org)
  • This product represents a full-length Acyl carrier protein (ACP), a vital component involved in the initiation and elongation steps of fatty acid synthesis in Staphylococcus aureus, an organism known for its robust resistance mechanisms and implications in human health. (cusabio.com)
  • to get instant updates about '3-Oxoacyl-(Acyl-Carrier-Protein) Reductase' on your MyPage . (rediff.com)
  • Other names in common use include beta-ketoacyl-(ACP) reductase , beta-ketoacyl acyl carrier protein (ACP) reductase , beta-ketoacyl reductase , beta-ketoacyl thioester reductase , beta-ketoacyl-ACP reductase , beta-ketoacyl-acyl carrier protein reductase , 3-ketoacyl acyl carrier protein reductase , NADPH-specific 3-oxoacyl-reductase , and 3-oxoacyl-reductase . (rediff.com)
  • For detailed information about pimeloyl-[acyl-carrier protein] synthase, go to the full flat file . (brenda-enzymes.de)
  • Beta ketoacyl acyl carrier protein synthase II (KASII) from Synechocystis sp. (expasy.org)
  • A crucial step in using peptides as antigens is their coupling to carrier proteins. (gbiosciences.com)
  • The carrier proteins, once coupled to the peptides, provide these additional motifs and generate a strong antibody response. (gbiosciences.com)
  • The carrier proteins are coupled to haptens, including peptides and small proteins, with the use of protein cross-linkers. (gbiosciences.com)
  • ActiveHOOK™ carrier proteins have been pre-activated with the heterobifunctional protein cross linker sulfoSMCC and therefore are ready for the addition of cysteine containing peptides or proteins for a simple one step reaction. (gbiosciences.com)
  • The ActiveHOOK™ BSA rapidly couples to free sulfhydryl groups on peptides and proteins. (gbiosciences.com)
  • Keyhole limpet hemocyanin is a widely used carrier protein due to its large molecular mass (4.5x105-1.3x107Da aggregates) and large number of primary amines that can react with cross-linkers for the coupling of peptides. (gbiosciences.com)
  • Construction of safe and effective delivery systems for proteins and peptides is demand of current clinical practices. (eurekaselect.com)
  • In this present review we have summarized various aspects related to the formulation and processing of biodegradable polymerized microparticles/ nanoparticles for delivery of therapeutic proteins and peptides. (eurekaselect.com)
  • Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)
  • By increasing the number of viral peptides per enzyme monomer, the average IC50 of hybrid proteins in a competitive enzyme-linked immunosorbent assay) have decreased to values close to that presented by natural virions. (uab.cat)
  • Owing to its small genome (about 800 protein-coding genes), it relies on the host for many basic biosynthetic processes, hindering the identification of potential antipathogenic drug targets. (rcsb.org)
  • Survival was generally better than that observed among patients with hypertrophic cardiomyopathy caused by other mutations in the genes for sarcomere proteins. (nih.gov)
  • In the majority of cases, Rf genes produce proteins that act directly on the CMS conferring mitochondrial transcripts by binding them specifically and promoting processing events. (frontiersin.org)
  • In the majority of cases, Rf genes produce proteins that bind specifically to the CMS conferring transcripts in the mitochondria and promote processing events leading to a strong reduction in the production of mitochondrial CMS-inducing proteins (reviewed in Chen and Liu, 2014 ). (frontiersin.org)
  • Survival of Motor Neuron 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • The new rules were established with the coordinated efforts of staff from MeSH, NCBI and scientists working in the field of HMG protein research. (bvsalud.org)
  • The ACPs are related in structure and mechanism to the peptidyl carrier proteins (PCP) from nonribosomal peptide synthases. (wikipedia.org)
  • Here, a plasmid carrying specific shDNA (SHT-DNA), small interfering RNA (siRNA), and the peptide (P-17) were loaded separately into folic acid (FA)-functionalized nano-carriers made of Bovine Serum Albumin (BSA). (cnr.it)
  • Structure of the complex between teicoplanin and a bacterial cell-wall peptide: use of a carrier-protein approach. (anl.gov)
  • A carrier-protein strategy was used to crystallize the complex of teicoplanin and its target peptide by fusing the cell-wall peptide to either MBP or ubiquitin via native chemical ligation and subsequently crystallizing the protein-peptide-antibiotic complex. (anl.gov)
  • In addition, a multidimensional antigenic analysis have grouped together the multiple-inserted proteins with the native virus, suggesting that increasing the number of insertions could be a good strategy to reproduce the antigenic properties of an immunoreactive peptide in a natural multimeric disposition. (uab.cat)
  • Feliu, JX, Carbonell, X & Villaverde, A 2000, ' Successful mimicry of a complex viral antigen by multiple peptide insertions in a carrier protein ', FEBS Letters , vol. 474, pp. 87-92. (uab.cat)
  • The two building blocks of the carrier, (BSA and FA) were used because of the high affinity of albumin for liver and for the overexpression of folate receptors on the membrane of hepatocellular carcinoma cells. (cnr.it)
  • Originated from the Staphylococcus aureus strain Mu50 / ATCC 700699, this recombinant acpP protein is expressed in an E.coli system and includes the complete sequence of 1-77 amino acids. (cusabio.com)
  • The carrier proteins that have been used include Tetanus toxoid (TT), Diphtheria toxoid (DT) and KLH. (biosyncorp.com)
  • Evaluation of the non-toxic mutant of the diphtheria toxin K51E/E148K as carrier protein for meningococcal vaccines. (ox.ac.uk)
  • Diphtheria toxin mutant CRM197 is a common carrier protein for glycoconjugate vaccines, which has been proven an effective protein vector for, among others, meningococcal carbohydrates. (ox.ac.uk)
  • Cross-talk between plant cells and their surroundings requires tight regulation of information exchange at the plasma membrane (PM), which involves dynamic adjustments of PM protein localization and turnover to modulate signal perception and solute transport at the interface between cells and their surroundings. (cas.cz)
  • The direction of auxin flow between cells is closely related to the polar localization of PIN proteins in cells. (chinbullbotany.com)
  • Of the many different immunotherapeutic vaccine technologies, vaccine formulation using the antigen coupled to carrier proteins has made tremendous progress in the clinic. (biosyncorp.com)
  • Carrier of the growing fatty acid chain in fatty acid biosynthesis. (cusabio.com)
  • The PIN protein contains a central hydrophilic loop (HL) and two separated hydrophobic regions, and the multiple phosphorylation sites on HL are the targets of protein kinases. (chinbullbotany.com)
  • Most of the transporters that had been characterized to date as Cs + transporters are directly or indirectly linked to K + . Using a combinatorial approach of physiology, genetics, cell biology and root uptake assay, here we identified two ATP-Binding Cassette (ABC) proteins, ABCG37 and ABCG33 as facilitators of Cs + influx. (u-tokyo.ac.jp)
  • Mammalian cells are devoid of folate biosynthesis and are therefore folate auxotrophs that take up folate vitamins primarily via the reduced folate carrier (RFC). (aspetjournals.org)
  • In this work, we decided to study for the first time the formation and the evolution of PC on the surface of nanostructured lipid carriers loaded with superparamagnetic iron oxide nanoparticles, before and after the crossing of an in vitro model of the blood-brain barrier (BBB). (tue.nl)
  • BACKGROUND: Bacterial infection causes accumulation of neutrophils that release antimicrobial proteins including heparin-binding protein (HBP). (lu.se)
  • Several isocyanate /protein conjugates were prepared using strain B6D2F1-mice concerning the induction of homocytotropic antibody suggested that the murine model of isocyanate induced homocytotropic antibody would be a convenient method of assessing the reliability and reproducibility of various isocyanate /protein reagents. (cdc.gov)
  • Overall, our data indicate that DT-K51E/E148K is a readily produced protein that now allows the added flexibility of E. coli production in vaccine development and that can be effectively used as protein carrier for a meningococcal conjugate vaccine. (ox.ac.uk)
  • Instead, testing should focus on physicochemical tests to monitor consistency of production of the polysaccharide, the protein carrier and the bulk conjugate. (who.int)
  • Conjugation with a protein carrier improves the effectiveness of polysaccharide vaccines by inducing T-lymphocyte-dependent immunologic function ( 2 ). (cdc.gov)
  • Meningococcal serogroup A (MenA) glycoconjugates were synthesized using CRM197 and DT-K51E/E148K as carrier proteins, obtaining the same conjugation yields and comparable biophysical profiles. (ox.ac.uk)
  • In humans the protein is encoded by a single gene found near the inversion telomere of a large inverted region of CHROMOSOME 5. (harvard.edu)
  • Here, we describe the fate of Arabidopsis PIN2 protein, required for directional cellular efflux of the phytohormone auxin, and identify cis- and trans-acting mediators of PIN2 ubiquitylation. (cas.cz)
  • Here we reviewed the research progress of PIN protein in Arabidopsis thaliana and cereal crops from the aspects of protein structure, activity regulation and functional verification to provide new ideas and clues for exploring the auxin polar transport mediated by PIN protein family. (chinbullbotany.com)
  • This graph shows the total number of publications written about "Survival of Motor Neuron 1 Protein" by people in Harvard Catalyst Profiles by year, and whether "Survival of Motor Neuron 1 Protein" was a major or minor topic of these publication. (harvard.edu)
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  • The ACPs are small negatively charged α-helical bundle proteins with a high degree of structural and amino acid similarity. (wikipedia.org)
  • SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)
  • Here we report the findings of structural, enzymatic, and binding studies of the FabG protein found in the causative agent of cholera, Vibrio cholerae (vcFabG). (rcsb.org)
  • B)Structural model of PIN protein with a short HL. (chinbullbotany.com)
  • This review critically focuses on opportunities to employ protein-graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. (mdpi.com)
  • In planta short term radioactive Cs + -uptake assay along with the growth and uptake assays in heterologous system confirmed ABCG33 and ABCG37 as Cs + -uptake carriers. (u-tokyo.ac.jp)
  • Potassium response and content were unaffected in the double mutant background and the yeast cells lacking potassium uptake carriers transformed with ABCG33 and ABCG37 failed to grow in absence of K + , confirming that Cs + uptake by ABCG33 and ABCG37 is independent of K + . Collectively, this work identified two ABC proteins as new Cs + -influx carriers, which act redundantly and independent of K + -uptake pathway. (u-tokyo.ac.jp)
  • They function as carriers to the cell surface in post-golgi recycling pathways. (nih.gov)
  • These findings suggest that these protein family members may function at the same site during vesicular transport rather than in separate pathways. (nih.gov)
  • Carrier protein specificity was also demonstrated. (cdc.gov)
  • It is one of the most abundant proteins in cells of E. coli. (wikipedia.org)
  • Likewise, cycloheximide inhibition of RBP accumulation followed a pattern similar to that of hepatic general protein synthesis. (iisc.ac.in)
  • Upon coming into contact with the biological environment, nanostructures are immediately covered by biomolecules, particularly by proteins forming the so-called "protein corona" (PC). (tue.nl)
  • In addition, biodegradable polymers based carriers designed for vaccine delivery has been incorporated in detail. (eurekaselect.com)
  • The wide-range use of this protein in massive vaccine production requires constant increase of production yields and adaptability to an ever-growing market. (ox.ac.uk)
  • Over the last several years, KLH has been routinely used as carrier protein in laboratory animal studies to enhance immune responses to administered antigens. (biosyncorp.com)
  • DNA sequences encoding cardiac myosin-binding protein C were determined in unrelated patients with familial hypertrophic cardiomyopathy. (nih.gov)
  • Early results suggest that specific cell mediated immunity can be induced by parenteral immunization of Hartley-guinea-pigs with isocyanate /protein conjugates emulsified in complete Freund's adjuvant. (cdc.gov)
  • Biodegradable polymers based particulates carriers fulfill much of the requirement in this applicable field. (eurekaselect.com)
  • Number of marketed products related to biodegradable polymers encapsulating proteins is increasing. (eurekaselect.com)
  • Functionalized biodegradable carrier(s) for site specific delivery of proteineous matter has also been discussed. (eurekaselect.com)
  • This data will allow for analysis of the selected steroid hormones and related binding protein that can be used to assist in disease diagnosis, treatment, and prevention of diseases, such as Polycystic Ovary Syndrome (PCOS), androgen deficiency, certain cancers, and hormone imbalances. (cdc.gov)
  • Binding to and carrying a protein between two different cellular components by moving along with the target protein. (ntu.edu.sg)
  • Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. (cusabio.com)
  • In animals and fungi, turnover of PM proteins is controlled by reversible ubiquitylation, which signals endocytosis and delivery to the cell's lytic compartment, and there is emerging evidence for related mechanisms in plants. (cas.cz)
  • Toward this end, a hemagglutinin (HA) epitope tagged hRFC (hRFC-HA) was introduced into a bicistronic vector (pIRES2-EGFP), upstream of an enhanced green fluorescent protein (EGFP) reporter gene. (aspetjournals.org)
  • Directly binding to a specific protein and delivering it to a specific cellular location. (yeastgenome.org)
  • The polar transport of auxin mainly depends on three transporters: AUX/LAX, PIN and ABCB protein families. (chinbullbotany.com)