AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
Cardioplegic SolutionsHeart Arrest, InducedMyocardial Reperfusion InjuryCardiopulmonary BypassMyocardiumPotassium ChlorideCoronary Artery BypassHeartSolutions
RetrogradeCrystalloidCardiopulmonary bypassArrestNECCReperfusionBretschneiderHospitalHypothermiaIntracellularMyocardial cellsInduce cardiacHistidine-tryptophan-keSystemicMyocardiumDecreasesAdenosineCardioplegia solutionLidocaineCardiac indexCommonlyHeartBloodResultsVehicleStopColdAdultsHeartsGroupTypeSingleContent
Retrograde3
  • Cardioplegic solution was delivered in antegrade and retrograde fashion in both groups. (tubitak.gov.tr)
  • Myocardial distribution of cardioplegic solution after retrograde delivery in patients undergoing cardiac surgical procedures. (rush.edu)
  • iii) retrograde infusion of St. Thomas' Hospital cardioplegic solution. (unipi.it)
Crystalloid2
  • Accordingly, we performed myocardial contrast echocardiography in 12 dogs undergoing cardiopulmonary bypass and measured the myocardial transit rate of microbubbles injected into the aortic root during delivery, of cardioplegic solutions containing arterial and venous blood and delivery of pure crystalloid cardioplegic solution. (elsevierpure.com)
  • Then the aorta is cross-clamped and the heart is stopped by injection of a cardioplegic solution (crystalloid or more commonly blood-based) that also contains substances that help myocardial cells tolerate ischemia and reperfusion. (msdmanuals.com)
Cardiopulmonary bypass1
  • Do … The potential for enhancing myocardial protection by adding high-energy phosphates to cardioplegic solutions was investigated in a rat heart model of cardiopulmonary bypass and ischemic arrest. (jrpole.com)
Arrest12
  • Myocardial contrast echocardiography was also performed in 12 patients undergoing coronary artery bypass who underwent sequential arterial and venous reperfusion after cardioplegic arrest. (elsevierpure.com)
  • Our results indicate that endothelial dysfunction after cardioplegic arrest may be ameliorated by reperfusion with venous rather than arterial blood. (elsevierpure.com)
  • Isolated rat hearts perfused with Krebs-Henseleit buffer were subjected to 30min of normothermic perfusion, then 4h of cardioplegic arrest at 4°C with St Thomas' Hospital solution, followed by reperfusion for 2h. (portlandpress.com)
  • Thus we conclude that ECE mRNA expression is increased following prolonged hypothermic cardioplegic arrest. (portlandpress.com)
  • The surgeon plans on using a clear pump prime with a hyperpolarized cardioplegic arrest. (ccasociety.org)
  • Which cardioplegia solution produces a hyperpolarized cardiac arrest? (ccasociety.org)
  • The ability to induce cardiac arrest and facilitate open-heart surgery by infusing a high potassium-containing solution into the coronaries was first demonstrated by Melrose et al. (ccasociety.org)
  • Cardioplegic solutions cause diastolic arrest, decrease cardiac metabolic demand, and improve myocardial tolerance to ischemia. (ccasociety.org)
  • Extracellular cardioplegic solutions often contain high concentrations of sodium (Na + ), calcium (Ca 2+ ), potassium (K + ), magnesium (Mg 2+ ), and bicarbonate and cause cardiac arrest by depolarizing the myocardial membrane. (ccasociety.org)
  • These solutions induce a hyperpolarizing arrest of the myocardium which decreases energy consumption and intracellular accumulation of Ca 2+ . (ccasociety.org)
  • HTK solution is particularly useful for long complex repairs as it reliably produces cardiac arrest for up to 120 minutes without redosing. (ccasociety.org)
  • Hyperkalemic cardioplegic solutions effectively arrest the heart but also induce membrane depolarization, which could lead to intracellular Ca 2+ loading and contribute to ventricular dysfunction associated with cardiac operations. (elsevierpure.com)
NECC1
  • In addition, one transplant patient with Aspergillus fumigatus infection who was administered NECC cardioplegic solution during surgery has been reported. (brandilaw.com)
Reperfusion2
  • Both administration of cardioplegic solution and blood reperfusion result in endothelial dysfunction. (elsevierpure.com)
  • A compounding factor in critically ill or cardiac surgical patients with compromised circulation is that the glycocalyx is easily disrupted by hypoxia, 6 by use of cold cardioplegia solutions, 7 and with ischemia-reperfusion. (silverchair.com)
Bretschneider2
  • Histidine-tryptophan-ketoglutarate (HTK) solution (Custodiol HTK®/Bretschneider solution) is an intracellular cardioplegic solution that was introduced in the 1970s. (ccasociety.org)
  • A single dose of 2,000 ml Bretschneider™ cardioplegic solution was used. (figshare.com)
Hospital3
  • The Buckberg and St. Thomas' Hospital cardioplegia solutions both contain high K + content and are delivered with blood. (ccasociety.org)
  • demonstrated a six-fold decrease in the rate of defibrillation post cross-clamp with del Nido cardioplegia compared to the St. Thomas Hospital solution. (ccasociety.org)
  • Hospital cardioplegic solution. (jrpole.com)
Hypothermia1
  • In the third and fourth groups, in addition to 28ºC systemic hypothermia, coronary infusion of 4ºC cardioplegic solutions were performed immediately and after 30 minutes of clamping of the aorta. (rbccv.org.br)
Intracellular2
  • Intracellular cardioplegia solutions have low levels of Na + and Ca 2+ mimicking the intracellular electrolyte concentration. (ccasociety.org)
  • Hyperkalemic solutions induced intracellular Ca 2+ loading (estimated intracellular Ca 2+ concentration, 88 ± 5 nmol/L before and 1,825 ± 112 nmol/L after addition of 16 mmol/L KCl). (elsevierpure.com)
Myocardial cells1
  • We may conclude that both cardioplegic solutions used, associated to hipothermia, protect efficiently the myocardial cells against anoxia. (rbccv.org.br)
Induce cardiac1
  • Cardioplegic solution is used to induce cardiac muscle paralysis during open heart surgery to prevent injury to the heart. (brandilaw.com)
Histidine-tryptophan-ke1
  • An example of a low [K+] low [Na+] solution is histidine-tryptophan-ketoglutarate. (wikipedia.org)
Systemic1
  • bed into the left ventricle, from where or intramyocardial, However, when a Most patients with calcification of it could reach any part of the body cyst is located in subendocardial en- the cyst wall remain asymptomatic for through systemic circulation [1-3]. (who.int)
Myocardium4
  • As the cardioplegia solution distributes to the entire myocardium, the ECG will change and eventually asystole will ensue. (wikipedia.org)
  • Cardioplegic solution is the means by which the ischemic myocardium is protected from cell death. (wikipedia.org)
  • The del Nido cardioplegia solution was developed for pediatric cardiac surgery due to the specific needs of an immature and developing myocardium. (ccasociety.org)
  • Electron microscopy also showed less edema of the myocardium and better myofibrillar architecture with del Nido solution. (ccasociety.org)
Decreases1
  • Chemically, the high potassium concentration present in most cardioplegic solutions decreases the membrane resting potential of cardiac cells. (wikipedia.org)
Adenosine2
  • Adenosine, which possesses cardioprotective properties, has been proposed as an adjunct to conventional cardioplegic solutions. (elsevierpure.com)
  • The property of adenosine to prevent hyperkalemia-induced Ca 2+ loading may contribute to the cytoprotective efficacy of this agent as an adjunct to conventional hyperkalemic cardioplegic solutions. (elsevierpure.com)
Cardioplegia solution1
  • There is no consensus regarding the "best" cardioplegia solution. (ccasociety.org)
Lidocaine2
  • To mitigate this effect, contemporary depolarizing cardioplegia solutions contain lidocaine and magnesium. (ccasociety.org)
  • Del Nido cardioplegia includes lidocaine and magnesium and is categorized as a modified extracellular depolarizing solution. (ccasociety.org)
Cardiac index1
  • The myocardial protective effects of these 2 different cardioplegic temperatures were compared in terms of the postoperative cardiac index and left ventricle stroke work index, dopamine and dobutamine requirements in the intensive care unit, intra aortic balloon pump requirement, intensive care unit stay length and mortality ratios. (tubitak.gov.tr)
Commonly1
  • Most commonly, however, the word cardioplegia refers to the solution used to bring about asystole of the heart, or heart paralysis. (wikipedia.org)
Heart2
Blood4
  • Given the relatively low circulating blood volume of newborns and infants compared with that of adults, the priming solution in the CPB circuit plays an important role in hemodilution. (medscape.com)
  • The red blood cell transit rate remained constant regardless of the cardioplegic perfusate infused. (elsevierpure.com)
  • It was not possible, however, to demonstrate any superiority of the blood solution over an acellular solution. (rbccv.org.br)
  • However, a recent 2018 study by Panigrahi et al suggests that the del Nido solution may offer some additional benefits including quicker resumption of normal cardiac rhythm and decreased inotropic support compared to conventional blood cardioplegia. (ccasociety.org)
Results1
  • Our results indicate that cardioplegic solution-enriched with hypoxic CM-BMSCs can be a novel and promising preservation solution for donor hearts. (researchsquare.com)
Vehicle1
  • Donor hearts were explanted, stored in cardioplegic solution supplemented with either a medium (Vehicle), normoxic CM (N-CM), or hypoxic CM (H-CM), and then heterotopically transplanted. (researchsquare.com)
Stop1
Cold1
  • The main goals of hypothermic cardioplegia are: Immediate and sustained electromechanical quiescence Rapid and sustained homogeneous myocardial cooling Maintenance of therapeutic additives in effective concentrations Periodic washout of metabolic inhibitors The most common procedure for accomplishing asystole is infusing cold cardioplegic solution into the coronary circulation. (wikipedia.org)
Adults1
  • Studies in adults have also shown benefit of the del Nido solution and it is used in many adult centers. (ccasociety.org)
Hearts1
  • Evaluation of myocardial protection by cardioplegic solutions and hipothermia in anoxic hearts. (rbccv.org.br)
Group2
  • In the first group (control), myocardial anoxia was induced in normothermia and no cardioplegic solution was administered. (rbccv.org.br)
  • In the second group, the body temperature was reduced to 28ºC before the onset of myocardial anoxia, and no cardioplegic solution was used. (rbccv.org.br)
Type1
  • A cardioplegic solution has been implicated as well as another type of steroid used for back injections. (castellilaw.com)
Single1
  • You then realise that you have never actually read a single paper on the comparison between these two solutions even though you use it every day and resolve to look up the evidence. (bestbets.org)
Content1
  • The higher cellular edema seen with the HTK solution may be related to its very low sodium content. (ccasociety.org)