• IgA cardiolipin antibody is occasionally detected in SLE and SLE-like patients and appears to be most commonly associated with cerebrovascular thrombosis. (umich.edu)
  • What is the purpose of a cardiolipin antibody test? (ganeshdiagnostic.com)
  • The product Assay kit for Guinea pig anti-cardiolipin antibody IgG,ACA-IgG (ELISA) should be kept between two and eight degrees Celsius to ensure the retention of the stability and reactivity of the reagents included in the kit. (igganti.com)
  • The product Assay kit for Guinea pig anti-cardiolipin antibody IgG,ACA-IgG (ELISA) is intended to be used for research purposes only. (igganti.com)
  • What are the benefits of CARDIOLIPIN ANTIBODY (ACL) - IGA Full Body Checkup? (hellodox.com)
  • The Diagnostic Automation Cardiolipin IgA, G, M ELISA kit is a solid phase enzyme immunoassay employing highly purified cardiolipin plus native human Beta2-glycoprotein I for the combined semi-quantitative and qualitative detection of IgA, IgG and IgM antibodies against cardiolipin in human serum. (rapidtest.com)
  • Antibodies against cardiolipin belong to the group of anti-phospholipid antibodies specific for negatively charged phospholipids, components of biological membranes.Cardiolipin is an acidic phospholipid derived from glycerol and was named because of its isolation from bovine heart in 1941. (rapidtest.com)
  • The occurrence of anti-cardiolipin antibodies in patients with SLE and related diseases is typical for a secondary anti-phospholipid syndrome (APS). (rapidtest.com)
  • In contrast, anti-cardiolipin antibodies in patients with no other autoimmune diseases characterize the primary anti-phospholipide syndrome (APS). (rapidtest.com)
  • Anti-cardiolipin antibodies mainly recognize specific epitopes on a complex composed out of cardiolipin and Beta2-glycoprotein I which are expressed only when Beta2-glycoprotein I interacts with cardiolipin. (rapidtest.com)
  • Rational Laboratory Diagnostics of Antiphospholipid Antibodies: Anti-Cardiolipin, Anti-β2-Glycoprotein I, Anti-Prothrombin and Anti-Annexin V Antibodies. (ncbcs.org)
  • Human cardiolipin screen ELISA kit is a procedure for screening in vitro quantitative concentrations of IgG, IgM and IgA auto-antibodies to screen cardiolipin (cardiolipin-IgG, cardiolipin-IgM, cardiolipin-IgA) in human serum and plasma. (elisakits.co.uk)
  • The minimum detection sensitivity level of IgG, IgA or IgM antibodies to screen cardiolipin (cardiolipin-IgG, cardiolipin-IgA, cardiolipin-IgM) using current cardiolipin ELISA kit was 1.0 U/ml. (elisakits.co.uk)
  • Anti Cardiolipin IgM kit is an indirect solid phase immunoassay kit for the quantitative measurement of IgM class auto-antibodies directed against Cardiolipin-β2-glycoprotein complex in human serum or plasma. (diametra.com)
  • REAADS Anti-Cardiolipin (aCL) IgA is an ELISA for the determination of IgA anti-cardiolipin antibodies in human serum or plasma in individuals with systemic lupus erythematosus (SLE) and lupus-like disorders (anti-phospholipid syndrome). (diapharma.com)
  • Diluted serum samples, calibrator sera, and controls are incubated in cardiolipin coated microwells, allowing aCL antibodies present in the samples to react with the immobilized antigen. (diapharma.com)
  • After the removal of unbound serum proteins by washing, antibodies specific for human IgA labeled with horseradish peroxidase (HRP) are added forming complexes with the cardiolipin bound antibodies. (diapharma.com)
  • Cardiolipin antibodies present in the sample will bind to the coated wells. (diapharma.com)
  • The blood test for cardiolipin antibodies, IgA, IgG, and IgM, is used to assess for antiphospholipid syndrome and occasionally other autoimmune illnesses, as well as to help discover the cause of recurrent miscarriage. (ganeshdiagnostic.com)
  • Tests for cardiolipin antibodies typically produce a positive or negative outcome. (ganeshdiagnostic.com)
  • By accident, the antibodies assault cardiolipins. (ganeshdiagnostic.com)
  • Why are cardiolipin antibodies so high? (ganeshdiagnostic.com)
  • How are cardiolipin antibodies managed? (ganeshdiagnostic.com)
  • Unusual cardiolipin antibodies: what are they? (ganeshdiagnostic.com)
  • Both cerebrospinal fluid (CSF) immunologic abnormalities and serum anti-cardiolipin antibodies (aCL) have been reported in patients with HIV-1 infection. (usuhs.edu)
  • Antiphospholipid antibodies, including cardiolipin, are common in lupus. (arthritis.org)
  • The RPR test measures IgM and IgG antibodies to lipoidal material released from damaged host cells, as well as to lipoprotein-like material and possibly cardiolipin released from the treponemes. (cdc.gov)
  • The aCL antibodies bind to b2GPI, or a complex formed by this b2GPI is a platelet adhesin glycoprotein and cardiolipin. (medscape.com)
  • The phospholipid cardiolipin is only found in mitochondrial membranes, making them special within the cell. (ganeshdiagnostic.com)
  • The mitochondrial signature phospholipid cardiolipin shows a stabilizing function on Mic10 oligomers. (rug.nl)
  • Here we show that synthesis of the mitochondrial phospholipid cardiolipin is indispensable for stimulating and sustaining thermogenic fat function. (ku.dk)
  • Anti-Cardiolipin IgA ist ein auf der ELISA Technik basierendes, automatisiertes In-vitro-Testsystem für die quantitative Bestimmung von IgA-Antikörpern gegen Cardiolipin in humanem Serum oder Plasma. (orgentec.com)
  • Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin. (cdc.gov)
  • This strain produced triglycerides (TG) as well as four common phospholipids: phosphatidylethanolamine (PE), phosphatidylglycerol (PG), cardiolipin (CL) and lysocardiolipin (LCL). (nature.com)
  • A highly purified cardiolipin is coated on micro-wells saturated with beta-2 glycoprotein I. (elisakits.co.uk)
  • Finally, a molecule of CDP-DAG is bound to PG to form one molecule of cardiolipin, catalyzed by the mitochondria-localized enzyme cardiolipin synthase (CLS). (wikipedia.org)
  • In prokaryotes such as bacteria, diphosphatidylglycerol synthase catalyses a transfer of the phosphatidyl moiety of one phosphatidylglycerol to the free 3'-hydroxyl group of another, with the elimination of one molecule of glycerol, via the action of an enzyme related to phospholipase D. The enzyme can operate in reverse under some physiological conditions to remove cardiolipin. (wikipedia.org)
  • Mimicking this response through overexpression of cardiolipin synthase (Crls1) enhances energy consumption in mouse and human adipocytes. (ku.dk)
  • In stationary phase, cardiolipin synthase activity has been observed to increase approximately 10-fold in the Gram-negative model organism Escherichia coli , suggesting CL is an essential membrane component to cope with starvation 4 . (nature.com)
  • The interaction of mitochondrial cytochrome (cyt) c with cardiolipin (CL) is involved in the initial stages of apoptosis. (essex.ac.uk)
  • We have utilized bovine heart cardiolipin as well as commercially available tetralinoleoyl cardiolipin oxidized with cytochrome c (cyt c) and hydrogen peroxide as well as with lipoxygenase to test the separation power of the system. (cdc.gov)
  • A role of flavonoids in cytochrome c-cardiolipin interactions. (nih.gov)
  • Assays of cardiolipin_levels. (elisakits.co.uk)
  • Some researchers suggest the use of PS instead of Cardiolipin in ELISA assays, for a more precise diagnosis. (diametra.com)
  • Briefly, CD8+ T cells, responsible for fighting infections and safeguarding our organism from cancer, rely on the presence of cardiolipin and on its regulated synthesis and remodeling to properly activate, expand and eliminate pathogens or tumor cells. (barthsyndrome.org)
  • Regulation of cardiolipin synthesis and the role of this phospholipid in adriamycin-i . . ." by Diego. (wayne.edu)
  • Phospholipase D (PLD) in the mitochondrion hydrolyses cardiolipin to phosphatidic acid. (wikipedia.org)
  • ATRA perturbs the homeostasis of numerous lipids and the most relevant effects are observed on cardiolipins, which are located in the mitochondrial inner membranes and play a role in oxidative-phosphorylation. (slub-dresden.de)
  • Alle Anti-Cardiolipin-Tests von ORGENTEC sind mit humanem beta-2-Glycoprotein I als Kofaktor beschichtet. (orgentec.com)
  • Autoantibodies (IgA/G/M) targeting cardiolipin and β 2 glycoprotein-I and specific nuclear antigens were analyzed by multiplexed bead technology. (lu.se)
  • Results: Both prevalence and titers of aPL of the IgG isotype (anti-cardiolipin and/or anti-β 2 glycoprotein-I) were higher in patients with MINOCA and MICAD than in controls. (lu.se)
  • Divisible Microplate: Consisting of 12 modules of 8 wells, highly purified human cardiolipin is bound to microwells. (elisakits.co.uk)
  • In mammalian cells, but also in plant cells, cardiolipin (CL) is found almost exclusively in the inner mitochondrial membrane, where it is essential for the optimal function of numerous enzymes that are involved in mitochondrial energy metabolism. (wikipedia.org)
  • Cardiolipin is the distinctive inner mitochondrial membrane phospholipid coupling structure with metabolism and signaling function. (barthsyndrome.org)
  • Metabolism and function of mitochondrial cardiolipin. (elisakits.co.uk)
  • Some isoforms may be involved in cardiolipin metabolism. (lu.se)
  • For instance, cardiolipin, an anionic phospholipid, has been found to be associated to a number of eukaryotic and prokaryotic respiratory complexes. (pasteur.fr)
  • In this review, we describe current knowledge of the functions associated with cardiolipin binding to respiratory complexes in prokaryotes as a frame to discuss how specific lipid binding may tune their reactivity towards quinone and participate to supercomplex formation of both aerobic and anaerobic respiratory chains. (pasteur.fr)
  • Among these, the Cardiolipin is the most commonly used phospholipid as an antigen for determining the aPL by ELISA method. (diametra.com)
  • There is evidence to suggest that the cardiolipin net content of MOM is elevated during the process of apoptosis. (elisakits.co.uk)
  • The tafazzin protein is involved in altering a fat (lipid) called cardiolipin, which plays critical roles in the mitochondrial inner membrane. (medlineplus.gov)
  • Once altered by tafazzin, cardiolipin is key in maintaining mitochondrial shape, energy production, and protein transport within cells. (medlineplus.gov)
  • Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane. (bvsalud.org)
  • Of note, investigating further the effects of cardiolipin deficiency or modification (oxidation/saturation) in the adaptive immune response is pivotal in the context of current (Tazpower) or future trials impacting cardiolipin remodeling and/or oxidation. (barthsyndrome.org)
  • We utilized three types of biological tissues and oxidative insults, namely rotenone treatment of lymphocytes to induce mitochondrial damage and cell death, pulmonary inhalation exposure to single walled carbon nanotube s, as well as total body irradiation, in order to identify cardiolipin oxidation products, critical to the cell damage/cell death pathways in these tissues following cellular stress/injury. (cdc.gov)
  • Our results indicate that selective cardiolipin (CL) oxidation is a result of a non-random free radical process. (cdc.gov)
  • Whether this might be mediated by the reduction or loss of cardiolipin or the accumulation of specific cardiolipin species, how this could happen and whether this could exacerbate or worsen muscle condition in Barth syndrome patients will be the core of this project. (barthsyndrome.org)
  • Moreover, polar and septal accumulation of cardiolipin in a number of prokaryotes may ensure proper spatial segregation and/or activity of proteins. (pasteur.fr)
  • First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. (elisakits.co.uk)
  • As there are four distinct alkyl chains in cardiolipin, the potential for complexity of this molecule species is enormous. (wikipedia.org)
  • However, in most animal tissues, cardiolipin contains 18-carbon fatty alkyl chains with 2 unsaturated bonds on each of them. (wikipedia.org)
  • Cardiolipin (IUPAC name 1,3-bis(sn-3'-phosphatidyl)-sn-glycerol, "sn" designating stereospecific numbering) is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid composition. (wikipedia.org)
  • Cardiolipin bicyclic structure Structure of NAO NAO & CL arranged in a highly ordered way The detection, quantification, and localisation of CL species is a valuable tool to investigate mitochondrial dysfunction and the pathophysiological mechanisms underpinning several human disorders. (wikipedia.org)
  • Our findings indicate that oxidized species of not only cardiolipin, but other phospholipid species, can be effectively separated from their non-oxidized counterparts in this two dimensional system. (cdc.gov)
  • Bacteria thriving at extremely high pH tend to produce more cardiolipin (CL) as well as bis-mono-acyl-glycero-phosphate (BMP) 3 . (nature.com)
  • The role of decreased cardiolipin and impaired electron transport chai" by J. Tam, A. Hong et al. (hofstra.edu)
  • The importance of cardiolipin in mitochondrial function is evidenced by the X-linked inherited pathology Barth syndrome a result of cardiolipin remodeling deficiency. (barthsyndrome.org)
  • Catabolism of cardiolipin may happen by the catalysis of phospholipase A2 (PLA) to remove fatty acyl groups. (wikipedia.org)
  • Autoantikörper gegen Cardiolipin sind auch ein immunologisches Klassifikationskriterium für den systemischen Lupus erythrematodes (SLE). (orgentec.com)
  • Defects in the adaptive branch of immunity might also further deteriorate muscle function if inflammation is modulated by cardiolipin deficiency. (barthsyndrome.org)
  • This compound belongs to the class of organic compounds known as cardiolipins. (drugbank.com)
  • Cardiolipin biosynthesis is robustly induced in brown and beige adipose upon cold exposure. (ku.dk)
  • As a result, tafazzin cannot alter cardiolipin, and levels of functional cardiolipin are reduced. (medlineplus.gov)
  • A lack of functional cardiolipin and an excess of MLCL are thought to impair normal mitochondrial shape and functions. (medlineplus.gov)
  • ATRA reduces the amounts of cardiolipins and the effect is associated with the growth-inhibitory activity of the retinoid. (slub-dresden.de)
  • Down-regulation of cardiolipins is due to a reduction of mitochondria, which is caused by an ATRA-dependent decrease in the expression of nuclear genes encoding mitochondrial proteins. (slub-dresden.de)
  • See the Cardiolipin Cardiolipin IgA, G, M ELISA Kit product insert for specific details on preparation, procedures, quality control, and test result interpretation. (rapidtest.com)
  • How is a Cardiolipin IgM test performed? (medreach.in)
  • Our findings indicate that the Mic10 core machinery of MICOS is regulated by several mechanisms, including interaction with cardiolipin and antagonistic actions of Mic26 and Mic27. (rug.nl)
  • The name "cardiolipin" is derived from the fact that it was first found in animal hearts. (wikipedia.org)
  • A phospholipid, or type of fat found in the blood, is called cardiolipin. (ganeshdiagnostic.com)