• cells
  • Three synthetic irreversible enzyme inhibitors (75 µ m di-isopropylphosphorofluoridate (DFP), 310 µ m Nα-p-tosyl-L-lysine (TLCK) and 240 µ m L-1-tosylamide-2-phenylethyl (TPCK) chloromethyl ketone), as well as the transition state analogue chymostatin, inhibit the development of Lewis lung adenocarcinoma (3LL) in C57 Bl/6 mice, when 3LL cells are treated once and for a limited period (60 min) prior to grafting. (aacrjournals.org)
  • The role of prostaglandin E 2 (PGE 2 ) in directly stimulating metastatic spread by Lewis lung carcinoma (LLC) cells was examined with the use of an in vitro migration model for tumor dissemination. (aacrjournals.org)
  • Injection of a mixture of metastatic and nonmetastatic LLC cells into mice s.c. resulted in a greater number of lung metastases than did injection of metastatic cells alone. (aacrjournals.org)
  • V. yedoensis extracts (VYE) can suppress the invasion of a highly metastatic human lung cancer cell line, A549 cells. (medsci.org)
  • VYE also suppressed the DNA binding activity of nuclear factor-kappa B. We concluded that VYE may inhibit tumor invasion by suppressing the activities of MMP and u-PA in lung cancer cells. (medsci.org)
  • Lung carcinoma, which develops from epithelial cells, is the most commonly diagnosed malignancy and the main cause of cancer-related deaths in Asian and Western countries with only approximately 15% chance of a 5-year survival rate [ 6 ]. (medsci.org)
  • We previously reported that a mouse Lewis lung carcinoma-derived stroma-inducing clone, P29, highly expresses a syndecan-like proteoglycan exhibiting specific binding to fibronectin, a major constituent of the interstitial matrix formed by the induced stromal cells, via its heparan sulphate chains [Itano, Oguri, Nakanishi and Okayama (1993) J. Biochem. (biochemj.org)
  • To address this question we explored miRNA expression patterns in mouse Lewis lung carcinoma LLC1 cells growing in laminin rich ECM microenvironment. (datamed.org)
  • In clonogenic and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays as well as in the in vivo Lewis lung carcinoma mouse tumor model, pentamidine is shown to possess the ability to selectively kill cancer cells. (aacrjournals.org)
  • Lewis lung carcinoma cells contain specific high-affinity binding sites for the eicosanoid 12( S )-hydroxy-5,8,10,14-eicosatetraenoic acid [12( S )-HETE]. (pnas.org)
  • In the Locke-Lewis solution, the more robust cells, such as fibroblasts and macrophages, had a tendency to migrate out of the explant and flatten, making them easy to observe under high magnifications. (wikipedia.org)
  • Lewis and her husband helped develop and put into practice the first experimental systems for observing and understanding somatic cell physiology in complex organisms, which demonstrated that the behavior of these autonomous cells had a significant relationship to the development, infection, immunity, physiology and development of cancer for the organism. (wikipedia.org)
  • Lewis observed that the connective tissue fibrils resulted from the cytoplasmic transformations of the cells. (wikipedia.org)
  • In her studies of explanted tissue cultures, Lewis noted that the cells choose to migrate away from the tissue sample and divide as individual cells, resulting in loss of the tissue's characteristic appearance. (wikipedia.org)
  • p16 plays an important role in cell cycle regulation by decelerating cells progression from G1 phase to S phase, and therefore acts as a tumor suppressor that is implicated in the prevention of cancers, notably melanoma, oropharyngeal squamous cell carcinoma, cervical cancer, and esophageal cancer. (wikipedia.org)
  • Tissues
  • In her work with chick embryos, Margaret Lewis studied connective tissue formation within the tissues as well as outside of an environment where factors involved in coagulation are present. (wikipedia.org)
  • Cell
  • Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. (medsci.org)
  • Safety and Efficacy Study of rhAngiostatin Administered in Combination With Paclitaxel and Carboplatin to Patients With Non-Small-Cell Lung Cancer - Full Text View - ClinicalTrials.gov Cao Y, Ji RW, Davidson D, et al. (wikipedia.org)
  • Margaret Adaline Reed Lewis (1881-1970) was an American cell biologist and embryologist who made contributions to cancer research and cell culture techniques, and was likely the first person to successfully grow mammalian tissue in vitro. (wikipedia.org)
  • Since the Lewises main interest was microscopic cell structures, their objective was to create optically clear media, which led to the creation of the Locke-Lewis solution. (wikipedia.org)
  • With so many avenues opened by cell culture to explore, Margaret Lewis and her husband diverged in their area of study, with Margaret Lewis choosing to focus on microbiological problems, which involved close observations of chick embryo intestines reacting to typhoid bacilli in the medium in which it was grown. (wikipedia.org)
  • shown
  • Conclusion In the research of animals with Lewis lung carcinoma was shown, that mechano- magnetochemically synthesized nanocomplex on the basis of nanoparticles from iron (II,III) oxide and doxorubicin had a greater antitumor effect than conventional doxorubicin. (techconnectworld.com)
  • growth
  • Our study shows that the growth kinetics of Lewis lung carcinoma and dissemination of tumor are dynamically similar to chaotic (nonlinear) processes. (techconnectworld.com)
  • The Lewises developed a growth medium called the Locke-Lewis solution and jointly received the Gerhard Gold Medal from the Pathological Society of Philadelphia. (wikipedia.org)