• Chronically infected persons are at increased lifetime risk for cirrhosis and hepatocellular carcinoma (HCC) and also serve as the main reservoir for continued HBV transmission. (cdc.gov)
  • Infection with HBV results in a wide spectrum of acute and chronic liver diseases that may lead to cirrhosis and hepatocellular carcinoma. (cdc.gov)
  • ABSTRACT The study's objective was to evaluate the clinical significance of sCD40L in HCV- associated hepatocellular carcinoma (HCV-HCC) patients. (who.int)
  • Guidelines on the management of hepatocellular carcinoma were published on March 1, 2022, by the American Gastroenterological Association in Gastroenterology . (medscape.com)
  • Cite this: Hepatocellular Carcinoma Clinical Practice Guidelines (AGA, 2022) - Medscape - Mar 02, 2022. (medscape.com)
  • FORT LEE, N.J., Sept. 19, 2023 (GLOBE NEWSWIRE) -- Elevar Therapeutics, Inc., a majority-owned subsidiary of HLB Co., Ltd. and a fully integrated biopharmaceutical company dedicated to elevating treatment experiences and outcomes for patients who have limited or inadequate therapeutic options, today announced a new partnership with the Benefactors Council of Blue Faery: The Adrienne Wilson Liver Cancer Association , a leading hepatocellular cancer (HCC) advocacy group. (centralillinoisproud.com)
  • Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update. (springer.com)
  • Surveillance for hepatocellular carcinoma (HCC) in patients with cirrhosis is recommended in clinical guidelines. (medscape.com)
  • Hepatocellular carcinoma (HCC) usually occurs in patients with cirrhosis and is common in areas where infection with hepatitis B and C viruses is prevalent. (msdmanuals.com)
  • Updated efficacy and safety data from IMbrave150: atezolizumab plus bevacizumab vs. sorafenib for unresectable hepatocellular carcinoma. (nature.com)
  • Sorafenib in advanced hepatocellular carcinoma. (nature.com)
  • Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial. (nature.com)
  • SORAMIC is a previously published randomised controlled trial assessing survival in patients with advanced hepatocellular carcinoma who received sorafenib with or without selective internal radiation therapy (SIRT). (cun.es)
  • The findings of selective celiac and/or hepatic arteriography in total 69 cases of confirmed hepatocellular carcinoma, with clinical and laboratory findings, were analyzed. (osti.gov)
  • Stuart, K. (2009) Primary hepatic carcinoma. (scirp.org)
  • Although the molecular mechanisms that regulate autophagy are not fully understood, recent work indicates that dysfunctional/impaired autophagic functions are associated with the development and progression of nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease (AFLD), and hepatocellular carcinoma (HCC). (hindawi.com)
  • MCLR exposure is associated with nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC). (nih.gov)
  • Hepatocellular carcinoma (HCC) is primarily a malignancy of the liver, advancing from a damaged, cirrhotic liver to HCC. (wjgnet.com)
  • Compared with more neoantigens in melanoma, the paucity and inefficient identification of effective neoantigens in hepatocellular carcinoma (HCC) remain enormous challenges in effectively treating this malignancy. (wjgnet.com)
  • Hepatocellular carcinoma (HCC), more commonly known as liver cancer, is a primary liver malignancy and is one of the leading causes of cancer-related deaths in the U.S. and worldwide. (naturalpedia.com)
  • Hepatocellular carcinoma (HCC), more commonly known as liver cancer, is a primary liver malignancy. (naturalpedia.com)
  • Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. (medscape.com)
  • NICE has also produced guidance on microwave ablation for hepatocellular carcinoma and for the treatment of metastases of the liver . (nice.org.uk)
  • Without immunohistological analysis, it is difficult to distinguish this HCC variant from clear cell carcinoma or metastases of renal cell carcinoma. (karger.com)
  • Llovet JM, BrĂș C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. (springer.com)
  • MRI detection of intratumoral fat in hepatocellular carcinoma: potential biomarker for a more favorable prognosis. (springer.com)
  • SIRT frequently has a negative, often subclinical, effect on liver function in patients with hepatocellular carcinoma, which may impair prognosis after treatment. (cun.es)
  • Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults and is currently the most common cause of death in people with cirrhosis. (wikipedia.org)
  • The Texas Hepatocellular Carcinoma Consortium was established in 2015 to reduce the burden and mortality of hepatocellular cancer (HCC) in Texas. (bcm.edu)
  • Hepatocellular carcinoma is cancer that starts in the liver. (medlineplus.gov)
  • Hepatocellular carcinoma is the most common type of liver cancer. (medlineplus.gov)
  • Hepatocellular carcinoma is not the same as metastatic liver cancer . (medlineplus.gov)
  • In most cases, the cause of hepatocellular liver cancer is long-term damage and scarring of the liver ( cirrhosis ). (medlineplus.gov)
  • Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma. (nature.com)
  • Hepatocellular carcinoma is a type of liver cancer. (healthline.com)
  • Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world and the third most fatal cancer [ 1 ]. (hindawi.com)
  • Hepatocellular carcinoma (HCC), the most common form of primary liver cancer in ALD, is responsible for one-third of ALD-related mortality, and one-third of all HCC-related deaths are attributed to alcohol use globally 2 . (nature.com)
  • Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. (wjgnet.com)
  • Liver cancer is the third leading cause of cancer-associated mortality, of which hepatocellular carcinoma (HCC) represents 90% of all primary liver cancers. (wjgnet.com)
  • 1 Hepatocellular carcinoma (HCC) has been the fastest rising cause of cancer-related deaths in the United States, increasing by 2% to 3% annually. (ajmc.com)
  • Recently, an increasing number of studies have revealed that microRNA-497 (miR-497) levels are decreased in tumors, and that it functions as a tumor suppressor in a number of types of human cancer, including colorectal, gastric, cervical and breast cancers, adrenocortical carcinoma and melanoma ( 12 - 20 ). (spandidos-publications.com)
  • Hepatocellular carcinoma primarily targets the liver, which lead to a cancer-related death. (naturalpedia.com)
  • Although surgical resection is one of the most effective way to treat liver cancer, its efficacy and safety in treatment of centrally located hepatocellular carcinoma (HCC) remains elusive. (doaj.org)
  • Hepatocellular carcinoma (HCC) is a largely fatal cancer, with the median survival time for patients being between four and eight months. (pharmafocus.com)
  • According to the World Health Organization (WHO), hepatocellular carcinoma (HCC) is the fifth most common cause of cancer worldwide [ 1 ]. (techscience.com)
  • Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, and shows an increasing incidence in many Western countries. (medscape.com)
  • Primary Liver Cancer Primary liver cancer is usually hepatocellular carcinoma (HCC). (msdmanuals.com)
  • Hepatitis and hepatocellular carcinoma : novel approaches : joint conference of the National Health Research Institutes (NHRI) and American Association for Cancer Research (AACR) in conjuction with 4th TCOG annual meeting. (who.int)
  • Hepatocellular carcinoma (HCC) is the most frequent primary malignant liver tumor , with more than 800,000 new cases diagnosed each year and with high mortality , ranking fourth in the world in cancer deaths. (bvsalud.org)
  • Infection with human papillomavirus increases the probability of developing carcinoma of the cervix, which is the second leading cause of cancer- related mortality in females worldwide, killing some 240 000 women per year.1 Making a correct diagnosis of a sexually transmitted infection is essential for the provision of appropriate and effective treatment. (who.int)
  • Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American Association for the Study of Liver Diseases. (springer.com)
  • Sherman, M. (2005) Diagnosis of small hepatocellular carcinoma. (scirp.org)
  • Emerging data indicate that the mortality rate of hepatocellular carcinoma (HCC) associated with cirrhosis is rising in some developed countries, whereas mortality from non-HCC complications of cirrhosis is decreasing or is stable. (nih.gov)
  • However, our search of the literature did not produce a significant volume of literature, or literature of sufficiently sound methodology, to permit our staff to make a determination regarding liver transplantation for other malignant diagnoses, such as metastatic disease, bile duct carcinoma and epithelioid hemangioendothelioma. (cms.gov)
  • On May 29, 2020 , atezolizumab in combination with bevacizumab was approved for treatment of patients with unresectable or metastatic hepatocellular carcinoma who have not received prior systemic therapy. (ascopost.com)
  • Attached is a request for a technology assessment that we need in order to develop a Medicare national coverage determination for liver transplantation for malignancies other than hepatocellular carcinoma. (cms.gov)
  • Certain benign liver tumors, such as hepatocellular adenoma, may sometimes be associated with coexisting malignant HCC. (wikipedia.org)
  • In male and female F344/DuCrj rats, drinking water containing quinoline increased the incidences of haemangiosarcoma (in various organs), and hepatocellular adenoma and carcinoma. (cdc.gov)
  • Liver imaging reporting and data system (LI-RADS) version 2018: imaging of hepatocellular carcinoma in at-risk patients. (springer.com)
  • Hepatocyte growth factor (HGF) signaling through its receptor Met has been implicated in hepatocellular carcinoma tumorigenesis and progression. (ebi.ac.uk)
  • The risk of hepatocellular carcinoma in type 2 diabetics is greater (from 2.5 to 7.1 times the nondiabetic risk) depending on the duration of diabetes and treatment protocol. (wikipedia.org)
  • Treatment protocols for hepatocellular carcinoma (HCC) are provided below. (medscape.com)
  • Immune-checkpoint inhibitors (ICIs) are now widely used for the treatment of patients with advanced-stage hepatocellular carcinoma (HCC). (nature.com)
  • With hepatocellular carcinoma, verified by histology/cytology, which is not amenable to curative treatment or transplantation. (knowcancer.com)
  • We investigated the role of MR metrics in pre-treatment prognostication of hepatocellular carcinoma (HCC). (springer.com)
  • Treatment of multifocal hepatocellular carcinoma (HCC) is challenging. (mdedge.com)
  • Thirdly, it helps to prevent serious complications such as tubal infertility, carcinoma of the cervix and maternal death. (who.int)
  • A suspected contributor to this increased risk is circulating insulin concentration such that diabetics with poor insulin control or on treatments that elevate their insulin output (both states that contribute to a higher circulating insulin concentration) show far greater risk of hepatocellular carcinoma than diabetics on treatments that reduce circulating insulin concentration. (wikipedia.org)
  • EudraCT 2009-012576-27, NCT01126645 LAY SUMMARY: This study of treatments in patients with hepatocellular carcinoma found that selective internal radiation therapy (SIRT) has an adverse effect on liver function that may affect patient outcomes. (cun.es)
  • The GAAD score is used to predict the probability of developing early-stage hepatocellular carcinoma (HCC). (loinc.org)
  • We found sufficient evidence related to hepatocellular carcinoma to allow us to make a favorable decision. (cms.gov)
  • The risk of developing hepatocellular carcinoma (HCC), a leading cause of death in humans infected with hepatitis virus (HV), is significantly enhanced by dietary exposure to aflatoxin (AF). (usda.gov)
  • SOUTH SAN FRANCISCO, Calif.--( BUSINESS WIRE )-- Exelixis, Inc. (NASDAQ:EXEL) today announced that its global phase 3 CELESTIAL trial met its primary endpoint of overall survival (OS), with cabozantinib providing a statistically significant and clinically meaningful improvement in median OS compared to placebo in patients with advanced hepatocellular carcinoma (HCC). (businesswire.com)
  • When patients present with hepatocelluar carcinoma (HCC) at the symptomatic stage, the disease is rapidly fatal, with a mean survival time of less than 4 months (1). (cdc.gov)
  • The role of hepatocellular carcinoma (HCC) surveillance is being questioned in alcoholic cirrhosis because of the relative low HCC risk. (nature.com)