• Birt-Hogg-Dubé syndrome (BHDS) is an autosomal dominant disorder clinically manifested by fibrofolliculomas, renal cell carcinoma, lung cysts, and spontaneous pneumothorax. (medscape.com)
  • The relationship between blood pressure and risk of renal cell carcinoma. (who.int)
  • Epidemiology of Renal Cell Carcinoma: 2022 Update. (who.int)
  • Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. (who.int)
  • Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. (who.int)
  • In cases of lung metastasis, large tumor masses underwent necrosis, with some of them hemorrhaging and even fewer exhibiting acute inflammation. (wikipedia.org)
  • The Lewis lung carcinoma tumor model's role in cancer has been its use for research into tumor metastasis and angiogenesis properties. (wikipedia.org)
  • Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)
  • Therefore, inhibiting cancer metastasis can be one of the strategies to effectively treat lung cancer. (frontiersin.org)
  • We tested the role of systemic fetuin in tumor cell growth and metastasis by injecting Lewis lung carcinoma (LLC) cells into fetuin-A null and their wild-type (WT) littermate control C57BL/6 mice via the tail vein, s.c., and intrasplenic routes. (ac.ke)
  • In the experimental metastasis assay, the lungs of the WT mice were filled with metastatic nodules, whereas the lungs of the fetuin-A null mutant mice were virtually free of colonies at the end of 2 weeks. (ac.ke)
  • Similarly, intrasplenic injection of LLC cells resulted in rapid colonization of the liver with metastasis to the lungs within 2 weeks in the WT but not fetuin-A null mice. (ac.ke)
  • The triterpenoid fraction (100 and 200 mg/kg) of the fruit bodies of Ganoderma lucidum inhibited primary solid-tumor growth in the spleen, liver metastasis and secondary metastatic tumor growth in the liver in intrasplenic Lewis lung carcinoma (LLC)-implanted mice. (nih.gov)
  • Main methods: Anticancer activity of the I. obliquus extract was examined in mouse models of Lewis lung carcinoma growth and spontaneous metastasis after 3 weeks of continuous extract intake at the dose of 6 mg/kg/day, which corresponded to that ingested daily with Chaga infusion in Japan. (researchgate.net)
  • Bromelain significantly reduced the number of lung metastasis induced by LLC transplantation, as observed with 5-FU. (greenmedinfo.com)
  • a The number of mice with (purple) or without (pink) lung metastasis 16 days after control (NTC) or AGC1-KD LLC1 cells (KD1, sh911 or KD2, sh908) were injected in the flanks. (biomedcentral.com)
  • H&E-stained lung slides were screened for metastasis. (biomedcentral.com)
  • It was discovered in 1951 by Dr. Margaret Lewis of the Wistar Institute and became one of the first transplantable tumors. (wikipedia.org)
  • Orthotopic models focus upon correctly modeling the tumor microenvironment by injecting or implanting tumors into the corresponding organ that they originated from (i.e. implanting a Lewis lung carcinoma into the lung of another C57BL mouse). (wikipedia.org)
  • Navelbine and carboplatin, two chemotherapeutics currently on the market, were tested in C57BL mice with Lewis lung carcinoma tumors in their hind flank. (wikipedia.org)
  • The results showed that lycopene reduced the number of metastatic tumors in the lungs, which was further suppressed by the combined treatment with sorafenib. (frontiersin.org)
  • d (left) Percent of the metastatic area in the lungs of mice that were bearing control (NTC), or AGC1-KD LLC1 tumors on the flanks 22 days after injections. (biomedcentral.com)
  • Multiple or bilateral renal carcinomas have been reported in association with this syndrome, most commonly hybrid oncocytic tumors with features of chromophobe renal carcinoma (50%), followed by chromophobe renal cancer, clear cell renal carcinoma, and renal oncocytoma. (medscape.com)
  • Carbon nanotube s enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells. (cdc.gov)
  • Multiple or bilateral renal carcinomas, commonly chromophobe renal carcinoma and renal oncocytomas, and rarely, clear cell renal carcinomas have been reported in association with this syndrome. (medscape.com)
  • Generally, Lewis lung carcinoma is highly metastatic in immunocompetent mice. (wikipedia.org)
  • Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice xenografted with Lewis lung carcinoma (LLC) cells. (frontiersin.org)
  • Metastatic establishment and growth of Lewis lung carcinoma is promoted by single-walled carbon nanotube s (SWCNT) in C57BL6/J mice. (cdc.gov)
  • If subcutaneously injected into mice, it is known to avidly metastasize to the lung. (wikipedia.org)
  • Targeting of CD169+ macrophages in order to inhibit tumor Lewis lung carcinoma growth also caused depletion of bone and bone marrow in mice. (wikipedia.org)
  • Lung colonization responded to the levels of serum fetuin-A in a dose-dependent manner, as observed by the formation of half as many colonies in mice heterozygous for the fetuin-A locus compared with homozygous WT mice and restoration of lung colonization by the administration of purified fetuin-A to fetuin-A-null mice. (ac.ke)
  • Studies of WI of immune organs were carried out in mice of the C57 Black line on the 28th day after transplantation of Lewis lung carcinoma. (researchbib.com)
  • Metastatis was likewise decreased and 25% of the mice had healthy lungs. (elsevierpure.com)
  • On the host side, antibiotic-induced dysbiosis caused elongated small intestines and ceca, and B16-F10 melanoma and Lewis lung carcinoma progressed more quickly than in control mice. (aacrjournals.org)
  • Researchers in America have discovered that vaccinating mice with embryonic stem cells prevented lung cancer in those animals that had had cancer cells transplanted into them after the vaccination or that had been exposed to cancer-causing chemicals. (fightaging.org)
  • Proteins Secreted by Lung Cancer Cells Induce the Onset of Proteinuria via Focal Adhesion Kinase Signaling in Mice. (bvsalud.org)
  • This implies that these mice can be used as a model of human disease and suggests that Lewis lung carcinoma 1 cell -secreted proteins (LCSePs) contain nephrotoxic molecules and cause inflammation in renal cells . (bvsalud.org)
  • IOX antitumor activity in vivo was assessed by use of the Lewis lung carcinoma (LLC) cells transplanted subcutaneously in the mice flank. (phytojournal.com)
  • A phase II study showed that patients with resected local-regionally advanced head and neck squamous cell carcinoma (HNSCC) had improved survival when pembrolizumab was added to adjuvant RT (NCT02641093). (nature.com)
  • The objective of this study was to determined whether SAA level could be used as a prognostic parameter in patients with esophageal squamous cell carcinoma (ESCC). (biomedcentral.com)
  • A previous study in sera from patients with esophageal squamous cell carcinoma (ESCC) that used mass spectrometry and proteomic technologies found that SAA was upregulated and could be used to differentiate patients from healthy individuals [ 18 ]. (biomedcentral.com)
  • Non-small-cell lung cancer (NSCLC), which primarily comprises lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), is the major type of primary lung cancer [ 2 ]. (biomedcentral.com)
  • The in vivo antitumoral/antileukemic activity was evaluated using the following panel of tumor lines: P-388 leukemia, sarcoma (S-37), Ehrlich ascitic tumor (EAT), Lewis lung carcinoma (LLC), MB-F10 melanoma and ADC-755 mammary adenocarcinoma. (greenmedinfo.com)
  • Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. (nature.com)
  • Abstract: Disclosed are methods of reducing lung inflammation in acute respiratory distress syndrome elicited by various factors such as COVID-19 infection by reduction of neutrophil extracellular trap formation through administration of mesenchymal stem cells and/or exosomes thereof. (therapeuticsolutionsint.com)
  • in particular IOX signiï¬ cantly reduced the survival rate of human oral epidermoid (KB) and human lung cancer (LU-1) cells with IC50 values of 2.51 and 3.52 µg/ml, respectively. (phytojournal.com)
  • Lewis lung carcinoma (LLC1) cells with AGC1-knockdown have higher potential to metastasize. (biomedcentral.com)
  • Some people use Panax ginseng to treat breast cancer and prevent ovarian cancer , liver cancer , lung cancer , and skin cancer . (emedicinehealth.com)
  • Further, the study demonstrated 24% of Birt-Hogg-Dubé syndrome patients and 34% of Birt-Hogg-Dubé syndrome family members screened for lung cysts had a history of spontaneous pneumothorax. (medscape.com)
  • After radical surgery for non-small cell lung cancer (NSCLC) patients, 3-10% of patients have recurrent lung lesions. (researchsquare.com)
  • This study aimed to compare the efficacy of SBRT and surgery in treating lung recurrence after radical NSCLC. (researchsquare.com)
  • A retrospective analysis of NSCLC patients who had undergone radical surgery at the Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) from November 2012 to December 2018 and had received SBRT or reoperation because of postoperative lung recurrence was performed. (researchsquare.com)
  • For patients with lung recurrence after radical NSCLC, no significant difference exists in the efficacy of SBRT and surgery. (researchsquare.com)
  • The current standard treatment for patients with early non-small cell lung cancer (NSCLC) is stereotactic body radiation therapy (SBRT) or surgery. (researchsquare.com)
  • This study aimed to investigate the difference in efficacy between SBRT and reoperation in NSCLC patients with lung recurrence after radical surgery. (researchsquare.com)
  • However, much remains unknown regarding whether circRNAs impact immune escape in non-small-cell lung carcinoma (NSCLC). (biomedcentral.com)
  • Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced malignancies, including non-small cell lung cancer (NSCLC). (mdpi.com)
  • 1-in-4 NSCLC Patients Alive at 5 Years After Pembrolizumab With up to a quarter of nonsmall-cell lung cancer patients treated with pembrolizumab "around 5 years from now, that completely changes our mindset," says David Graham, MD, Levine Cancer Institute. (medscape.com)
  • Basically, Afatinib 30mg tablet uses for treating lung cancer by blocking certain molecules that promote tumor growth. (blogsunit.com)
  • Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program. (who.int)
  • According to the World Health Organization, lung cancer has the highest mortality rate of all cancers. (frontiersin.org)
  • Afatinib is a medication that has shown potential in treating several advanced cancers, including those of the lung and breast. (blogsunit.com)
  • For example, loss-of-function mutations in Ptc1 , or gain-of-function mutations in Smo, Shh, Gli1 , and Gli2 , can each contribute to skin cancers, most notably basal cell carcinomas - the most common of all human cancers. (bcm.edu)
  • Out of a sense of gratitude for all the help they got, Lewis and Amy decided to start a support group for people with head and neck cancers. (cdc.gov)
  • 1985). "An analysis of lung cancer risk from exposure to hexavalent chromium. (cdc.gov)
  • Margaret R. Lewis del Wistar Institut en 1951. (bvsalud.org)
  • [ 35 ] Expression of the Birt-Hogg-Dubé syndrome protein has been widespread in a variety of tissues, including the kidneys, lungs, and skin. (medscape.com)
  • Lung cancer mortality among workers making lead chromate and zinc chromate pigments at three English factories. (cdc.gov)
  • Panax ginseng is also used for depression , anxiety , general fatigue and chronic fatigue syndrome (CFS), multiple sclerosis , for boosting the immune system, and for fighting particular infections in a lung disease called cystic fibrosis. (emedicinehealth.com)
  • The postoperative pathological report confirmed that the margin was negative, and the pathological type was non-small cell lung cancer. (researchsquare.com)
  • Further, lung fibroblasts were cultured with and without cell supernatants from previously established cell cultures for 24 h. (medscimonit.com)
  • Recently, small cell lung cancer was shown to be dependent on activated hedgehog signaling. (bcm.edu)
  • MCPyV is associated with Merkel cell carcinoma a CFX96 real-time thermocycler (BioRad, Hercules, CA, ( 3 ), and TSPyV has been linked to trichodysplasia USA). (cdc.gov)
  • The pleura is a thin membrane that covers the outer surface of the lungs as well as the mediastinum, diaphragm, and inner surface of the chest wall. (medscimonit.com)
  • According to a 2015 review article, Lewis lung carcinoma is the only reproducible syngeneic lung cancer model, meaning that it is the only reproducible lung cancer model that utilizes a transplant that is immunologically compatible. (wikipedia.org)
  • Melittin, a polypeptide found in bee venom, on tumor-associated macrophages has been examined in a Lewis lung carcinoma model. (wikipedia.org)
  • Therefore, in this mouse model of lung cancer , FAK signaling prompts podocyte FP effacement and proteinuria , indicative of PNS. (bvsalud.org)
  • Patients who had received SBRT or surgical treatment of lung lesions at the Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) from November 2012 to December 2018 were included, and the clinical stage before treatment was T1-3N0M0. (researchsquare.com)
  • RÉSUMÉ Les proches des patients cancéreux en Arabie saoudite ont tendance à penser que le fait de dire la vérité au patient peut lui faire du mal et le faire souffrir. (who.int)
  • Determination of weight indices (WI) of thymus and spleen in animals with carcinoma after photodynamic therapy with peptidomimetics: LMB002 and LMB033. (researchbib.com)
  • Ferritin-based protein C nanoparticles (PCNs), known as TFG and TFMG, were generated and tested in Lewis lung carcinoma (LLC) allograft and MMTV-PyMT spontaneous breast cancer models. (biomedcentral.com)
  • I still have a high risk of the cancer coming back, but I'm still going to live my life," Lewis says. (cdc.gov)
  • Opium use and risk of lung cancer: A multicenter case-control study in Iran. (who.int)
  • Interaction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in men. (cdc.gov)
  • Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. (who.int)
  • Before receiving SBRT or surgical treatment, they had received radical surgery for carcinoma of the lungs. (researchsquare.com)
  • Then, in December of 2015, Lewis found a sore on his tongue that wouldn't go away, even with steroid treatment. (cdc.gov)
  • Kensler, TW , Cooney, DA & McGee, EK 1981, ' Alterations in PRPP and uridine nucleotide pools in the Lewis lung carcinoma by N-(phosphonacetyl)-L-aspartate (PALA) ', Proceedings of the American Association for Cancer Research , vol. (johnshopkins.edu)
  • In fact, a 1996 study found that the carcinoma predominantly metastasized into the lungs after tail vein injections. (wikipedia.org)
  • Lung cancer remains the most common malignancy and is the leading cause of cancer-related death globally [ 1 ]. (biomedcentral.com)
  • Lewis had seven chemotherapy treatments and 35 radiation treatments over the course of the next seven weeks. (cdc.gov)