EnzymesPancreaticLysineInhibitorGeneEnzymeProlyl carboxypeptidaseSerine carboxypeptidasesGlutamate carboxypeptidaseNeurotrophicProteinPeptideHydrolysisPutativeAntibodyCatalyticAmino acidSerumSpecificityImmunohistochemistryPlasmaMicePeptidesHumanHippocampusTissuesActivityMethotrexateFamilyPrimaryReleaseFormCells
Enzymes2
- Enzymes that use a metal in the active site are called "metallo-carboxypeptidases" (EC number 3.4.17). (wikipedia.org)
- carboxypeptidases Two enzymes (A and B) found in pancreatic juice. (fao.org)
Pancreatic2
- Initial studies on carboxypeptidases focused on pancreatic carboxypeptidases A1, A2, and B in the digestion of food. (wikipedia.org)
- In the case of pancreatic carboxypeptidase A, the inactive zymogen form - pro-carboxypeptidase A - is converted to its active form - carboxypeptidase A - by the enzyme trypsin. (wikipedia.org)
Lysine1
- Carboxypeptidases that cleave positively charged amino acids (arginine, lysine) are called carboxypeptidase B (B for basic). (wikipedia.org)
Inhibitor6
- 2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM. (dcchemicals.com)
- Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents. (dcchemicals.com)
- CPA inhibitor is a potent inhibitor for carboxypeptidase A (CPA). (dcchemicals.com)
- 2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is an potent inhibitor of carboxypeptidase A (CPA). (dcchemicals.com)
- GCPII-IN-1 is a glutamate carboxypeptidase II (GCPII, or PSMA) inhibitor scaffold with a Ki of 44.3 nM. (dcchemicals.com)
- Furthermore, the dual prolyl carboxypeptidase (PCP)-prolyl endopeptidase (PEP) inhibitor Z-prolyl-prolinal reduced ANG-(1-7) formation in ACE2 KO mice, while the ACE2 inhibitor MLN-4760 had no effect. (nih.gov)
Gene6
- Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase 1. (nih.gov)
- Glutamate carboxypeptidase II ( GCPII ), also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase , or prostate-specific membrane antigen ( PSMA ) is an enzyme that in humans is encoded by the FOLH1 ( folate hydrolase 1 ) gene . (wikidoc.org)
- This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. (novusbio.com)
- We report here that the carboxypeptidase E gene (CPE) is alternatively spliced in human tumors to yield an N-terminal truncated protein (CPE-ΔN) that drives metastasis. (jci.org)
- The technology from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), describes that direct administration of an adenovirus carrying the Carboxypeptidase E (CPE) gene to the hippocampus results in overexpression of the CPE protein in an experimental mouse model of AD. (nih.gov)
- 2023) Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer's Disease male mice. (nih.gov)
Enzyme4
- A carboxypeptidase (EC number 3.4.16 - 3.4.18) is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. (wikipedia.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Carboxypeptidase A4 (CPA4) in serum, plasma, tissue homogenates and other biological fluids. (lotuskringpoeldijk.nl)
- Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry. (nih.gov)
- Carboxypeptidase E was thought to be the only enzyme responsible. (elsevierpure.com)
Prolyl carboxypeptidase1
- Background Prolyl carboxypeptidase (PRCP) is involved in the regulation of body weight, likely by hydrolysing alpha-melanocyte-stimulating hormone and apelin in the hypothalamus and in the periphery. (uantwerpen.be)
Serine carboxypeptidases2
- Other carboxypeptidases that use active site serine residues are called "serine carboxypeptidases" (EC number 3.4.16). (wikipedia.org)
- Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings. (nih.gov)
Glutamate carboxypeptidase4
- All of which refer to the same protein glutamate carboxypeptidase II. (wikidoc.org)
- Glutamate Carboxypeptidase II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
- This graph shows the total number of publications written about "Glutamate Carboxypeptidase II" by people in this website by year, and whether "Glutamate Carboxypeptidase II" was a major or minor topic of these publications. (wakehealth.edu)
- Below are the most recent publications written about "Glutamate Carboxypeptidase II" by people in Profiles. (wakehealth.edu)
Neurotrophic1
- Carboxypeptidase E (CPE) also known as Neurotrophic factor-α1 (NF-α1), was first identified as an exopeptidase and is highly expressed in the nervous and endocrine systems. (nih.gov)
Protein2
- Humans, animals, bacteria and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation. (wikipedia.org)
- Recombinant protein encompassing a sequence within the center region of human Carboxypeptidase E. The exact sequence is proprietary. (novusbio.com)
Peptide2
- The extensive distribution of carboxypeptidase D in both glial and neuronal cells indicates the important role of carboxypeptidase D in peptide processing, possibly working together with furin, a ubiquitously expressed proprotein convertase. (elsevierpure.com)
- Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. (abcam.com)
Hydrolysis1
- The carboxypeptidase A hydrolysis reaction has two mechanistic hypotheses, via a nucleophilic water and via an anhydride. (wikipedia.org)
Putative2
- Functional characterization of a putative serine carboxypeptidase in vascular smooth muscle cells. (nih.gov)
- We have generated a molecular model of CPE, and structural alignment with other carboxypeptidases revealed a putative sorting signal binding domain that is independent of the enzymatic site. (nih.gov)
Antibody4
- Western Blot: Carboxypeptidase E/CPE Antibody [NBP2-15699] - Analysis of CPE expression in transfected 293T cell line by CPE polyclonal antibody. (novusbio.com)
- Western Blot: Carboxypeptidase E/CPE Antibody [NBP2-15699] - Sample (20 ug of whole cell lysate) A: mouse brain 10% SDS PAGE gel, diluted at 1:10000. (novusbio.com)
- Immunohistochemistry-Paraffin: Carboxypeptidase E/CPE Antibody [NBP2-15699] - Human breast cancer. (novusbio.com)
- Carboxypeptidase E antibody [N2C2], Internal dilution: 1:500. (novusbio.com)
Catalytic1
- A transmembrane glycoprotein with an extracellular catalytic domain which functions as a carboxypeptidase. (nih.gov)
Amino acid1
- A carboxypeptidase that catalyzes the release of a C-terminal amino acid with a broad specificity. (lookformedical.com)
Serum2
- Description: A sandwich ELISA kit for detection of Carboxypeptidase A4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lotuskringpoeldijk.nl)
- Description: A competitive ELISA for quantitative measurement of Rat Carboxypeptidase A4(CPA4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (lotuskringpoeldijk.nl)
Specificity1
- Carboxypeptidases of broad specificity with optimum pH 4.5-6.0, inhibited by the action of diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents. (expasy.org)
Immunohistochemistry1
- Immunohistochemistry showed the intracellular distribution of carboxypeptidase D with a perinuclear pattern. (elsevierpure.com)
Plasma1
- VORAXAZE is a carboxypeptidase indicated to reduce toxic plasma methotrexate concentration (greater than 1 micromole per liter) in adult and pediatric patients with delayed methotrexate clearance (plasma methotrexate concentrations greater than 2 standard deviations of the mean methotrexate excretion curve specific for the dose of methotrexate administered) due to impaired renal function. (nih.gov)
Mice2
- Recent studies with carboxypeptidase E-deficient mice, Cpe(fat)/Cpe(fat), indicated the existence of carboxypeptidase E-like carboxypeptidases, such as carboxypeptidase D. In order to define potential redundant functions in vivo, we compared the distributions of both carboxypeptidases in the rat central nervous system and selected endocrine tissues. (elsevierpure.com)
- The co-localization of carboxypeptidases D and E suggests that carboxypeptidase D may, at least partially, compensate for carboxypeptidase E processing functions in Cper(fat)/Cpe(fat) mice. (elsevierpure.com)
Peptides2
- They also regulate biological processes, such as the biosynthesis of neuroendocrine peptides such as insulin requires a carboxypeptidase. (wikipedia.org)
- Carboxypeptidases hydrolyze peptides at the first amide or polypeptide bond on the C-terminal end of the chain. (wikipedia.org)
Human1
- Orthologous to human SCPEP1 (serine carboxypeptidase 1). (nih.gov)
Hippocampus1
- Carboxypeptidase D messenger RNA was abundantly expressed in glial cells in the gray and white matter, while neurons in several brain regions, such as the piriform cortex, basolateral amygdala and hippocampus, also expressed high levels of carboxypeptidase D messenger RNA. (elsevierpure.com)
Tissues2
- Co-localization of carboxypeptidases E and D messenger RNAs was observed in many brain regions, the spinal cord and endocrine tissues. (elsevierpure.com)
- Carboxypeptidase Q (CPQ) mRNA expression was higher in glioblastoma (GBM) tissues than in normal tissues. (amegroups.org)
Activity2
Methotrexate2
Family1
- In peptidase family S10 (carboxypeptidase C family). (genome.jp)
Primary1
- A ZINC-dependent carboxypeptidase primary found in the DIGESTIVE SYSTEM. (lookformedical.com)
Release1
- Carboxypeptidases that are primarily found the DIGESTIVE SYSTEM that catalyze the release of C-terminal amino acids . (lookformedical.com)
Form1
- The membrane-bound form of Carboxypeptidase E (CPE) was identified as a sorting receptor for the regulated secretory pathway through studies carried out in our lab. (nih.gov)
Cells1
- This mechanism ensures that the cells wherein pro-carboxypeptidase A is produced are not themselves digested. (wikipedia.org)