• derivatives
  • The direct conversion of various amides to isoquinoline and β-carboline derivatives via mild electrophilic amide activation, with trifluoromethanesulfonic anhydride in the presence of 2-chloropyridine followed by cyclodehydration upon warming provides the desired products with short overall reaction times. (organic-chemistry.org)
  • A group of β-carboline derivatives, termed eudistomins were extracted from ascidians (marine tunicates of the family Ascidiacea), like Ritterella sigillinoides, Lissoclinum fragile or Pseudodistoma aureum. (wikipedia.org)
  • A series of novel β-carboline-based hydroxamate derivatives ( 8a-n ) as HDAC inhibitors have been designed and synthesized. (rsc.org)
  • Together, our findings suggest that these novel β-carboline-based hydroxamate derivatives may provide a new framework for the discovery of novel antitumor agents for the intervention of human carcinoma cells. (rsc.org)
  • ZK-93423 has also been used as a base to develop new and improved beta-carboline derivatives and help map the binding site of the GABAA receptor. (wikipedia.org)
  • harmine
  • As components of the liana Banisteriopsis caapi, the β-carbolines harmine, harmaline, and tetrahydroharmine play a pivotal role in the pharmacology of the indigenous psychedelic drug ayahuasca by preventing the breakdown of dimethyltryptamine in the gut by reversibly inhibiting monoamine oxidase, thus making it psychoactive upon oral administration. (wikipedia.org)
  • Harmine, a naturally occurring β-carboline alkaloid, has long been used in folk medicine in the Middle East and in Asia ( Sourkes, 1999 ) and as a hallucinogenic drug ( Wink & van Wyk, 2008 ). (peerj.com)
  • Harmine, also known as telepathine, is a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds. (wikipedia.org)
  • anxiolytic
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  • ZK-93423 is an anxiolytic drug from the β-Carboline family, closely related to abecarnil. (wikipedia.org)
  • serotonin
  • Comparison of the inhibition kinetics of tetrahydro-β-carbolines for serotonin and epinephrine reuptake to that of the platelet aggregation response to these amines has shown that 5-hydroxymethtryptoline, methtryptoline, and tryptoline are poor inhibitors of reuptake. (wikipedia.org)
  • Indoles
  • A wide range of functionalized β-carbolines and γ-carbolines can be prepared from readily accessible indoles and nitriles in good to excellent yields under the optimal conditions. (rsc.org)
  • An enantioselective aza-Friedel-Crafts alkylation reaction of indoles with 1-trifluoromethyl-3,4-dihydro-β-carbolines catalyzed by a chiral spirocyclic phosphoric acid has been realized. (rsc.org)
  • structural
  • Different levels of saturation are possible in the third ring, which is indicated here in the structural formula by colouring the optionally double bonds red and blue: Some of the more important β-carbolines are tabulated by structure below. (wikipedia.org)
  • known
  • As a result of the presence of β-carbolines in the cuticle of scorpions, their skin is known to fluoresce when exposed to certain wavelengths of ultraviolet light such as that produced by a blacklight. (wikipedia.org)
  • route
  • This methodology provides a facile route to 1-trifluoromethyl-1-indole-substituted tetrahydro-β-carbolines featuring a CF 3 -containing quaternary stereocenter in considerable yields and good enantioselectivities. (rsc.org)