Carbenoxolone (CBX) is a glycyrrhetinic acid derivative with a steroid-like structure, similar to substances found in the root of the licorice plant. (wikipedia.org)
Carbenoxolone is an anti-inflammatory compound and a derivate of a natural substance from the licorice plant. (huji.ac.il)
Sodium4
Formulations used clinically typically contain carbenoxolone sodium. (guidetopharmacology.org)
It is a palatable tablet containing 20 mg carbenoxolone sodium plus aluminium hydroxide, magnesium trisilicate, sodium bicarbonate and alginic acid. (bmj.com)
The daily dose of carbenoxolone is 100 mg (less than in the treatment of gastric ulcer) and the daily sodium 'load' is 13 mmol. (bmj.com)
In part, confusion arises from the many different forms of the herb, its constituents, concentrates, and derivatives, such as the antiulcer drug carbenoxolone sodium, deglycyrrhizinated licorice (DGL), or parenteral products such as SNMC (no longer available) from Japan. (interactionsguide.com)
Junctions3
Carbenoxolone is a modestly potent, reasonably effective, water-soluble blocker of gap junctions. (wikipedia.org)
The endothelium-derived hyperpolarising factor (EDHF) response in mesenteric arteries was investigated using wire myography, and the involvement of myoendothelial gap junctions (MEGJs) was assessed using the putative gap junction inhibitor carbenoxolone. (gla.ac.uk)
Carbenoxolone attenuated the EDHF response in the WKY, suggestive of the involvement of myoendothelial gap junctions in EDHF. (gla.ac.uk)
Probenecid1
PANX1 channel inhibition using probenecid (PBN) or carbenoxolone (CBX) reduced the proliferation of our panel of high-risk NB cell lines. (jcancer.org)
PANX11
Carbenoxolone, spironolactone, mefloquine and other old, well-known drugs have been shown to have Panx1 blocking activity as an off-target pharmacological effect and found to be effective in in vivo animal tumor models. (pannextherapeutics.com)
Compound1
To 11β-HSD1, the compounds were anchored similar than unselective compound carbenoxolone, whereas in 11β-HDS2, they adopted a flipped binding mode. (helsinki.fi)
Blocker3
In this study we investigated the effects of carbenoxolone, as a gap-junction blocker, on spatial learning in the rat. (medscimonit.com)
Conclusions: The results of this study suggest that carbenoxolone as a gap-junction channel blocker can decelerate the learning performances of rats in a spatial memory task, such as the MWM, that requires the integrity of the hippocampus. (medscimonit.com)
A response inhibited by the hemi-channel blocker carbenoxolone (200µM, 30mins). (lincoln.ac.uk)
Derivatives1
The 4 include crude extracts of the whole plant, DGL combined with other agents (ie, Caved-S), DGL alone, and drug analogs of glycyrrhizin derivatives (eg, carbenoxolone, enoxolone). (naturalmedicinejournal.com)
Glucocorticoid1
Carbenoxolone may decrease the amount of active glucocorticoid in the brain, because the drug inhibits 11β-HSD, an enzyme which regenerates cortisol, an active glucocorticoid, from inactive cortisone. (wikipedia.org)
Blockers1
This L-Lactate-induced neuroprotection is blocked by carbenoxolone and glibenclamide, respectively blockers of pannexins and KATP. (edu.sa)
Lung1
Both systemic and intranasal administrations of carbenoxolone effectively minimize metastatic formation in a lung colonization model in mice. (huji.ac.il)
Drug2
Notably, the therapeutic effect of a single intranasal administration of 25 mg/kg carbenoxolone, in the form of drug-loaded particles, had a similar effect in reducing metastatic lesions in the lungs to that of a 10-fold dose of the free drug via intraperitoneal injections, three times per week over the course of four weeks. (huji.ac.il)
To further enhance carbenoxolone{\textquoteright}s activity and localization in the lungs, thereby reducing the potential adverse side effects resulting from systemic exposure, we developed a poly(lactic-co-glycolic acid) (PLGA) slow-release system for pulmonary delivery which maintains drug activity in-vitro, as demonstrated in the anoikis assay. (huji.ac.il)
Effects1
Carbenoxolone has also been investigated for nootropic effects. (wikipedia.org)
Search1
The carbenoxolone group failed to use a selective search strategy during the fi nal test trial, in which the platform was removed. (medscimonit.com)
Reduce1
Results: The results showed that carbenoxolone could signifi cantly reduce the percentages of time spent, distance traveled, and entry into Q2 (the target quadrant) compared with the control group. (medscimonit.com)
Group1
We previously showed that carbenoxolone reduces the metastatic burden in the lungs of mice through its antagonistic effect on high mobility group box 1 (HMGB1). (huji.ac.il)
Side2
Electrolyte imbalance is a serious side effect of carbenoxolone when used systemically. (wikipedia.org)
Carbenoxolone (1.23, 2.46, 4.92 µg/side), scopolamine (3 µg/side), and saline were injected through the cannulas before 4 consecutive training trials and one test trial that conducted 24 h after the training trials with the platform removed. (medscimonit.com)
Activity1
Half of the rats received intravenous carbenoxolone to inhibit renal 11β-HSD activity. (portlandpress.com)
Chemical2
Carbenoxolone is derived from licorice root, and has a steroid-like chemical structure. (guidetopharmacology.org)
Carbenoxolone prevents chemical eye ischemia-reperfusion-induced cell death via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. (ac.ir)
Treatment3
Carbenoxolone is used for the treatment of peptic, esophageal and oral ulceration and inflammation. (wikipedia.org)
Carbenoxolone has also been used in topical creams such as Carbosan gel, marketed for treatment of lip sores and mouth ulcers. (wikipedia.org)
Carbenoxolone (duogastrone) and cimetidine in the treatment of duodenal ulcer--a therapeutic trial. (ox.ac.uk)
Glycyrrhetinic acid1
Carbenoxolone (CBX) is a glycyrrhetinic acid derivative with a steroid-like structure, similar to substances found in the root of the licorice plant. (wikipedia.org)
Disodium Salt1
Blockade of gap junctions with carbenoxolone or Ca 2+ -activated chloride channels (CaCCs) with 4,4′-diisothiocyanato-2,2′-stilbenedisulphonic acid disodium salt prevented Ca 2+ transients in PCA and venular pericytes and disrupted the synchrony of Ca 2+ transients in capillary and PCV pericytes. (edu.au)
Inhibitor3
The gap-junction inhibitor carbenoxolone suppresses the differentiation of Th17 cells through inhibition of IL-23 expression in antigen presenting cells. (uchicago.edu)
Cx43-induced Pb uptake was attenuated after blockage of Cx43 hemichannels with its inhibitor, carbenoxolone. (nih.gov)
Importantly, the responses to the uncaging stimuli shown in Figure 3B were not significantly attenuated by the gap junction inhibitor carbenoxolone (Figure S4), suggesting that gap junctions do not contribute to the LE-mediated currents evoked by uncaging CYLE around the soma. (camkkinases.com)
Junction2
We found that these gap junction blockers decreased the mean number of FRs and the mean number of oscillation cycles per FR event in the hippocampus, both during and at different times after carbenoxolone and quinine administration. (hindawi.com)
Carbenoxolone has also been used in topical creams such as Carbosan gel, marketed for treatment of lip sores and mouth ulcers. (wikipedia.org)
Treatment of herpes genitalis with carbenoxolone and cicloxolone creams: a double blind placebo controlled clinical trial. (bmj.com)
Inflammation1
Carbenoxolone is used for the treatment of peptic, esophageal and oral ulceration and inflammation. (wikipedia.org)
Rats2
12. Carbenoxolone treatment ameliorated metabolic syndrome in WNIN/Ob obese rats, but induced severe fat loss and glucose intolerance in lean rats. (nih.gov)
Effects of carbenoxolone in lean and obese Zucker rats. (nih.gov)
Similar1
Cabbage contains gefarnate -compound similar to carbenoxolone, a remedy used in ulcers treatments. (healthyfoodhouse.com)