OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth CareGeographicals
CarbapenemsThienamycinsbeta-LactamasesImipenembeta-Lactam ResistanceAnti-Bacterial Agentsbeta-LactamsAcinetobacter baumanniiMicrobial Sensitivity TestsEnterobacteriaceae InfectionsKlebsiella pneumoniaeAcinetobacter InfectionsDrug Resistance, Multiple, BacterialPseudomonas aeruginosaGram-Negative BacteriaEnterobacteriaceaeGram-Negative Bacterial InfectionsDrug Resistance, BacterialKlebsiella InfectionsCilastatinPseudomonas InfectionsDipeptidasesAcinetobacterCross InfectionEnterobacter cloacaeCephalosporinsLactamsGlycosuria, RenalClavulanic AcidPenicillanic AcidBacterial ProteinsPorinsGram-Positive BacteriaSerratia InfectionsCeftazidimeHospitalsKlebsiella oxytocaFormularies, HospitalBacteremiaAeromonas hydrophilaPeptidyl TransferasesIntegronsElectrophoresis, Gel, Pulsed-FieldConjugation, GeneticSerratia marcescensColistinIntensive Care UnitsBacteroides fragilisDrug Resistance, MicrobialPiperacillinBacteroides InfectionsMonobactamsPlasmidsMolecular TypingDNA, BacterialAztreonamMinocyclineEscherichia coliPneumonia, Bacterialbeta-AlanineKlebsiellaCitrobacter freundiiMuramoylpentapeptide CarboxypeptidaseFluoroquinolonesHospitals, UniversityPenicillin-Binding ProteinsEnterobacter aerogenesBacterial Outer Membrane ProteinsMultilocus Sequence TypingDrug UtilizationBacteria, AnaerobicSulbactamPenicillinsAminoglycosidesDrug Resistance, MultipleStenotrophomonas maltophiliaHexosyltransferasesDisk Diffusion Antimicrobial TestsHydrolysisBacterial InfectionsGenes, BacterialIsoelectric FocusingQuinolonesGreeceMolecular Sequence DataBacterial LoadSequence Analysis, DNACefoxitinEscherichia coli InfectionsBacteria, AerobicFlavobacteriumBacteriaCephalosporin ResistancePneumonia, Ventilator-AssociatedPolymerase Chain ReactionHospitals, TeachingStructure-Activity Relationship
AntibioticsEnterobacteriaceaeCaused by carbapenem-resistantPseudomonasMeropenemIsolatesAcinetobacterErtapenemPenicillinsResistant to carbapenemsBacteriaSpread of carbapenem-resistantPatients with carbapenem-resistantBroad spectrumFluoroquinolonesPneumoniaeAntibiotic resistanceMonobactamsGenesAeruginosaAntimicrobialEnterobacteralesResistancesMechanismsDrugsMolecularHospitalsInhibitSubgroupMetalloBacterial infectionsCommonly used to treatTreatments
Antibiotics20
  • Similar to penicillins and cephalosporins, carbapenems are members of the beta-lactam antibiotics drug class, which kill bacteria by binding to penicillin-binding proteins, thus inhibiting bacterial cell wall synthesis. (wikipedia.org)
  • medical citation needed] Carbapenem antibiotics were originally developed at Merck & Co. from the carbapenem thienamycin, a naturally derived product of Streptomyces cattleya. (wikipedia.org)
  • Various types of β-lactam antibiotics, for example carbapenems, contain β-lactam rings in their structures and can be inactivated by β-lactamase enzymes. (frontiersin.org)
  • Carbapenems are strong antibiotics that are commonly used to treat serious infections. (clickpress.com)
  • Beta-lactam antibiotics include Cephalosporins, Penicillins, monobactams and Carbapenems. (clickpress.com)
  • Increase in the number of people requiring inpatient medical assistance, growing number of healthcare facilities, increased number of complex surgeries, multiple use of several antibiotics and rise in use of medical devices in the body, such as urinary catheters, intravenous catheters and ventilators, are few of the major factors responsible for growth in the Carbapenem-resistant enterobacteriaceae testing market. (clickpress.com)
  • Carbapenemases are a versatile group of Ã�-lactamases that are characterised by their resistance to virtually all Ã�-lactam antibiotics including cephalosporins and carbapenems, complicating therapy and limiting treatment options. (omicsonline.org)
  • Carbapenem class antibiotics are often used in this setting and carbapenem resistance has emerged. (eur.nl)
  • Carbapenems are last-resort antibiotics for treating severe infections caused by MDR Enterobacteriaceae [ 3 ]. (biorxiv.org)
  • Carbapenem antibiotics are atypical β-lactam antibiotics with the broadest antibacterial spectrum and the strongest antibacterial activity and have become one of the most important antibacterial drugs for the treatment of serious bacterial infections because of their stability to β-lactamases and low toxicity. (e-cspc.com)
  • Carbapenems are broad-spectrum antibiotics. (msdmanuals.com)
  • Like other beta-lactam antibiotics, carbapenems work by preventing bacteria from forming this cell wall, resulting in death of the bacteria. (msdmanuals.com)
  • Carbapenem-resistant Pseudomonas aeruginosa is defined as a textquotedblleftcriticaltextquotedblright priority pathogen for the development of new antibiotics. (pacb.com)
  • Timely identification of carbapenem-resistant organisms is crucial to orient antibiotics and save lives. (biomerieuxconnection.com)
  • Australia: New antibiotics are similar to carbapenems in terms of safety and clinical response for the treatment of complicated urinary tract infections (cUTIs), according to a recent study published in the journal Open Forum Infectious Diseases. (medicaldialogues.in)
  • This systematic review and meta-analysis by Yukiko Ezure, University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia, and colleagues evaluated the clinical efficacy and safety of carbapenems for the treatment of cUTIs with the comparators being new antibiotics evaluated for this indication. (medicaldialogues.in)
  • However, it is noteworthy that the clinical response and safety profile of new antibiotics were not different from carbapenems," concluded the authors. (medicaldialogues.in)
  • Pseudomonas aeruginosa is an opportunistic pathogen with increasing incidence of multidrug-resistant strains, including resistance to last-resort antibiotics, such as carbapenems. (unit.no)
  • The carbapenem group of antibiotics is the last resort for antibiotic-resistant infections and is approved for children. (michiganradio.org)
  • But carbapenems are not widely used because they're expensive, they're administered by IV - and doctors are concerned that bacteria could develop resistance to these antibiotics. (michiganradio.org)
Enterobacteriaceae26
  • Concern has arisen in recent years over increasing rates of resistance to carbapenems, as there are few therapeutic options for treating infections caused by carbapenem-resistant bacteria (such as Klebsiella pneumoniae and other carbapenem-resistant Enterobacteriaceae). (wikipedia.org)
  • The carbapenems imipenem and meropenem are recommended by the American Thoracic Society and the Infectious Disease Society of America as one of several first-line therapy options for people with late-onset hospital-acquired or ventilator-associated pneumonia, especially when Pseudomonas, Acinetobacter, or extended spectrum beta-lactamase producing Enterobacteriaceae are suspected pathogens. (wikipedia.org)
  • Carbapenem-resistant Enterobacteriaceae (CRE) are a major concern for patients in healthcare facilities. (cdc.gov)
  • We evaluated the number of deaths attributable to care facilities around the world ( 6 - 13 ), and in some plac- carbapenem-resistant Enterobacteriaceae by using studies es, CRE have become endemic ( 14 - 18 ). (cdc.gov)
  • DeathsAttributabletoCRE Enterobacteriaceae with susceptible isolates) were excluded, as were studies Statistical Analysis that compared patients who had carbapenem-resistant in- We calculated pooled risk ratios (RRs) and 95% CIs fections with patients who were not infected. (cdc.gov)
  • These are called Carbapenem-resistant Enterobacteriaceae. (clickpress.com)
  • Carbapenem-resistant Enterobacteriaceae Testing Market is considered to be a gram-negative pathogen testing. (clickpress.com)
  • A few infections caused by carbapenem-resistant Enterobacteriaceae outside the bowel include wound infection, urinary tract infection (UTI) and pneumonia. (clickpress.com)
  • People prone to Carbapenem-resistant enterobacteriaceae include people admitted to hospitals or other healthcare settings. (clickpress.com)
  • Carbapenem-resistant enterobacteriaceae testing includes disc diffusion or automated systems, selective agar Carbapenem-resistant enterobacteriaceae testing, minimal inhibitory concentration (MIC) for Carbapenem-resistant enterobacteriaceae testing, synergy Carbapenem-resistant enterobacteriaceae testing, modified Hodge tests, whole genome sequencing, spectrometrics and various other molecular methods. (clickpress.com)
  • People admitted to any healthcare setting for medical care are more prone to infection and to go for Carbapenem-resistant enterobacteriaceae testing than healthy people. (clickpress.com)
  • Growing awareness about prevention of Carbapenem resistance and increased efforts by governments through the implementation of infection prevention and control measures might hinder the growth of the Carbapenem-resistant enterobacteriaceae testing market during the forecast period. (clickpress.com)
  • In Carbapenem-resistant Enterobacteriaceae Testing, Modified Hodge tests are anticipated to be one of the leading test types for Carbapenem-resistant enterobacteriaceae testing because of high accuracy of test results. (clickpress.com)
  • These tests are easy to perform and can be performed in a routine laboratory, which makes them more feasible and thus, one of the leading test types in Carbapenem-resistant enterobacteriaceae testing market. (clickpress.com)
  • Healthcare settings, such as nursing homes and acute care centers, where constant medical care is required for a longer duration of time are more prone to CRE and thus, the demand for Carbapenem-resistant enterobacteriaceae testing is higher in these settings. (clickpress.com)
  • According to The Centers for Disease Control and Prevention (CDC), by 2013 Carbapenem-resistant enterobacteriaceae was found in almost 42 states. (clickpress.com)
  • CDC also stated that enterobacteriaceae proportion of Carbapenem-resistance has consistently increased and has increased four-fold in the past ten years. (clickpress.com)
  • However, the breakout of CRE in the northeast spread through the US, thereby boosting the market for Carbapenem-resistant enterobacteriaceae testing in the region. (clickpress.com)
  • The aim of this study was to characterise the molecular mechanism of resistance in the clinical isolates of Enterobacteriaceae causing bacteremia and showing resistance to β-lactams, including carbapenems. (omicsonline.org)
  • In this work, we studied the antimicrobial resistance and performed a comparative genomics analysis of ten CR- Kp isolates from the Chilean surveillance of carbapenem-resistant Enterobacteriaceae . (biorxiv.org)
  • There is no vaccine information available for Carbapenem-Resistant Enterobacteriaceae (CRE). (phila.gov)
  • There are no patient or community resources for Carbapenem-Resistant Enterobacteriaceae (CRE). (phila.gov)
  • There are no posters for Carbapenem-Resistant Enterobacteriaceae (CRE). (phila.gov)
  • Leaders in infectious disease and infection control can use this toolkit to develop interventions to control carbapenem-resistant Enterobacteriaceae (CRE). (ahrq.gov)
  • Therefore, our study aimed to describe the epidemiology and clinical characteristics of patients with carbapenem-resistant Enterobacteriaceae in a referral hospital in a developing country . (bvsalud.org)
  • Extended-spectrum beta-lactamase produc- ing Enterobacteriaceae was found in 37.5% (54) isolates and carbapenem resistant bacteria were identified in 27.8% of patients. (who.int)
Caused by carbapenem-resistant2
  • Several outbreaks caused by carbapenem-resistant Italian, Spanish, or Greek were not evaluated. (cdc.gov)
  • Conclusion High number of resistant microorganisms was isolated, and increased mortality was documented from infections caused by carbapenem-resistant bacteria. (who.int)
Pseudomonas5
Meropenem5
  • 0.10 was for infected patients from those for colonized patients and defined to indicate the presence of heterogeneity) and studies that reported on isolates resistant to a carbapenem the I 2 index (for assessing the degree of heterogeneity) other than imipenem, meropenem, or doripenem. (cdc.gov)
  • Carbapenems, including meropenem, can be used for the treatment of meningitis. (medscape.com)
  • A broad-spectrum carbapenem antibiotic, meropenem inhibits cell wall synthesis and has bactericidal activity. (medscape.com)
  • This study describes the proteomic responses of two carbapenem-resistant P. aeruginosa strains of high-risk clones ST235 and ST395 to subminimal inhibitory concentrations (sub-MICs) of meropenem by identifying differentially regulated proteins and pathways. (unit.no)
  • Sub-MICs of meropenem cause marked changes in the proteomes of carbapenem-resistant strains of P. aeruginosa exhibiting different resistance mechanisms, involving a wide range of proteins, many uncharacterized, which might play a role in the susceptibility of P. aeruginosa to meropenem. (unit.no)
Isolates11
  • Only azithromycin, members of the carbapenem class, and tigecycline remain effective against XDR isolates. (medscape.com)
  • Carbapenemases are a class of enzymes that can confer earchbasic) databases on April 9, 2012, by using the fol- resistance to carbapenems and other -lactam antibiotic lowing search terms: carbapenem-resistant or carbapen- drugs, but not all carbapenemase-producing isolates are emase-producing or KPC and outcome or mortality. (cdc.gov)
  • A total of 110 clinical isolates of A. baumannii , collected in a recent 2-year period, were tested for carbapenem antibiotic susceptibility, followed by a molecular analysis of carbapenemase genes. (frontiersin.org)
  • Sixty-seven of the 110 isolates (60.9%) were resistant to carbapenems, 80.60% (54/67) of which carried the bla OXA-23 gene. (frontiersin.org)
  • Isolates of E.coli (n=42) and K. pneumoniae (n=134) from blood culture collected during 2013-2015 were screened for carbapenemase production by using carba NP test and the presence of carbapenem resistant genes (KPC, IMP, VIM, NDM and OXA- 48 like). (omicsonline.org)
  • Detection of NDM-1 and VIM Genes in Carbapenem-Resistant Klebsiella pneumoniae Isolates from a Tertiary Health-Care Center in Kathmandu, Nepal. (tropmedres.ac)
  • Overall, AST detected 60.34% (35/58) carbapenem-resistant isolates, while the MHT phenotypically confirmed 51.72% (30/58) isolates as carbapenemase-producers and 48.28% (28/58) as carbapenemase nonproducers. (tropmedres.ac)
  • In the same assay among 28 carbapenem nonproducing isolates, 9 (32.14%) isolates were positive for blaNDM-1 gene while none of them were tested positive for blaVIM gene.ConclusionsMolecular detection of resistant genes provides greater specificity and sensitivity than those with conventional techniques, thus aiding in accurate identification of antimicrobial resistance and clinical management of the disease. (tropmedres.ac)
  • Almost all carbapenem-resistant isolates were sporadic cases of hyperproduction of a beta-lactamase (AmpC or ESBL) combined with porin loss. (unboundmedicine.com)
  • The modified Hodge test was used to identify carbapenem-resistant isolates, which detects the probability of isolates being able to produce carbapenemases enzyme and out of the isolates, 11 (33.3%) were Hodge positive. (edu.iq)
  • The bla IMP gene (578 bp) was the most frequently detected MBL gene, being present in 15 (45.5%) of the carbapenem-resistant isolates. (edu.iq)
Acinetobacter5
Ertapenem6
  • The carbapenem ertapenem is one of several first-line agents recommended by the Infectious Disease Society of America for the empiric treatment of community-acquired intra-abdominal infections of mild-to-moderate severity. (wikipedia.org)
  • Towards optimizing carbapenem selection in stewardship strategies: a prospective propensity score-matched study of ertapenem versus class 2 carbapenems for empirical treatment of third-generation cephalosporin-resistant Enterobacterales bacteraemia. (altmetric.com)
  • Selecting ertapenem has been proposed as a strategy to reduce carbapenem resistance development. (altmetric.com)
  • To compare the efficacy of empirical ertapenem and class 2 carbapenems for the treatment of 3GCRE bacteraemia. (altmetric.com)
  • Empirical carbapenems were prescribed in 427/1032 (41%) patients with 3GCRE bacteraemia, of whom 221 received ertapenem and 206 received class 2 carbapenems. (altmetric.com)
  • Ertapenem may be of comparable efficacy to class 2 carbapenems in the empirical treatment of 3GCRE bacteraemia. (altmetric.com)
Penicillins3
Resistant to carbapenems3
  • Background: To investigate the resistance mechanism of Klebsiella pneumoniae (Kpn) resistant to carbapenems. (biomedres.info)
  • Six isolated strains were identified and collected, which were resistant to carbapenems using modified Hodge test. (biomedres.info)
  • Another example is the proportion of K pneumoniae , which are resistant to carbapenems. (medscape.com)
Bacteria6
  • Carbapenems are less commonly used in the treatment of community-acquired pneumonia, as community-acquired strains of the most common responsible pathogens (Streptococcus pneumoniae, Haemophilus influenazae, atypical bacteria, and Enterobactericeace) are typically susceptible to narrower spectrum and/or orally administered agents such as fluoroquinolones, amoxicillin, or azithromycin. (wikipedia.org)
  • Carbapenems exhibit broad spectrum activity against gram-negative bacteria and somewhat narrower activity against gram-positive bacteria. (wikipedia.org)
  • The spectrum of activity of the carbapenems against gram-positive bacteria is fairly broad, but not as exceptionally so as in the case of gram-negative bacteria. (wikipedia.org)
  • The emergence and spread of carbapenem-hydrolysing ß-lactamases amongst gram-negative bacteria over the past decade represents a serious issue in the hospital environment. (aid-diagnostika.com)
  • Modifiable risk factors associated with later gut decolonization of carbapenem-resistant Gram-negative bacteria in children: A prospective cohort study. (qxmd.com)
  • Age 65 years, presence of septic shock, and presence of carbapenem-resistant bacteria were independently associated with in- creased in-hospital mortality. (who.int)
Spread of carbapenem-resistant2
  • With the global spread of carbapenem-resistant organisms, there is an urgent need for new treatment options. (doe.gov)
  • This study evaluated the clonal spread of carbapenem-resistant P. aeruginosa producing SPM-1 type metallo-beta-lactamase (MBL), at the university hospital of Florianopolis, Santa Catarina, Brazil, compared to an epidemic clone previously reported, as well as strains collected in other three Brazilian states. (unifesp.br)
Patients with carbapenem-resistant2
  • Serious concur- fromaroundtheworldpublishedbeforeApril9,2012.At- rent conditions ( 3 , 4 , 19 - 22 ) and prior use of fluoroquino- tributabledeathwasdefinedasthedifferenceinall-cause lones ( 20 , 23 , 24 ), carbapenems ( 22 , 25 ), or broad-spectrum deaths between patients with carbapenem-resistant infec- cephalosporins ( 20 , 22 ) have been independently associated tions and those with carbapenem-susceptible infections. (cdc.gov)
  • Epidemiology and clinical characteristics of patients with carbapenem-resistant enterobacterales infections: experience from a large tertiary care center in a developing country. (bvsalud.org)
Broad spectrum2
  • Because of its weak hydrolytic acivity against broad spectrum cephalosporin and carbapenems, these may go undetected in routine screening. (omicsonline.org)
  • Purpose We aimed to assess broad-spectrum beta-lactam prescriptions (except carbapenems) and the impact of controlled dispensing, antimicrobial management team and antibiotic treatment reassessment in 48-72 hours. (bmj.com)
Fluoroquinolones6
Pneumoniae7
  • Multidrug and carbapenem-resistant K. pneumoniae (CR- Kp ) are considered critical threats to global health and key traffickers of resistance genes to other pathogens. (biorxiv.org)
  • Multidrug-resistant (MDR) and hypervirulent Klebsiella pneumoniae , particularly carbapenem-resistant strains (CR- Kp ) causing high mortality and morbidity, are critical concerns[ 1 ]. (biorxiv.org)
  • The most concerning carbapenem resistance mechanism corresponds to carbapenem-inactivating beta-lactamases, especially the K. pneumoniae carbapenemase (KPC) distributed worldwide, showing the highest prevalence. (biorxiv.org)
  • The main objective of this study was to detect the carbapenem-resistant genes blaNDM-1 and blaVIM in K. pneumoniae isolated from different clinical specimens.MethodsA total of 585 clinical specimens (urine, pus, sputum, blood, catheter tips, and others) from human subjects attended at Annapurna Neurological Institute and Allied Sciences, Kathmandu were obtained in the period between July 2018 and January 2019. (tropmedres.ac)
  • Conclusion: We thought that the key factor of the resistance mechanism to carbapenem for Klebsiella pneumoniae maybe these pathogens contain blaKPC-2 gene. (biomedres.info)
  • If you take the K pneumoniae resistance to carbapenems, for example, which is under 1% in Germany, then this is actually comparable in almost every country in northwest Europe," said Eckmanns. (medscape.com)
  • KPC prévalence de la non sensibilité à l'ertapénème dans un hôpital de soins tertiaires en Égypte était principalement imputable aux mécanismes de résistance médiés par les carbapénèmases dans les isolats de K. pneumoniae . (who.int)
Antibiotic resistance3
  • Furthermore, carbapenems are typically unaffected by emerging antibiotic resistance, even to other beta-lactams. (wikipedia.org)
  • It is generally believed that OXA-23 is responsible for carbapenem antibiotic resistance. (frontiersin.org)
  • To understand the main determinants behind worldwide antibiotic resistance dynamics, scientists from the Institut Pasteur, Inserm, Université de Versailles Saint-Quentin-en-Yvelines and Université Paris-Saclay developed a statistical model based on a large-scale spatial-temporal analysis. (pasteur.fr)
Monobactams1
Genes1
  • strain CCUG 70744 carries no known acquired carbapenem-resistance genes and exhibits 'non-classical' carbapenem-resistance. (unit.no)
Aeruginosa1
  • En comparaison avec d'autres études, la prévalence de P. Aeruginosa dans les piscines était relativement faible, et le profil d'antibiorésistance de ces isolats communautaires était peu élevé. (who.int)
Antimicrobial1
  • Of particular concern is resistance to carbapenem, which is an antimicrobial agent listed as critically important by the World Health Organization. (doe.gov)
Enterobacterales3
  • Third-generation cephalosporin-resistant Enterobacterales (3GCRE) are increasing in prevalence, leading to greater carbapenem consumption. (altmetric.com)
  • Carbapenem-resistant Enterobacterales has been found in Texas. (texas.gov)
  • Carbapenem -resistant Enterobacterales (CREs) are a significant source of healthcare -associated infections . (bvsalud.org)
Resistances1
  • The analysis of global data for the period 2006-2019 initially revealed an increase in resistance to carbapenems for several species, although global trends were stable for other resistances. (pasteur.fr)
Mechanisms1
  • reported the dissemination of MDR OXA-23-producing A. baumannii clones throughout multiple cities in China, but little is known about the molecular mechanisms of resistance to carbapenems in western China. (frontiersin.org)
Drugs1
  • We feel it is likely that drugs with antianaerobic activity, like carbapenems, have a deleterious effect on the vaginal flora. (medicaldialogues.in)
Molecular1
  • The above illustration depicts a molecular model for a carbapenem drug. (michiganradio.org)
Hospitals2
  • Adult patients with monomicrobial 3GCRE bacteraemia receiving carbapenems within 24 h were included at two hospitals in Thailand. (altmetric.com)
  • the finding of a unique SPM-1 producer clone suggests that its dissemination has contributed to the high resistance to carbapenems in Brazilian hospitals. (unifesp.br)
Inhibit1
Subgroup1
  • THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain. (wakehealth.edu)
Metallo1
  • Resistance to carbapenem is mostly conferred by metallo β-lactamase (IMP, VIM and NDM) and carbapenem hydrolyzing class D β-lactamase (OXA-48 like). (omicsonline.org)
Bacterial infections2
Commonly used to treat1
  • Carbapenems are a type of antibiotic commonly used to treat severe infections. (texas.gov)
Treatments4
  • For bloodstream infections known to be due to extended spectrum beta-lactamase producing Enterobacteriaceace, carbapenems are superior to alternative treatments. (wikipedia.org)
  • But neww antibiotic treatments showed a superior microbiological response compared to carbapenems.This systematic review and. (medicaldialogues.in)
  • A pooled estimate examining clinical response alone showed no difference between treatment arms (RR=1.00), however, new antibiotic treatments were superior to carbapenems for microbiological response (RR=0.85). (medicaldialogues.in)
  • New antibiotic treatments demonstrated a superior microbiological response compared to carbapenems in clinical trials of cUTI, despite an absence of carbapenem resistance. (medicaldialogues.in)