• Be sure to mention any of the following: carbachol (Miostat) or pilocarpine (Isopto Carpine, Salagen). (medlineplus.gov)
  • Cyclopentolate may interfere with the ocular anti-hypertensive action of carbachol, pilocarpine, or ophthalmic cholinesterase inhibitors. (nih.gov)
  • May interfere w/ ocular antihypertensive action of carbachol, pilocarpine, or ophthalmic cholinesterase inhibitors. (mims.com)
  • Carbachol, also known as carbamylcholine and sold under the brand name Miostat among others, is a cholinomimetic drug that binds and activates acetylcholine receptors. (wikipedia.org)
  • Carbachol is not easily metabolized by cholinesterase, it has a 2 to 5 minute onset of action and its duration of action is 4 to 8 hours with topical administration and 24 hours for intraocular administration. (wikipedia.org)
  • We are manufacturers and exporters of Optichol- 0.01 Carbachol Intraocular Solution use for obtaining miosis during surgery. (disposablesurgicalproducts.com)
  • Our customers ca avail these Carbachol Intraocular Solution from us at reasonable prices. (disposablesurgicalproducts.com)
  • The S-S reducing agent, dithiothreitol (DTT) altered the properties of nicotinic receptors in rat superior cervical ganglia such that (i) carbachol became less active as a depolarizing agent and (ii) bromo- acetylcholine produced an irreversible depolarization. (ox.ac.uk)
  • They show that treating cultured mouse neurons expressing human APP with the acetylcholine receptor agonist carbachol increased the production of α-secretase cleavage products, but no such effect occurred in cells from M1 knockout mice. (alzforum.org)
  • The muscarinic receptor agonist carbachol competed for [3H]QNB and [3H]PZ binding with a Hill slope of less than 1 in cerebral cortex, but not in cerebellum. (unboundmedicine.com)
  • Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs). (wikipedia.org)
  • These results indicate that carbachol mimics some of the effects of light on the circadian system in the Djungarian hamster and support the hypothesis that cholinergic mechanisms may play a role in mediating some of the phase-shifting effects of light on the circadian clock of mammals. (northwestern.edu)
  • To examine the influence of autonomic receptor stimulation and blockade (noradrenaline, prazosin, terbutaline, propranolol, carbachol and atropine), and of pudendal nerve blockade on urethral stress relaxation. (nih.gov)
  • Carbachol is a parasympathomimetic that stimulates both muscarinic and nicotinic receptors. (wikipedia.org)
  • Use of carbachol, as well as all other muscarinic receptor agonists, is contraindicated in patients with asthma, coronary insufficiency, gastroduodenal ulcers, and incontinence. (wikipedia.org)
  • In addition, Davis and coworkers show that treating neurons from M1 knockout mice with carbachol increased Aβ production, probably via stimulation of other non-M1 muscarinic receptor subtypes. (alzforum.org)
  • Carbachol is a choline carbamate and a positively charged quaternary ammonium compound. (wikipedia.org)
  • Carbachol may be prepared in a 2 step process beginning with the reaction of 2-chloroethanol with urea to form a 2-chloroethyl-carbamate, which is then quaternised by a reaction with trimethylamine. (wikipedia.org)
  • Expressing M1 receptor in knockout cells restored carbachol-induced α-secretase processing. (alzforum.org)
  • GTP did not alter the interactions of carbachol or oxotremorine with the solubilized receptor. (unboundmedicine.com)
  • Carbachol has shown prolonged sweat stimulation in directly stimulated regions for five hours or longer. (rsc.org)
  • Since carbachol is poorly absorbed through topical administration, benzalkonium chloride is mixed in to promote absorption. (wikipedia.org)
  • A recent review indicates that carbachol is a strong promoter of ICC activity, which is mediated through the calcium-activated chloride channel, anoctamin 1. (wikipedia.org)
  • Carbachol is primarily used in the treatment of glaucoma, but it is also used during ophthalmic surgery. (wikipedia.org)
  • Carbachol may be used also in treatment of glaucoma. (pharmacology2000.com)
  • A specific and time-dependent association of tubulin with plasma membranes was observed when SK-N-SH cells were treated with carbachol. (jneurosci.org)
  • In SK-N-SH cells, carbachol induced a rapid and transient translocation of tubulin to the plasma membrane, microtubule reorganization, and a change in cell shape as demonstrated by confocal immunofluorescence microscopy. (jneurosci.org)
  • In the cat and rat, carbachol is well known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. (wikipedia.org)
  • No consistent phase shifts were observed in response to carbachol injections at other circadian times. (northwestern.edu)
  • Response was measured as a percent of maximal carbachol contraction. (cdc.gov)
  • Both the carbachol PRC and the PRC for light pulses in the Djungarian hamster have phase delay regions in the early subjective night. (northwestern.edu)
  • Concurrent stimulation with carbachol and morphine promoted MOP receptor internalization, desensitization and down-regulation and this facilitation was not dependent on PKC activation. (gla.ac.uk)
  • The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. (nih.gov)
  • In addition, carbachol, 0.01%, is an effective hypotensive drug that lowers intraocular pressure (IOP) during the crucial 24-hour period after surgery. (aao.org)
  • CARBASTAT ® (Carbachol Intraocular Solution, USP) 0.01% is a sterile balanced salt solution of carbachol for intraocular injection. (nih.gov)
  • In addition, Carbastat ® (Carbachol Intraocular Solution USP) reduces the intensity of intraocular pressure elevation in the first 24 hours after cataract surgery. (nih.gov)
  • Use of carbachol, as well as all other muscarinic receptor agonists, is contraindicated in patients with asthma, coronary insufficiency, gastroduodenal ulcers, and incontinence. (wikipedia.org)
  • Because there is a direct relationship between phosphatidylinositol (PI) metabolism and airway smooth muscle contraction induced by muscarinic agonists, the authors examined the effects of carbachol (CCh), norepinephrine (NE), and hypocapnia on PI turnover in the airway smooth muscle. (silverchair.com)
  • IP3-mediated Ca2+ release also was observed in the presence of the metabotropic agonists t-ACPD and carbachol when backpropagating spikes were generated. (nih.gov)
  • Carbachol is primarily used in the treatment of glaucoma, but it is also used during ophthalmic surgery. (wikipedia.org)
  • No information is available on the use of carbachol ophthalmic drops during breastfeeding. (nih.gov)
  • Carbachol is a prescription medication used to constrict the pupil and lower eye pressure during surgery as well as reduce the pressure elevation in the eye after cataract surgery. (rxwiki.com)
  • Response was measured as a percent of maximal carbachol contraction. (cdc.gov)
  • To evaluate safety and efficacy, Dr Abdelkader compared the combination of carbachol and brimonidine with placebo in two groups of patients with emmetropic presbyopia. (medscape.com)
  • In the first group, the nondominant eye of 30 patients was treated with a combination of 2.25% carbachol plus 0.2% brimonidine, and of 18 patients was treated with placebo. (medscape.com)
  • In the second group, 10 patients received 3% carbachol, 0.2% brimonidine, a combination of the two, or placebo. (medscape.com)
  • From these results, Dr Abdelkader determined that the optimal formula is a combination of carbachol and brimonidine. (medscape.com)
  • The people who received the carbachol and brimonidine combination said they liked it and would use it as a therapy if it were available. (medscape.com)
  • Carbachol is a parasympathomimetic that stimulates both muscarinic and nicotinic receptors. (wikipedia.org)
  • Carbachol is also available as an injection and is given into the eye during the eye procedure. (rxwiki.com)
  • Notably, retinas from rats treated with a single subcutaneous injection of 100 mg/kg fenthion showed decreases in carbachol-stimulated release of inositol phosphate, an indicator of cholinergically-mediated intracellular second messenger systems. (epa.gov)
  • The cholinergic agonist carbachol, after 24 h in vitro, increased the length of the axon, without affecting the length of minor neurites. (nih.gov)
  • Carbachol eyedrops are used to decrease the pressure in the eye for people with glaucoma. (wikipedia.org)
  • Carbachol is also used to treat glaucoma. (rxwiki.com)
  • Effects of Helicobacter pylori on histamine and carbachol stimulated acid secretion by human parietal cells. (bmj.com)
  • Bronchospasms occur in instances of high levels of carbachol or potassium, which are able to cause tracheal tissue contractions by simultaneously opening L-type calcium channels and stimulating muscarinic receptors. (discovermagazine.com)
  • The effect of carbachol was mediated by the M(1) subtype of muscarinic receptors. (nih.gov)
  • C7/3-phth also produced supra-additive inhibition of the negative inotropic effects of carbachol when combined with NMS. (aspetjournals.org)
  • 8. Carbachol alleviates myocardial injury in septic rats through PI3K/AKT signaling pathway. (nih.gov)
  • Moreover, cardamom extracts were observed to relax carbachol- and potassium-induced contractions in tracheal tissues [2], effectively relieving bronchospasms in asthma attacks. (discovermagazine.com)
  • carbachol and potassium interaction with these signaling pathways leads to airway constrictions. (discovermagazine.com)
  • In the study, cardamom showed inhibitory effects against carbachol and potassium, enabling relaxation of the contracted tissues. (discovermagazine.com)
  • Side effects such as flushing, sweating, epigastric distress, abdominal cramps, tightness in urinary bladder, and headache have been reported with topical or systemic application of carbachol. (nih.gov)
  • Serious side effects have been reported with carbachol. (rxwiki.com)
  • This is not a complete list of carbachol side effects. (rxwiki.com)
  • Effects of in vivo ischemia on contractile responses of rabbit bladder to field stimulation, carbachol, ATP and KCl. (upstate.edu)
  • The main differences between waves in neocortical neurons and in previously described hippocampal pyramidal neurons were, (a) Ca2+ waves in L5 neurons could be evoked further out along the main shaft, (b) Ca2+ waves extended slightly further out into the oblique dendrites and (c) higher concentrations of bath-applied t-ACPD and carbachol were required to generate Ca2+ release events by backpropagating action potentials. (nih.gov)
  • Carbachol-induced axonal growth was also observed in pyramidal neurons from the neocortex but not in granule neurons from the cerebellum. (nih.gov)
  • Carbachol constricts the pupil during medical procedures. (rxwiki.com)
  • During either generalized forebrain activation or selective thalamic activation caused by carbachol infusion in the VPM, the responses to AWs enhance so that VPM receptive fields become much larger. (nih.gov)
  • In addition, down-regulation of ERK1/2 with small interfering RNA abolished the neuritogenic effect of carbachol. (nih.gov)
  • Patients who received carbachol monotherapy experienced a drop to a little above 5 in the first hour, which rose to just above 7 at 8 hours. (medscape.com)
  • A "mild burning sensation" was reported by some subjects in each of the groups, including the placebo group, but most frequently in the carbachol monotherapy group. (medscape.com)
  • Carbachol belongs to a group of medications called cholinergics. (rxwiki.com)
  • Carbachol can also be used to stimulate bladder emptying to treat the condition of underactive bladder. (wikipedia.org)
  • Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs). (wikipedia.org)
  • Inward cationic current was activated by the application of 50 pM carbachol (I(CCh)) at a holding potential of -60 mV with the same CsCl-rich solution in both pipette and bath. (ewha.ac.kr)