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  • years
  • In recent years the role of HPV in other cancers has been increasingly recognized which has facilitated a shift towards vaccinating a wider population, most significant has been the inclusion of males in routine vaccine recommendations in some countries. (pitchengine.com)
  • Biologics
  • Genetic Immunity works to create and commercialize immunotherapeutic biologics to treat chronic viral infections, allergies, and cancers to prolong the life of the patient and improve their quality of life. (wikipedia.org)
  • viruses
  • Some types of cancer , such as cervical cancer and some liver cancers , are caused by viruses (oncoviruses). (wikipedia.org)
  • This only works in developing vaccines against viruses. (medicalnewstoday.com)
  • The potential of viruses as anti-cancer agents was first realised in the early twentieth century, although coordinated research efforts did not begin until the 1960s. (wikipedia.org)
  • A connection between cancer regression and viruses has long been theorised, and case reports of regression noted in cervical cancer, Burkitt lymphoma and Hodgkin lymphoma, after immunisation or infection with an unrelated virus appeared at the beginning of the 20th century. (wikipedia.org)
  • Herpes simplex virus (HSV) was one of the first viruses to be adapted to attack cancer cells selectively, because it was well understood, easy to manipulate and relatively harmless in its natural state (merely causing cold sores) so likely to pose fewer risks. (wikipedia.org)
  • development
  • A cancer vaccine is a vaccine that either treats existing cancer or prevents development of a cancer. (wikipedia.org)
  • The conference will also aim to provide solutions to circumvent the challenges which face the development of successful targeted cancer treatments, within a competitive and important market. (smi-online.co.uk)
  • Currently, Dr. Riolobos is working with the CVI on the development and characterization of vaccines for lung cancers. (washington.edu)
  • GlaxoSmithKline also has a slightly different HPV vaccine in development. (redorbit.com)
  • Salem's research interests include nanotechnology, microfabrication, particle and drug delivery systems, implantable chips, the design of gene delivery systems, regenerative medicine, and the development of vaccines. (wikipedia.org)
  • Lewis' research has contributed to the development of innovative cancer treatments and treatment approaches. (wikipedia.org)
  • the very frequent development of an immune response, while harmless to the patient, destroyed the virus and thus prevented it from destroying the cancer. (wikipedia.org)
  • autologous
  • Some/many of the vaccines are "autologous", being prepared from samples taken from the patient, and are specific to that patient. (wikipedia.org)
  • immunity
  • The main goal of the therapeutic vaccines is to elicit cellular immunity. (wikipedia.org)
  • HPV immunity is type-specific, so a successful series of Cervarix shots will not block infection from cervical cancer-causing HPV types other than HPV types 16 and 18 and some related types, so experts continue to recommend routine cervical Pap smears even for women who have been vaccinated. (wikipedia.org)
  • Therapeutics
  • Salem is currently the leader of the Experimental Therapeutics (ET) program at the Holden Comprehensive Cancer Center and co-director of the Nanotoxicology Core at the Environmental Health Sciences Research Center. (wikipedia.org)
  • Lewis was a Professor of Surgery and Medicine Memorial Sloan-Kettering Cancer Center, before working in the biotechnology industry, first as chief medical officer of Antigenics, then as chairman and chief executive officer of ZIOPHARM Oncology, Inc. He is currently chairman of the Molecular Ninja Group and chief executive officer of Samus Therapeutics. (wikipedia.org)
  • tumour
  • Whole tumour vaccines use the whole cancer cell, not just an antigen, to make the vaccine. (cancer.ca)
  • As the infected cancer cells are destroyed by oncolysis, they release new infectious virus particles or virions to help destroy the remaining tumour. (wikipedia.org)
  • The herpes simplex virus type 1 (HSV-1) mutant 1716 lacks both copies of the ICP34.5 gene, and as a result is no longer able to replicate in terminally differentiated and non-dividing cells but will infect and cause lysis very efficiently in cancer cells, and this has proved to be an effective tumour-targeting strategy. (wikipedia.org)
  • In a wide range of in vivo cancer models, the HSV1716 virus has induced tumour regression and increased survival times. (wikipedia.org)
  • biomarkers
  • After graduation, she worked as a Research scientist at Protein Alternatives in Madrid where she optimized the Phage Display technology to obtain specific antibodies against colorectal cancer biomarkers. (washington.edu)
  • Cervarix
  • The 3 HPV vaccines available in Canada are Gardasil, Cervarix and Gardasil 9. (cancer.ca)
  • Cervarix is a vaccine against certain types of cancer-causing human papillomavirus (HPV). (wikipedia.org)
  • Cervarix is designed to prevent infection from HPV types 16 and 18, that cause about 70% of cervical cancer cases. (wikipedia.org)
  • Cervarix is a preventative HPV vaccine, not therapeutic. (wikipedia.org)
  • Cervarix is indicated for the prevention of the following diseases caused by oncogenic HPV types 16 and 18: cervical cancer, cervical intraepithelial neoplasia (CIN) grade 2 or worse and adenocarcinoma in situ, and CIN grade 1. (wikipedia.org)
  • The active components of the vaccine are: Human Papillomavirus type 16 L1 protein 20 micrograms Human Papillomavirus type 18 L1 protein 20 micrograms AS04 adjuvant, containing: 3-O-desacyl-4'- monophosphoryl lipid A (MPL) 50 micrograms adsorbed on aluminium hydroxide, hydrated (Al(OH)3) 0.5 milligrams Al 3+ in total Cervarix is created using the L1 protein of the viral capsid. (wikipedia.org)
  • Subsequent studies showed Cervarix generated higher antibody levels than Gardasil, the other commercially available HPV vaccine, upon testing seven months later, with twice the level for HPV type 16 and six times for HPV type 18. (wikipedia.org)
  • Therapy
  • Farzin has published over 200 scientific papers and two edited books on the Functional Analysis of the Genome and Cancer Gene Therapy. (smi-online.co.uk)
  • In my opinion, what is most exciting is that there is no reason that this approach to tumor therapy is limited to any particular kind of cancer," he said. (innovations-report.com)
  • His research has also focused on monocytic-myeloid derived suppressor cells and polymorphonuclear-myeloid derived suppressor cells and what impact they might have on cancer therapy, since myeloid derived suppressor cells negatively regulate anti-tumor activity. (wikipedia.org)
  • The topical DermaVir vaccine is an improvement upon the ex vivo dendritic cell- based immunization that could offer a new alternative therapy for patients with HIV. (wikipedia.org)
  • Lewis has authored over 200 scientific publications, which include work in the biology and treatment of sarcoma, the biology and treatment of pancreatic cancer, molecular cancer vaccines, gene therapy and the translation of laboratory findings to the clinic, in addition to writing chapters or sections in 15 textbooks. (wikipedia.org)
  • breast
  • Aliasger Salem has been or is a member of a number of grant review study sections including panels for the American Cancer Society, the National Institutes of Health, the National Science Foundation, and the Department of Defense (DoD): Congressionally Directed Medical Research Programs (CDMRP) Prostate and Breast Cancer Research Programs. (wikipedia.org)
  • The acquisition included the breast cancer drug NeuVax. (wikipedia.org)
  • infection
  • This is because genital wart infection takes a while to cause cancer. (redorbit.com)
  • Efforts to treat cancer through immunisation or virotherapy (deliberate infection with a virus), began in the mid-20th century. (wikipedia.org)
  • prostate
  • It received U.S. Food and Drug Administration (FDA) approval for use in the treatment of advanced prostate cancer patients on April 29, 2010. (wikipedia.org)
  • An international team of scientists has used DNA from healthy cells have been used to create a cancer vaccine to treat prostate tumours. (theconversation.com)
  • Institute
  • Prior to joining The Wistar Institute, Gabrilovich was a senior member at the Moffitt Cancer Center in Tampa. (wikipedia.org)
  • During her time working at the National Cancer Institute she was the Head of the Antiviral Unit at the Laboratory of Tumor Cell Biology. (wikipedia.org)